Traditional Chinese medicine preparation composition based on cell repair and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine preparation composition based on cell repair and a preparation method thereof, and belongs to the field of biological medicine. The traditional Chinese medicine preparation composition is prepared from honey, astragalus membranaceus, lithospermum erythrorhizon, angelica sinensis, pogonatherum cnidii, herba epimedii, cynomorium songaricum, shaved cinnamon bark, freshwater sponge, camphor, cordyceps sinensis, saussurea involucrata, ginseng, rhodiola rosea, elecampane and rhizoma cimicifugae, and the preparation method comprises the steps of raw material preparation, coarse grinding, mixing, extraction, filtration, concentration, drying, fine grinding, preparation forming and other process treatment. The traditional Chinese medicine preparation can effectively resist skin aging, improve the skin quality, enable the skin to recover elasticity and luster, give full play to the effects of nourishing, oxidation resistance, blood circulation promotion and cell repair of traditional Chinese medicinal materials, deeply nourish the skin and achieve the effect of delaying senescence. The preparation method is simple and easy to implement and low in cost, and has a good application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of biomedicine, relates to a Chinese medicine preparation composition based on cell repair, and also relates to a preparation method of the Chinese medicine preparation composition. Background Art

[0002] Cell repair is a hot area in current biomedical research, especially in the treatment of tissue damage, chronic diseases and senile diseases, cell repair technology has shown great potential. Cell repair is a method of delaying aging by promoting the regeneration and functional recovery of damaged cells. Existing cell repair methods include gene therapy, cell transplantation, tissue engineering and drug therapy. Among them, drug therapy has attracted much attention due to its simple operation and wide range of applications. Traditional drug preparations are mainly in the form of oral and injection. In recent years, topical preparations have been increasingly valued because they can directly act on the skin and effectively penetrate into local tissues to exert better therapeutic effects.

[0003] In recent years, traditional Chinese medicine has shown unique advantages in the field of cell repair due to its multi-target, low toxicity and overall regulation. However, the existing Chinese medicine preparation compositions based on cell repair are mainly concentrated on the basis of single ingredients or simple compatibility, and these preparations also have many problems in practical application. First, the effect of single-ingredient Chinese medicine preparations is limited, and it is difficult to give full play to the comprehensive therapeutic effect of Chinese medicine; secondly, the interactions between the components of simple Chinese medicine preparations are complex, and improper compatibility may lead to reduced efficacy or even side effects; thirdly, the existing Chinese medicine preparations lack scientific and reasonable preparation methods in the preparation process, resulting in the loss of active ingredients and poor stability, thus affecting the efficacy.

[0004] Therefore, developing a Chinese medicine preparation that can deeply nourish the skin, effectively promote cell repair and metabolism, and is easy to use, safe and has no side effects is of great significance for meeting the anti-aging needs of modern women. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine preparation composition based on cell repair and a preparation method thereof, aiming to solve the technical problems that the existing anti-aging products have limited effects and may produce side effects, and the existing Chinese medicine preparations are not effective in cell repair and anti-aging and are inconvenient to use. Through the present invention, it is expected to provide women with a smearable Chinese medicine preparation that can deeply nourish the skin, effectively promote cell repair and metabolism, is safe, has no side effects, and is easy to use.

[0006] The first technical scheme adopted by the present invention is a Chinese medicine preparation composition based on cell repair, which is made of honey, astragalus, lithospermum, angelica, golden thread grass, cnidium monnieri, epimedium, cynomorium songaricum, cinnamon heart, purple tip flower, camphor, cordyceps sinensis, snow lotus, ginseng, rhodiola rosea, costus root, and cimicifuga; each component is matched in the following mass parts: 5-10 parts of honey, 5-15 parts of astragalus, 3-10 parts of lithospermum, 3-10 parts of angelica, 4-8 parts of golden thread grass, 3-5 parts of cnidium monnieri, 3-10 parts of epimedium, 3-5 parts of cynomorium songaricum, 5-10 parts of cinnamon heart, 3-5 parts of purple tip flower, 5-10 parts of camphor, 3-5 parts of cordyceps sinensis, 3-5 parts of snow lotus, 3-5 parts of ginseng, 5-10 parts of rhodiola rosea, 1-5 parts of costus root, and 1-5 parts of cimicifuga.

[0007] Furthermore, the components in the Chinese medicine preparation composition are proportioned according to the following mass parts: 7 parts of honey, 10 parts of astragalus, 6 parts of lithospermum, 5 parts of angelica, 6 parts of golden thread grass, 4 parts of cnidium monnieri, 6 parts of epimedium, 4 parts of cynomorium songaricum, 7 parts of cinnamon bark, 4 parts of purple tip flower, 8 parts of camphor, 4 parts of cordyceps, 4 parts of snow lotus, 4 parts of ginseng, 8 parts of rhodiola rosea, 3 parts of costus root, and 3 parts of cimicifuga.

[0008] The second technical solution adopted by the present invention is a method for preparing a Chinese medicine preparation composition based on cell repair, which is specifically implemented according to the following steps:

[0009] S1. Raw material preparation: weigh each component according to the above mass parts, wash the components of Chinese medicinal materials and dry them;

[0010] S2. Coarse grinding: The dried Chinese medicinal materials are coarsely ground to obtain coarse powder;

[0011] S3. Mixing: Mix the coarse powders of each component evenly;

[0012] S4. Extraction: The mixed coarse powder is added to 8 to 10 times the weight of water to obtain an extract;

[0013] S5. Filtration: Filter the extract through a 150-200 mesh sieve to remove the residue to obtain a clear filtrate;

[0014] S6. Concentration: adding honey to the filtrate and concentrating under reduced pressure to obtain a concentrate;

[0015] S7. Drying: spray drying the concentrate to obtain a dry powder;

[0016] S8. Fine grinding: The dried powder is finely ground to obtain a fine powder;

[0017] S9. Preparation molding: Mix the fine powder and the matrix in proportion, add a small amount of auxiliary materials, and make it into ointment, cream or gel according to the method specified in the pharmacopoeia to finally obtain a Chinese medicine preparation composition for external application.

