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High voltage bias circuit of avalanche diode apd used in weak fluorescence measurement

An avalanche diode and fluorescence measurement technology, which is applied in the field of biomedical detection, can solve problems such as bias voltage changes, and achieve the effects of high voltage output, high temperature stability, and high voltage output

Active Publication Date: 2016-06-29
苏州中科医疗器械产业发展有限公司
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Problems solved by technology

[0007] The purpose of the present invention is to overcome the problem that the bias voltage output of the traditional APD high-voltage bias circuit will decrease with the increase of the optical signal and the bias voltage will change with the drift of the temperature, so that the APD can be more accurately Perform bioluminescent tests

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  • High voltage bias circuit of avalanche diode apd used in weak fluorescence measurement
  • High voltage bias circuit of avalanche diode apd used in weak fluorescence measurement

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Embodiment Construction

[0020] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0021] refer to figure 1 As shown, the high-voltage bias circuit of the avalanche diode APD applied to weak fluorescence measurement includes a control signal unit 1, a control signal conditioning unit 2, a temperature-free amplification unit 3, an output buffer unit 4 and a feedback unit 5;

[0022] refer to figure 2 As shown, the temperature-free amplifying unit 3 mainly includes two complementary PNP transistors 31 and a first NPN transistor 33, wherein the emitter of the PNP transistor 31 is connected to the base of the first NPN transistor 33. stage, and connected to a high level Vcc through a resistor 32, the collector of the PNP transistor 31 is grounded, the emitter of the first NPN transistor 33 is grounded through a resistor 35, and its collector is connected to a high level through a resistor 34 HV;

[0023] The contro...

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Abstract

The invention discloses a high-voltage bias circuit of an avalanche diode APD applied to weak fluorescence measurement, including a control signal unit, a control signal conditioning unit, a temperature-free amplification unit, an output buffer unit and a feedback unit, and the control signal is processed through the control signal conditioning unit. The signal is conditioned, and then amplified by the temperature-free amplifying unit to obtain the required bias voltage value, and then the output buffer unit and the feedback unit are used to control the stability of the output. The invention adopts the method of mutual coupling of temperature drift coefficients between components, which eliminates the problem of voltage drift with temperature in the previous high-voltage bias circuit, and has the advantages of high-voltage output with high temperature stability, and the output does not decrease with the increase of the signal. Meet the high-voltage bias requirements for APD operation.

Description

technical field [0001] The invention belongs to the field of biomedical detection, and in particular relates to a high-voltage bias circuit of an avalanche diode APD used in weak fluorescence measurement. Background technique [0002] In the field of biomedicine, fluorescence technology is often used for qualitative and quantitative measurement of substances, research on immune proteins on the cell surface, and determination of DNA content. Because the fluorescence intensity is very weak, and APD (avalanche diode) can achieve avalanche multiplication, and has high quantum efficiency and low price, it is often used to test the fluorescence intensity. The normal operation of APD requires a high-voltage bias of tens to hundreds of volts, and its multiplication factor changes with the increase of the voltage. Therefore, in order to ensure the accuracy of the measurement results, a stable bias voltage needs to be provided to ensure that the APD can perform fluorescence accurately...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64H01L31/107
Inventor 武晓东陈忠祥王策马玉婷裴智果钟金凤严心涛吴云良
Owner 苏州中科医疗器械产业发展有限公司
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