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Methods for treating anemia

A technology for anemia and thalassemia, applied in chemical instruments and methods, blood diseases, pharmaceutical formulations, etc., can solve problems such as not describing the role of GDF-11

Inactive Publication Date: 2015-10-14
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to date there is no evidence describing the role of GDF-11 in erythropoiesis

Method used

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  • Methods for treating anemia
  • Methods for treating anemia
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Embodiment Construction

[0031] 5.1 Overview

[0032] In one aspect, provided herein are methods for treating anemia, wherein the methods comprise administering to a patient in need thereof an antagonist of growth differentiation factor 11 (GDF11; also known as bone morphogenic protein 11 (BMP-11)). In certain embodiments, the methods comprise administering to an individual in need thereof (eg, an individual suffering from anemia) a therapeutically effective amount of a GDF11 antagonist. In certain specific embodiments, the GDF11 antagonist is not an ActRII receptor or a derivative of an ActRII receptor, eg, is not an ActRIIA-Fc fusion protein or an ActRIIB-Fc fusion protein. GDF11 antagonists can act on GDF11 at any level, ie, reduce or eliminate GDF11 expression, decrease GDF11 stability (eg, by increasing GDF11 degradation), or antagonize GDF11 activity (eg, by preventing GDF11 from binding to its receptor). A more detailed description of GDF11 antagonists can be found in the Error! section below....

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Abstract

Provided herein are methods for the treatment of anemia, wherein the methods comprise administration of antagonists of Growth differentiation factor 11 (GDFl 1; also known as bone morphogenetic protein 11 (BMP11)) to a subject in need of the treatment.

Description

[0001] This application claims priority to US Provisional Patent Application No. 61 / 718,128, filed October 24, 2012, the disclosure of which is incorporated herein by reference in its entirety. [0002] 1 Introduction [0003] Provided herein are methods for treating anemia, wherein the methods comprise administering to a subject in need of such treatment an antagonist of Growth Differentiation Factor 11 (GDF11; also known as Bone Morphogenetic Protein 11 (BMP11)). 2. Background of the invention [0004] Anemia is a disease in which the number of red blood cells is reduced or smaller than normal, or the function of the hemoglobin in the blood is reduced. Anemia is the most common blood disorder. [0005] Anemia may be caused by ineffective erythropoiesis. Ineffective erythropoiesis exists if efficient erythropoiesis occurs but mature erythrocytes do not develop at an appropriate rate. Progenitor cells undergo apoptosis before reaching erythroid maturation. Anemia also incl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K38/00
CPCC07K16/22A61K39/3955A61K47/48276C07K14/71C07K2317/76C07K2319/30A61K47/6425A61P7/06G01N33/68G01N33/53
Inventor 维多利亚·松拉杰什·乔普拉奥利维尔·赫尔米内伊凡·克鲁兹莫拉迈克尔·杜赛特蒂亚戈·特罗瓦蒂马切尔奥雷利·弗里克
Owner CELGENE CORP
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