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Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
InactiveUS20130171110A1High expressionAccelerate self-renewalBiocideCulture processInduced pluripotent stem cellAntioxidant
Compositions and methods that employ various combinations of such factors as retinoic acid signaling inhibitors, antioxidants, BMP4, VEGF, prostaglandin E2 pathway stimulants, TPO, SCF, FLT-3, EPO, TGFβ1, p38 MAPK inhibitors, beta adrenergic receptor agonists, cell cycle inhibitors, RXR agonists, Cripto, and chromatin remodelers to drive differentiation of pluripotent stem cells towards primitive blood cells. Uses of such primitive blood cells are provided.
Owner:NUCLEUS BIOLOGICS LLC
In vitro culture-amplified human liver progenitor cell and preparation thereof
InactiveCN101275121AAccelerate self-renewalConvenient sourceArtificially induced pluripotent cellsNon-embryonic pluripotent stem cellsCell-Extracellular MatrixECM Protein
The present invention provides a preparing method of a human hepatic progenitor cell which is amplified and cultivated in vitro, including: a. separating the human hepatic progenitor cell; b. co-cultivating a feeder cell and the human hepatic progenitor cell separated from the step a by a medium having no serum on an extracellular matrix containing human fibrin sealant or other analogues, obtaining a human hepatic progenitor cell colony by amplification. The human hepatic progenitor cell colony is easy to separate from the surface of human fibrin sealant by the simple gelatinolytic band process, purified or / and subcultured by further single cell preparation technology process such as enzymatic degradation etc. The human hepatic progenitor cell prepared by the method is hepatic progenitor cell treatment, including a cell transplantation and a bioartificial liver support system, providing excellent human hepatocyte source for cytotoxicity test platform in the drug screening, virus infection and drug screening platform etc.
Owner:芦银雪
Protein skin care product with skin repairing and maintenance functions
InactiveCN107260571ASpeed up entryPromote absorptionCosmetic preparationsToilet preparationsMedicineSkin repair
The invention relates to a protein skin care product with skin repairing and maintenance functions. The protein skin care product contains a keratin composition, wherein the keratin composition contain the following components in mass fraction in the protein skin care product: 0.3-5% of keratin, 0.1-1% of sodium alginate and 0.1-5% of polysaccharide; the keratin has the molecular weight of 10000-70000 Dalton; and the polysaccharide is at least one of fructose, fructo-oligosaccharide, cationic fructo-oligosaccharide, hyaluronic acid and salt thereof as well as chitosan. The protein skin care product provided by the invention can promote absorption of cells on protein, so that self renewing and repairing capability of skin cells is further improved, and especially the effect of repairing skin after ultraviolet burn is improved.
Owner:刘佩华
Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells
ActiveUS8158415B2Inhibition of differentiationAccelerate self-renewalOrganic active ingredientsBiocideCombined usePolynucleotide
Owner:PROCELL THERAPEUTICS
Medicine for inhibiting proliferation of esophageal cancer cells
InactiveCN108187050AImprove tolerancePromote proliferationOrganic active ingredientsAntineoplastic agentsCancer cell linesCisplatin
The invention discloses a medicine for inhibiting proliferation of esophageal cancer cells. The roles of SOX9 in the occurrence and development of esophageal squamous cell carcinoma and a downstream molecular mechanism regulated by the SOX9 are researched from the view of tumor stem cells by detecting clinical specimens and establishing an in vitro cell model and an in vivo mouse model; experiments proves that the SOX9 is highly expressed in the tissues of the esophageal squamous cell carcinoma and in esophageal cancer stem cell balls, and can promote the proliferation and self-renewal of a cell line of the esophageal squamous cell carcinoma, the formation of tumor stem cell balls, the growth of transplantation tumor in nude mice, and the tolerance to chemotherapeutic drug cisplatin. The invention provides a theoretical basis and an experimental basis for further clarifying the occurrence and development mechanism and targeted treatment of esophageal cancer.
