A kind of cedaronic acid is used for reversing the application of ovarian cancer to paclitaxel drug resistance

A technology for ovarian cancer and drug resistance, applied in the field of medicine, can solve the problems of high recurrence rate and high mortality rate of this disease

Active Publication Date: 2021-01-19
QINGDAO CENT HOSPITAL
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  • Abstract
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Problems solved by technology

However, the drug resistance of ovarian cancer cells to chemotherapy drugs leads to a high recurrence rate and high mortality rate of the disease, which has become a bottleneck in clinical treatment.

Method used

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  • A kind of cedaronic acid is used for reversing the application of ovarian cancer to paclitaxel drug resistance
  • A kind of cedaronic acid is used for reversing the application of ovarian cancer to paclitaxel drug resistance

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Experimental program
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Effect test

Embodiment Construction

[0013] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0014] 1. Experimental materials

[0015] Comfrey acid, comfrey alkyd, cedarwood acid and cedarwood alcohol are self-made, the purity is ≥98%, and the structural formula is as follows figure 1 shown. Paclitaxel (Taxol) was purchased from Xi'an Kangnuo Chemical Co., Ltd., with a purity of ≥98%. Dimethylsulfoxide (DMSO) was purchased from Sigma. Tetramethylthiazole light blue (MTT) was purchased from Biyuntian Biotechnology Research Institute.

[0016] Fetal bovine serum and DMEM medium were purchased from Gibco.

[0017] Human ovarian cancer paclitaxel-resistant cell line A2780 / Taxol was purchased from Shanghai Meixuan Biotechnology Co., Ltd.

[0018] 2. Experimental method

[0019] 1. Cell culture

[0020] DMEM medium containing 10% fetal bovine serum at 37°C, 5% CO 2 C...

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Abstract

The invention discloses a use of cedar acid in reversing paclitaxel medical resistance in ovarian cancer. Ovarian cancer is one of the three major malignant tumors of female reproductive system, and the survival time of most patients with advanced ovarian cancer is less than 5 years. Clinical treatment of ovarian cancer usually uses cytoreductive surgery and postoperative chemotherapy with platinum and paclitaxel. However, ovarian cancer cell resistance to chemotherapy drugs leads to high recurrence rate and mortality, so it becomes the bottleneck of clinical treatment. The invention disclosesthat yew antler acid, yew antler alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees, improve the sensitivity of cells to Taxol, and can be developed as a medicine for reversing the resistance of ovarian cancer to taxol. The use is characterized in that the yew antler acid, yew antler alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees and improve the sensitivity of cells to Taxol.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the discovery of drugs for reversing drug resistance of ovarian cancer to paclitaxel. Background technique [0002] Ovarian cancer is one of the three major malignant tumors of the female reproductive system, and the survival time of most advanced ovarian cancer patients is less than 5 years. The clinical treatment of ovarian cancer usually uses tumor cytoreductive surgery, supplemented by chemotherapy with platinum and paclitaxel after surgery. However, the drug resistance of ovarian cancer cells to chemotherapeutic drugs leads to a high recurrence rate and high mortality rate of the disease, which has become a bottleneck in clinical treatment. Contents of the invention [0003] The purpose of the present invention is to provide a drug for reversing drug resistance of ovarian cancer to paclitaxel. [0004] The present invention realizes through following technical scheme: [0005] Appl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K31/045A61P35/00
CPCA61K31/045A61K31/19A61P35/00
Inventor 程海燕栾婕刘霞郑嘉荣区伟平万超
Owner QINGDAO CENT HOSPITAL
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