Traditional Chinese medicine composition for relieving gout and application thereof

Abstract

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for relieving gout and application thereof. The invention provides a traditional Chinese medicine composition for relieving gout. The traditional Chinese medicine composition comprises the following components in parts by mass: 8-12 parts of an American ginseng extract, 3-6 parts of a poria cocos extract, 6-9 parts of a turmeric extract, 0.8-1.2 parts of a dried ginger extract, 7-13 parts of a cyclocarya paliurus extract, 6-10 parts of a salted cortex phellodendri extract, 4-8 parts of a gynura procumbens extract, 8-12 parts of a nine-processed rhizoma polygonati extract, 8-12 parts of a coix seed extract and 2-6 parts of a corn stigma extract. The traditional Chinese medicine composition can effectively reduce the activity of xanthine oxidase and the content of uric acid in blood, so that gout is relieved, and the effect of the traditional Chinese medicine composition is superior to that of conventionally used western medicine allopurinol.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a Chinese medicine composition for relieving gout and application thereof. Background Art

[0002] Uric acid is a product generated by hypoxanthine and xanthine under the action of xanthine oxidase. Gout is a metabolic disease caused by long-term purine metabolism disorder or increased blood uric acid causing tissue damage. When the uric acid concentration is higher than normal, it precipitates in the form of urate crystals. The acute attack of gout is an acute inflammatory reaction caused by the deposition of urate in the joints and peri-articular tissues in the form of crystals. At present, the commonly used gout relief drugs in clinical practice are mainly Western medicines, including Febuxostat, Benzbromarone, Allopurinol, etc. However, they often cause serious side effects such as cardiovascular and cerebrovascular damage, kidney damage, and gastrointestinal reactions. Therefore, there is an urgent need for gout relief drugs with low toxic and side effects from the same source of medicine and food to treat gout.

[0003] Medicine and food have the same origin, which means that medicine and food have the same origin. Its basic connotation is to regard medicine and food as one. Medicine and food have the same origin, which emphasizes the use of food to supplement medicine and medicine to supplement food, linking medicine, food and health together, which can not only ensure the safety of long-term consumption, but also use the effective ingredients in them to treat diseases. Therefore, with Chinese medicines of medicine and food as the material basis, foods with the effect of relieving gout are developed to reduce side effects and improve drug efficacy. Although Chinese medicine books record a variety of Chinese medicines of medicine and food with the effect of relieving gout, the overall effect of relieving gout is not ideal. The reason may be related to the unsatisfactory effect of a single Chinese medicine of medicine and food in relieving gout, or it may be related to the fact that the ingredients used to relieve gout contained in the Chinese medicines of medicine and food in the relevant drugs or food preparations are too low.

[0004] The present invention is proposed based on this. Summary of the invention

[0005] The object of the present invention is to provide a Chinese medicine composition for relieving gout, which can effectively reduce the activity of xanthine oxidase and the content of uric acid in the blood.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a traditional Chinese medicine composition for relieving gout, comprising the following components in parts by weight: 8-12 parts of American ginseng extract, 3-6 parts of Poria cocos extract, 6-9 parts of turmeric extract, 0.8-1.2 parts of dried ginger extract, 7-13 parts of Cyclocarya paliurus extract, 6-10 parts of Phellodendron chinense extract, 4-8 parts of Chrysanthemum procumbens extract, 8-12 parts of Polygonatum sibiricum extract, 8-12 parts of Coix seed extract, and 2-6 parts of Corn silk extract.

[0008] Preferably, the preparation method of the American ginseng extract comprises the following steps: mixing and soaking American ginseng and water to obtain a mixture; extracting the mixture under a pressure of 450-600 MPa, filtering, and taking the filtrate to obtain an American ginseng extract; concentrating the American ginseng extract, and drying to obtain the American ginseng extract;

[0009] The preparation method of the Poria cocos extract comprises the following steps: mixing and soaking Poria cocos and water to obtain a mixture; extracting the mixture under a pressure of 250 to 400 MPa, filtering, and taking the filtrate to obtain a Poria cocos extract; concentrating the Poria cocos extract, and drying to obtain a Poria cocos extract;

[0010] The preparation method of the turmeric extract comprises the following steps: mixing and soaking turmeric and an ethanol solution to obtain a mixture; extracting the mixture under a pressure of 350-500 MPa, filtering, and taking the filtrate to obtain a turmeric extract; and concentrating and drying the turmeric extract to obtain the turmeric extract.

[0011] Preferably, the preparation method of the dried ginger extract comprises the following steps: mixing dried ginger and an ethanol solution to obtain a mixture; subjecting the mixture to ultrasonic extraction, filtering, and taking a filtrate to obtain a dried ginger extract; concentrating and drying the dried ginger extract to obtain a dried ginger extract;

[0012] The ultrasonic extraction is performed at a temperature of 3 to 5°C, a power of 150 to 250W, and a time of 20 to 50 minutes;

[0013] The preparation method of the Cyclocarya paliurus extract comprises the following steps: mixing Cyclocarya paliurus leaves and water to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking the filtrate to obtain a Cyclocarya paliurus extract; concentrating the Cyclocarya paliurus extract, and drying to obtain a Cyclocarya paliurus extract;

[0014] The temperature of the ultrasonic extraction is 50-60°C, the power is 300-500W, and the time is 30-60min;

[0015] The preparation method of the salt cortex phellodendri extract comprises the following steps: mixing salt cortex phellodendri with a solvent to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking the filtrate to obtain a salt cortex phellodendri extract; concentrating and drying the salt cortex phellodendri extract to obtain a salt cortex phellodendri extract;

[0016] The solvent is a mixed solution of hydrochloric acid and methanol; the volume ratio of hydrochloric acid to methanol in the mixed solution is 1:90-110;

[0017] The mass volume ratio of the mixture of the salt cortex phellodendri and the solvent is 1g:20-30mL;

[0018] The temperature of the ultrasonic extraction is 20-30° C., the power is 200-300 W, and the time is 30-40 min.

