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A kind of composite microneedle and microneedle patch

A technology of microneedle and manufacturing method, applied in the field of microneedle, can solve the problems of insufficient hardness and toughness, easy to break, etc., and achieve the effects of low production cost, high safety, and simple manufacturing process

Active Publication Date: 2021-06-22
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, dextran of biological origin is non-toxic, good biocompatibility and biodegradability, and will not cause immune response in biological tissues. It is an ideal raw material for microneedles and microneedle patches, but due to Its hardness and toughness are not enough, and it is often easy to break when used as a material for microneedles, and it is not easy to penetrate the skin
[0005] In addition, when microneedles and microneedle patches are specially used to deliver pharmaceutical active ingredients or cosmetic active ingredients, how to control macromolecular pharmaceutical active ingredients or cosmetic active ingredients not to aggregate together and release in a controlled manner after reaching the dermis or epidermis become very important, so the existing process methods still need to be improved

Method used

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  • A kind of composite microneedle and microneedle patch
  • A kind of composite microneedle and microneedle patch
  • A kind of composite microneedle and microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] First, the PDMS mold was prepared as follows:

[0043] First prepare a stainless steel male mold containing multiple conical protrusions, the density of the conical protrusions is 50 / cm 2 , each conical protrusion has a width of 800 μm (conical bottom) and a height of 500 μm. Place the stainless steel positive mold in a disposable plate, pour polydimethylsiloxane (polydimethylsiloxane, PDMS) prepolymer, and dry in an oven at 60°C for 4 hours, separate the stainless steel positive mold from PDMS, and form a PDMS conical concave negative mold.

[0044] (1) The large molecular weight water-soluble dextran powder (molecular weight 100000) after deionized ultrapure water is dissolved and purified to a final concentration of 80g / L, and the large molecular weight water-soluble dextran is prepared by the prior art, adding Small molecular weight water-insoluble dextran powder (molecular weight: 5000) to a final concentration of 10 g / L, and quickly mixed on a vortex mixer to ob...

Embodiment 2

[0050] First, the PDMS mold was prepared as follows:

[0051] First, prepare a stainless steel male mold comprising a plurality of conical protrusions, the density of the conical protrusions is 2 / cm2, the width of each conical protrusion is 20 μm (conical bottom), and the height is 1000 μm. Put the stainless steel positive mold in a disposable flat plate, pour polydimethylsiloxane (polydimethylsiloxane, PDMS) prepolymer, and dry in an oven at 70°C for 1 hour, separate the stainless steel positive mold from PDMS, and form a PDMS conical concave negative mold .

[0052] (1) Dissolve large molecular weight water-soluble dextran powder (molecular weight 300,000) in deionized ultrapure water to a final concentration of 60g / L. Sugar powder (molecular weight: 2000) was added to a final concentration of 5 g / L, and quickly mixed on a vortex mixer to obtain a matrix solution. The preparation method of described small molecular weight water-insoluble dextran is:

[0053] Using the dex...

Embodiment 3

[0058] First, the PDMS mold was prepared as follows:

[0059] First prepare a stainless steel male mold containing multiple conical protrusions, the density of the conical protrusions is 100 / cm 2 , each conical protrusion has a width of 10 μm (conical bottom) and a height of 2000 μm. Place the stainless steel positive mold in a disposable flat plate, pour polydimethylsiloxane (polydimethylsiloxane, PDMS) prepolymer, and dry in an oven at 40°C for 12 hours, separate the stainless steel positive mold from PDMS, and form a PDMS conical concave negative mold.

[0060] (1) Dissolve the dried and purified large molecular weight water-soluble dextran powder (molecular weight 500000) in deionized ultrapure water to a final concentration of 30g / L. The large molecular weight water-soluble dextran is prepared by the prior art, adding Small molecular weight water-insoluble dextran powder (molecular weight: 1000) to a final concentration of 0.5 g / L, and quickly mixed on a vortex mixer to...

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Abstract

The invention discloses a composite microneedle, a microneedle patch and a preparation method thereof. The composite microneedle includes a microneedle-shaped matrix and active ingredients embedded in the matrix. The matrix is ​​a mixture of large molecular weight water-soluble dextran and small molecular weight water-insoluble dextran. The active ingredient has medical or Substances with cosmetic effects. The composite microneedle of the present invention has good toughness and hardness, good long-term stability, good biocompatibility and biodegradability and high safety, no toxic and side effects, can be quickly dissolved in the skin without The production of medical waste is in line with the concept of green development, and it occupies a small volume, is convenient to transport, has a simple manufacturing process, low production cost, and can be mass-produced on a large scale.

Description

technical field [0001] The present invention relates to microneedles, and more specifically, to a composite microneedle and a microneedle patch for transdermal delivery of active substances with pharmaceutical, medical or cosmetic effects. Background technique [0002] Human skin, especially the stratum corneum, provides an effective barrier against the penetration of microbial pathogens and toxic chemicals into the body. While this property of the skin is generally beneficial, it complicates transdermal drug administration. Most of the effective drug delivery methods for various medicines applicable to the human body are injected into the medicine in liquid form through a hypodermic needle. However, hypodermic injection needles with a diameter of about several millimeters irritate multiple pain points on the skin, thereby causing pain to the patient, and a one-time subcutaneous injection usually has a large amount of administration, which is likely to cause toxic and side ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053
Inventor 方艳古蕾姜岷马江锋吴昊董维亮信丰学
Owner NANJING TECH UNIV
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