Owner:SHIHEZI UNIVERSITY
Method for inducing self-renewal of mammary stem cells
InactiveCN104450603AAccelerate self-renewalScale upMicrobiological testing/measurementArtificial cell constructsCell Self RenewalStem cell
The invention provides a method for inducing self-renewal of mammary stem cells. The invention discloses a new application of microRNA31. Experiments show that through over-expression of microRNA31, the proportion of mammary stem cells is obviously regulated up, clone formation ability is enhanced and therefore the self-renewal of the mammary stem cells is promoted.
Owner:CHINA AGRI UNIV
Drug for treating bone marrow hematopoietic dysfunction
ActiveCN108670969AAccelerate self-renewalOrganic active ingredientsAntineoplastic agentsDiseaseBone marrow
The invention provides application of a SphK2 inhibiting agent ABC294640 in improving hematopoietic stem cell functions and treating hematopoietic dysfunction. The ABC294640 can be used for treating essential hematopoietic dysfunction, or radiation and chemical drug irritated hematopoietic dysfunction, and is capable of improving hematopoietic stem cell functions to improve the recovery rate and the survive rate of hematopoietic function of a patient after chemotherapy is carried out for a plurality of times. According to the drug, a new drug source is provided to treat essential or induced hematopoietic dysfunction diseases.
Owner:SUN YAT SEN UNIV
Skin barrier repairing composite and application thereof
ActiveCN109431910ARecovery functionIncrease vitalityCosmetic preparationsHair cosmeticsAllergyGluconates
The invention relates to a skin barrier repairing composite and application thereof. The skin barrier repairing composite comprises sodium pyrrolidonecarboxylate, ecdysterone, an itching relieving anti-allergy composite and a metabolic balance composite, wherein the itching relieving anti-allergy composite comprises a radix stephaniae tetrandrae extractive, potassium lactate, dipotassium glycyrrhizinate and phenoxyethanol; the metabolic balance composite comprises magnesium aspartate, zinc gluconate and copper gluconate. According to the skin barrier repairing composite, the sodium pyrrolidonecarboxylate and the ecdysterone are adopted to repair the skin barrier, the metabolic balance composite (M3) is adopted to improve cell activity and accelerate metabolic balance, the itching relievinganti-allergy composite (Comthing tetra) is adopted to lower itching and scratching caused by inflammation or histamine release, the skin barrier is protected from mechanical injury, the scalp barrierfunction is effectively recovered, and the susceptibility of the scalp is lowered.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD
Ovarian cancer stem cell vaccine and preparation method thereof
InactiveCN105219731AHigh activityHigh tumorigenicityTumor/cancer cellsAntibody medical ingredientsCancer cellNatural Killer Cell Inhibitory Receptors
The invention relates to the field of molecular biology and discloses an ovarian cancer stem cell vaccine and a preparation method and application thereof. Cancer stem cells are insensitive to radiotherapy and chemotherapy, which is the root of cancer metastasis and recurrence. Aiming at active immunotherapy of the cancer stem cells, satisfactory therapeutic effect can be gained only on the condition that cancer 'seed' cells, namely the cancer stem cells are eliminated. The ovarian cancer stem cell CD117+CD44+ vaccine is capable of improving blood serum IFN (interferon)-gamma level, lowering TGF (transforming growth factor)-beta expression, enhancing NK cell activity, decreasing the number of ovarian cancer stem cells CD117+CD44+ remarkably and inhibiting cancer growth in animal experiments.
Owner:SOUTHEAST UNIV +1
Application method of small molecules capable of promoting self-status-renewal of embryonic stem cells
ActiveCN109722411AAccelerate self-renewalImprove growthEmbryonic cellsGerm cellsCell Self RenewalMouse Embryonic Stem Cell
Owner:ANHUI UNIVERSITY
Efficient and reliable preparation method of hESC-MSC
ActiveCN110872574AActivity remains stableGood conditionSkeletal/connective tissue cellsCell culture supports/coatingCytologyProliferative capacity
The invention belongs to the technical field of biological medicines, and provides a preparation method of hESC-MSC. The method comprises that a supporting / coating material is changed and a culture solution system is changed. Embryonic stem cells (hESCs) start a differentiation process by a method based on mechanical partitioning and planking. The hESC gradually enters the differentiation mode, and the high survival rate is kept in the differentiation process, so that the better differentiation efficiency is achieved. Meanwhile, screening is performed by adjusting a passage mode, adopting a partitioning method and then adopting a digestion method according to the growth characteristics of hESC and MSC, so that the operation is simple and convenient, and the effect is obvious. The obtainedhESC-MSC can be used for inhibiting CD4+T-cell proliferation and promoting the increasing of CD4+Foxp3+(Treg). The hESC-MSC has an immunomodulatory capacity equivalent to or higher than that of umbilical cord MSCs and has powerful proliferative capacity and a simple, convenient and efficient differentiation effect in a short time, and derived cells have typical MSC cytological characteristics.