[0019] Preferably, the preparation method of the notoginseng extract comprises the following steps: mixing notoginseng with an ethanol solution to obtain a mixture; subjecting the mixture to reflux extraction, filtering, and taking the filtrate to obtain a notoginseng extract; concentrating and drying the notoginseng extract to obtain a notoginseng extract;

[0020] The temperature of the reflux extraction is 60-80° C., and the time is 1-3 hours.

[0021] Preferably, the preparation method of the nine-processed polygonatum sibiricum extract comprises the following steps: mixing and soaking the nine-processed polygonatum sibiricum and water to obtain a mixture; subjecting the mixture to subcritical water extraction, filtering, and taking the filtrate to obtain a nine-processed polygonatum sibiricum extract; concentrating the nine-processed polygonatum sibiricum extract, and drying to obtain the nine-processed polygonatum sibiricum extract;

[0022] The extraction pressure of the subcritical water extraction is 4.5-6Mpa, and the temperature is 110-130°C.

[0023] Preferably, the preparation method of the coix seed extract comprises the following steps: mixing coix seed and water for decoction, filtering, and taking the filtrate to obtain a decoction liquid; mixing the decoction liquid with α-amylase for decoction, filtering, and taking the filtrate to obtain a second decoction liquid; mixing the second decoction liquid with saccharifying enzyme for decoction, filtering, and taking the filtrate to obtain a coix seed extract; concentrating the coix seed extract and drying to obtain a coix seed extract;

[0024] The mass volume ratio of the coix seed and water is 1g:8-12mL;

[0025] The volume ratio of the decoction and α-amylase is 1:0.01-0.03;

[0026] The volume of the second decoction liquid and the saccharifying enzyme mixed is 1:0.005-0.015.

[0027] Preferably, the preparation method of the corn silk extract comprises the following steps: mixing corn silk and brewer's yeast for fermentation to obtain a fermentation product; mixing the fermentation product with an ethanol solution for decoction, filtering, and obtaining a filtrate to obtain a corn silk extract; concentrating the corn silk extract, and drying to obtain the corn silk extract;

[0028] The mass ratio of the corn silk and the brewer's yeast is 1:0.05-0.15;

[0029] The fermentation temperature is 32-38°C; the fermentation time is 20-30h;

[0030] The mass ratio of the fermentation product and the ethanol solution is 1:3-7;

[0031] The initial concentration of the ethanol solution is 50-70%;

[0032] The decoction temperature is 60-80°C;

[0033] The decoction time is 3 to 6 hours.

[0034] The present invention also provides application of the traditional Chinese medicine composition in preparing a preparation for relieving gout.

[0035] The present invention also provides a Chinese medicine patch for relieving gout, comprising a Chinese medicine composition and a conditioning agent;

[0036] The mass volume ratio of the Chinese medicine composition and the conditioning agent is 1g:2-3mL;

[0037] The blending agent is a mixture of ginger juice and honey, and the volume ratio of ginger juice to honey in the blending agent is 1:3-6;

[0038] The Chinese medicine composition is the Chinese medicine composition described.

[0039] The present invention also provides a method for preparing the Chinese medicine patch, comprising the following steps: mixing the Chinese medicine composition and the blending agent to prepare the Chinese medicine patch.

[0040] Beneficial effects of the present invention:

[0041] The invention provides a Chinese medicine composition for relieving gout. The Chinese medicine composition is prepared by scientifically combining and proportioning American ginseng extract, Poria cocos extract, Curcuma longa extract, Dry ginger extract, Cyclocarya paliurus extract, Phellodendron chinense extract, Panax notoginseng extract, Polygonatum sibiricum extract, Coix lachryma-jobi extract and Corn silk extract. The Chinese medicine composition can effectively reduce the activity of xanthine oxidase and the content of uric acid in the blood, thereby relieving gout, and the effect is better than that of the conventionally used Western medicine allopurinol.

[0042] The invention prepares extracts of various Chinese medicine components through different preparation methods, thereby improving the effects thereof and improving the effects of the Chinese medicine composition. DETAILED DESCRIPTION

[0043] The present invention provides a traditional Chinese medicine composition for relieving gout, comprising the following components in parts by weight:

[0044] 8 to 12 parts of American ginseng extract, preferably 9 to 11 parts, more preferably 10 parts;

[0045] 3 to 6 parts of Poria cocos extract, preferably 4 to 5 parts, more preferably 4.5 parts;

[0046] 6 to 9 parts of turmeric extract, preferably 7 to 8 parts, more preferably 7.5 parts;

[0047] 0.8 to 1.2 parts of dried ginger extract, preferably 0.9 to 1.1 parts, more preferably 1.0 parts;

[0048] 7 to 13 parts of Cyclocarya paliurus extract, preferably 9 to 11 parts, more preferably 10 parts;

[0049] 6 to 10 parts of Phellodendron chinense extract, preferably 7 to 9 parts, more preferably 8 parts;

[0050] 4 to 8 parts of Chrysanthemum procumbentum extract, preferably 5 to 7 parts, more preferably 6 parts;

[0051] 8 to 12 parts of processed polygonatum sibiricum extract, preferably 9 to 11 parts, more preferably 10 parts;

[0052] 8 to 12 parts of coix seed extract, preferably 9 to 11 parts, more preferably 10 parts;

[0053] 2 to 6 parts of corn silk extract, preferably 3 to 5 parts, more preferably 4 parts.

