High-immunity digestion-promoting piglet compound feed as well as preparation method and application thereof

Abstract

The invention provides a high-immunity digestion-promoting piglet compound feed as well as a preparation method and application thereof. The high-immunity digestion-promoting piglet compound feed comprises the following components in parts by weight: 60-80 parts of a base material, 1-5 parts of a functional additive and 1-2 parts of a premix. The high-immunity digestion-promoting piglet compound feed provided by the invention is good in palatability, can promote ingestion of piglets, stimulate rapid maturation of digestive systems of the piglets, improve the digestion and utilization rate of the piglets to nutrient substances, avoid dyspepsia of the piglets and influence on intestinal health, and also can enhance the immunity of the piglets and improve the disease resistance of the piglets.

Description

Technical Field

[0001] This invention belongs to the field of animal feed technology, specifically relating to a high-immunity, digestive-promoting compound feed for piglets, its preparation method, and its application. Background Technology

[0002] The piglet stage is a crucial phase in pig farming, and the level of feeding and management during this stage directly determines the pig's later growth potential. However, due to the incomplete development of the piglet's gastrointestinal tract and immune system, piglets are prone to problems such as indigestion, diarrhea, stunted growth, disease infection, and even death after weaning, resulting in huge economic losses for pig farmers.

[0003] Piglets have a very rapid metabolism and growth rate, and their nutritional requirements are also very high. While there is much research on piglet feed nutrition, it hasn't fully considered the piglets' feed digestibility and utilization rate, as well as their own immunity, resulting in a failure to fully realize their growth potential. Piglet growth performance directly affects the economic benefits of the pig farming industry. Enhancing piglets' immunity and improving their digestibility and absorption of feed nutrients are key to promoting rapid piglet growth and improving the efficiency of the pig farming industry.

[0004] Therefore, there is an urgent need to develop a compound feed for piglets that promotes strong immunity and digestion, so as to encourage piglets to eat, enhance their immunity, and improve their digestibility and utilization of the compound feed. This will prevent indigestion and damage to intestinal health caused by the underdeveloped digestive system of piglets, which can affect their growth. Summary of the Invention

[0005] To address the shortcomings of existing technologies, the present invention aims to provide a high-immunity, digestive-promoting compound feed for piglets, its preparation method, and its application. The high-immunity, digestive-promoting compound feed for piglets provided by this invention has good palatability, promotes feed intake in piglets, stimulates the rapid maturation of the piglet's digestive system, improves the digestibility and utilization of nutrients, prevents indigestion and intestinal health, and also enhances the piglet's immunity and disease resistance.

[0006] To achieve this objective, the present invention adopts the following technical solution:

[0007] In a first aspect, the present invention provides a high-immunity, digestive-promoting compound feed for piglets, wherein the high-immunity, digestive-promoting compound feed for piglets comprises, by weight, 60-80 parts of base feed, 1-5 parts of functional additives, and 1-2 parts of premix.

[0008] The base material can be 60, 65, 70, 75, or 80 parts, the functional additives can be 1, 2, 3, 4, or 5 parts, and the premix can be 1, 1.2, 0.4, 1.6, 1.8, or 2 parts, but is not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0009] Preferably, the functional additives include, by weight, 1-3 parts of deer antler polypeptide, 10-30 parts of plant extract, 0.02-0.1 parts of sinomenine and 0.01-0.1 parts of cypermethrin.

[0010] The proportions of deer antler polypeptide can be 1 part, 1.5 parts, 2 parts, 2.5 parts, or 3 parts, etc.; the proportions of plant extract can be 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 26 parts, 28 parts, or 30 parts, etc.; the proportions of sinomenine can be 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, or 0.1 parts, etc.; and the proportions of cypermethrin can be 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, or 0.1 parts, etc., but are not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0011] Deer antler polypeptides are not only easily digested and absorbed, but also improve the palatability of feed, thereby promoting piglets' feed intake, stimulating the rapid maturation of the piglets' digestive system, improving the digestibility and utilization of nutrients, and promoting rapid growth.

[0012] Sinomenine has anti-inflammatory and immune-stimulating effects. The addition of sinomenine to this invention can stimulate the rapid maturation of the piglet's immune system, improve the digestion and utilization of nutrients, and prevent piglet diarrhea.

[0013] Asparagine has anti-inflammatory, antioxidant, and immunomodulatory effects. The addition of asparagine in this invention can prevent intestinal damage caused by poor digestion of exogenous nutrients in piglets and improve the digestive and absorptive functions of the gastrointestinal tract of piglets.

