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Method for regulating self-renewal and differentiation of neural stem cells

A neural stem cell and neuron technology, applied in the field of regulating neural stem cell self-renewal and differentiation, can solve the problem of not being able to simulate the extracellular matrix environment well, and achieve effective stem cell self-renewal ability and directional differentiation ability, and stem cell self-renewal ability. and the effect of regulating the ability of directed differentiation

Active Publication Date: 2019-01-22
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Problems solved by technology

However, in these studies, the antibodies on the surface of the material are statically displayed to the cells, which cannot simulate the natural extracellular matrix environment well.

Method used

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  • Method for regulating self-renewal and differentiation of neural stem cells
  • Method for regulating self-renewal and differentiation of neural stem cells
  • Method for regulating self-renewal and differentiation of neural stem cells

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Embodiment Construction

[0016] Aiming at many defects in the prior art, the inventor of this case proposes the technical solution of the present invention after long-term research and extensive practice. The technical solution, its implementation process and principles will be further explained as follows. However, it should be understood that within the scope of the present invention, the above-mentioned technical features of the present invention and the technical features specifically described in the following (embodiments) can be combined with each other to form new or preferred technical solutions. Due to space limitations, we will not repeat them here.

[0017] The meanings of the technical terms mentioned in the description of the present invention are known to those skilled in the art unless otherwise specified. One aspect of the embodiments of the present invention provides a method for regulating the self-renewal and differentiation of neural stem cells, which includes: seeding neural stem...

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Abstract

The invention discloses a method for regulating self-renewal and differentiation of neural stem cells, comprising the steps of inoculating neural stem cells onto the surfaces of solid-supported phospholipid membranes with different fluidity and conducting cultivating, so as to regulate proliferation of the neural stem cells and promote differentiation of the neural stem cells along different differentiation directions. By the method for regulating self-renewal and differentiation of neural stem cells provided by the present invention, effective regulation of self-renewal ability and directed differentiation ability of stem cells can be achieved.

Description

technical field [0001] The invention specifically relates to a method, system and application for regulating the self-renewal and differentiation of neural stem cells. Background technique [0002] Stem cells are a kind of pluripotent cells with self-renewal ability, which have important potential in tissue engineering and regenerative medicine research. Previous studies have shown that there are many factors that affect the self-renewal and differentiation capabilities of stem cells, including chemical and physical factors. Recently, a large amount of work has been devoted to investigating the influence of biophysical factors, such as topology, viscoelasticity, and stiffness, on stem cells. [0003] Cells are in a dynamic and complex extracellular matrix environment in vivo. At present, a large number of research efforts have attempted to simulate the extracellular matrix, including modifying bioactive molecules on the surface of the material and regulating the physical p...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0797C12N5/0793
CPCC12N5/0619C12N5/0623C12N2533/00C12N2533/52
Inventor 戴建武陈艳艳郝王平
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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