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60 results about "Cell Self Renewal" patented technology
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The ability of certain cell types, such as progenitor cells or tumor cells, to go through numerous cycles of CELL DIVISION while still maintaining an undifferentiated or partially differentiated state.
Prospective identification and characterization of breast cancer stem cells
InactiveUS20050089518A1Capacity loseOrganic active ingredientsPeptide/protein ingredientsAbnormal tissue growthSurface marker
Human breast tumors contain hetrogeneous cancer cells. using an animal xenograft model in which human breast cancer cells were grown in immunocompromised mice we found that only a small minority of breast cancer cells had capacity to form new tumors. The ability to form new tumors was not a slochastic property, rather certain populations of cancer cells were depleted for the ability to form new tumors, while other populations were enriched for the ability to form new tumors. Tumorigenic cells could be distinguished from non-tumorigenic cancer cells based on surface marker expression. We prospectively identified and isolated the tumorigenic cells as CD4430CD24− / lowLINEAGE A few as 100 cells from this population were able to form tumors the animal xenograft model, while tens of thousands of cells from non-tumorigenic populations failed to form tumors. The tumorigenic cells could be serially passaged, each time generating new tumors containing and expanded numbers of CD44+CD24 Lineage tumorigenic cells as well as phenotypically mixed populations of non-tumorigenic cancer cells. This is reminiscent of the ability of normal stem cells to self-renew and differentiate. The expression of potential therapeutic targets also differed between the tumorigenic and non-tumorigenic populations. Notch activation promoted the survival of the tumorigenic cells, and a blocking antibody against Notch 4 induced tumorigenic breast cancer cells to undergo apoptosis.
Owner:RGT UNIV OF MICHIGAN
Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
ActiveUS20050261181A1Improve biological activityPromote mineralizationBiocidePeptide/protein ingredientsOsteoblastWnt inhibitor
Compositions and methods for the treatment of bone diseases, bone fractures, bone injuries and other bone abnormalities involving the use of Dkk protein, a Wnt antagonist, a Wnt inhibitor, or any other related protein for the stimulation or enhancement of mineralization and for stimulating the renewal of cells. One Dkk protein, Dickkopf-2 (Dkk-2), acts to stimulate bone formation independently of Wnt proteins which may be inhibited and / or antagonized by Dkk-2. Dkk-2 displayed enhanced specific targeting ability and enhanced biological activity in stimulating or enhancing mineralization. Dkk-2 also played a role in the differentiation and self-renewal of hematopoietic stem cells and mesenchymal stem cells, particularly in osteoblastogenesis and osteoclastogenesis.
Owner:ENZO BIOCHEM
Identification and isolation of acute myeloid leukemia stem cells
ActiveUS20080187950A1Microbiological testing/measurementArtificial cell constructsCancers diagnosisFunctional assay
Acute myeloid leukemia stem cells (AMLSC) are identified. The cells can be prospectively isolated or identified from patient samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
1,5-dihydro-2h-pyrrol-2-one compounds and methods of using same
ActiveUS20180214458A1Good synergyReduced activityOrganic active ingredientsDigestive systemProgenitorCell Self Renewal
The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Owner:FREQUENCY THERAPEUTICS INC
Isolation and use of melanoma cancer stem cells
ActiveUS9151760B2Peptide/protein ingredientsMicrobiological testing/measurementPrimary tumorFunctional assay
A set of markers for melanoma cancer stem cells are provided. The cells can be prospectively isolated or identified from primary tumor samples, and possess the unique properties of cancer stem cells in functional assays for tumor initiation, cancer stem cell self-renewal and differentiation. In addition, cancer stem cells can be used as a predictor for disease progression. The CSC have the phenotype of being positive for expression CD271.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Identification and isolation of transitional cell carcinoma stem cells
InactiveUS7781179B2Microbiological testing/measurementBiological material analysisPrimary tumorFunctional assay
Transitional cell carcinoma stem cells (TCCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Identification and isolation of squamous carcinoma stem cells
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