[0014] The above-mentioned ingredients are a combination of four components: deer antler polypeptide, plant extract, sinomenine, and cypermethrin. The synergistic effect of these four components makes the product palatable, promotes piglet feed intake, stimulates the rapid maturation of the piglet's digestive system, improves the piglet's digestion and utilization rate of nutrients, and promotes gastrointestinal motility, further improving the digestion and utilization rate of nutrients, avoiding indigestion and affecting intestinal health. It also has an immunomodulatory effect, which can enhance the piglet's immunity and improve its disease resistance.

[0015] Preferably, the plant extract includes any one or a combination of at least two of the following: Ariol extract, Hexagram daisy extract, or honeysuckle berry extract.

[0016] Preferably, the plant extract is a combination of Ali red extract, six-angled chrysanthemum extract and blue honeysuckle fruit extract.

[0017] Hexagram extract has rich nutritional value and pharmacological activity, with multiple effects such as anti-inflammatory and antioxidant properties. It can improve the antioxidant capacity of piglets, thereby reducing stress and improving their health.

[0018] Ali Red Extract has multiple effects such as anti-inflammatory, antioxidant, and immunomodulatory properties, which can enhance the immunity of piglets, improve their disease resistance, and promote their growth.

[0019] Honeysuckle berry extract is rich in polyphenols, which have antioxidant and anti-inflammatory effects. It can improve the oxidative stress resistance of piglets, improve the intestinal health of piglets, and promote the digestion and absorption of nutrients.

[0020] The above-mentioned extracts of Chrysanthemum indicum, along with extracts of Ariol and Erythrina variegata, can work synergistically to promote gastrointestinal motility in piglets, thereby improving the digestibility and utilization of nutrients, enhancing piglet growth, and further improving the product's efficacy.

[0021] Preferably, the mass ratio of the Ali Red Extract, the Hexagram Chrysanthemum Extract, and the Blue Honeysuckle Fruit Extract is (1-3):(3-5):(1-2), wherein the Ali Red Extract can be 1, 1.5, 2, 2.5, or 3 parts, the Hexagram Chrysanthemum Extract can be 3, 3.5, 4, 4.5, or 5 parts, and the Blue Honeysuckle Fruit Extract can be 1, 1.2, 1.4, 1.6, 1.8, or 2 parts, but is not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0022] Preferably, the base material includes any one or a combination of at least two of corn, puffed corn, or puffed soybeans.

[0023] Preferably, the high-immunity and digestive-promoting piglet compound feed further includes, by weight, 8-12 parts whey powder, 1-5 parts fish meal, and 1-3 parts oil.

[0024] The number of parts of whey powder can be 8, 9, 10, 11 or 12, etc.; the number of parts of fish meal can be 1, 2, 3, 4 or 5, etc.; and the number of parts of oil can be 1, 1.5, 2, 2.5 or 3, etc., but is not limited to the values ​​listed above. Other unlisted values ​​within the above range are also applicable.

[0025] Preferably, the premix includes trace elements and vitamins.

[0026] Preferably, the oil comprises coconut oil.

[0027] Secondly, the present invention provides a method for preparing the above-mentioned high-immunity and digestive-promoting compound feed for piglets, the preparation method comprising the following steps:

[0028] The base material is crushed, then mixed with functional additives and premixed feed for conditioning and granulation to obtain the high-immunity and digestive piglet compound feed.

[0029] Preferably, the mixing further includes mixing with whey powder, fish meal, and oil.

[0030] Thirdly, the present invention also provides the application of the above-mentioned high-immunity and digestive-promoting compound feed for piglets in piglet breeding.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] This invention provides a high-immunity, digestive-promoting compound feed for piglets. By combining deer antler polypeptide, plant extracts, sinomenine, and cypermethrin, the effects are synergistic, resulting in a product with good palatability. It can promote piglets' feed intake, stimulate the rapid maturation of the piglets' digestive system, and has a high digestibility and utilization rate. It can also promote the piglets' gastrointestinal motility, further improving the piglets' digestibility and utilization of nutrients, avoiding indigestion and affecting intestinal health. It also has an immune-regulating effect, which can enhance the piglets' immunity and improve their disease resistance. Detailed Implementation

[0033] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred preparation examples. However, the present invention is not limited to the preparation examples.