[0054] In the present invention, the preparation method of the American ginseng extract comprises the following steps: mixing and soaking American ginseng and water to obtain a mixture; extracting the mixture under a pressure of 450-600 MPa, filtering, and taking the filtrate to obtain an American ginseng extract; concentrating the American ginseng extract, and drying to obtain the American ginseng extract;

[0055] Before the American ginseng is mixed and soaked in water, the American ginseng needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0056] The mass volume ratio of the mixture of American ginseng and water is 1g:30-50mL, preferably 1g:35-45mL, and more preferably 1g:40mL;

[0057] The soaking time is 0.5 to 2 hours, preferably 1 to 1.5 hours, and more preferably 1.25 hours;

[0058] The pressure is preferably 500-550 MPa, more preferably 525 MPa;

[0059] The extraction time is 5 to 8 minutes, preferably 6 to 7 minutes, and more preferably 6.5 minutes;

[0060] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0061] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the vacuum degree of the drying is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa; the vacuum degree of the drying is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0062] The preparation method of the Poria cocos extract comprises the following steps: mixing and soaking Poria cocos and water to obtain a mixture; extracting the mixture under a pressure of 250 to 400 MPa, filtering, and taking the filtrate to obtain a Poria cocos extract; concentrating the Poria cocos extract, and drying to obtain a Poria cocos extract;

[0063] Before mixing the Poria cocos and water, the Poria cocos needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0064] The mass volume ratio of the mixture of Poria cocos and water is 1g:20-40mL, preferably 1g:25-35mL, and more preferably 1g:30mL;

[0065] The soaking time is 0.5 to 2 hours, preferably 1 to 1.5 hours, and more preferably 1.25 hours;

[0066] The pressure is preferably 300-350 MPa, more preferably 325 MPa;

[0067] The extraction time is 3 to 7 minutes, preferably 4 to 6 minutes, and more preferably 5 minutes;

[0068] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0069] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the vacuum degree of the drying is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa; the vacuum degree of the drying is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0070] The preparation method of the turmeric extract comprises the following steps: mixing and soaking turmeric and an ethanol solution to obtain a mixture; extracting the mixture under a pressure of 350 to 500 MPa, filtering, and taking the filtrate to obtain a turmeric extract; concentrating the turmeric extract, and drying to obtain a turmeric extract;

[0071] Before mixing the turmeric and the ethanol solution, the turmeric needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0072] The mass volume ratio of the turmeric and ethanol solution is 1g:20-40mL, preferably 1g:25-35mL, and more preferably 1g:30mL;

[0073] The initial concentration of the ethanol solution is 90-100 vt%, preferably 93-97 vt%, and more preferably 95 vt%;

[0074] The soaking time is 0.5 to 2 hours, preferably 1 to 1.5 hours, and more preferably 1.25 hours;

[0075] The pressure is preferably 400-450 MPa, more preferably 425 MPa;

[0076] The extraction time is preferably 4 to 8 minutes, preferably 5 to 7 minutes, and more preferably 6 minutes;

[0077] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0078] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the drying vacuum degree is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0079] In the present invention, the preparation method of the dried ginger extract comprises the following steps: mixing dried ginger and ethanol solution to obtain a mixture; subjecting the mixture to ultrasonic extraction, filtering, and taking the filtrate to obtain a dried ginger extract; concentrating the dried ginger extract, and drying to obtain a dried ginger extract;

[0080] Before mixing the dried ginger and the ethanol solution, the dried ginger needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0081] The mass volume ratio of the dried ginger and the ethanol solution is 1g:20-40mL, preferably 1g:25-35mL, and more preferably 1g:30mL;

[0082] The initial concentration of the ethanol solution is 90-100 vt%, preferably 93-97 vt%, and more preferably 95 vt%;

[0083] Before the ultrasonic extraction, precooling is required, and the precooling temperature is 3-5°C, preferably 4°C;

[0084] The temperature of the ultrasonic extraction is 3-5°C, preferably 4°C; the power is 150-250W, preferably 180-220W, more preferably 200W; the time is 20-50min, preferably 30-40min, more preferably 35min;

[0085] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0086] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the drying vacuum degree is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0087] The preparation method of the Cyclocarya paliurus extract comprises the following steps: mixing Cyclocarya paliurus leaves and water to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking the filtrate to obtain a Cyclocarya paliurus extract; concentrating the Cyclocarya paliurus extract, and drying to obtain a Cyclocarya paliurus extract;

[0088] Before mixing the Cyclocarya paliurus leaves and water, the Cyclocarya paliurus leaves need to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0089] The mass volume ratio of the mixture of Salix babylonica leaves and water is 1g:5-15mL, preferably 1g:8-12mL, and more preferably 1g:10mL;

[0090] The temperature of the ultrasonic extraction is 50-60°C, preferably 53-57°C, and more preferably 55°C; the power is 300-500W, preferably 350-450W, and more preferably 400W; the time is 30-60min, preferably 40-50min, and more preferably 45min;

[0091] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0092] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the drying vacuum degree is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0093] The preparation method of the salt cortex phellodendri extract comprises the following steps: mixing salt cortex phellodendri with a solvent to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking the filtrate to obtain a salt cortex phellodendri extract; concentrating and drying the salt cortex phellodendri extract to obtain a salt cortex phellodendri extract;

[0094] The preparation process of salted Phellodendron amurense comprises the following steps: mixing and infiltrating Phellodendron amurense silk and salt solution to obtain infiltrated Phellodendron amurense silk; frying the infiltrated Phellodendron amurense silk to obtain salted Phellodendron amurense;

[0095] The mass volume ratio of the mixture of the Phellodendron chinense silk and the salt solution is 1g:10-20mL, preferably 1g:13-17mL, and more preferably 1g:15mL;

[0096] The initial concentration of the salt solution is 1-3 wt%, preferably 2 wt%;

[0097] The soaking time is 1 to 2 hours, preferably 1.3 to 1.7 hours, and more preferably 1.5 hours;

[0098] The frying temperature is 80-120°C, preferably 90-110°C, and more preferably 100°C;

[0099] The frying time is 15 to 25 minutes, preferably 18 to 22 minutes, and more preferably 20 minutes;

[0100] Before the salt cork is mixed with the solvent, the salt cork needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0101] The solvent is a mixed solution of hydrochloric acid and methanol; the volume ratio of hydrochloric acid to methanol in the mixed solution is 1:90-110, preferably 1:95-105, and more preferably 1:100;

[0102] The mass volume ratio of the mixture of salt cortex phellodendri and solvent is 1g:20-30mL, preferably 1g:23-27mL, and more preferably 1g:25mL;

[0103] The temperature of the ultrasonic extraction is 20-30°C, preferably 23-27°C, and more preferably 25°C; the power is 200-300W, preferably 230-270W, and more preferably 250W; the time is 30-40min, preferably 33-37min, and more preferably 35min.

