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The manufacturing process of highly active leech micropowder directly orally

A manufacturing process, high activity technology, applied in powder transportation, medical raw materials derived from leeches/worms, freeze-drying transportation, etc., can solve problems such as failure to describe microorganisms and standard sterilization methods, and reduce potential risks and processes. Simple, low equipment investment

Active Publication Date: 2016-08-31
杭州德润全健康产业发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Chinese patent CN200610147493.7 discloses a leech freeze-drying process, which can completely retain the active ingredients of leeches, it fails to explain how to sterilize the microorganisms up to the standard

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Weigh 500 g of fresh and live leeches broad-bodied, add 500 ml of acetic acid solution with a volume ratio of 9%, and beat to obtain leech slurry containing acetic acid. Put the slurry statically for 4 hours, freeze-dry until the water content is less than 5%, and then carry out low-temperature micro-grinding (the fineness is not less than 300 mesh, and the temperature of low-temperature ultra-fine grinding is not higher than 40°C 3), to obtain high-activity non-radiation According to direct oral administration of leech micropowder. This manufacturing process is defined as an acetic acid treatment process.

[0028] Weigh 500 g of fresh and live wide-bodied golden leeches, add 500 ml of hydrochloric acid solution with pH=1.5, after homogenization, adjust the pH of the leech slurry to 2.0 with the hydrochloric acid solution with pH=1.5. The leech slurry is packed into a freeze-drying tray, and after standing still for 4 hours in a sterile workshop, it is trans...

Embodiment 2

[0036] Example 2: Weigh 500 g of fresh and live Hirudo phenanthrene, add 500 ml of acetic acid solution with a volume ratio of 9%, and beat to obtain a leech slurry containing acetic acid. Put the slurry statically for 6 hours, freeze-dry until the water content is less than 5%, and then carry out low-temperature micro-grinding (the fineness is not less than 300 mesh, and the temperature of low-temperature ultra-fine grinding is not higher than 40°C), to obtain high-activity non-irradiated Oral leech micropowder directly. This manufacturing process is defined as an acetic acid treatment process.

[0037] Weigh 500 g of fresh and live Hirudo phenanthrene, add 500 ml of hydrochloric acid solution with pH=1.5, after homogenization, adjust the pH of the leech slurry to 2.0 with the hydrochloric acid solution with pH=1.5. This leech slurry is packed in the freeze-drying tray, in the aseptic workshop, after standing still for 8 hours, transfer to freeze-drying machine and carry out...

Embodiment 3

[0044] Example 3: Weigh 500 g of fresh and live Hirudo phenanthrene, add 500 ml of acetic acid solution with a volume ratio of 6%, and beat to obtain a leech slurry containing acetic acid. Put the slurry statically for 8 hours, freeze-dry until the water content is less than 5%, and then perform low-temperature micro-grinding (the fineness is not less than 300 mesh, and the temperature of low-temperature ultra-fine grinding is not higher than 40°C), to obtain high-activity non-irradiated Oral leech micropowder directly. This manufacturing process is defined as an acetic acid treatment process.

[0045] Weigh 500 g of fresh and live Hirudo phenanthae, add 400 ml of hydrochloric acid solution with pH=1.5, after homogenization, adjust the pH of the leech slurry to 2.5. This leech slurry is packed in the freeze-drying tray, in the aseptic workshop, after standing still for 6 hours, transfer to freeze-drying machine and carry out freeze-drying, make its moisture content less than ...

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PUM

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Abstract

The invention discloses a preparation process of high-activity Hirudo micropowder for direct oral administration. preparation process includes the following steps: (S1) adding Hirudo into an acid solution, and pulping to obtain Hirudo slurry; (S2) standing the Hirudo slurry in a freeze-drying dish for 4-12h; (S3) freeze-drying the settled Hirudo slurry into a freeze drier until water content is less than 5%; and (S4) pulverizing the freeze-dried Hirudo at a low temperature into superfine powder, thus obtaining high-activity Hirudo micropowder for oral administration. The invention has the following beneficial effects: the preparation process can maximally retain the active ingredients of Hirudo, has the characteristics of simple process, low equipment investigation and low production cost, and can meet the microbial limit requirement for direct oral administration without irradiation and high temperature, so as to save cost and reduce potential risk due to irradiation.

Description

technical field [0001] The invention relates to the processing field of traditional Chinese medicine leech, in particular to a manufacturing process of highly active leech micropowder directly orally. Background technique [0002] Leech was first recorded in "Shen Nong's Materia Medica" (hereinafter referred to as "The Classic"), and it has been recorded in successive dynasties of herbal medicines. "Herbal Classic" refers to leech: "taste is salty, flat." "Famous Doctors" said: "bitter, slightly cold, poisonous." "It says: "Enter the two meridians of liver and bladder." According to various sources, leech tastes bitter, salty and fishy, ​​and slightly cold in nature. It enters the two meridians of liver and bladder. , Clinically used to treat blood accumulation, lumps in the abdomen, accumulation, amenorrhea in women, tuberculosis due to dried blood, injury from falls, pain in the eyes, clouding and other diseases. Pharmacological studies have shown that leech has: (1) ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/62A61K9/19
Inventor 陈小林赵敏胡基埂
Owner 杭州德润全健康产业发展有限公司
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