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New application of disaccharide compound
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A compound and application technology, applied in the field of disaccharide compounds, to improve the quality of life, enhance biological activity, and improve immune function
Inactive Publication Date: 2013-03-27
LUZHOU MEDICAL COLLEGE
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[0008] This compound was first found in Rhodiola angustifolia, at present, only the extraction method [Helmut Wiedenfeld, Monika Zych, Waldemar, et al.Newcompounds from Rhodiola kirilowii.Scientia Pharmaceutical.75,29-34(2007) of this compound has been reported in the literature )], there is no relevant report on the pharmacodynamic effect of the disaccharide compound
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Embodiment 1
[0024] Embodiment 1 The preparation method of formula 1 compound of the present invention
[0025] 10kg of coarse powder of Radix isatidis, soaked in 50% ethanol for 1 hour, and refluxed for 3 times, 1 hour each time. The extracts were combined, the ethanol was recovered under reduced pressure until there was no alcohol smell, vacuum-dried at 50° C., and pulverized to obtain 1560 g of dry extract powder of the crude extract, with a yield of 15.6%. Take 500g of crude extract dry extract powder and extract with 95% ethanol under reflux for 3 times, each time for 1 hour, filter, combine the extracts, recover ethanol under reduced pressure until there is no alcohol smell, vacuum dry at 50°C, and crush to obtain Radix Radix dry infusion Paste powder 168g, the yield is 5.2%.
[0026] The dry extract powder of Radix isatidis was separated by dry column chromatography on a silica gel column, eluted with dichloromethane-methanol (100:0-1:1) gradient, checked by thin-layer chromatograp...
Embodiment 2
[0033] The preparation of embodiment 2 pharmaceutical compositions of the present invention
[0034] Take the compound of formula 1 prepared in Example 1, mix evenly with an appropriate amount of microcrystalline cellulose, and directly pack into capsules to obtain the capsules of the pharmaceutical composition of the present invention.
Embodiment 3
[0035] The preparation of embodiment 3 pharmaceutical composition of the present invention
[0036] Take the compound of formula 1 prepared in Example 1, mix evenly with appropriate amount of sucrose and starch, use 80% ethanol as binder, and granulate to obtain the pharmaceutical composition granules of the present invention.
[0037] The beneficial effect of the compound of formula 1 is demonstrated by specific test examples below.
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Abstract
The invention provides new application of disaccharide compound which has a formula I to the preparation of medicament for resisting the tumor and the virus or enhancing the immunity. The compound which has the formula I is the same as sucrose in the structure and is the simple disaccharide compound. After entering the human body, the disaccharide compound can exert strong biological activity and can effectively inhibit the growth of the tumor; the disaccharide compound has obvious tumor resisting effect, can enhance the immunity of the body of the normal people and the body of the patient, can be used for treating with chemotherapy and can improve the immune function of the patient treated with chemotherapy so as to improve the life quality of the patient; and the disaccharide compound can effectively inhibit the growth of influenza A (H3N2) virus and has the obvious influenza virus resisting effect.
Description
technical field [0001] The invention relates to a new application of a disaccharide compound. Background technique [0002] Disaccharides are formed by two molecules of monosaccharides through glycosidic bonds. After hydrolysis, two monosaccharide molecules can be formed. Naturally occurring free and functional sugars are represented by lactose in mammals, trehalose in bacteria and insect blood, and plant sucrose. They are used as energy sources for various organisms, or as raw materials for organisms. [0003] Common disaccharides include lactose, maltose, and sucrose. Among them, sucrose is formed from a molecule of glucose and a molecule of fructose. After entering the human body, it is decomposed into glucose and fructose to provide energy for the human body. [0004] At present, another disaccharide compound similar to sucrose structure is found, which is also formed by condensation of one molecule of fructose and one molecule of glucose, that is, β-fructopyranose-(1→4...
Claims
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Application Information
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