[0034] In the following examples, the deer antler polypeptide was purchased from Xi'an Bensuo Biotechnology Co., Ltd.

[0035] Qingteng alkaloids were purchased from Xi'an Meihe Biotechnology Co., Ltd.

[0036] Ali red extract was purchased from Xi'an Sinote Biotechnology Co., Ltd.

[0037] Hexagram extract was purchased from Xiqiancao Biotechnology Co., Ltd.

[0038] The honeysuckle fruit extract was purchased from Fufeng Sinote Biotechnology Co., Ltd.

[0039] The herbal extract was purchased from Chengdu Desite Biotechnology Co., Ltd.

[0040] Preparation Example 1

[0041] This preparation example provides a functional additive with the following specific components (in parts by weight):

[0042] Two parts of deer antler polypeptide, 20 parts of plant extracts (Alihong extract, Hexagrammia extract, and Blue honeysuckle extract in a mass ratio of 2:4:1.5), 0.06 parts of sinomenine, and 0.05 parts of cypermethrin.

[0043] The above raw materials are mixed to obtain the product.

[0044] Preparation Example 2

[0045] This preparation example provides a functional additive with the following specific components (in parts by weight):

[0046] One part of deer antler polypeptide, 30 parts of plant extracts (Alihong extract, Hexagrammia extract, and Blue honeysuckle extract in a mass ratio of 1:3:1), 0.02 parts of sinomenine, and 0.1 parts of cypermethrin.

[0047] The above raw materials are mixed to obtain the product.

[0048] Preparation Example 3

[0049] This preparation example provides a functional additive with the following specific components (in parts by weight):

[0050] 3 parts of deer antler polypeptide, 10 parts of plant extracts (Alihong extract, Hexagrammia extract, and Blue honeysuckle extract in a mass ratio of 3:5:3), 0.1 parts of sinomenine, and 0.01 parts of cypermethrin.

[0051] The above raw materials are mixed to obtain the product.

[0052] Preparation Example 4

[0053] This preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that the Ali Red Extract is not added and a portion is allocated proportionally to the Hexagram Chrysanthemum Extract and the Blue Honeysuckle Fruit Extract.

[0054] The preparation method is the same as in Preparation Example 1.

[0055] Preparation Example 5

[0056] This preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that the extract of Chrysanthemum indicum is not added and a portion of it is allocated proportionally to the extracts of Ariol and Lonicera japonica.

[0057] The preparation method is the same as in Preparation Example 1.

[0058] Preparation Example 6

[0059] This preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that the honeysuckle fruit extract is not added and a portion is allocated proportionally to the six-angled chrysanthemum extract and alihong extract.

[0060] The preparation method is the same as in Preparation Example 1.

[0061] Preparation Example 7

[0062] This comparative preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that no deer antler polypeptide is added, and a portion of the components is proportionally allocated to plant extracts, sinomenine, and cypermethrin.

[0063] The preparation method is the same as in Preparation Example 1.

[0064] Preparation Example 8

[0065] This comparative preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that no plant extracts are added and a portion of the components is proportionally allocated to deer antler polypeptide, sinomenine, and cypermethrin.

[0066] The preparation method is the same as in Preparation Example 1.

[0067] Preparation Example 9

[0068] This comparative preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that sinomenine is not added and a portion is allocated proportionally to plant extracts, deer antler polypeptides, and cypermethrin.

[0069] The preparation method is the same as in Preparation Example 1.

[0070] Preparation Example 10

[0071] This comparative preparation example provides a functional additive whose specific components are identical to those in Preparation Example 1, except that it does not contain cypermethrin, and the proportions of the components are reduced and allocated to plant extracts, sinomenine, and deer antler polypeptide.

[0072] The preparation method is the same as in Preparation Example 1.

[0073] Example 1

[0074] This embodiment provides a high-immunity, digestive-promoting compound feed for piglets, with the following specific components:

[0075] 25 parts corn, 15 parts puffed corn, 25 parts puffed soybeans, 12 parts whey powder, 3 parts fish meal, 3 parts functional additives provided in Preparation Example 1, 1 part premix, and 3 parts coconut oil.