[0104] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0105] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -65°C, and the drying time is 12 to 24 hours, preferably 18 hours.

[0106] In the present invention, the preparation method of the notoginseng extract comprises the following steps: mixing notoginseng with an ethanol solution to obtain a mixture; subjecting the mixture to reflux extraction, filtering, and taking a filtrate to obtain a notoginseng extract; concentrating and drying the notoginseng extract to obtain the notoginseng extract;

[0107] Before mixing the flat chrysanthemum Panax notoginseng with the ethanol solution, the flat chrysanthemum Panax notoginseng needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0108] The mass volume ratio of the mixture of the flat chrysanthemum Panax notoginseng and the ethanol solution is 1g:20-40mL, preferably 1g:25-35mL, and more preferably 1g:30mL;

[0109] The initial concentration of the ethanol solution is 70-90 vt%, preferably 75-85 vt%, and more preferably 80 vt%;

[0110] The reflux extraction temperature is 60-80°C, preferably 65-75°C, more preferably 70°C; the time is 1-3h, preferably 1.5-2.5h, more preferably 2h;

[0111] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0112] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the drying vacuum degree is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0113] In the present invention, the preparation method of the nine-processed polygonatum sibiricum extract comprises the following steps: mixing and soaking the nine-processed polygonatum sibiricum and water to obtain a mixture; subjecting the mixture to subcritical water extraction, filtering, and taking the filtrate to obtain a nine-processed polygonatum sibiricum extract; concentrating the nine-processed polygonatum sibiricum extract, and drying to obtain the nine-processed polygonatum sibiricum extract;

[0114] Before the processed polygonatum sibiricum and water are mixed and soaked, the processed polygonatum sibiricum needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0115] The mass volume ratio of the nine-processed polygonatum and water is 1g:20-40mL, preferably 1g:25-35mL, and more preferably 1g:30mL;

[0116] The soaking time is 0.5 to 2 hours, preferably 1 to 1.5 hours, and more preferably 1.25 hours;

[0117] The extraction pressure of the subcritical water extraction is 4.5-6Mpa, preferably 5-5.5Mpa, and more preferably 5.25Mpa; the temperature is 110-130°C, preferably 115-125°C, and more preferably 120°C; the extraction time is 8-12min, preferably 9-11min, and more preferably 10min;

[0118] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0119] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the drying vacuum degree is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0120] In the present invention, the preparation method of coix seed extract comprises the following steps: mixing coix seed and water for decoction, filtering, taking filtrate, and obtaining decoction liquid; mixing the decoction liquid with α-amylase for decoction, filtering, taking filtrate, and obtaining a second decoction liquid; mixing the second decoction liquid with saccharifying enzyme for decoction, filtering, taking filtrate, and obtaining coix seed extract; concentrating the coix seed extract, and drying, and obtaining coix seed extract;

[0121] Before the coix seeds and water are mixed and boiled, the coix seeds need to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0122] The mass volume ratio of the coix seed and water is 1g:8-12mL, preferably 1g:9-11mL, and more preferably 1g:10mL;

[0123] The decoction temperature is 50-70°C, preferably 55-65°C, and more preferably 60°C;

[0124] The decoction time is 2 to 5 hours, preferably 3 to 4 hours, and more preferably 3.5 hours;

[0125] The volume ratio of the decoction and α-amylase is 1:0.01-0.03, preferably 1:0.02;

[0126] The decoction temperature is 50-70°C, preferably 55-65°C, and more preferably 60°C;

[0127] The decoction time is 1 to 3 hours, preferably 1.5 to 2.5 hours, and more preferably 2 hours;

[0128] The volume of the second decoction liquid and the saccharifying enzyme mixed is 1:0.005-0.015, preferably 1:0.008-0.012, and more preferably 1:0.010;

[0129] The decoction temperature is 50-70°C, preferably 55-65°C, and more preferably 60°C;

[0130] The decoction time is 30 to 60 minutes, preferably 40 to 50 minutes, and more preferably 45 minutes;

[0131] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0132] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -70 to -60°C, and more preferably -65°C; the drying time is 12 to 24 hours, preferably 16 to 20 hours, and more preferably 18 hours; the drying vacuum degree is 1 to 10Pa, preferably 4 to 7Pa, and more preferably 5.5Pa.

[0133] In the present invention, the preparation method of the corn silk extract comprises the following steps: mixing corn silk and brewer's yeast for fermentation to obtain a fermentation product; mixing the fermentation product with an ethanol solution for decoction, filtering, and obtaining a filtrate to obtain a corn silk extract; concentrating the corn silk extract, and drying to obtain the corn silk extract;

[0134] Before the corn silk and brewer's yeast are mixed and fermented, the corn silk needs to be crushed to a particle size of 50 to 70 meshes, preferably 55 to 65 meshes, and more preferably 60 meshes;

[0135] The mass ratio of the corn silk to the brewer's yeast is 1:0.05-0.15, preferably 1:0.08-0.12, and more preferably 1:0.10;

[0136] The fermentation temperature is 32-38°C, preferably 34-36°C, and more preferably 35°C; the fermentation time is 20-30h, preferably 23-27h, and more preferably 25h;

[0137] The mass ratio of the fermentation product to the ethanol solution is 1:3-7, preferably 1:4-6, and more preferably 1:5;

[0138] The initial concentration of the ethanol solution is 50-70 vt%, preferably 55-65 vt%, and more preferably 60 vt%;

[0139] The decoction temperature is 60-80°C, preferably 65-75°C, and more preferably 70°C;

[0140] The decoction time is 3 to 6 hours, preferably 4 to 5 hours, and more preferably 4.5 hours;

[0141] The concentration method is low-temperature and reduced-pressure concentration; the concentration temperature is 23 to 26°C, preferably 24 to 25°C, and more preferably 24.5°C; the concentration pressure is 7.0 to 9.0 kPa, and preferably 8.0 kPa.

