Method for screening functional targets of medicinal materials with same base source and different growth parts

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and relates to asame-source medicinal material functional target screening method which comprises the following steps of 1) identifying chemical components of a same-source medicinal material, 2) further obtaining action targets of the same-source medicinal materials, and generating a 'chemical component-target' set, 3) generating a 'disease-target' set, 4) sequentially obtaining intersection target spots and key target spots of the same-source medicinal materials from the 'chemical component-target' set and the 'disease-target' set, 5) obtaining 'target-pathway' information and a protein interaction network of the same-source medicinal materials from the intersection target and the key target, and (6) constructing a 'component-disease-target' associated network diagram according to the information, obtaining an action mechanism of the same-source medicinal materials, and completing screening of the same-source medicinal materials. The difference of functional targets among medicinal materials of different medicinal parts of the same base source is compared, and the difference of action mechanisms of the medicinal materials is clarified, so that the compound compatibility effectiveness and the clinical administration safety are ensured.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a method for screening functional targets of medicinal materials with different growth parts from the same source. Background technique [0002] When Chinese medicinal materials are used, in terms of quality, there are often cases of mixed use of medicinal materials from different growth parts of the same base source and mutual substitution of medicinal materials from different application parts of the same base source; There are still many medicinal materials of the same origin because of the difference in the location of the drug, and the meridian distribution of nature and flavor is also different, resulting in different medicinal effects and functions; Factors, screen out the traditional Chinese medicine that acts on the target from the homologous medicinal materials, and ensure the safety, effectiveness and controllability of the medicine. [0003] Take F...

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Problems solved by technology

[0002] When Chinese medicinal materials are used, in terms of quality, there are often cases of mixed use of medicinal materials from different growth parts of the same base source and mutual substitution of medicinal materials from different application parts of the same base source; There are still many medicinal materials of the same origin because of the difference in the location of the drug, and the meridian distribution of nature and flavor is also different, resulting in different medicinal effects and functions; Factors, screen out Chinese medicines that act on the target from homologous medicinal materials, and ensure the safety, effectiveness and controllability of the medicines

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