[0076] The premix comprises the following components in parts by weight:

[0077] The premix contains the following per kg of feed: FeSO4·7H2O, 400 mg; CuSO4·5H2O, 20 mg; MnSO4·H2O, 15 mg; ZnSO4·7H2O, 400 mg; KI, 0.5 mg; NaSeO3, 1.0 mg; VB1, 5 mg; VB2, 5 mg; VK, 10 mg; VD3, 3000 IU; VB12, 35 μg; VE, 30 IU; VA, 10000 IU; and choline chloride, 50 mg.

[0078] The preparation method is as follows:

[0079] Corn, puffed corn, and puffed soybeans are pulverized and mixed evenly with whey powder, fish meal, the functional additives provided in Preparation Example 1, premix, and coconut oil. The mixture is then conditioned at low temperature (60°C) and granulated to obtain the final product.

[0080] Example 2-10

[0081] Examples 2-10 provide a high-immunity, digestive-promoting compound feed for piglets. The specific components are the same as those in Example 1, except that the functional additives provided in Preparation Example 1 are replaced with the functional additives provided in Preparation Examples 2-10.

[0082] The preparation method is the same as in Example 1.

[0083] Effect test:

[0084] Feed intake and diarrhea rate

[0085] 330 Duroc-Landrace-Large White crossbred weaned piglets (approximately 8.5 kg / head) were selected and randomly divided into 11 groups, with 3 replicates per group and 10 piglets per replicate. The piglets were fed with the high-immunity and digestive-promoting compound feed provided in Examples 1-10 and commercially available compound feed for piglets (control group). The pre-trial period was 7 days and the formal trial period was 40 days.

[0086] Record the daily weight gain, feed conversion ratio, and diarrhea rate of piglets during the trial period, and calculate the average values.

[0087] Diarrhea rate = Number of diarrhea episodes in piglets during the experimental period / (Number of pigs in the experiment × Number of days in the experiment) × 100%;

[0088] The results are as follows:

[0089] Group Daily feed intake (g / head) Daily weight gain (g) Material ratio Diarrhea rate (%) control group 656 321 2.04 25.83 Example 1 748 436 1.72 4.17 Example 2 742 430 1.73 6.67 Example 3 743 429 1.73 5.83 Example 4 728 412 1.77 10.00 Example 5 731 406 1.80 9.17 Example 6 726 402 1.81 8.33 Example 7 680 353 1.93 12.50 Example 8 683 355 1.92 14.17 Example 9 701 375 1.87 20.00 Example 10 695 370 1.88 18.33

[0090] Piglet nutrient digestibility

[0091] 150g of feed samples were collected from each treatment using the quartering method, vacuum-packed in sample bags and labeled accordingly, and stored at -20℃ for nutrient content analysis. The digestibility test was conducted on day 5 of the above experiment (endogenous indicator method), using acid-insoluble ash (AIA) as the endogenous indicator. 10mL of 10% sulfuric acid solution and 2 drops of toluene were added to every 100g of fresh fecal sample to fix nitrogen and prevent fecal putrefaction. Fecal samples collected on day 3 were thoroughly mixed, and an appropriate amount was placed in an oven (65℃) to constant weight. After drying and pulverizing, the samples were sieved through a 40-mesh sieve and stored at -20℃ for routine nutrient content analysis.

[0092] Hydrochloric acid insoluble ash was used as an endogenous indicator in digestion tests. The methods for determining approximate nutrients are described in "Feed Analysis and Feed Quality Testing Technology". The method for determining hydrochloric acid insoluble ash is based on the standard "Determination of Hydrochloric Acid Insoluble Ash in Feed" (GB / T23742). The formula for calculating the digestibility of a nutrient in the diet is as follows: Nutrient digestibility (%) = 100 - A1B2 / A2B1 × 100, where A1 is the content of hydrochloric acid insoluble ash in the feed sample (%); A2 is the content of hydrochloric acid insoluble ash in the fecal sample (%); B1 is the content of a nutrient in the feed sample (%); and B2 is the content of a nutrient in the fecal sample (%).

[0093] The results are as follows:

[0094]

[0095] Immunological and antioxidant tests

[0096] On the morning of day 41 of the above experiment, two piglets were randomly selected from each replicate. Blood was collected from the anterior vena cava in an empty stomach. After collecting 3 ml of blood in a vacuum non-anticoagulated blood collection tube, the blood was allowed to stand for 30 min, centrifuged at 4500 r / min for 15 min, and the upper serum layer in the blood collection tube was carefully aspirated and placed in a 1.5 mL centrifuge tube. The tube was stored at -20℃, and serum biochemical and immune indicators were measured.