[0142] The drying is vacuum freeze drying, the drying temperature is -80 to -50°C, preferably -65°C, and the drying time is 12 to 24 hours, preferably 18 hours.

[0143] The present invention also provides the use of the traditional Chinese medicine composition in preparing a preparation for relieving gout;

[0144] The preparations include liquid, granules and patches.

[0145] The present invention also provides a Chinese medicine patch for relieving gout, comprising a Chinese medicine composition and a conditioning agent;

[0146] The mass volume ratio of the Chinese medicine composition and the conditioning agent is 1g:2-3mL, preferably 1g:2.5mL;

[0147] The conditioning agent is a mixture of ginger juice and honey, and the volume ratio of ginger juice to honey in the conditioning agent is 1:3-6, preferably 1:4-5, and more preferably 1:4.5;

[0148] The Chinese medicine composition is the Chinese medicine composition described.

[0149] The present invention also provides a method for preparing the Chinese medicine patch, comprising the following steps: mixing the Chinese medicine composition and the blending agent to prepare the Chinese medicine patch.

[0150] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0151] Example 1

[0152] (1) Preparation of American ginseng extract

[0153] The American ginseng was crushed to a particle size of 60 mesh, and then mixed with water at a mass volume ratio of 1g:40mL, and soaked for 1.5 hours to obtain a mixture; the mixture was extracted at a pressure of 520Mpa for 6 minutes, filtered, and the filtrate was taken to obtain an American ginseng extract; the American ginseng extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18 hours to obtain an American ginseng extract;

[0154] (2) Preparation of Poria cocos extract

[0155] The poria cocos was crushed to a particle size of 60 mesh, and then mixed with water at a mass volume ratio of 1g:30mL, and soaked for 1.5 hours to obtain a mixture; the mixture was extracted at a pressure of 320Mpa for 5 minutes, filtered, and the filtrate was taken to obtain a poria cocos extract; the poria cocos extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18 hours to obtain a poria cocos extract;

[0156] (3) Preparation of turmeric extract

[0157] The turmeric was crushed to a particle size of 60 mesh, and then mixed with a 95vt% ethanol solution at a mass volume ratio of 1g:30mL to obtain a mixture; the mixture was extracted at a pressure of 420Mpa for 6min, filtered, and the filtrate was taken to obtain a turmeric extract; the turmeric extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain a turmeric extract;

[0158] (4) Preparation of dried ginger extract

[0159] The dried ginger was crushed to a particle size of 60 mesh, and then mixed with a 95vt% ethanol solution at a mass volume ratio of 1g:30mL to obtain a mixture; the mixture was precooled to 4°C, and then ultrasonically extracted at 4°C and 200W for 35min, filtered, and the filtrate was taken to obtain a dried ginger extract; the dried ginger extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain a dried ginger extract;

[0160] (5) Preparation of Cyclocarya paliurus Extract

[0161] The leaves of Cyclocarya paliurus were crushed to a particle size of 60 mesh, and then mixed with water at a mass volume ratio of 1g:10mL to obtain a mixture; the mixture was ultrasonically extracted at 55°C and 400W for 45min, filtered, and the filtrate was taken to obtain a Cyclocarya paliurus extract; the Cyclocarya paliurus extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain a Cyclocarya paliurus extract;

[0162] (6) Preparation of Phellodendron chinense extract

[0163] Salted Phellodendron amurense: Phellodendron amurense silk and 2wt% salt solution were mixed and soaked for 1.5h at a mass volume ratio of 1g:15mL to obtain soaked Phellodendron amurense silk; the soaked Phellodendron amurense silk was fried at 100°C for 20min to obtain salted Phellodendron amurense;

[0164] Salt Cortex Phellodendri extract: grind the salt Cortex Phellodendri into 60 mesh, and then mix it with a solvent (hydrochloric acid: methanol = 1:100) at a mass volume ratio of 1g:25mL to obtain a mixture; ultrasonically extract the mixture at 25°C and 250W for 35min, filter, and take the filtrate to obtain the salt Cortex Phellodendri extract; concentrate the salt Cortex Phellodendri extract at 25°C and 8.0kPa, and then dry it at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain the salt Cortex Phellodendri extract;

[0165] (7) Preparation of Panax notoginseng extract

[0166] The flat chrysanthemum Panax notoginseng was crushed into 60 meshes, and then mixed with 80vt% ethanol solution at a mass volume ratio of 1g:30mL to obtain a mixture; the mixture was refluxed and extracted at 70°C for 2h, filtered, and the filtrate was taken to obtain a flat chrysanthemum Panax notoginseng extract; the flat chrysanthemum Panax notoginseng extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain a flat chrysanthemum Panax notoginseng extract;

[0167] (8) Preparation of Polygonatum sibiricum Extract

[0168] The processed polygonatum sibiricum was crushed into 60 meshes, and then mixed with water at a mass volume ratio of 1g:30mL, and soaked for 1.5 hours to obtain a mixture; the mixture was subjected to subcritical water extraction at 5Mpa and 120°C for 10 minutes, filtered, and the filtrate was taken to obtain a processed polygonatum sibiricum extract; the processed polygonatum sibiricum extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18 hours to obtain a processed polygonatum sibiricum extract;

