C19-diterpenoid alkaloid, preparation method of C19-diterpenoid alkaloid, medical composite with C19-diterpenoid alkaloid used as active ingredient and application of medical composite

Abstract

The invention relates to C19-diterpenoid alkaloid which has cardiotonic and hart failure-resistance activities and is shown in the formula I, pharmaceutically acceptable salts of the C19-diterpenoid alkaloid, preparation methods of the C19-diterpenoid alkaloid and the salts, and medicines containing the C19-diterpenoid alkaloid and the salts, as well as application of the C19-diterpenoid alkaloid and the salts as medicines with cardiotonic and hart failure-resistance effects. In the formula I, R1 is hydrogen, hydroxyl or methoxyl; R2 is hydrogen or methyl; and R3, R4 and R5 represent hydrogen or hydroxyl.

Description

Technical field: The present invention relates to C with medicinal value 19 - Diterpene alkaloids N-desethylaconitine, bucurine, N-desethylaconine and isodelnine and their homologues. They are isolated from aconitine or prepared semi-synthetically from aconitine. The present invention also relates to two C 19 - Unine and subunine among the diterpene alkaloids. They are prepared by semi-synthesis from aconitine which is isolated from the plant aconitum. At the same time, a preparation method of the above compound and a pharmaceutical composition using the compound as an active ingredient are disclosed. The invention belongs to the technical field of extraction and preparation of active ingredients of natural medicines. Background technique: Aconitum carmichaeli Debx., a traditional Chinese medicine, is a processed product of the root of the ranunculaceae plant Aconitum carmichaeli Debx. It has the function of recovering yang and rescuing adversity, tonifying fire and ...

AI Technical Summary

Problems solved by technology

However, no diterpene alkaloid compounds isolated from aconite have been reported to have cardiotonic effects