[0097] Serum immune markers, including immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM), were measured using an enzyme-linked immunosorbent assay (ELISA) reader. The reagent kits used were purchased from Nanjing Jiancheng Biotechnology Institute.

[0098] Serum antioxidant indicators, including serum catalase, glutathione peroxidase (GSH-Px) activity, malondialdehyde (MDA) content, and total antioxidant capacity (T-AOC), were measured using a kit (Nanjing Jiancheng Bioengineering Institute).

[0099] The results are as follows:

[0100] Group IgA (g / L) IgG g / L) IgM g / L) control group 0.18 3.45 0.44 Example 1 0.38 4.63 0.78 Example 2 0.35 4.51 0.70 Example 3 0.36 4.56 0.72 Example 4 031 4.21 0.65 Example 5 0.32 4,18 0.60 Example 6 033 4,30 0.62 Example 7 0.23 3.89 0.49 Example 8 0.25 3.92 0.54 Example 9 0.22 4.05 0.50 Example 10 0.24 3.96 0.51

[0101]

[0102] The results above show that the product provided by this invention can effectively promote piglets' feed intake, improve the digestibility and utilization of nutrients, reduce diarrhea, enhance the antioxidant capacity of piglets, and improve their immunity. Comparative studies of Examples 1 and 4-10 reveal that this invention, through the use of a compound of deer antler polypeptide, plant extracts, sinomenine, and cypermethrin, along with the synergistic effects of specific extracts of *Chrysanthemum indicum*, *Alihongia serratifolia*, and *Lysimachia christinae*, can further improve the digestibility and utilization of nutrients in piglets, enhance their antioxidant capacity and immunity, improve piglet growth, and further enhance the product's efficacy.

[0103] The applicant declares that this invention illustrates the high-immunity, digestive-promoting compound feed for piglets, its preparation method, and its application through the above-described preparation examples. However, this invention is not limited to the above embodiments, meaning that this invention does not necessarily rely on the above embodiments for implementation. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of the raw materials for the product, addition of auxiliary components, and selection of specific methods all fall within the protection and disclosure scope of this invention.

[0104] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0105] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A high-immunity and digestion-promoting piglet feed, characterized in that: The high-immunity and digestion-promoting piglet compound feed comprises, by weight, 60-80 parts of a base material, 1-5 parts of a functional additive, and 1-2 parts of a premix.

2. The highly immune and digestion-promoting piglet compound feed according to claim 1, characterized in that: The functional additives include, by weight, 1-3 parts of velvet antler polypeptide, 10-30 parts of plant extract, 0.02-0.1 parts of sinomenine and 0.01-0.1 parts of sinomenine.

3. The highly immune and digestion-promoting piglet compound feed according to claim 2, characterized in that: The plant extract comprises any one of alfalfa extract, chrysanthemum officinale extract or blue lobelia fruit extract or a combination of at least two thereof.

4. The highly immune and digestion-promoting piglet compound feed according to claim 3, characterized in that: The plant extract is a combination of iris extract, chrysanthemum extract and blue lonicera caerulea extract.

5. The highly immune and digestion-promoting piglet compound feed according to claim 4, characterized in that: The mass ratio of the red cyperus rotundus extract, the chrysanthemum officinale extract and the blue indigo fruit extract is (1-3):(3-5):(1-2).

6. The highly immune and digestion-promoting piglet compound feed according to any one of claims 1 to 5, characterized in that: The base material comprises any one of corn, puffed corn or puffed soybeans or a combination of at least two thereof; Preferably, the high-immunity and digestion-promoting piglet compound feed further comprises, by weight, 8-12 parts of whey powder, 1-5 parts of fish meal and 1-3 parts of oil.

7. The highly immune and digestion-promoting piglet compound feed according to claim 6, characterized in that: The oil includes coconut oil.

8. The highly immune and digestion-promoting piglet compound feed according to any one of claims 1 to 7, characterized in that: The premix includes trace elements and vitamins.

9. A method for preparing a highly immune and digestion-promoting piglet feed according to any one of claims 1 to 8, characterized in that: The preparation method comprises the following steps: The base material is crushed, and then mixed with functional additives and premixes for conditioning and granulation to obtain the high-immunity and digestion-promoting piglet compound feed; Preferably, the mixing further comprises mixing with whey powder, fish meal and oil.

10. Use of the highly immune and digestion-promoting piglet feed according to any one of claims 1 to 8 in piglet breeding.

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