[0169] (9) Preparation of coix seed extract

[0170] The coix seeds were crushed into 60 meshes, and then mixed with water at a mass volume ratio of 1g:10mL, decocted at 60°C for 3.5h, filtered, and the filtrate was taken to obtain a decoction; the decoction was mixed with α-amylase at a volume ratio of 1:0.02, decocted at 60°C for 2h, filtered, and the filtrate was taken to obtain a second decoction; the second decoction was mixed with saccharifying enzyme at a volume ratio of 1:0.010, decocted at 60°C for 45min, filtered, and the filtrate was taken to obtain a coix seed extract; the coix seed extract was concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain a coix seed extract;

[0171] (10) Preparation of Corn Silk Extract

[0172] The corn silk is crushed into 60 mesh, and then mixed with brewer's yeast in a mass ratio of 1:0.10, and fermented at 35°C for 25 hours to obtain a fermentation product; the fermentation product is mixed with 60vt% ethanol solution in a mass ratio of 1:5, boiled at 70°C for 4.5 hours, filtered, and the filtrate is obtained to obtain a corn silk extract; the corn silk extract is concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18 hours to obtain a corn silk extract.

[0173] Example 2 A Chinese medicine composition for relieving gout

[0174] Take 10g of the American ginseng extract described in Example 1, 5g of Poria cocos extract, 8g of turmeric extract, 1g of dried ginger extract, 10g of Cyclocarya paliurus extract, 8g of Phellodendron chinense extract, 6g of Panax notoginseng extract, 10g of Polygonatum sibiricum extract, 10g of Coix lachryma-jobi extract, and 4g of Corn silk extract and mix them to obtain a Chinese medicine composition.

[0175] Example 3 A Chinese medicine composition for relieving gout

[0176] Take 8g of the American ginseng extract described in Example 1, 6g of Poria cocos extract, 9g of turmeric extract, 1.2g of dried ginger extract, 7g of Cyclocarya paliurus extract, 10g of Phellodendron chinense extract, 4g of Panax notoginseng extract, 8g of Polygonatum sibiricum extract, 8g of Coix seed extract, and 6g of Corn silk extract and mix them to obtain a Chinese medicine composition.

[0177] Example 4 A Chinese medicine composition for relieving gout

[0178] Take 12g of the American ginseng extract described in Example 1, 3g of Poria cocos extract, 6g of turmeric extract, 0.8g of dried ginger extract, 13g of Cyclocarya paliurus extract, 6g of Phellodendron chinense extract, 8g of Panax notoginseng extract, 12g of Polygonatum sibiricum extract, 12g of Coix seed extract, and 2g of Corn silk extract and mix them to obtain a Chinese medicine composition.

[0179] Comparative Example 1 A Chinese medicine composition for relieving gout

[0180] Preparation of American ginseng extract: crush American ginseng to a particle size of 60 mesh, and then mix it with water at a mass volume ratio of 1g:20mL to obtain a mixture; reflux the mixture at 70°C for 2h, filter, and take the filtrate to obtain an American ginseng extract; concentrate the American ginseng extract at 25°C and 8.0kPa, and then freeze-dry at -65°C for 18h to obtain an American ginseng extract;

[0181] The preparation methods of Poria cocos extract, turmeric extract, dried ginger extract, Cyclocarya paliurus extract, Phellodendron chinense extract, Panax notoginseng extract, Polygonatum sibiricum extract, Coix seed extract, and Corn silk extract are the same as the preparation method of American ginseng extract;

[0182] Take 10g of American ginseng extract, 5g of Poria cocos extract, 8g of turmeric extract, 1g of dried ginger extract, 10g of Cyclocarya paliurus extract, 8g of Phellodendron chinense extract, 6g of Panax notoginseng extract, 10g of Polygonatum sibiricum extract, 10g of Coix seed extract, and 4g of Corn silk extract and mix them to obtain a traditional Chinese medicine composition.

[0183] Comparative Example 2 A Chinese medicine composition for relieving gout

[0184] The difference from Example 2 is that the Cyclocarya paliurus extract is replaced by Cyclocarya paliurus alcohol extract;

[0185] The preparation method of the Cyclocarya paliurus alcohol extract is as follows: crushing Cyclocarya paliurus leaves to a particle size of 60 mesh, and then mixing with ethanol at a mass volume ratio of 1g:10mL to obtain a mixture; ultrasonically extracting the mixture at 55°C and 400W for 45min, filtering, and taking the filtrate to obtain a Cyclocarya paliurus alcohol extract; concentrating the Cyclocarya paliurus extract at 25°C and 8.0kPa, and then freeze-drying at -65°C for 18h to obtain a Cyclocarya paliurus alcohol extract.

[0186] Comparative Example 3: A Chinese medicine composition for relieving gout

[0187] The difference from Example 2 is that the salt Phellodendron chinense extract is replaced with Phellodendron chinense extract;

[0188] The preparation method of Phellodendron chinense extract is as follows: Phellodendron chinense is crushed into 60 mesh, and then mixed with a solvent (hydrochloric acid: methanol = 1:100) at a mass volume ratio of 1g:25mL to obtain a mixture; the mixture is ultrasonically extracted at 25°C and 250W for 35min, filtered, and the filtrate is taken to obtain a Phellodendron chinense extract; the Phellodendron chinense extract is concentrated at 25°C and 8.0kPa, and then dried at a temperature of -65°C and a vacuum degree of 5Pa for 18h to obtain a salt Phellodendron chinense extract.

[0189] Comparative Example 4: A Chinese medicine composition for relieving gout

[0190] The difference from Example 2 is that the notoginseng extract is not added.

[0191] Comparative Example 5 A Chinese medicine composition for relieving gout

[0192] The difference from Example 2 is that no corn decoction liquid is added.

[0193] Comparative Example 6: A Chinese medicine for relieving gout

[0194] The American ginseng extract described in Example 1.