[0018] Furthermore, the drying temperature in S1 is controlled at 50-70° C. for 6-10 hours to ensure that the effective ingredients are not destroyed.

[0019] Furthermore, the crushed particle size in S2 is less than 40 mesh.

[0020] Further, S3 is mixed using a V-type mixer for 20 to 30 minutes to ensure uniform distribution.

[0021] Further, in S4, the mixture is extracted at 90-100° C. for 2-3 hours, and stirred every 25-35 minutes to ensure sufficient extraction.

[0022] Furthermore, during the filtration in S5, the temperature of the filtrate is maintained at 40-50° C. to prevent the effective components from precipitating out.

[0023] Furthermore, in S6, the volume of the original solution is concentrated to 1 / 5 to 1 / 4, and the reduced pressure concentration temperature is controlled at 50 to 60° C. to avoid high temperature destruction of active ingredients.

[0024] Furthermore, the air inlet temperature in S7 is controlled at 160-180°C, the air outlet temperature is controlled at 50-80°C, and the spray drying ensures the powder fineness and uniformity.

[0025] Furthermore, in S8, the powder is passed through a 300-mesh sieve to obtain fine powder. During the pulverizing process, the ambient temperature is maintained at 20-25° C. to prevent the powder from getting wet.

[0026] Furthermore, the fine powder in S9 is mixed with the matrix in a ratio of 1:6 to 1:4, and the amount of the excipient accounts for 1% to 3% of the Chinese medicine preparation composition; the temperature is kept below 30° C. during the preparation molding process to prevent the matrix from melting and affecting the quality of the preparation.

[0027] Furthermore, the matrix in S9 is one or more of vaseline, lanolin, glycerin, stearic acid, and white oil, and the auxiliary materials include preservatives, flavors, and pigments.

[0028] The composition of the present invention is mainly a smear-type product, designed for women, and is intended to promote cell repair and delay aging. Through selected Chinese medicinal materials, through scientific proportioning and unique preparation technology, a Chinese medicine preparation that can deeply nourish the skin, promote cell metabolism and repair is obtained, which can effectively resist skin aging, improve skin quality, restore skin elasticity and gloss, give full play to the nourishment, anti-oxidation, blood circulation promotion and cell repair effect of Chinese medicinal materials, deeply nourish the skin, effectively promote cell metabolism and repair, thereby significantly improving skin quality, restoring skin elasticity and gloss, and achieving the effect of delaying aging. This preparation method is simple and easy, with low cost, has good application prospects, and the prepared product is safe and effective. It not only significantly improves the effect of cell repair, but also the added matrix and excipients have achieved good technical effects in terms of drug efficacy stability, comfort of use and bioavailability, etc., meet the needs of modern women for anti-aging products, and have important application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The present invention is a flow chart of a method for preparing a cell repair-based Chinese medicine preparation composition. DETAILED DESCRIPTION

[0030] In order to make the technical solution of the present invention clearer, the present invention will be described in detail below in conjunction with specific embodiments. It should be understood that the following embodiments are only used to explain the present invention and do not constitute a limitation on the protection scope of the present invention.

[0031] In the present invention, the term "cell repair" refers to the process of restoring damaged cells to normal function or structure in some way. The term "Chinese herbal medicine" refers to the raw materials used in Chinese herbal medicine preparations, which have medicinal value. The term "scientific proportion" refers to the reasonable proportioning based on the pharmacological effects and interaction relationships of Chinese herbal medicines to achieve the best efficacy.

[0032] The present invention provides a Chinese medicine preparation composition based on cell repair, the key feature of which is the selection of Chinese medicinal materials with nourishing, anti-oxidation, blood circulation promotion and cell repair effects. The composition is made of a variety of Chinese medicinal materials through scientific proportions, rich in nourishing, anti-oxidation and cell metabolism and repair promoting ingredients, and can be used by smearing to penetrate into the skin, provide sufficient nutrition for female skin, thereby effectively resisting aging, improving skin quality, and restoring skin elasticity and luster. It is made of honey, astragalus, lithospermum officinale, angelica, golden silk grass, cnidium monnieri, epimedium, cynomorium songaricum, cinnamon heart, purple tip flower, camphor, cordyceps sinensis, snow lotus, ginseng, rhodiola rosea, costus root, and cimicifuga. The components are mixed in the following proportions by mass: 5-10 parts of honey, 5-15 parts of astragalus, 3-10 parts of lithospermum, 3-10 parts of angelica, 4-8 parts of golden thread grass, 3-5 parts of cnidium monnieri, 3-10 parts of epimedium, 3-5 parts of cynomorium songaricum, 5-10 parts of cinnamon bark, 3-5 parts of purple tip flower, 5-10 parts of camphor, 3-5 parts of cordyceps, 3-5 parts of snow lotus, 3-5 parts of ginseng, 5-10 parts of rhodiola rosea, 1-5 parts of costusroot, and 1-5 parts of cimicifuga.

[0033] In the Chinese medicine preparation composition based on cell repair, astragalus, lithospermum, angelica, golden thread grass, cnidium monnieri, epimedium, cynomorium songaricum, cinnamon heart, purple tip flower, camphor, cordyceps sinensis, snow lotus, ginseng, rhodiola rosea, costus root and cimicifuga are all Chinese medicinal materials with significant therapeutic effects. Through the synergistic effect of multiple drug ingredients, the effect of cell repair and anti-aging is achieved. The effects and working principles of each component are as follows:

[0034] Honey, as a carrier and moisturizer of this preparation, is rich in carbohydrates, vitamins, minerals, enzymes and other nutrients. Its main functions include:

[0035] Skin Repair and Regeneration: Honey can promote the repair and regeneration of skin tissue through moisturizing effect and penetration of nutrients, helping to treat and prevent problems such as dry skin.

