Continuous albumin dialysis adsorption purification system and applications thereof in child artificial liver

Abstract

The invention discloses a continuous albumin dialysis adsorption purification system and applications thereof in child artificial liver. The system comprises a blood loop and an albumin regeneration circulation loop. The blood loop comprises a high-flux dialyzer connected to human body circulation; and the albumin regeneration circulation loop is sequentially connected to the high-flux dialyzer, abroad-spectrum adsorption column and a bilirubin adsorption column through dialysis pipelines, and the loop is filled with albumin dialysate. The volume of the blood dialysis loop is small, and the problem of unstable circulation caused by overlarge volume of extracorporeal blood loop can be avoided. The albumin regeneration circulation can effectively remove protein-binding toxins of the children with hepatic failure, and can sequentially remove water-soluble medium and small molecular toxins by a blood dialysis and / or filtration system. The system provided by the invention has a wide rangeof self-selection of consumable materials, and the albumin dialysate can be recycled, so that the cost of artificial liver treatment for children is effectively reduced. The operation flow is simple,so that the working pressure of medical staff can be effectively reduced.

Description

technical field [0001] The invention relates to a non-biological artificial liver system for children. Background technique [0002] Artificial Liver Support System (ALSS), referred to as artificial liver, is an in vitro support system that temporarily replaces part of the liver's functions. Through mechanical, physical, chemical and biological devices outside the body, it removes various harmful substances, supplements essential substances, and improves To create conditions for the recovery of liver function, or as a bridge before liver transplantation. Artificial livers are divided into non-biological artificial livers, biological artificial livers and hybrid artificial livers. Non-biological artificial liver technology essentially belongs to the category of blood purification technology. Based on the basic principles of blood purification of diffusion, convection and adsorption, a series of artificial liver technologies have been developed, including plasma exchange, pla...

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Problems solved by technology

[0004] In order to solve the problems existing in the prior art, the present invention provides a continuous albumin dialysis adsorption purification system and its application in children's artificial liver to solve the problem that the existing artificial liver hybridization technology is not suitable for small body weight due to the large extracorporeal circulation capacity. children's problems

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