Owner:SHANXI UNIV
Skin care serum containing stem cell active factors and application thereof
InactiveCN110934814AAccelerate self-renewalPromote regenerationCosmetic preparationsToilet preparationsVitamin CGlycerol
The invention, which belongs to the related technical field of skin care products, discloses skin care serum containing stem cell active factors and application thereof. The skin care serum comprisesthe following components, by weight: 10 to 20 parts of a stem cell active factor extracting solution, 0.08 to 0.2 part of silk protein, 0.2 to 0.6 part of asiaticoside, 1 to 2 parts of yeast extract,0.2 to 2 parts of allantoin, 0.05 to 2 parts of tocopherol, 5 to 8 parts of squalane, 0.3 to 1 part of olive oil, .5 to 0.8 part of EDTA-2Na, 0.05 to 0.2 part of triethanolamine, 0.6 to 3 parts of polyglutamic acid, 0.05 to 0.2 part of vitamin C, 5 to 10 parts of glycerol and 80 to 100 parts of water. According to the invention, a large number of bioactive factors beneficial to skin regeneration and repair, especially stem cell active factors, are contained in the formula, so that skin self-renewal and regeneration are promoted and the striae gravidarum repair effect is enhanced.
Owner:杭州恩格生物医疗科技有限公司
Method and device for updating software
InactiveCN103488503AAccelerate self-renewalImprove repair effectProgram loading/initiatingSoftware updateSoftware engineering
The invention discloses a method and a device for updating software. The method is implemented by the aid of an updating module on the basis of software. The method includes steps of enabling the updating module to acquire a version of the software; connecting the updating module with a network and acquiring the latest version of the software; enabling the updating module to compare the version of the software to the latest version of the software; connecting the updating module with the network to download software in the latest version if the latest version of the software is higher than the version of the software, and updating the software. The method and the device for updating the software in an embodiment of the invention have the advantages that the updating software is arranged on the outside of the software, so that the version and information of the software can be independently acquired by the updating module without being affected by the software, the software still can be updated under the condition that the software fails or is collapsed, the self-updating and repairing ability of the software can be improved, and the user experience can be enhanced.
Owner:TVMINING BEIJING MEDIA TECH
Haemorrhoid paste containing Zingiber corallinum Hance essential oil
InactiveCN101862438APromote circulationAccelerate self-renewalHydrocarbon active ingredientsAnthropod material medical ingredientsSide effectHemorrhoids
The invention provides a haemorrhoid paste which has the functions of analgesia, antiphlogosis and detumescence, takes effect fast, and uses Zingiber corallinum Hance essential oil as the main curative component. The haemorrhoid paste is prepared from the following raw materials in parts by weight: 0.5-3 parts of Zingiber corallinum Hance essential oil, 0.5-2 parts of zanthoxylum oil, 2-5 parts of glycerin, 70-82 parts of vaseline and 15-20 parts of beeswax. The preparation method comprises the following steps: heating beeswax and vaseline commonly to melt and then boil, cooling to 35-45 DEG C, adding Zingiber corallinum Hance essential oil, zanthoxylum oil and glycerin to stir evenly, cooling, and sealing for 7-10 days to obtain the finished product. The haemorrhoid paste has obvious effects of analgesia, antiphlogosis and detumescence and can improve microcirculatory disturbance, promote blood circulation and accelerate the recovery of patients with haemorrhoid. The haemorrhoid paste takes effect fast, and has short treatment period, high recovery rate and no toxic or side effects.