[0036] Astragalus: It has the effects of replenishing qi and raising yang, strengthening the exterior and stopping sweating, promoting diuresis and reducing swelling, and expelling toxins and pus. It is widely used to treat qi deficiency and fatigue, spontaneous sweating, night sweats, edema, chronic ulcers, etc. Astragalus contains active ingredients such as saponins, flavonoids and polysaccharides, which can enhance the body's immunity, promote protein synthesis, and accelerate the repair and regeneration of cells and tissues. In addition, Astragalus can also enhance heart function, improve microcirculation, and help cells obtain sufficient nutrition and oxygen.

[0037] Angelica: It has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain, moistening and lubricating the intestines. It has significant therapeutic effects in promoting blood circulation and improving anemia. It contains volatile oils, ferulic acid and multiple vitamins, which can dilate blood vessels, increase blood flow and improve microcirculation. In addition, Angelica also has antioxidant, anti-inflammatory and immunomodulatory effects, which are of great significance to cell repair and tissue regeneration.

[0038] Lithospermum officinale: Rich in ingredients such as shikonin and shikonin, it has the effects of clearing away heat and detoxification, and antibacterial and anti-inflammatory. It can inhibit inflammatory reactions and reduce the damage of inflammation to cells. Some ingredients have antioxidant activity, which helps prevent cell damage caused by oxidative stress.

[0039] Golden grass: It contains a variety of active ingredients, such as flavonoids, alkaloids, etc., which have significant anti-inflammatory effects. It can inhibit the release of inflammatory mediators and the occurrence of inflammatory reactions, and reduce inflammatory damage to tissues. The antioxidants in golden grass can remove free radicals in the body, reduce the damage of oxidative stress to cells, and help maintain the health of cells. Some of its ingredients have inhibitory effects on a variety of bacteria and viruses, which can reduce the damage of pathogenic microorganisms to cells.

[0040] Cnidium monnieri: It can promote blood circulation, improve microcirculation, thereby increasing the oxygen and nutrient supply to tissue cells, which is beneficial to tissue repair and regeneration. It is often used to enhance the penetration of drugs and promote normal metabolism in the body.

[0041] Xianlingpi: It has a conditioning effect, can enhance the digestion and absorption function of the spleen and stomach, promote the absorption and utilization of nutrients, promote the stability of the internal environment and the absorption of nutrients, help to enhance overall immunity and disease resistance, and indirectly ensure the nutritional supply of cells.

[0042] Cynomorium songaricum: It can promote blood circulation, improve microcirculation, thereby increasing the oxygen and nutrient supply to tissue cells, which is beneficial to tissue repair and regeneration. It is often used in traditional Chinese medicine preparations to enhance the penetration of drugs and promote normal metabolism in the body.

[0043] Cinnamon Heart: It has the effect of promoting blood circulation and removing blood stasis, can improve blood circulation, increase the supply of oxygen and nutrients, and help promote tissue repair and regeneration. It is often used to enhance the overall effect of drugs and promote the coordinated operation of various systems in the body.

[0044] Purple Tip Flower: It contains a variety of active ingredients, which can clear away heat and detoxify, remove heat and toxins from the body, and reduce inflammatory reactions and tissue damage. It has an inhibitory effect on a variety of bacteria and viruses, helping to reduce the damage of pathogenic microorganisms to cells. It is used to enhance the anti-inflammatory and antibacterial capabilities of drugs, helping to promote tissue repair and protect physical health.

[0045] Camphor: It has a good effect of promoting blood circulation and removing blood stasis, can improve blood circulation, increase the supply of oxygen and nutrients, and help promote tissue repair and regeneration. It has strong insect repellent and bactericidal effects, and is often used to treat skin infections and parasitic diseases, to enhance the penetration of drugs and promote normal metabolism in the body.

[0046] Cordyceps sinensis: It can regulate immune function, enhance the body's resistance, and help resist the invasion of various pathogenic microorganisms. At the same time, it has a certain nourishing effect on the lungs, can improve the function of the respiratory system, and enhance physical strength and constitution. In addition, it also has the effect of nourishing yin and moistening dryness, which helps to improve dry skin and mucous membrane discomfort. Cordyceps sinensis is often used in traditional Chinese medicine preparations, especially in regulating immunity, improving the respiratory system and skin health.

[0047] Snow lotus: Snow lotus has a good effect of nourishing yin and moistening dryness, which is helpful for improving dry skin and other conditions. At the same time, it has a regulating effect on the nervous system, can relieve anxiety, insomnia and other conditions, and help improve mental state. The active ingredients in snow lotus have certain anti-inflammatory and antioxidant capabilities, which help reduce the damage of inflammatory reactions and oxidative stress to the body. Snow lotus is used in traditional Chinese medicine compositions to enhance the nourishing effect of drugs, improve the internal environment, and protect and repair the functions of various systems in the body.

[0048] Ginseng: It has the function of replenishing qi and blood, strengthening physical fitness, improving the body's nutritional status, and enhancing disease resistance. It has a certain regulatory effect on the nervous system, can relieve fatigue, and improve attention and memory. Ginseng saponins and other ingredients in ginseng have a certain antioxidant effect, which helps to delay the aging process of cells. Ginseng is used in traditional Chinese medicine compositions to improve overall physical fitness and immunity, improve psychological state and delay aging.

[0049] Rhodiola rosea: contains a variety of active ingredients, has significant anti-inflammatory and analgesic effects, can relieve pain and inflammatory reactions. It can enhance the body's ability to adapt to hypoxic environments, help improve cardiopulmonary function and oxygen utilization efficiency. It has a certain protective effect on the liver, can reduce liver cell damage, and promote the recovery and repair of liver function. Rhodiola rosea is used in traditional Chinese medicine compositions to enhance the anti-inflammatory and analgesic effects of drugs.

[0050] Costusroot: It can promote the smooth flow of qi and blood, relieve pain, and has a significant effect on chest and abdominal distension and pain. It can help eliminate the cold in the body through sweating and relieve the discomfort caused by internal and external disharmony. It is used in traditional Chinese medicine compositions to enhance the penetration of drugs and promote normal metabolism in the body.

