Intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome

A sleep apnea and rat model technology, applied in the field of medical experiments, can solve the problem of lack of animal models of OSAHS in children

Inactive Publication Date: 2012-03-28
SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0003] The purpose of the present invention is to provide a kind of children's obstructive sleep apnea hypopnea syndrome intermittent hypoxia rat model, to solve the defect that lacks children's OSAHS animal model in the prior art

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  • Intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome
  • Intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome

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Embodiment Construction

[0016] The present invention will be further described below in conjunction with accompanying drawing.

[0017] Children's obstructive sleep apnea hypopnea syndrome intermittent hypoxia rat model comprises box body (9), and the inner cavity of box body (9) is divided into three cavities by door A15, door B19, partition A17 and partition B21, Namely: the hypoxic chamber 3, the transition chamber 5 and the animal chamber 7, the three cavities are relatively airtight; the door A15 and the door B19 are respectively provided with a sling A16 and a sling B20, and the sling A16 and the sling B20 are connected with the motor A6 and the motor B4 respectively. The power output shafts are connected, and the motor A6 and the motor B4 can rotate forward or reversely, thereby driving the door A15 and the door B19 to rise or fall, and guide grooves can also be set at the places where the two sides of the door A15 and the door B19 are in contact with the box body; The bottom of the body (9) i...

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Abstract

The invention discloses an intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome, which belongs to an experimental apparatus in medical experimental field and solves the shortcomings of the current intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome, comprising a box body, wherein a partition A, a partition B, a door A and a door B are arranged in the box body. The inner cavity of the box body is divided into a hypoxia chamber, a transition chamber and an animal chamber. The animal chamber communicates with air, and the door A and door B can slide upwards and downwards to open. An animal breeding box is arranged in the box body, and the animal breeding box can move leftwards and rightwards. The hypoxia chamber is provided with a nitrogen valve and a oxygen concentration sensor. The invention is mainly applied to the animal experiments in the medical field.

Description

technical field [0001] The invention belongs to an experimental device in the field of medical experiments, and in particular relates to a rat model of children obstructive sleep apnea hypopnea syndrome intermittent hypoxia. Background technique [0002] Obstructive sleep apnea hypopnea syndrome (OSAHS) in children is a relatively common disease in childhood. Children with OSAHS are characterized by frequent partial or total upper airway obstruction during sleep, causing hypoventilation or temporary cessation of ventilation, disrupting children's normal ventilation and sleep structure and causing a series of pathophysiological changes. Long-term sleep apnea and hypoventilation may cause growth retardation, mental retardation, abnormal psychological behavior, conductive deafness, facial deformities and even changes in heart function in children. However, the current domestic and foreign research on OSAHS in children is still in the clinical trial stage. Due to the limitation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K1/03A01K1/035
Inventor 侯瑾闫静康全清
Owner SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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