A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same

An IL-33, antibody technology, applied in the direction of antibodies, antibody medical components, chemical instruments and methods, etc.

Active Publication Date: 2018-05-22
MEDIMMUNE LTD
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  • Abstract
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Advantageously, this mechanism only enhances in vivo mechanisms that terminate signaling via ST2

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  • A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same
  • A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same
  • A novel IL33 form, mutated forms of IL33, antibodies, assays and methods of using the same

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Embodiment Construction

[0510] I. Definition

[0511] "Isolated" as used herein refers to a protein in a non-native environment, especially isolated from nature, eg, the term does not include proteins in vivo, nor in samples taken from the human or animal body. Typically, the protein will be in a carrier such as a liquid or medium, or can be formulated, frozen or lyophilized, and all of these forms are encompassed by "isolated" as appropriate. In one embodiment, separated does not refer to the protein in a gel, such as a gel or the like used in Western blot analysis.

[0512] IL-33 protein as used herein refers to interleukin 33, especially mammalian interleukin 33 protein, eg the human protein deposited under UniProt number 095760. However, in light of the findings of the inventors, it is evident that this entity is not a single species but exists in reduced and oxidized forms. Given the rapid oxidation of the reduced form in vivo, for example within a period of 5 minutes to 40 minutes, and in vit...

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Abstract

The present invention provides isolated IL-33 proteins, active fragments thereof and antibodies, antigen binding fragments thereof, against IL-33 proteins. Also provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders.

Description

[0001] Inventors: Suzanne Cohen (GB / GB), David Lowe (GB / GB), Robin Butler (GB / GB), Ian Scott (GB / GB), Katherine Vousden (GB / GB), Martin Strain (GB / GB), Sara Carmen (GB / GB), Elizabeth England (GB / GB), Benjamin Kemp (GB / GB), Gareth Rees (GB / GB), Catherine Overed-Sayer (GB / GB), Tomas Mustelin (US / US), Matthew Sleeman (GB / GB), Kirsty Houslay (GB / GB) [0002] The present disclosure relates to novel IL-33 forms; novel IL-33 mutants; binding proteins, such as antibodies specific for any of said proteins, especially binding proteins capable of modulating the amount of the presently described forms; Compositions comprising proteins or binding proteins such as antibodies according to the present disclosure; and uses of any of the above, especially in therapy, eg in the prophylactic treatment of inflammatory diseases. The disclosure herein also extends to assays for identifying and / or quantifying different IL-33 forms. Background technique [0003] Interleukin-33 (IL-33), also known as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/54C07K16/24C12N15/13G01N33/68A61K39/395A61P29/00A61P11/00A61P11/06A61P37/08
CPCC07K14/54C07K16/244G01N33/6869G01N2333/54A61K2039/505C07K2317/21C07K2317/34C07K2317/33C07K2317/76C07K2317/92C07K2317/567C07K2317/565C07K2317/622C07K2319/30A01K67/0278A01K2217/072A01K2227/105A01K2267/03A61P11/06A61K39/3955A61P29/00A61P37/08G01N33/6863A61K39/39533
Inventor E.S.科亨D.C.洛R.巴特勒I.C.斯科特K.A.沃斯登M.D.斯特兰S.卡门E.H.恩格兰B.P.肯普D.G.里斯C.L.奥弗雷-赛耶T.M.穆斯特林M.斯利曼K.豪斯莱
Owner MEDIMMUNE LTD
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