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Dry cow mamma perfusion agent for preventing and curing cow mastitis and preparation method thereof

A technique for cow mastitis and perfusion agent, which is applied in the directions of anti-inflammatory agents, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve the problem that the effect of recessive mastitis in cows is not obvious, and the udder tissue has no anti-inflammatory effect and no anti-inflammatory ingredients. and other problems, to achieve the effect of reducing the incidence of clinical mastitis, no toxic side effects, and low treatment costs

Inactive Publication Date: 2005-09-14
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has the disadvantage of short action time and only acts on Gram-positive bacteria or Gram-negative bacteria, that is, it does not have a broad spectrum, and the effect on preventing recessive mastitis in dairy cows is not obvious
There are also some dairy farms that use foreign dry cow perfusion agents (such as dry cow udder perfusion agents produced in France and Australia) for prevention and treatment, but these perfusion agents are mostly compound agents composed of several antibiotics, without anti-inflammatory ingredients, and only for specific Bacterial infection has a preventive effect, but it has no anti-inflammatory effect on the breast tissue of dairy cows during the dry period, and most of them are more expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1:                       Embodiment 2

[0027] According to the prescription volume per 10ml, take: According to the prescription volume per 10ml, take:

[0028] (1) Ampicillin 125mg; (1) Ampicillin 130mg;

[0029] (2) Prednisone acetate 4.5 mg; (2) Prednisone acetate 5 mg;

[0030] (3) Sodium chloride 450mg; (3) Sodium chloride 420mg;

[0031] (4) Vegetable oil 6.2ml; (4) Vegetable oil 6.5ml;

[0032] (5) Polysorbate 0.8ml; (5) Polysorbate 0.75ml;

[0033] The rest is sterile distilled water. The rest is sterile distilled water.

Embodiment 3:                       Embodiment 4

[0035] According to the prescription volume per 10ml, take: According to the prescription volume per 10ml, take:

[0036] (1) Amoxicillin 105mg (1) Amoxicillin 145mg

[0037] (2) Prednisone acetate 5 mg; (2) Prednisone acetate 6.5 mg;

[0038] (3) Sodium chloride 420mg; (3) Sodium chloride 520mg;

[0039] (4) Vegetable oil 6.2ml; (4) Vegetable oil 6.5ml;

[0040] (5) polysorbate 0.75ml; (5) polysorbate 0.8ml;

[0041] The rest is sterile distilled water. The rest is sterile distilled water.

[0042] Each component in the above-mentioned four embodiments is made into perfusion agent according to the following process:

[0043] (1) Mix vegetable oil, sodium chloride, and sterilized distilled water, and stir evenly;

[0044] (2) Add polysorbate in gained mixed solution, make mixed solution fully emulsify 30 minutes;

[0045] (3) Add prednisone hydrochloride acetate to the above emulsion, mix well, add ampicillin, mix evenly, and emulsify at a low temperature of 10°C for 20...

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PUM

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Abstract

The invention discloses a dried cow breast perfusion agent and its process method for treating cow mastitis. It is in the characterized in that: perfusion agents of each 10 ml prescriptions comprise ampicillin or amoxicillin of 100-150 mg; prednisolone acetate is 4-7 mg; sodium chloride is 400-550 mg; vegetable oil is 6-6.5 ml; polysorbate os 0.75-0.82 ml; left is distiller water. And the process method is: vegetable oil. Sodium chloride, and distilled water are mix uniformly to be added polysorbate for emulsion; ampicillin or amoxicillin are added to mixed after prednisolone acetate being added, then emulsified in low temperature; aseptic package to attain finish products. Said invention has significantly effect on prevention and treatment of dried cow occult mastitis without waste, and it has low process cost and low treatment cost.

Description

Technical field: [0001] The invention relates to a new type of veterinary medicine for preventing and treating recessive and clinical mastitis in the dry period and postpartum period of dairy cows. Specifically, a udder perfusate for the prevention of mastitis in dry cows. Background technique: [0002] Mastitis is a common disease of dairy cows and is prevalent in four seasons. In the feeding and management of dairy cows, when the management measures for the dairy herd are improper, it will lead to the occurrence of dairy cow mastitis. Mastitis is one of the most costly diseases in dairy cows. Often a dairy cow infected can reduce milk production by 10% to 20%. In addition, with the milk scrapped, the antibiotics used and the cows that were eliminated early because of the disease, the loss is even greater. [0003] Cow mastitis is divided into clinical mastitis and recessive mastitis. Clinical mastitis has clinical manifestations, is easy to find and easy to treat. Sub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61P15/14A61P29/00A61P31/04
Inventor 王根林阎玉琴宋维龙
Owner NANJING AGRICULTURAL UNIVERSITY
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