3 results about "Stem Cell Self-Renewal" patented technology

The invention provides labdane diterpenoid compounds, a preparation method and application thereof, pharmaceutical compositions and application thereof, and relates to the technical field of extraction and separation. The labdane diterpenoid compound provided by the invention has pancreatic cancer stem cell inhibition activity and high anti-tumor activity, and has a good application prospect in preparation of drugs for treating pancreatic tumors and preventing and treating pancreatic cancer invasion and metastasis. Pharmacological activity experiments prove that the labdane type diterpenoid compound provided by the invention can inhibit pancreatic cancer PANC-1 cell proliferation, selectively inhibit self-renewal and dry characteristics of tumor stem cells and induce pancreatic cancer stem cell apoptosis, and has pancreatic cancer proliferation resisting activity; the compound can inhibit pancreatic cancer PANC-1 cell scratch fusion and cell migration, has the activity of inhibiting pancreatic cancer invasion and metastasis, and can be applied to preparation of drugs for preventing postoperative tumor recurrence and metastasis.

The invention relates to the field of biomedicine, and discloses application of EPTMPA in hematopoietic stem cell in-vitro amplification culture. The invention identifies a brand-new novel small molecule compound EPTMPA capable of remarkably promoting in-vitro expansion and in-vivo transplantation of hematopoietic stem cells and hematopoietic progenitor cells of umbilical cord blood, and the novel small molecule compound EPTMPA can remarkably promote in-vitro expansion of CD34 + hematopoietic stem cells and hematopoietic progenitor cells and maintain the stem property and differentiation potential. EPTMPA is a new discovery and new way for in-vitro amplification of hematopoietic stem cells, but needs more studies to understand the action mechanism, targeting genes and proteins of the hematopoietic stem cells and the regulation effect on self-renewal and differentiation balance of the stem cells. The researches are of great significance to clinical application and product development in the future.

The present invention relates to a composition for inhibiting the growth of cancer stem cells, and a use thereof. A WDR34 inhibitor of the present invention inhibits the conversion of cancer cells into cancer stem cells and exhibits activity of inhibiting self-renewal, invasion, and migration of cancer stem cells, and thus can be effectively used as a cancer cell growth or metastasis inhibitor or a cancer stem cell growth inhibitor.