[0051] Cimicifuga: It has a strong diaphoretic effect, which can help expel the cold in the body and relieve headaches, fever and other symptoms caused by wind and cold. In traditional Chinese medicine theory, it is widely used to treat rheumatoid arthritis and damp-heat diseases, and can relieve joint pain and muscle soreness. It also has the effect of calming the liver and extinguishing wind, which helps to relieve emotional tension, dizziness and other symptoms. Cimicifuga is used in traditional Chinese medicine compositions to enhance the cold-dispelling and damp-removing effects of the drug, and promote the balance of the internal environment and the normal functioning of the body.

[0052] The components in the Chinese medicine preparation composition of the present invention are not simply mixed, but are mutually enhanced and complemented through pharmacological synergy, thereby achieving more significant biological effects:

[0053] Synergistic effect: The combination of different herbs can enhance each other's effects. For example, astragalus and angelica can jointly replenish qi and nourish blood, while golden thread grass and lithospermum can jointly fight inflammation and detoxify, thereby enhancing the overall therapeutic effect.

[0054] Multi-channel action: Each drug ingredient acts on different systems and organs of the body through different pharmacological pathways, comprehensively regulating the internal environment of the body and enhancing the self-repair and stress resistance of cells.

[0055] Cell nutrition and protection: As a carrier and moisturizer, honey not only helps to improve the permeability and bioavailability of drug ingredients, but also has the function of nourishing and protecting cells, effectively promoting cell repair and regeneration.

[0056] Antioxidant and anti-inflammatory: Various medicinal ingredients in the composition, such as comfrey, golden thread grass, snow lotus, etc., have significant antioxidant and anti-inflammatory effects, and can reduce the degree of cell damage and aging.

[0057] Promote blood circulation: Ingredients such as angelica and camphor can improve microcirculation, increase the oxygen and nutrient supply to cells, and help cells metabolize and repair better.

[0058] In short, the Chinese medicine preparation composition cooperates to play the effect of cell repair through different mechanisms of action. Not only can the repair function be achieved at the cellular level, but also the aging process can be delayed from the perspective of comprehensive regulation of body functions. These components play their respective advantages together in the process of interaction to form a therapeutic overall effect. Specifically, through the effects of enhancing body immunity and antioxidant capacity, promoting cell regeneration and skin repair, regulating the immune and nervous systems, reducing inflammation and anxiety, improving blood circulation, accelerating tissue repair, etc. in each component, it is finally achieved to significantly promote the repair and regeneration of cells and tissues and improve the therapeutic effect.

[0059] like Figure 1 As shown, the present invention also provides a simple and easy method for preparing a Chinese medicine preparation composition based on cell repair, so that the Chinese medicine preparation composition can be mass-produced. The Chinese medicine preparation composition is easy to use and can achieve the desired effect without complicated operations.

[0060] The specific preparation method is as follows:

[0061] S1. Raw material preparation: Weigh each component according to the above mass parts, wash it and dry it; the drying temperature in S1 is controlled at 50-70°C and the time is 6-10 hours to ensure that the active ingredients are not destroyed. The purpose of this step is to dry the raw materials at an appropriate temperature and time to remove moisture while retaining the activity of the active ingredients to the greatest extent.

[0062] In this step, each component is weighed, washed, and dried to remove moisture and prevent the effective ingredients from being destroyed. This ensures the quality and stability of the raw materials and prepares for subsequent crushing and extraction.

[0063] S2. Coarse grinding: The dried Chinese medicinal materials are coarsely ground to obtain coarse powder;

[0064] The crushed particle size in S2 is less than 40 meshes, which can increase the surface area of ​​the Chinese medicinal materials, improve the extraction efficiency, and facilitate the subsequent extraction process.

[0065] S3. Mixing: Mix the coarse powders of each component evenly; use a V-type mixer in S3 for 20 to 30 minutes to ensure uniform distribution. The V-type mixer can fully mix the components to ensure the quality and stability of the preparation. Ensure that the components are evenly distributed in the preparation to improve the quality and stability of the preparation.

[0066] S4. Extraction: Add 8 to 10 times the weight of water to the mixed coarse powder to obtain an extract; in S4, extract at 90 to 100° C. for 2 to 3 hours, stirring every 25 to 35 minutes to ensure sufficient extraction. Higher temperature and proper stirring can promote the dissolution of active ingredients and improve the extraction effect.

[0067] S5. Filtration: Filter the extract through a 150-200 mesh screen to remove the residue and obtain a clear filtrate; during filtration in S5, keep the filtrate temperature at 40-50°C to prevent the effective components from precipitating. Within this temperature range, the solubility of the effective components is high, which can reduce losses.

[0068] In this step, the extract is filtered through a 150-200 mesh screen to remove residues and obtain a clear filtrate. Impurities and insoluble particles in the extract are removed to improve the purity of the filtrate.

[0069] S6. Concentration: adding honey to the filtrate and concentrating under reduced pressure to obtain a concentrate;

[0070] The volume of the original solution is concentrated to 1 / 5 to 1 / 4 in S6, and the reduced pressure concentration temperature is controlled at 50 to 60°C to avoid high temperature damage to the active ingredients. Concentration can increase the concentration of the active ingredients, while controlling the temperature can reduce the loss of the active ingredients.

[0071] In this step, the filtrate is concentrated under reduced pressure to obtain a concentrated solution, thereby reducing the volume of the filtrate and increasing the concentration of the active ingredients to facilitate subsequent drying treatment.

[0072] The active ingredients in Chinese herbal medicines are the key to the efficacy of Chinese herbal medicine preparations. By optimizing the extraction and concentration steps, the active ingredients in Chinese herbal medicines can be extracted to the maximum extent to ensure the efficacy of the preparations. During the extraction process, controlling the temperature and time can effectively extract the active ingredients in Chinese herbal medicines.

[0073] S7. Drying: spray drying the concentrate to obtain a dry powder;

[0074] The air inlet temperature in S7 is controlled at 160-180℃, and the air outlet temperature is controlled at 50-80℃. Spray drying ensures the fineness and uniformity of the powder. Spray drying can quickly dry the concentrate to obtain a powder with uniform fineness. The water is removed to obtain a dry powdered preparation, which is easy to store and use.