[0195] Comparative Example 7 A Chinese medicine for relieving gout

[0196] The Poria cocos extract described in Example 1.

[0197] Comparative Example 8: A Chinese medicine for relieving gout

[0198] The turmeric extract described in Example 1.

[0199] Comparative Example 9: A Chinese medicine for relieving gout

[0200] The dried ginger extract described in Example 1.

[0201] Comparative Example 10 A Chinese medicine for relieving gout

[0202] The Cyclocarya paliurus extract described in Example 1.

[0203] Comparative Example 11 A Chinese medicine for relieving gout

[0204] The Phellodendron chinense salt extract described in Example 1.

[0205] Comparative Example 12 A Chinese medicine for relieving gout

[0206] The notoginseng extract of Example 1.

[0207] Comparative Example 13: A Chinese medicine for relieving gout

[0208] The nine-processed polygonatum sibiricum extract described in Example 1.

[0209] Comparative Example 14: A Chinese medicine for relieving gout

[0210] The coix seed extract described in Example 1.

[0211] Comparative Example 15: A Chinese medicine for relieving gout

[0212] The corn silk extract described in Example 1.

[0213] Experimental Example 1

[0214] The hyperuricemia mouse model was established by inducing potassium oxonate, a uricase inhibitor. SPF Kunming male mice (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) were randomly divided into 19 groups, namely, a blank group, a model group, a positive control group, an example 2 group, and comparative examples 1 to 15 groups, with 5 mice in each group. The model group, the positive control group, the example group, and the comparative examples 1 to 15 groups were injected intraperitoneally with 250 mg kg -1 ·d -1 Xanthine was given by gavage at 250 mg kg -1 ·d -1 Potassium oxonate; 1 hour later, mice in the positive control group were given 4 mg kg -1 Allopurinol was administered orally to mice in Example 2 and Comparative Examples 1 to 15 at 300 mg / kg -1 ·d -1 The Chinese medicine composition described in Example 2, the Chinese medicine composition described in Comparative Examples 1 to 5, and the Chinese medicines of Comparative Examples 6 to 15 were administered by gavage; the mice in the blank control group and the model group were administered with an equal amount of normal saline by gavage for 21 days.

[0215] After 20 days of administration, the mice were fasted but not watered. On the 21st day, blood was collected from the mouse eyeballs 1 hour after intragastric administration. The blood was naturally coagulated at 25°C for 1 hour and then centrifuged at 3500 rpm for 10 minutes at 4°C. The supernatant was taken to obtain serum. The uric acid content in the mouse serum was measured using a uric acid determination kit (purchased from Shandong Kelisen Biological Co., Ltd.), and the xanthine oxidase activity detection kit (purchased from Shanghai Keaibo Biotechnology Co., Ltd.) was used to measure the xanthine oxidase content in the blood. The test results are shown in Table 1.

[0216] After blood was collected from mice, the mice were killed by cervical dislocation, and liver samples from each group of mice were taken. Physiological saline precooled at 4°C was added to make a 10% liver tissue homogenate at a mass ratio of 1:9. After centrifugation at 4°C and 4000rpm for 10 minutes, the surface fat tissue was gently removed, and the supernatant was slowly aspirated. The supernatant was used to measure the xanthine oxidase content in the liver using a xanthine oxidase activity detection kit (purchased from Shanghai Ke Ai Bo Biotechnology Co., Ltd.). The test results are shown in Table 1.

[0217] Table 1 Determination results of uric acid content and xanthine oxidase content

[0218]

[0219] As can be seen from Table 1, the Chinese medicine composition described in Example 2 can effectively reduce the activity of xanthine oxidase and the content of uric acid in the blood, thereby relieving gout, and the effect is better than that of the positive control allopurinol group;

[0220] It can be seen from Comparative Examples 1 to 2 that the preparation method of the Chinese medicine extract will affect its effect; the effect of the Chinese medicine composition prepared by extracting the Chinese medicine extract using the same method in Comparative Example 2 and the Chinese medicine composition prepared by replacing the water extract of Cyclocarya paliurus with the alcohol extract of Cyclocarya paliurus in Comparative Example 2 are both lower than the Chinese medicine composition described in Example 2 of the present invention;

[0221] It can be seen from Comparative Examples 3 to 5 that replacing or deleting a component in the Chinese medicine composition described in Example 2 will reduce the effect of the Chinese medicine composition, and the effects of Comparative Examples 3 to 5 are all lower than those of the Chinese medicine composition described in Example 2;

[0222] It can be seen from Comparative Examples 6 to 15 that the uric acid-lowering efficacy of a single extract is lower than that of the combination, further indicating that the combination has a synergistic effect of lowering uric acid, thereby relieving gout.

[0223] Example 5 A Chinese medicine patch for relieving gout

[0224] 50 g of the Chinese medicine composition described in Example 2 was mixed with 15 mL of ginger juice and 60 mL of honey to prepare a Chinese medicine patch.

[0225] Example 6 A Chinese medicine patch for relieving gout

[0226] 50 g of the Chinese medicine composition described in Example 2 was mixed with 25 mL of ginger juice and 125 mL of honey to prepare a Chinese medicine patch.

[0227] It can be seen from the above embodiments that the present invention provides a Chinese medicine composition for relieving gout and its application. The Chinese medicine composition can effectively reduce the activity of xanthine oxidase and the content of uric acid in the blood, thereby relieving gout, and the effect is better than the commonly used Western medicine allopurinol.

[0228] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for relieving gout, characterized in that: The invention comprises the following components in parts by weight: 8-12 parts of American ginseng extract, 3-6 parts of Poria cocos extract, 6-9 parts of turmeric extract, 0.8-1.2 parts of dried ginger extract, 7-13 parts of Cyclocarya paliurus extract, 6-10 parts of Phellodendron chinense extract, 4-8 parts of Chrysanthemum procumbens extract, 8-12 parts of Polygonatum sibiricum extract, 8-12 parts of Coix seed extract and 2-6 parts of Corn silk extract.