ActiveUS10568883B2Increase cell densityImproved auditory functioningSenses disorderInorganic active ingredientsCell Self RenewalElectrophonic hearing
Method and compositions for inducing the self-renewal of stem / progenitor supporting cells comprised by a cochlear cell population, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:THE BRIGHAM & WOMEN S HOSPITAL INC +1
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using gsk3 inhibitors: iii
ActiveUS20170252449A1Preventing and reducing ototoxic effectSafe and effective and prolongedPharmaceutical delivery mechanismPharmaceutical non-active ingredientsProgenitorCell Self Renewal
The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:FREQUENCY THERAPEUTICS INC
Culture method capable of maintaining self-renewal state of mouse epiblast stem cells
ActiveCN106635966AImprove growthNo differentiationCell culture supports/coatingCell culture active agentsCell Self RenewalEmbryonic stem cell
The invention discloses a culture method capable of maintaining the self-renewal state of mouse epiblast stem cells. The culture method includes: acquiring, performing passage on and culturing the mouse epiblast stem cells under culture conditions, and observing and detecting the self-renewal state of the cultured mouse epiblast stem cells. The culture method has the advantages that the problems that the state of cells cultured under traditional culture conditions is unstable, passage operation is inconvenient, and existing culture conditions are high in cost, complex in action factors and unfavorable for subsequent researches, and the like are solved; the method is economic, efficient, convenient to operate, stable in effect, beneficial to researches, and the like; the method can provide a clue for the improvement of the culture conditions of current human embryonic stem cells and other kinds of pluripotent stem cells and plays an important role in the promotion of the smooth development of stem cell foundation and application researches.
Owner:ANHUI UNIVERSITY
Methods for controlled proliferation of stem cells / generating inner ear hair cells using gsk-3-alpha inhibitors
InactiveUS20190093079A1Increases fractionIncrease cell densitySenses disorderMicrobiological testing/measurementProgenitorValproic Acid
Provided are compositions and methods for inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells, and including compositions and methods of using GSK3-alpha inhibitors, and salts thereof, optionally in combination with a Differentiation Inhibitor such as a Notch agonist or an HDAC inhibitor (e.g., valproic acid).
Owner:FREQUENCY THERAPEUTICS INC
Isolation and Use of Melanoma Cancer Stem Cells
ActiveUS20120225073A1Delay is slowSufficient amountPeptide/protein ingredientsMicrobiological testing/measurementPrimary tumorFunctional assay
A set of markers for melanoma cancer stem cells are provided. The cells can be prospectively isolated or identified from primary tumor samples, and possess the unique properties of cancer stem cells in functional assays for tumor initiation, cancer stem cell self-renewal and differentiation. In addition, cancer stem cells can be used as a predictor for disease progression. The CSC have the phenotype of being positive for expression CD271.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Application of apigenin to prepare medicine for treating pancreatic cancer
InactiveCN104840456APrevent proliferationDown ratioOrganic active ingredientsAntineoplastic agentsApigeninIntervention trial
The invention belongs to the field of pharmacy, and relates to an application of a TCM monomer of apigenin to prepare a medicine for treating the pancreatic cancer. A CCK-8 method for evaluation, repeated screening and optimization, and a pharmacodynamic test for inhibiting proliferation of pancreatic cancer SW1990 cells are adopted to screen an effective monomer, having a strong anti-tumor effect, of apigenin. Moreover, an equipment of apigenin for interfering a Sonic Hedgehog signal channel of human pancreatic cancer SW1990 stem cells is carried out. The result shows that apigenin can obviously inhibit proliferation of pancreatic cancer stem cells, lower the ratio of pancreatic cancer stem cells, and reduce self-renewable ability of pancreatic cancer stem cells. The ratio of CD24+CD44+ cells is obviously lowered through flow cytometry; the amount of cancer stem cells cultured free of serum decreases; and expression of members in the Sonic Hedgehog signal channel at mRNA and protein levels is obviously lowered. The TCM monomer of apigenin can be taken as an individual unique active component for preparing the medicine for treating the pancreatic cancer.
Owner:FUDAN UNIV SHANGHAI CANCER CENT
Identification and isolation of acute myeloid leukemia stem cells
ActiveUS7767410B2Microbiological testing/measurementVertebrate cellsCancers diagnosisFunctional assay
Acute myeloid leukemia stem cells (AMLSC) are identified. The cells can be prospectively isolated or identified from patient samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Thermoreversible compositions for administration of therapeutic agents
ActiveUS20170252448A1Organic active ingredientsPharmaceutical delivery mechanismProgenitorCell Self Renewal
The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:FREQUENCY THERAPEUTICS INC
Application of baicalein in preparation of drugs for treating pancreatic cancer
InactiveCN106924238APrevent proliferationInhibition of self-renewalOrganic active ingredientsAntineoplastic agentsSurface markerSignalling pathways
The invention belongs to the field of pharmacy and relates to application of baicalein as an SHH (Sonic Hedgehog) signaling pathway inhibitor in the preparation of drugs for treating pancreatic cancer; results of animal experiments show that baicalein regulates Sonic Hedgehog signaling pathway to inhibit the proliferation of pancreatic cancer cells, induce apoptosis, and inhibit self-update of pancreatic cancer stem cells; the baicalein down-regulates IC50 of PANC-1 pancreatic cancer cells, weakening the in-vitro motor ability of the cells; the baicalein down-regulates the activity of CD44+ / CD24+PANC-1 pancreatic cancer cells and down-regulates surface marker CD24 and CD44 protein expression for pancreatic cancer cells, thereby reducing nuclear transcription factor OCT-4 and SOX-2 protein-level expression, inhibiting SHH, PTCH-1, SMO and GLI2, and reducing OCT-4 and SOX-2 protein-level expression. The baicalein may act as an SHH signaling pathway inhibitor to prepare drugs for treating pancreatic cancer.
Owner:FUDAN UNIV SHANGHAI CANCER CENT
Method and reagent for regulation and control of germ layer differentiation of embryonic stem cell and early embryo
The invention relates to a method and a reagent for regulation and control of germ layer differentiation of an embryonic stem cell and an early embryo. The invention first reveals that activation of a Calcinuerin-NFAT signal path is closely related embryonic stem (ES) cell differentiation or self-renewal, wherein ES cell germ layer differentiation can be initiated through activation of the Calcinuerin-NFAT signal path, and ES cell self-renewal can be maintained for a long time through inhibition of the Calcinuerin-NFAT signal path.
Owner:SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Method for inducing self-renewal of mammary stem cells
InactiveCN104450603AAccelerate self-renewalScale upMicrobiological testing/measurementArtificial cell constructsCell Self RenewalStem cell
The invention provides a method for inducing self-renewal of mammary stem cells. The invention discloses a new application of microRNA31. Experiments show that through over-expression of microRNA31, the proportion of mammary stem cells is obviously regulated up, clone formation ability is enhanced and therefore the self-renewal of the mammary stem cells is promoted.
Owner:CHINA AGRI UNIV
Thermoreversible compositions for administration of therapeutic agents
ActiveUS10213511B2Organic active ingredientsPharmaceutical delivery mechanismProgenitorCell Self Renewal
The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:FREQUENCY THERAPEUTICS INC
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using gsk3 inhibitors: i
ActiveUS20170252340A1Induces and maintains stem cell propertyHigh degreeAerosol deliveryOintment deliveryProgenitorCell Self Renewal
The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:FREQUENCY THERAPEUTICS INC
Method for inducing transdifferentiation of mesenchymal stem cells into skin stem cells
ActiveCN106318979ASolve the conversion rateResolution timeOther foreign material introduction processesForeign genetic material cellsTransdifferentiationHuman body
The invention discloses a method for inducing transdifferentiation of mesenchymal stem cells (AD-MSCs) into skin stem cells (AD-SSCs). The method specifically comprises: S1, rapidly separating and purifying homogeneous adipose mesenchymal stem cells; S2, selecting a variety of small RNA molecules stem capable of being used for stem cell epigenetic regulation; S3, assembling and transfecting nucleic acid polypeptide nanoparticles; S4, preparing a culture medium for inducing transdifferentiation of mesenchymal stem cells into skin stem cells; and S5, activating a variety of related genes for guiding the self-renewing and the transdifferentiation of the skin stem cells. According to the present invention, the human adipose mesenchymal stem cells with characteristics of easy obtaining, abundant source, no moral and ethical issue, safty and effectiveness are used as the induced object and are subjected to large-scale, rapid and high-purity transdifferentiation by transfecting the two small RNAs molecules under the effect of the special serum-free culture medium to obtain the AD-SSCs, wherein the induced skin stem cells are the same as the skin stem cells naturally produced in human body, and have the self-renewing ability and the potential for differentiation into the skin cells.
Owner:黄兵 +1
Yap1 inhibitors that target the interaction of yap1 with oct4
Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small celllung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
Owner:H LEE MOFFITT CANCER CENT & RES INST INC
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
ActiveUS10201540B2High degreeHigh purityAerosol deliveryOintment deliveryProgenitorCell Self Renewal
The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:FREQUENCY THERAPEUTICS INC
Identification and isolation of transitional cell carcinoma stem cells
InactiveUS20100267079A1Microbiological testing/measurementBiological material analysisPrimary tumorCancers diagnosis
Transitional cell carcinoma stem cells (TCCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III
ActiveUS10016507B2High degreeHigh purityPharmaceutical delivery mechanismPharmaceutical non-active ingredientsProgenitorCell Self Renewal
The present invention relates to compositions and methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Owner:FREQUENCY THERAPEUTICS INC
Application method of small molecules capable of promoting self-status-renewal of embryonic stem cells
ActiveCN109722411AAccelerate self-renewalImprove growthEmbryonic cellsGerm cellsCell Self RenewalMouse Embryonic Stem Cell
Owner:ANHUI UNIVERSITY
Methods for controlled proliferation of stem cells / generating inner ear hair cells using 3-(pyridin-2-yl)-1H-indol-2-ol based compounds
ActiveUS9968615B2High proportionInduce self-renewal of a populationOrganic active ingredientsPharmaceutical delivery mechanismProgenitorCell Self Renewal
The present invention relates to methods of inducing the self-renewal of stem / progenitor supporting cells, including inducing the stem / progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 3-(pyridin-2-yl)-1H-indol-2-ol containing moiety having a Formula I:and pharmaceutically acceptable salts thereof.
Owner:FREQUENCY THERAPEUTICS INC
Method for stimulating self-renewal of neural stem cells and enhancing neurogenesis
InactiveUS7901936B2Promote self-renewalFacilitated DiffusionNervous system cellsArtificial cell constructsNeurulationEndothelial cell culture
Owner:ALBANY MEDICAL COLLEGE
Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
ActiveUS8343922B2Improve biological activityPromote mineralizationBiocidePeptide/protein ingredientsOsteoblastWnt inhibitor
Compositions and methods for the treatment of bone diseases, bone fractures, bone injuries and other bone abnormalities involving the use of Dkk protein, a Wnt antagonist, a Wnt inhibitor, or any other related protein for the stimulation or enhancement of mineralization and for stimulating the renewal of cells. One Dkk protein, Dickkopf-2 (Dkk-2), acts to stimulate bone formation independently of Wnt proteins which may be inhibited and / or antagonized by Dkk-2. Dkk-2 displayed enhanced specific targeting ability and enhanced biological activity in stimulating or enhancing mineralization. Dkk-2 also played a role in the differentiation and self-renewal of hematopoietic stem cells and mesenchymal stem cells, particularly in osteoblastogenesis and osteoclastogenesis.
Owner:ENZO BIOCHEM
Control of ES cell self renewal and lineage specification, and medium therefor
InactiveCN1659273AReduce differentiationCulture processRecombinant DNA-technologyLineage specificationCell Self Renewal
Self renewal of pluripotent cells in culture is promoted using a combination of an activator of a signalling pathway downstream of a receptor of the TGF-beta superfamily and an activator of a gp130 downstream signalling pathway.
Owner:THE UNIV OF EDINBURGH
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