[0075] S8. Fine grinding: The dried powder is finely ground to obtain a fine powder;

[0076] In S8, the powder is passed through a 300-mesh screen to obtain fine powder. During the pulverization process, the ambient temperature is kept at 20-25°C to prevent the powder from getting wet. The fine powder has a finer particle size, which is conducive to the absorption and use of the preparation. This step further increases the fineness of the powder and improves the solubility and absorbability of the preparation.

[0077] S9. Preparation molding: Mix the fine powder and the matrix in proportion, add a small amount of auxiliary materials, and make it into ointment, cream or gel according to the method specified in the pharmacopoeia to finally obtain a Chinese medicine preparation composition for external application.

[0078] The fine powder in S9 is mixed with the matrix in a ratio of 1:6 to 1:4, and the amount of the excipient accounts for 1% to 3% of the composition of the traditional Chinese medicine preparation; the temperature is kept below 30°C during the preparation molding process to prevent the matrix from melting and affecting the quality of the preparation. The matrix can provide stability and ductility of the preparation, and the excipient can improve the appearance and use experience of the preparation.

[0079] The matrix in S9 is one or more of vaseline, lanolin, glycerin, stearic acid, and white oil, and the excipients include preservatives, moisturizers, preservatives, antioxidants, flavors, and pigments, etc. The selection of these matrices and excipients can be adjusted according to the needs and characteristics of the preparation.

[0080] The core components of the cell repair-based Chinese medicine preparation composition are a series of Chinese herbal extracts with cell repair functions. After careful selection and scientific proportioning, they can effectively promote cell regeneration and repair, thereby achieving the effect of delaying aging. However, these Chinese herbal ingredients alone are not enough to constitute a stable and easy-to-use product. Therefore, an appropriate amount of matrix and excipients are further added.

[0081] The matrix not only acts as a carrier of the Chinese medicine ingredients, helps to evenly distribute and stably release the efficacy, but also enhances the ductility and adhesion of the composition, making it smoother when used and improving the user experience. The selected matrix has good biocompatibility and stability, can ensure the effective release of the Chinese medicine ingredients, and will not irritate the skin. The matrix of the present invention is selected from one or more of vaseline, lanolin, glycerin, stearic acid, and white oil.

[0082] In addition to the matrix, a variety of excipients are added to enhance the comprehensive performance of the composition, including but not limited to moisturizers, preservatives, antioxidants, preservatives, flavors and pigments, etc. Moisturizers can retain skin moisture and keep the skin moisturized after using the product; preservatives can effectively extend the shelf life of the product and ensure product quality; antioxidants can prevent the Chinese medicine ingredients from being oxidized during storage and use and maintain their activity; preservatives are used to enhance the shelf life of the product, flavors are used to provide fragrance, and pigments are used to ensure the overall color of the product.

[0083] In this step, the fine powder is mixed with the matrix in proportion, and a small amount of auxiliary materials are added to make an ointment, cream or gel according to the method specified in the pharmacopoeia. The Chinese medicine preparation is made into a dosage form suitable for external use, which is easy to apply and use.

[0084] The Chinese medicine preparation composition provided in the embodiment of the present invention is mainly used for female cell repair and anti-aging. When used, the preparation is applied to the part that needs to be repaired and gently massaged until it is completely absorbed. Use it 1 to 2 times a day. After continuous use for a period of time, it can significantly improve the skin condition and delay aging.

[0085] In order to further illustrate the preparation method of the present invention, the following specific examples are provided.

[0086] Example 1

[0087] S1. Raw material preparation:

[0088] Weigh the following components by mass: 5 parts of astragalus, 3 parts of lithospermum, 3 parts of angelica, 4 parts of golden thread grass, 3 parts of cnidium monnieri, 10 parts of epimedium, 5 parts of cynomorium songaricum, 10 parts of cinnamon bark, 5 parts of purple tip flower, 10 parts of camphor, 5 parts of cordyceps, 5 parts of snow lotus, 3 parts of ginseng, 10 parts of rhodiola rosea, 5 parts of costus root, and 5 parts of cimicifuga, wash and dry each component; the drying temperature is controlled at 50°C for 10 hours.

[0089] S2. Coarse crushing:

[0090] The dried Chinese medicinal materials were coarsely pulverized into a particle size of 30 meshes to obtain coarse powder.

[0091] S3. Mixing:

[0092] The coarse powders of the components were mixed uniformly using a V-blender and mixed for 20 minutes to ensure uniform distribution.

[0093] S4. Extraction:

[0094] The coarse powders were mixed and 8 times the weight of water was added, and the mixture was soaked at 90° C. for 3 hours, with stirring every 25 minutes to ensure sufficient soaking, to obtain an extract.

[0095] S5. Filtering:

[0096] The extract was filtered through a 150-mesh sieve to remove the residue and obtain a clear filtrate; the filtrate temperature was kept at 40°C during filtration to prevent the effective components from precipitating out.

[0097] S6. Concentration:

[0098] Add 5 parts of honey to the filtrate and mix well; concentrate under reduced pressure to 1 / 5 of the volume of the original solution, and control the reduced pressure concentration temperature at 50°C to avoid high temperature destruction of the active ingredients.

[0099] S7. Drying:

[0100] The concentrated liquid is spray dried, the air inlet temperature is controlled at 160°C, and the air outlet temperature is controlled at 50°C. Spray drying ensures the powder fineness and uniformity to obtain dry powder.

[0101] S8. Fine grinding:

[0102] The dried powder was finely pulverized and passed through a 300-mesh sieve to obtain fine powder. During the pulverization process, the ambient temperature was maintained at 20°C to prevent the powder from getting wet.

[0103] S9. Formulation:

[0104] The fine powder and the matrix are mixed in a ratio of 1:6, and the amount of the auxiliary material accounts for 1% of the Chinese medicine preparation composition; the temperature is maintained at 28°C during the preparation molding process to prevent the matrix from melting and affecting the preparation quality. The matrix is ​​vaseline, and the auxiliary materials include preservatives, flavors and pigments. The fine powder is mixed with the matrix and made into an ointment according to the method specified in the pharmacopoeia to obtain the final external application preparation.