Owner:重庆灵方生物技术有限公司
Compound plant anti-oxidation mixture as well as preparation method and application thereof
The invention belongs to the technical field of cosmetics, and discloses a compound plant antioxidant mixture as well as a preparation method and application thereof. The composition comprises the following components: a rosa roxburghii tratt fruit extract, an acanthopanax senticosus extract, a caesalpinia spinosa fruit extract, a capparis spinosa fruit extract and a kiwi fruit extract. According to the composition, the mode that five plant extracts including the rosa roxburghii tratt fruit extract, the acanthopanax senticosus extract, the caesalpinia spinosa fruit extract, the capparis spinosa fruit extract and the kiwi fruit extract are combined with one another is adopted, so that better free radical scavenging performance is achieved, and the kiwi fruit extract has an obvious synergistic effect on scavenging free radicals; and the composition has a synergistic anti-wrinkle effect on skin wrinkles, so that the skin is rich in elasticity and luster.
Owner:SHENZHEN YONGJITAI TECH
Formula for preparing mask by Xinhui orange flower extracting solution and technology
InactiveCN108852999AInhibitionEasy to removeCosmetic preparationsToilet preparationsSkin cellWater irrigation
The invention discloses a formula for preparing a mask by a Xinhui orange flower extracting solution. The formula comprises the following components in percentage by mass: 1.0 to 8.0% of Xinhui organflower extracting solution, 0.5 to 2.0% of pearl powder, 5.0 to 10.0% of anti-oxidizing compound, and 80.0 to 93.5% of cosmetic auxiliary material substrate. The invention also discloses a technologymethod of the mask using the Xinhui orange flower extracting solution. The formula has the advantages that the Xinhui orange flower extracting solution is compounded with other anti-oxidizing matters,so that the function is mild, the irrigation is avoided, and the self-updating and repair of skin cells are accelerated; the obvious anti-aging, whitening and moisturizing effects are realized, the skin quality can be quickly improved, the skin elasticity is improved, and the wrinkles are smoothed.
Owner:广东温和堂健康科学有限公司
Therapeutic ozone agent and treatment
InactiveUS20180133248A1Accelerate self-renewalPromote growthInorganic active ingredientsAntinoxious agentsAutoimmune conditionAutoimmune disease
The use of a medical therapeutic ozone agent in vivo to treat a variety of disorders including, but not limited to hypoxic conditions, autoimmune disease, fibrotic disease, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and vascular disease, metabolic disease, and cancer, wherein the therapeutic ozone agent is administered in a therapeutically effective amount, which can convert carbon monoxide to carbon dioxide, thereby treating or preventing the disease in a patient.
Owner:CAPLAN JAMES A
Therapeutic ozone agent and treatment
InactiveUS20160175354A1Accelerate self-renewalPromote growthBiocideGenetic material ingredientsCarbon dioxideVascular disease
The use of a medical therapeutic ozone agent in vivo to treat a variety of disorders including, but not limited to hypoxic conditions, autoimmune disease, fibrotic disease, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and vascular disease, metabolic disease, and cancer, wherein the therapeutic ozone agent is administered in a therapeutically effective amount, which can convert carbon monoxide to carbon dioxide and significantly raise systemic oxygen partial pressure to increase the delivery of oxygen to all tissue, systemically, to enable the reversal of hypoxic conditions of the human and animal body and the consequences of those hypoxic conditions, thereby treating or preventing the disease in a patient.
