Preparation method of 2,3-dimethoxybenzoyl chloride

A technology of dimethoxybenzoyl and dimethoxyformyl, applied in the field of medicine, can solve the problems of low yield, complex synthesis process, unstable yield and the like

Inactive Publication Date: 2018-12-21
SHANGHAI HUAJIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing 2, the preparation method yield of 3-dimethoxybenzoyl chloride is not high, and synthetic technique is complicated, and yield is unstable, and needs to invent a kind of new preparation method, overcomes the deficiencies in prior art, in order to achieve Energy saving, environmental protection, green purpose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: the preparation of 2,3-dimethoxybenzoyl chloride:

[0008] Add 1821 mg of 2,3-dimethoxybenzoic acid to the reactor, add 40 ml of tetrahydrofuran, stir, add 0.5 ml of N,N-dimethylformamide at room temperature, then stir at room temperature for 0.5 hours, drop 3 g of thionyl chloride, and then continued to stir the reaction at room temperature for 8 hours. After the reaction was completed, the compound 2,3-dimethoxybenzoyl chloride was obtained through the post-treatment and purification process with a yield of 81.8%.

Embodiment 2

[0009] Embodiment 2: the preparation of 2,3-dimethoxybenzoyl chloride:

[0010] Add 1821 mg of 2,3-dimethoxybenzoic acid to the reactor, add 40 ml of tetrahydrofuran, stir, add 0.5 ml of N,N-dimethylformamide at room temperature, then stir at room temperature for 0.5 hours, drop 3 g of thionyl chloride, and then continued to stir the reaction at room temperature for 8 hours. After the completion of the reaction, the compound 2,3-dimethoxybenzoyl chloride was obtained through post-treatment and purification process with a yield of 82.9%.

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PUM

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Abstract

The invention relates to a preparation method of 2,3-dimethoxybenzoyl chloride, which belongs to the technical field of medicine technology. The invention solves the technical problem of a more advanced preparation method of 2,3-dimethoxybenzoyl chloride. The invention is characterized by providing a novel preparation method. (The formula is shown in the description.).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to a preparation method of 2,3-dimethoxybenzoyl chloride. Background technique [0002] 2,3-Dimethoxybenzoyl chloride is an important intermediate raw material for the synthesis of pharmaceutical products. [0003] Existing 2, the preparation method yield of 3-dimethoxybenzoyl chloride is not high, and synthetic technique is complicated, and yield is unstable, and needs to invent a kind of new preparation method, overcomes the deficiencies in prior art, in order to achieve The purpose of energy saving, environmental protection and green. Contents of the invention [0004] The present invention adopts a new technology, aiming at the shortcomings of the existing 2,3-dimethoxybenzoyl chloride preparation method that the yield is not high, the synthesis process is complicated, the yield is unstable, and the purchase cost of the required raw materials is high. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C65/21C07C51/60
CPCC07C51/60C07C65/21
Inventor 不公告发明人
Owner SHANGHAI HUAJIN BIOTECH CO LTD
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