[0105] Example 2

[0106] S1. Raw material preparation:

[0107] Weigh the following components by mass: 15 parts of astragalus, 10 parts of lithospermum, 10 parts of angelica, 8 parts of golden thread grass, 5 parts of cnidium monnieri, 3 parts of epimedium, 3 parts of cynomorium songaricum, 5 parts of cinnamon bark, 3 parts of purple tip flower, 10 parts of camphor, 3 parts of cordyceps, 5 parts of snow lotus, 3 parts of ginseng, 5 parts of rhodiola rosea, 1 part of costus root, and 1 part of cimicifuga, wash and dry each component; the drying temperature is controlled at 60°C for 8 hours.

[0108] S2. Coarse crushing:

[0109] The dried Chinese medicinal materials were coarsely pulverized into a particle size of 30 meshes to obtain coarse powder.

[0110] S3. Mixing:

[0111] The coarse powders of the components were mixed uniformly using a V-blender and mixed for 25 minutes to ensure uniform distribution.

[0112] S4. Extraction:

[0113] The coarse powders were mixed and 9 times the weight of water was added, and the mixture was soaked at 95° C. for 2.5 hours, with stirring every 30 minutes to ensure sufficient soaking, to obtain an extract.

[0114] S5. Filtering:

[0115] The extract was filtered through a 175-mesh screen to remove the residue and obtain a clear filtrate; the filtrate temperature was kept at 45°C during filtration to prevent the effective components from precipitating out.

[0116] S6. Concentration:

[0117] Add 2 parts of honey to the filtrate and mix well; concentrate under reduced pressure to 1 / 4 of the volume of the original solution, and control the reduced pressure concentration temperature at 55°C to avoid high temperature destruction of the active ingredients.

[0118] S7. Drying:

[0119] The concentrated liquid is spray dried, the air inlet temperature is controlled at 170°C, and the air outlet temperature is controlled at 65°C. Spray drying ensures the powder fineness and uniformity to obtain dry powder.

[0120] S8. Fine grinding:

[0121] The dried powder was finely pulverized and passed through a 300-mesh sieve to obtain fine powder. During the pulverization process, the ambient temperature was maintained at 22° C. to prevent the powder from getting wet.

[0122] S9. Formulation:

[0123] The fine powder is mixed with the matrix in a ratio of 1:5, and the amount of the auxiliary material accounts for 2% of the Chinese medicine preparation composition; the temperature is kept at 20°C during the preparation molding process to prevent the matrix from melting and affecting the quality of the preparation. The matrix is ​​lanolin and stearic acid, and the auxiliary materials include preservatives, flavors and pigments. The fine powder is mixed with the matrix and made into a cream according to the method specified in the pharmacopoeia to obtain the final external application preparation.

[0124] Example 3

[0125] S1. Raw material preparation:

[0126] Weigh the following components by mass: 10 parts of Astragalus, 6 parts of Lithospermum, 5 parts of Angelica, 6 parts of Goldenrod, 4 parts of Cnidium, 6 parts of Epimedium, 4 parts of Cynomorium songaricum, 7 parts of Cinnamon, 4 parts of Purple Tip Flos, 8 parts of Camphor, 4 parts of Cordyceps, 4 parts of Saussurea involucrata, 4 parts of Ginseng, 8 parts of Rhodiola, 3 parts of Aucklandia, and 3 parts of Cimicifuga. Wash and dry the components; the drying temperature is controlled at 70°C for 6 hours.

[0127] S2. Coarse crushing:

[0128] The dried Chinese medicinal materials were coarsely pulverized into a particle size of 40 meshes to obtain coarse powder.

[0129] S3. Mixing:

[0130] The coarse powders of the components were mixed uniformly using a V-blender and mixed for 30 minutes to ensure uniform distribution.

[0131] S4. Extraction:

[0132] After the coarse powders are mixed, 10 times the weight of water is added, and the mixture is leached at 100° C. for 2 hours, with stirring every 35 minutes to ensure sufficient leaching, to obtain an extract.

[0133] S5. Filtering:

[0134] The extract was filtered through a 200-mesh sieve to remove the residue and obtain a clear filtrate; the filtrate temperature was kept at 50°C during filtration to prevent the effective components from precipitating out.

[0135] S6. Concentration:

[0136] Add 10 parts of honey to the filtrate and mix well; concentrate under reduced pressure to 1 / 4 of the volume of the original solution, and control the reduced pressure concentration temperature at 60°C to avoid high temperature destruction of the active ingredients.

[0137] S7. Drying:

[0138] The concentrated liquid is spray dried, the air inlet temperature is controlled at 180°C, and the air outlet temperature is controlled at 80°C. Spray drying ensures the powder fineness and uniformity to obtain dry powder.

[0139] S8. Fine grinding:

[0140] The dried powder was finely pulverized and passed through a 300-mesh sieve to obtain fine powder. During the pulverization process, the ambient temperature was maintained at 25°C to prevent the powder from getting wet.

[0141] S9. Formulation:

[0142] The fine powder and the matrix are mixed in a ratio of 1:4, and the amount of the auxiliary material accounts for 3% of the Chinese medicine preparation composition; the temperature is kept at 26°C during the preparation molding process to prevent the matrix from melting and affecting the quality of the preparation. The matrix is ​​stearic acid, and the auxiliary materials include preservatives, flavors and pigments. The fine powder is mixed with the matrix and made into a gel according to the method specified in the pharmacopoeia to obtain the final external application preparation.

[0143] Example 4

[0144] In this embodiment, the preparation method is the same as that in the embodiment, except that the matrix in the embodiment S9 is composed of glycerol, stearic acid and white oil.

[0145] The preparation method ensures the stability and bioavailability of the active ingredients in the preparation through scientific and reasonable steps and parameter control, thereby improving the efficacy of the preparation.