Owner:CAPLAN JAMES A
Sunblocking cream containing zingiber corallinum hance essential oil
ActiveCN102000003APromote divisionEnhance resilienceCosmetic preparationsToilet preparationsActive agentUltraviolet a
The invention provides a sunblocking cream which is natural and resists ultraviolet B (UVB) radiation and ultraviolet A (UVA) radiation, and can improve the resisting and defending capacity of the human body cells to ultraviolet radiation. The product comprises the following raw materials in parts by weight: 0.5-5 parts of zingiber corallinum hance essential oil, 0.5-1 parts of curcuma oil, 0.5-1parts of zedoary turmeric oil, 5-8 parts of emulsifier, 1-5 parts of humectant, 1-3 parts of active agent, 8-10 parts of excipient and 62.8-72.3 parts of pure water, and is prepared by the following steps: mixing and heating aqueous phase substances, namely the humectant, active agent and pure water to the temperature of 85-87 DEG C; evenly mixing and heating oil phase substances, namely the zingiber corallinum hance essential oil, curcuma oil, zedoary turmeric oil, emulsifier and excipient to the temperature of 85-87 DEG C; and slowly pouring the oil phase into the aqueous phase, stirring and evenly mixing, homogenizing for 5-10 minutes at the temperature of 85-87 DEG C, and cooling. The sunblocking cream of the invention resists the UVB radiation and UVA radiation, can improve the resisting and defending capacity of the human body cells to ultraviolet radiation, can promote skin cell division and accelerates self renewal of the skin cells; the skin does not generate erythema after being exposed to the sun, and can not be tanned; and the sunblocking cream has good sunblocking effect, low application cost, simple and feasible preparation method.
Owner:重庆灵方生物技术有限公司
A kind of mask liquid containing chitosan and preparation method thereof
ActiveCN105560160BNon-irritatingAchieve antiseptic and bactericidal effectCosmetic preparationsToilet preparationsWrinkle skinBletilla striata
The invention belongs to the technical field of cosmetics, and particularly relates to facial mask essence containing chitosan and a preparation method thereof. The facial mask essence is prepared from the following raw materials in percentage by mass: 0.5-5 percent of chitosan, 0.5-5 percent of yeast beta-glucan, 1-15 percent of marine collagen, 3-8 percent of glycerinum, 0.05-0.2 percent of allantoin, 0.05-0.2 percent of bletilla striata polysaccharide, 1-10 percent of plant extract, 0.000001-0.0003 percent of growth factor and 50-95 percent of deionized water. The facial mask essence containing chitosan is mild in property, does not irritate skin, has the advantage that the active ingredient can be easily absorbed by skin so as to accelerate self-renewal and repair of skin cells, has remarkable effects of relieving senescence, moistening, diminishing inflammation, alleviating allergy and whitening skin, and can be used for quickly improving skin texture, increasing skin elasticity, smoothing wrinkles and the like.
Owner:广东省华桑丽皙生物技术有限公司
Credible knowledge ecosystem
InactiveCN109582858AFind out quicklyAccelerate self-renewalSpecial data processing applicationsText database clustering/classificationSemi-structured dataPersonal knowledge base
The invention discloses a credible knowledge ecosystem which comprises an automatic learning resource collection module for collecting learning materials with specific themes from internet open resources according to needs, carrying out data cleaning and data reduction, and storing structured or semi-structured data in an internal learning resource library credibly; The resource learning module learns resources to form a personal knowledge base, and the personal knowledge base is stored on the platform in a credible mode; The knowledge management module organizes and fuses knowledge elements in the personal knowledge base and updates the knowledge elements to an existing knowledge system; The knowledge sharing module is used for credibly sharing knowledge to a specific user (group); The knowledge innovation module is combined with an existing knowledge system to produce personal achievements and form a personal achievement library; And the achievement submitting module is used for submitting the personal achievements to a platform. In the invention, the knowledge flowing process promotes the continuous self-updating of the knowledge base to form a knowledge ecosystem with continuous circulation and self-growth.
Owner:BEIJING UNIV OF POSTS & TELECOMM
Anti-inflammatory and analgesic lipstick containing natural Zingiber corallinum Hance essential oil
InactiveCN101862283AAccelerate self-renewalImprove self-healing abilityCosmetic preparationsMake-upSide effectLanolin
The invention provides a functional lipstick which has broad antibacterial spectrum, has the functions of antiphlogosis, detumescence and analgesia, is used for treatment or prevention, and has short treatment period, low cost and simple and practical preparation method. The preparation method comprises the following steps: weighting the following raw materials in parts by weight: 0.5-3 parts of Zingiber corallinum Hance essential oil, 10-15 parts of tea tree oil, 10-15 parts of castor oil, 10-15 parts of beeswax, 8-10 parts of paraffin oil, 20-40 parts of essential oil, 10-20 parts of glyceryltri(2-ethylhexanoate) and 2-6 parts of lanolin; heating tea tree oil, castor oil, beeswax, paraffin oil, lanolin and glyceryltri(2-ethylhexanoate) for eutectic melting, stirring evenly, cooling to 35-45 DEG C, adding Zingiber corallinum Hance essential oil, fully and evenly stirring, and cooling to obtain the finished product. The invention has remarkable effects of antiphlogosis, detumescence and analgesia, improves the microcirculatory disturbance caused by the inflammation of the lip, promotes the blood circulation and the self-renewing and self-repairing abilities of tissues, takes effect fast, and has short treatment period, high recovery rate and no toxic or side effects.
