Dual inhibitors of met and vegf for the treatment of castration resistant prostate cancer and osteoblastic bone metastases

A technology for castration resistance and prostate cancer, which is applied in the direction of anti-inflammatory agents, organic active ingredients, non-central analgesics, etc., and can solve the problem of limited improvement of survival period

Inactive Publication Date: 2013-11-13
EXELIXIS INC
View PDF46 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite advances in systemic therapy for CRPC, improvements in survival remain limited and nearly all patients die from the disease, with a median survival of approximately 2 years

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dual inhibitors of met and vegf for the treatment of castration resistant prostate cancer and osteoblastic bone metastases
  • Dual inhibitors of met and vegf for the treatment of castration resistant prostate cancer and osteoblastic bone metastases
  • Dual inhibitors of met and vegf for the treatment of castration resistant prostate cancer and osteoblastic bone metastases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0164] In one embodiment, the compound of formula I is a compound of formula Ia:

[0165]

[0166] Formula Ia

[0167] or a pharmaceutically acceptable salt thereof, wherein:

[0168] R 1 is a halo group;

[0169] R 2 is a halo group;

[0170] R 3 Yes (C 1 -C 6 ) alkyl or (C optionally substituted by heterocycloalkyl 1 -C 6 ) alkyl; and

[0171] Q is CH or N.

[0172] In another embodiment, the compound of formula I is a compound of formula Ib:

[0173]

[0174] Formula Ib

[0175] or a pharmaceutically acceptable salt thereof, wherein:

[0176] R 1 is a halo group;

[0177] R 2 is halo; and

[0178] R 3 Yes (C 1 -C 6 ) alkyl or (C optionally substituted by heterocycloalkyl 1 -C 6 )alkyl.

[0179] In another embodiment, the compound of formula I is compound 1.

[0180]

[0181] Compound 1

[0182] In another embodiment, the compound of formula I is compound 2.

[0183]

[0184] Compound 2

[0185] In one embodiment, the compound of formula ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to view more

Abstract

This invention is directed to the treatment of cancer, particularly castration- resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Application No. 61 / 386,971, filed September 27, 2010, U.S. Provisional Application No. 61 / 386,993, filed September 27, 2010, and U.S. Provisional Application No. 61 / 386,983, filed September 27, 2010 priority interest, said application is incorporated herein by reference. field of invention [0003] The present invention relates to the treatment of cancer, particularly castration-resistant prostate cancer and osteogenic bone metastases, with dual inhibitors of MET and VEGF. Background of the invention [0004] Castration-resistant prostate cancer (CRPC) is a leading cause of cancer-related death in men. Despite advances in systemic therapy for CRPC, improvements in survival have remained limited, and nearly all patients succumbed to the disease, with a median survival of approximately 2 years. The major cause of morbidity and mortality in CRPC is metastases to the bone, which o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K31/47A61K31/5377A61K45/06A61P35/00A61P35/04
CPCC07D215/22A61K31/47A61K31/5377A61K45/06A61P13/08A61P19/00A61P29/00A61P35/00A61P35/04A61P43/00A61K2300/00
Inventor D.史密斯M.侯赛因
Owner EXELIXIS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap