Continuous albumin dialysis and adsorption purification system and application thereof in child artificial liver

Abstract

The invention discloses a continuous albumin dialysis and adsorption purification system and application thereof in a child artificial liver. The system comprises a blood loop and an albumin regeneration cycle loop; the blood loop comprises high-flux dialyzer which is connected with human body circulation, and the albumin regeneration cycle loop is sequentially connected with the high-flux dialyzer, a broad-spectrum adsorption column and a bilirubin adsorption column through a dialysis pipeline, and filled with albumin dialyzate. The blood dialysis loop has a small volume, and circulation instability caused when the in-vitro blood loop has a too large capacity can be avoided; through albumin regeneration cycle, protein binding toxins of children with hepatic failure can be efficiently removed, a blood dialysis and / or filtering system can be made sequential, and water-soluble medium and small molecular toxins are removed. The automatic selection range of consumables of the system is large, the albumin dialyzate can be recycled, the treatment cost for the child artificial liver is effectively lowered, the operational process is simple, and the working pressure of medical personnel can be effectively alleviated.

Description

technical field [0001] The invention relates to a non-biological artificial liver system for children. Background technique [0002] Artificial Liver Support System (ALSS), referred to as artificial liver, is an in vitro support system that temporarily replaces part of the liver's functions. Through mechanical, physical, chemical and biological devices outside the body, it removes various harmful substances, supplements essential substances, and improves To create conditions for the recovery of liver function, or as a bridge before liver transplantation. Artificial livers are divided into non-biological artificial livers, biological artificial livers and hybrid artificial livers. Non-biological artificial liver technology essentially belongs to the category of blood purification technology. Based on the basic principles of blood purification of diffusion, convection and adsorption, a series of artificial liver technologies have been developed, including plasma exchange, pla...

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Problems solved by technology

[0004] In order to solve the problems existing in the prior art, the present invention provides a continuous albumin dialysis adsorption purification system and its application in children's artificial liver to solve the problem that the existing artificial liver hybridization technology is not suitable for small body weight due to the large extracorporeal circulation capacity. children's problems

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