Owner:重庆灵方生物技术有限公司
Micro-needle based in vitro culture method for testicular tissue and applications thereof
ActiveCN113322227AImprove the situation of deathMaintain physiological structureCulture processCell culture active agentsEngineeringTesticle
The invention relates to a micro-needle based in vitro culture method for testicular tissue and applications thereof, and belongs to the technical field of biology. The method for in vitro culturing testicular tissue to promote proliferation of spermatogonial stem cells is provided. The method includes: soaking PEGDA micro-needles in a culture medium for replacement, so as to obtain a culture system including replaced PEGDA micro-needles and the culture medium; and adding isolated testicular tissue in the culture system to culture, so as to proliferate the spermatogonial stem cells in the isolated testicular tissue. The method improves situations of death of tissue centers during tissue culture in vitro, so that large tissue culture can be realized. Therefore, a physiological structure of the tissue can be maintained to the greatest extent, which is more in line with in vivo situations. In addition, the method can promote the proliferation of the spermatogonial stem cells in vitro, the self-renewal of the spermatogonial stem cells (SSCs) is supported, and the dryness of the spermatogonial stem cells can be maintained.
Owner:NANJING MEDICAL UNIV
A mask with excellent moisturizing and repairing effects
ActiveCN112545915BImprove the immunityExtension of timeCosmetic preparationsToilet preparationsActive proteinHyaluronidase
Owner:四川省恩乐生物工程有限公司
Culture fluid for maintaining pluripotency of human amniotic epithelial stem cells
ActiveCN105734011ASuitable for training requirementsFull of nutritionCulture processCell culture active agentsCulture fluidEssential amino acid
The invention discloses culture fluid for maintaining the pluripotency of human amniotic epithelial stem cells. The culture fluid comprises base culture fluid, 15%-25% of serum substitutes, 0.1%-2% of non-essential amino acid, 1 mmol / L-5 mmol / L of essential amino acid, 0.01 mmol / L-1 mmol / L of dithiothreitol, 30 ng / ml-120 ng / ml of growth factors and 0.1%-2% of system stabilizing factors. The culture fluid has the advantages that in-vivo survival environments of the stem cells can be simulated by the culture fluid, accordingly, the pluripotency of the stem cells can be maintained when the stem cells are subjected to in-vitro culture, and stem cells with high pluripotency still can be obtained after repeated pass culture is carried out.
Owner:COBAXER BIOTECH
Cosmetic uses of dedifferentiated plant cells
ActiveCN104812368BAccelerate self-renewalImprove self-renewal abilityCosmetic preparationsHair cosmeticsActive agentPlant cell
The present invention relates to the cosmetic use of dedifferentiated plant cells of Rosa plants or of extracts or lyophilizates of said cells as active agents for the care of aging skin or aging hair. The present invention also relates to rose dedifferentiated cells, especially rose dedifferentiated cells of Lancome.
Owner:LOREAL SA
Application of substance for inhibiting expression of TGF-betaR1 in treatment and/or prevention of esophageal cancer
PendingCN112843236APromote proliferationAccelerate self-renewalOrganic active ingredientsDigestive systemParanasal Sinus CarcinomaOncology
The invention discloses application of a substance for inhibiting TGF-betaR1 expression in treatment and / or prevention of esophageal cancer. It finds that TGF-betaR1 is highly expressed in esophageal cancer stem cell spheres and can promote proliferation and self-renewal of esophageal squamous carcinoma cells and formation, migration and invasion of tumor stem cell spheres, and substances for inhibiting expression of TGF-betaR1 can reverse the phenomenon. The invention further provides a theoretical basis and an experimental basis for defining the occurrence and development mechanism of esophageal cancer and targeted therapy.
Owner:SHIHEZI UNIVERSITY
Formula of shower gel made from Xinhui orange peel and orange flower extract and process
InactiveCN108938505AGood skin cleansingPromote repairCosmetic preparationsToilet preparationsPEG-120 METHYL GLUCOSE DIOLEATESorbitan tristearate
The invention discloses a formula of shower gel made from Xinhui orange peel and orange flower extract and a process. The formula comprises the following components in percentage by mass: 5-10% of sodium laureth sulfate, 1-5% of ammonium lauryl sulfate, 0.2-0.5% of polyquaternium-7, 0.1-0.3% of PEG-120 methyl glucose dioleate, 0.1% of methylparaben, 0.1-0.4% of polyoxyethylene sorbitan tristearate, 2-7% of cocamidopropyl betaine, 1-6% of cocoanut fatty acid diethanolamide, 0.5-1% of Xinhui orange peel extract, 0.5-1% of Xinhui orange flower extract, 1-5% of glycerin, 0.1-0.5% of chitosan, 0.1-0.2% of EDTA (Ethylene Diamine Tetraacetic Acid) disodium and the balance of water. The Xinhui orange peel and orange flower extract is combined with other moisturizing components, so that the made shower gel is mild in effect and non-irritating, and can achieve the effects of accelerating self-renewal and repair of skin cells and achieving skin repair and moisturize and moistening effects while cleansing skin.
Owner:广东温和堂健康科学有限公司
Method for promoting over-expression of TSP4 in mesenchymal stem cells, and preparation and application of mesenchymal stem cells
InactiveCN111826399APromotes paracrine functionAccelerate self-renewalGenetically modified cellsNucleic acid vectorDiseaseLentivirus Infections
The invention belongs to the technical field of biology, and in particular relates to a method for promoting the over-expression of TSP4 in mesenchymal stem cells through lentivirus infection. The pENTR11-TSP4 expression plasmid is obtained through the pCMV6-Thbs4 plasmid and a pENTR11 plasmid vector; then the pENTR11-TSP4 expression plasmid and Plv-Easy-T plasmid are connected to obtain Plv-Easy-GFP-TSP4 lentiviral expression plasmid; then Plv-Easy-GFP-TSP4 lentivirus is obtained through packaging; and finally the Plv-Easy-GFP-TSP4 lentivirus is used to infect mesenchymal stem cells. Viral gene fragments are integrated into the genome of the mesenchymal stem cells to obtain TSP4-over-expressed mesenchymal stem cells, so that the activation efficiency of the TSP4-over-expressed mesenchymalstem cells for promoting angiogenesis is improved, and thereby the TSP4-over-expressed mesenchymal stem cells are applied in drugs for the treatment of ischemic diseases, and especially applied in drugs for the treatment of ischemic stroke.
Owner:SHENZHEN LUOHU PEOPLELS HOSPITAL
In vitro culture-amplified human liver progenitor cell and preparation thereof
InactiveCN101275121BAccelerate self-renewalConvenient sourceArtificially induced pluripotent cellsNon-embryonic pluripotent stem cellsCell-Extracellular MatrixECM Protein
The present invention discloses a method for preparing a human hepatic progenitor cell which is amplified and cultivated in vitro, including: a. separating the human hepatic progenitor cell; b. co-cultivating a feeder cell and the human hepatic progenitor cell separated from the step a by a medium having no serum on an extracellular matrix containing human fibrin sealant or other analogues, obtaining a human hepatic progenitor cell colony by amplification. The human hepatic progenitor cell colony is easy to separate from the surface of human fibrin sealant by the simple gelatinolytic band process. The human hepatic progenitor cell can be purified or / and subcultured by further single cell preparation technology process such as enzymatic degradation etc. The human hepatic progenitor cell prepared by the method provides good human hepatic progenitor cell source for hepatic cell treatment, including a hepatic cell transplantation and a bioartificial liver support system, cytotoxicity test platform in the drug screening, hepatitis virus infection and drug screening platform and the like.
Owner:芦银雪
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