T cell modification

A technology of cells and cell populations, applied in the field of T cell modification, which can solve problems such as undetermined

Pending Publication Date: 2020-06-19
ADAPTIMMUNE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, methods for the safe delivery of cytokines such as IL-7 and other bioactive molecules to T cells remain undefined

Method used

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Embodiment Construction

[0041] The present invention relates to modified T cells that inducibly express a biologically active molecule, such as IL-7, and constitutively express an antigen receptor. A modified T cell may comprise a nucleic acid construct comprising;

[0042] (i) a first nucleotide sequence encoding a biologically active molecule

[0043] (ii) a second nucleotide sequence encoding an antigen receptor;

[0044] (iii) an inducible promoter operably linked to said first nucleotide sequence, and

[0045] (iv) a constitutive promoter operably linked to said second nucleotide.

[0046] T cells (also known as T lymphocytes) are white blood cells that play a key role in cell-mediated immunity. T cells can be distinguished from other lymphocytes by the presence of the T cell receptor (TCR) on the cell surface. There are several types of T cells, each with different functions.

[0047] T helper cells (T H cells) are called CD4 + T cells because they express the CD4 surface glycoprotein. ...

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Abstract

This invention relates to modified T cells that inducibly express a bioactive molecule, such as IL-7, and constitutively expresses an antigen receptor, such as a T cell receptor or chimeric antigen receptor that binds to a tumour antigen. The modified T cells may comprise a nucleic acid construct that comprises a first nucleotide sequence encoding the bioactive molecule,a second nucleotide sequence encoding the antigen receptor;an inducible promoter operably linked to the first nucleotide sequence and a constitutive promoter operably linked to the second nucleotide. Nucleic acid constructs andvectors are provided, as well as T cells comprising such constructs and vectors and therapeutic methods and uses thereof.

Description

technical field [0001] The present invention relates to the modification of T cells to increase their cytotoxic activity, and the use of the modified T cells in immunotherapy, for example in the treatment of cancer. Background technique [0002] T cells (or T lymphocytes) are found to be widely distributed in tissues and tumor environments. T cells are distinguished from other lymphocytes by the presence of the T cell receptor (TCR) on the cell surface. TCRs are multisubunit transmembrane complexes that mediate antigen-specific activation of T cells. TCRs confer antigen specificity to T cells by recognizing antigenic peptide ligands presented on target cells through major histocompatibility complex (MHC) molecules. [0003] Although peptides derived from altered or mutated proteins in tumor target cells can be recognized as foreign by T cells expressing specific TCRs, many antigens on tumor cells are simply upregulated or overexpressed (so-called autoantigens), And does n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00C07K16/30C07K14/54C07K14/47C07K14/725A61P35/00
CPCA61K39/0011C07K14/5418C07K14/7051C07K16/30C07K14/4748A61K2039/5156A61K2039/5158C07K2317/622C07K2319/03C07K2319/33A61P35/00C12N5/0636C07K16/244C07K16/2833
Inventor G·汉密尔顿J·希尔克C·盖根
Owner ADAPTIMMUNE
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