Glucose sensor as well as preparation method and application thereof

Abstract

The invention discloses a glucose biosensor as well as a preparation method and application thereof. The preparation method of the glucose biosensor comprises the following steps: A) preparing a triblock polymer; B) coating the triblock polymer. The selective infiltration membrane is prepared from the triblock polymer containing the biocompatible group, has a very small temperature coefficient, can effectively and accurately regulate glucose when being applied to a dynamic glucometer, and performs in-situ temperature correction by using impedance of a glucose sensor.

Description

technical field [0001] The invention relates to a glucose sensor and a preparation method and application thereof. Background technique [0002] With the development of the economy and the improvement of life, diabetes has become the three major diseases affecting human health worldwide, along with cardiovascular and cerebrovascular diseases and cancer. Diabetes is a metabolic disease characterized by hyperglycemia as a typical clinical symptom. Long-term hyperglycemia can lead to various complications and even threaten the lives of patients. Although there is no medical technology to cure diabetes at present, years of clinical research have proved that if diabetic patients can control their blood sugar within the normal range as much as possible by adjusting their diet and living habits and assisting drug treatment, they can greatly reduce complications. symptoms or reduce the risk of complications. As one of the main tools for blood sugar regulation, the blood glucose me...

AI Technical Summary

Problems solved by technology

Although they can regulate glucose very effectively, their permeability is greatly affected by temperature. A temperature change of one degree Celsius will cause an 8-10% change in the signal of the continuous blood glucose meter, which directly affects the accuracy of blood glucose monitoring. One has to introduce a temperature correction mechanism

However, the measurement of temperature is not carried out at the same position as the glucose sensor in the body, and temperature correction based on in vitro temperature measurement can only improve the accuracy of blood glucose monitoring to a limited extent.

In addition, there is a chemical cross-linking reaction in the existing hydrogel-based biocompatible film formulation, which greatly shortens the service life of the biocompatible film solution and virtually increases the lifespan of the dynamic blood glucose meter. Production cost (such as US patent US9777307, US9042954), more seriously, with the increase of the use time in the production process of continuous blood glucose meter, the chemical cross-linking reaction is more and more, the viscosity of the biocompatible membrane solution is also more and more is getting bigger and bigger, which seriously affects the consistency of the product

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