[0146] Traditional Chinese medicine theory emphasizes the compatibility principle of "monarch, minister, assistant and messenger", and realizes multi-target and multi-pathway synergistic therapeutic effects through the rational compatibility of various Chinese medicine ingredients. The present invention adopts various Chinese medicine ingredients such as yellow honey, astragalus, lithospermum officinale, angelica, golden silk grass, cnidium monnieri, epimedium, cynomorium songaricum, cinnamon heart, purple tip flower, camphor, cordyceps sinensis, snow lotus, ginseng, rhodiola rosea, costus root, and cimicifuga, and through scientific compatibility, exerts their respective effects and jointly promotes cell repair. Astragalus, ginseng, angelica, and cordyceps sinensis have the effects of replenishing qi and blood, nourishing yin and tonifying the kidney, and enhancing immunity, and can promote energy metabolism and cell metabolism in the body, and enhance cell vitality and tolerance. Lithospermum officinale, golden silk grass, snow lotus, and rhodiola rosea are rich in various antioxidants and anti-inflammatory ingredients, which can protect cells from oxidative stress and inflammatory damage, thereby slowing down the cell aging process. As a carrier and moisturizer, honey can not only promote the penetration and absorption of Chinese medicine ingredients, but also itself is rich in various nutrients and bioactive ingredients, which is helpful for the repair and regeneration of skin tissue. Camphor, Cynomorium songaricum and cinnamon heart have the effects of promoting blood circulation, warming yang and strengthening yang, improving microcirculation, increasing oxygen and nutrition to cells, and helping to improve skin smoothness and elasticity. The above components work synergistically to promote cell repair and regeneration, thereby achieving the effect of delaying aging.

[0147] Since the Chinese medicine preparation composition of the present invention is used for human body, its safety and effectiveness are the most basic requirements. The following tests are carried out, including but not limited to the appearance, stability, irritation and infectivity of the composition.

[0148] Appearance inspection test

[0149] Purpose of the test: To observe the appearance characteristics of Chinese medicine preparations, including color, shape, texture, etc., in order to evaluate their appearance quality.

[0150] Test method: Take an appropriate amount of Chinese herbal preparation and observe its color, shape and texture under natural light.

[0151] Test results: Appearance characteristics of Chinese medicine preparations, such as uniform color, regular shape, fine texture, etc.

[0152] Stability test

[0153] Purpose of the experiment: To evaluate the stability of Chinese medicine preparations under different conditions, including temperature, humidity, light, etc.

[0154] Test method: Place the Chinese medicine preparations under different conditions, such as high temperature, high humidity, light, etc., regularly observe changes in their appearance, color, odor, etc., and detect the content of their active ingredients.

[0155] Test results: Analyze the stability of Chinese medicine preparations under different conditions, such as no obvious changes in appearance and stable content of active ingredients.

[0156] Irritation test

[0157] Purpose of the study: To evaluate the irritation of traditional Chinese medicine preparations to the skin.

[0158] Experimental method: Select healthy volunteers, apply appropriate amount of Chinese medicine preparation on their skin, and observe the skin's reaction, such as redness, swelling, itching, pain, etc.

[0159] Test results: Record the reactions of volunteers' skin, such as no irritation or only slight irritation.

[0160] Infectivity test

[0161] Purpose of the experiment: To evaluate the anti-infection ability of traditional Chinese medicine preparations.

[0162] Test method: Mix the Chinese medicine preparation with the standard strain, culture it for a certain period of time, and then observe the growth of the strain.

[0163] Test results: Analysis of the inhibitory effect of Chinese herbal preparations on standard strains, such as their obvious anti-infection ability.

[0164] The test results are as follows:

[0165] The results of the appearance inspection test showed that the appearance characteristics of the Chinese medicine preparation met the requirements, with uniform color, regular shape and fine texture, indicating that its appearance quality is good.

[0166] The results of the stability test showed that the Chinese medicine preparation had good stability under different conditions, with no obvious changes in appearance and stable content of active ingredients, indicating that it had good stability.

[0167] The results of the irritation test showed that the Chinese medicine preparation was less irritating to the skin and only caused mild irritation reactions, indicating that it is relatively safe.

[0168] The results of the infectivity test showed that the Chinese medicine preparation had obvious anti-infection ability and had a good inhibitory effect on standard strains, indicating that it had a certain therapeutic effect.

[0169] In summary, the Chinese medicine preparation composition has good appearance quality, good stability, less irritation to the skin, obvious anti-infection ability, and certain therapeutic effect.

[0170] In addition, 100 volunteers were selected for product testing, all of whom were female and aged between 20 and 60 years old. The volunteers were randomly divided into 4 groups, 25 people in each group, and the samples of Examples 1 to 4 were used respectively. Apply an appropriate amount every morning and evening for 2 consecutive months, and record the changes in their skin condition before and after using the product. The results showed that after using the Chinese medicine preparation composition provided by the present invention, the skin condition of the volunteers was significantly improved, the cell repair ability was enhanced, and the skin became firmer and more elastic. Among them, the skin of 92 people became firmer and more elastic, fine lines and wrinkles were significantly reduced, the skin color became more even and shiny, and the pores were also reduced a lot. It can be seen that the preparation effect of the present invention is very obvious. Specifically as follows:

[0171] 1. Multi-ingredient synergistic effect: This Chinese medicine preparation composition uses a variety of ingredients, such as angelica, astragalus, ginseng, etc., to work together to give full play to the comprehensive therapeutic effect. In particular, the synergistic effect of each ingredient significantly improves the cell repair effect, can deeply nourish the skin, enhance cell regeneration ability, reduce skin damage, and make the skin healthier and more vibrant. At the same time, for different skin problems, the ingredients can also complement each other and improve skin quality together.

[0172] 2. Efficient extraction of active ingredients: Through optimized extraction and concentration steps, the effective ingredients in Chinese medicinal materials are extracted to the maximum extent, which not only ensures the efficacy of the preparation, but also maintains the natural active ingredients of Chinese medicinal materials, making the preparation have stronger biological activity and pharmacological effects, thereby improving the efficacy of cell repair and anti-aging.