2. The Chinese medicine composition according to claim 1, characterized in that: The preparation method of the American ginseng extract comprises the following steps: mixing and soaking American ginseng and water to obtain a mixture; extracting the mixture under a pressure of 450-600 MPa, filtering, and taking the filtrate to obtain an American ginseng extract; concentrating the American ginseng extract, and drying to obtain the American ginseng extract; The preparation method of the Poria cocos extract comprises the following steps: mixing and soaking Poria cocos and water to obtain a mixture; extracting the mixture under a pressure of 250 to 400 MPa, filtering, and taking the filtrate to obtain a Poria cocos extract; concentrating the Poria cocos extract, and drying to obtain a Poria cocos extract; The preparation method of the turmeric extract comprises the following steps: mixing and soaking turmeric and an ethanol solution to obtain a mixture; extracting the mixture under a pressure of 350-500 MPa, filtering, and taking the filtrate to obtain a turmeric extract; and concentrating and drying the turmeric extract to obtain the turmeric extract.

3. The Chinese medicine composition according to claim 2, characterized in that: The preparation method of the dried ginger extract comprises the following steps: mixing dried ginger and an ethanol solution to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking a filtrate to obtain a dried ginger extract; concentrating and drying the dried ginger extract to obtain the dried ginger extract; The ultrasonic extraction is performed at a temperature of 3 to 5°C, a power of 150 to 250W, and a time of 20 to 50 minutes; The preparation method of the Cyclocarya paliurus extract comprises the following steps: mixing Cyclocarya paliurus leaves and water to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking the filtrate to obtain a Cyclocarya paliurus extract; concentrating the Cyclocarya paliurus extract, and drying to obtain a Cyclocarya paliurus extract; The temperature of the ultrasonic extraction is 50-60°C, the power is 300-500W, and the time is 30-60min; The preparation method of the salt cortex phellodendri extract comprises the following steps: mixing salt cortex phellodendri with a solvent to obtain a mixture; performing ultrasonic extraction on the mixture, filtering, and taking the filtrate to obtain a salt cortex phellodendri extract; concentrating and drying the salt cortex phellodendri extract to obtain a salt cortex phellodendri extract; The solvent is a mixed solution of hydrochloric acid and methanol; the volume ratio of hydrochloric acid to methanol in the mixed solution is 1:90-110; The mass volume ratio of the mixture of the salt cortex phellodendri and the solvent is 1g:20-30mL; The temperature of the ultrasonic extraction is 20-30° C., the power is 200-300 W, and the time is 30-40 min.

4. The Chinese medicine composition according to claim 3, characterized in that: The preparation method of the notoginseng extract comprises the following steps: mixing the notoginseng with an ethanol solution to obtain a mixture; subjecting the mixture to reflux extraction, filtering, and taking a filtrate to obtain a notoginseng extract; concentrating and drying the notoginseng extract to obtain the notoginseng extract; The temperature of the reflux extraction is 60-80° C., and the time is 1-3 hours.

5. The Chinese medicine composition according to claim 4, characterized in that: The preparation method of the nine-processed polygonatum sibiricum extract comprises the following steps: mixing and soaking the nine-processed polygonatum sibiricum and water to obtain a mixture; subjecting the mixture to subcritical water extraction, filtering, and taking the filtrate to obtain a nine-processed polygonatum sibiricum extract; concentrating the nine-processed polygonatum sibiricum extract, and drying to obtain the nine-processed polygonatum sibiricum extract; The extraction pressure of the subcritical water extraction is 4.5-6Mpa, and the temperature is 110-130°C.

6. The Chinese medicine composition according to claim 5, characterized in that: The preparation method of coix seed extract comprises the following steps: mixing coix seed and water for decoction, filtering, taking filtrate, and obtaining decoction liquid; mixing the decoction liquid with α-amylase for decoction, filtering, taking filtrate, and obtaining a second decoction liquid; mixing the second decoction liquid with saccharifying enzyme for decoction, filtering, taking filtrate, and obtaining coix seed extract; concentrating the coix seed extract, and drying, and obtaining coix seed extract; The mass volume ratio of the coix seed and water is 1g:8-12mL; The volume ratio of the decoction and α-amylase is 1:0.01-0.03; The volume of the second decoction liquid and the saccharifying enzyme mixed is 1:0.005-0.

015.

7. The Chinese medicine composition according to claim 6, characterized in that: The preparation method of the corn silk extract comprises the following steps: mixing corn silk and brewer's yeast for fermentation to obtain a fermentation product; mixing the fermentation product with an ethanol solution for decoction, filtering, and obtaining a filtrate to obtain a corn silk extract; concentrating the corn silk extract, and drying to obtain the corn silk extract; The mass ratio of the corn silk and the brewer's yeast is 1:0.05-0.15; The fermentation temperature is 32-38°C; the fermentation time is 20-30h; The mass ratio of the fermentation product and the ethanol solution is 1:3-7; The initial concentration of the ethanol solution is 50-70%; The decoction temperature is 60-80°C; The decoction time is 3 to 6 hours.

8. Use of the Chinese medicine composition according to any one of claims 1 to 7 in the preparation of a preparation for relieving gout.

9. A Chinese medicine patch for relieving gout, characterized in that: Including Chinese medicine compositions and concoctions; The mass volume ratio of the Chinese medicine composition and the conditioning agent is 1g:2-3mL; The blending agent is a mixture of ginger juice and honey, and the volume ratio of ginger juice to honey in the blending agent is 1:3-6; The Chinese medicine composition is the Chinese medicine composition according to any one of claims 1 to 7.

10. The method for preparing the Chinese medicine patch according to claim 9, characterized in that: The method comprises the following steps: mixing the Chinese medicine composition and the blending agent to prepare the Chinese medicine patch.

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