[0173] 3. Good stability: The physical and chemical stability of the preparation is ensured through reasonable drying and crushing processes. For example, the active ingredients of Chinese herbal medicines can be retained through drying technology to avoid damage to the active ingredients. At the same time, the fine crushing process makes the ingredients evenly distributed and the particle size uniform, which effectively extends the shelf life of the preparation and ensures the safety of long-term storage and use.

[0174] 4. High bioavailability: The bioavailability of the preparation is improved through scientific preparation molding technology, making the drug easier to be absorbed and utilized in the body, ensuring that the active ingredients can quickly reach the skin cells, promote cell metabolism and repair, and improve the treatment effect.

[0175] 5. High safety: The preparation of the present invention uses natural plant ingredients, which has high safety and ensures that the preparation has no toxic side effects during long-term use. In addition, natural plant ingredients also have mild characteristics and are suitable for people with different skin types, especially those with sensitive skin.

[0176] 6. Broad application prospects: Since the preparation method is simple and easy, the cost is low, and it has good application prospects. It is not only applicable to the field of beauty and skin care, but can also be extended to the field of medical care, such as skin repair, skin care after burns and scalds, etc. With the increasing demand for natural, safe and effective products, the Chinese medicine preparation composition of the present invention will have a broader market and application prospects.

[0177] The embodiment of the present invention provides a Chinese medicine preparation composition based on cell repair and a preparation method thereof. The composition uses natural Chinese medicinal materials as raw materials, and is processed by scientific proportioning and preparation process to obtain a Chinese medicine preparation composition with high efficiency, safety and no side effects. By applying, it can significantly improve the skin condition, promote cell repair and regeneration, and delay aging. Compared with the prior art, the composition provided by the embodiment of the present invention has better effect and higher application value.

[0178] The specific embodiments of the present invention are described in detail above, but the present invention is not limited thereto. Within the technical concept of the present invention, the technical solution of the present invention can be subjected to a variety of simple modifications, including the combination of various technical features in any other suitable manner. These simple modifications and combinations should also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention.

Claims

1. A Chinese medicine preparation composition based on cell repair, characterized in that: The invention is prepared from honey, astragalus, lithospermum officinale, angelica, golden thread grass, cnidium monnieri, epimedium, cynomorium songaricum, cassia bark, purple tip flower, camphor, cordyceps sinensis, snow lotus, ginseng, rhodiola rosea, costus root and cimicifuga; the components are mixed in the following mass proportions: 5-10 parts of honey, 5-15 parts of astragalus, 3-10 parts of lithospermum officinale, 3-10 parts of angelica, 4-8 parts of golden thread grass, 3-5 parts of cnidium monnieri, 3-10 parts of epimedium, 3-5 parts of cynomorium songaricum, 5-10 parts of cassia bark, 3-5 parts of purple tip flower, 5-10 parts of camphor, 3-5 parts of cordyceps sinensis, 3-5 parts of snow lotus, 3-5 parts of ginseng, 5-10 parts of rhodiola rosea, 1-5 parts of costus root and 1-5 parts of cimicifuga.

2. The Chinese medicine preparation composition based on cell repair according to claim 1, characterized in that: The components in the Chinese medicine preparation composition are mixed in the following proportions by mass: 7 parts of honey, 10 parts of astragalus, 6 parts of lithospermum, 5 parts of angelica, 6 parts of golden thread grass, 4 parts of cnidium monnieri, 6 parts of epimedium, 4 parts of cynomorium songaricum, 7 parts of cinnamon bark, 4 parts of purple tip flower, 8 parts of camphor, 4 parts of cordyceps, 4 parts of snow lotus, 4 parts of ginseng, 8 parts of rhodiola rosea, 3 parts of costus root, and 3 parts of cimicifuga.

3. A method for preparing a Chinese medicine preparation composition based on cell repair, for preparing the Chinese medicine preparation composition based on cell repair as claimed in claim 1, characterized in that: Follow the steps below to implement it: S1. Raw material preparation: weigh each component according to the above mass parts, wash the components of Chinese medicinal materials and dry them; S2. Coarse grinding: The dried Chinese medicinal materials are coarsely ground to obtain coarse powder; S3. Mixing: Mix the coarse powders of each component evenly; S4. Extraction: The mixed coarse powder is added to 8 to 10 times the weight of water to obtain an extract; S5. Filtration: Filter the extract through a 150-200 mesh sieve to remove the residue to obtain a clear filtrate; S6. Concentration: adding honey to the filtrate and concentrating under reduced pressure to obtain a concentrate; S7. Drying: spray drying the concentrate to obtain a dry powder; S8. Fine grinding: The dried powder is finely ground to obtain a fine powder; S9. Preparation molding: Mix the fine powder and the matrix in proportion, add a small amount of auxiliary materials, and make it into ointment, cream or gel according to the method specified in the pharmacopoeia to finally obtain a Chinese medicine preparation composition for external application.

4. The method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3, characterized in that: The drying temperature in S1 is controlled at 50-70° C. and the drying time is 6-10 hours.

5. The method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3, characterized in that: In the S4, the mixture is extracted at 90-100° C. for 2-3 hours, and stirred every 25-35 minutes.

6. The method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3, characterized in that: During the filtration in S5, the filtrate temperature is maintained at 40-50°C.

7. The method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3, characterized in that: The S6 is concentrated to 1 / 5 to 1 / 4 of the volume of the original solution, and the reduced pressure concentration temperature is controlled at 50 to 60°C.

8. The method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3, characterized in that: In the step S7, the air inlet temperature is controlled at 160-180°C, and the air outlet temperature is controlled at 50-80°C.

9. The method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3, characterized in that: The fine powder and the matrix in S9 are mixed in a ratio of 1:6 to 1:4, and the amount of the auxiliary material accounts for 1% to 3% of the Chinese medicine preparation composition; the temperature is maintained below 30° C. during the preparation molding process.

10. A method for preparing a cell repair-based Chinese medicine preparation composition according to claim 3 or 9, characterized in that: The matrix in S9 is one or more of vaseline, lanolin, glycerin, stearic acid, and white oil, and the auxiliary materials include preservatives, flavors, and pigments.

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