Plasma collection system and collection method thereof

Abstract

The invention discloses a plasma collection system and a collection method thereof, and belongs to the field of plasma collection. The plasma collection system comprises an equipment box and further comprises a separation box fixed to the top of the equipment box, a filtering part for separating blood from plasma is arranged in the separation box, a liquid storage ring is arranged at the top of the separation box, and a dropwise adding part for adding anticoagulant into the separation box is arranged on the liquid storage ring; the refrigerator is fixed to the equipment box, a refrigerating bin is formed in the side wall of the equipment box, and the output end of the refrigerator is communicated with an inner cavity of the refrigerating bin; through the repulsion effect of the piston plate and the magnetic plate, the air pressure in the separation box is continuously reduced, blood can move into the separation box more quickly, and the blood sampling efficiency is effectively improved; and the rotating shaft is matched to drive the filter hopper to rotate, so that the filter hopper generates a centrifugal force effect, plasma components in blood quickly and effectively penetrate through the filter membrane, and the separation effect is effectively improved.

Description

Technical Field

[0001] The present invention relates to the technical field of plasma collection, and in particular to a plasma collection system and a collection method thereof. Background Art

[0002] Plasma is the liquid part of blood, accounting for about 55% of the total blood volume. It is a complex mixture of water, protein, electrolytes, nutrients, hormones and other small molecules dissolved in it. The plasma part of the blood is used in daily blood transfusions. Plasma collection refers to the process of separating plasma from the blood donor through medical technology.

[0003] At present, when plasma is collected and filtered by membrane technology, the penetration of plasma is insufficient, and it is difficult to achieve a good separation effect. It is easy for part of the plasma to flow away with the blood, which reduces the plasma collection effect. In addition, the ambient temperature has a great influence on the quality of the collected plasma. Too high a temperature can easily lead to plasma inactivation. Therefore, a plasma collection system and a collection method are proposed. Summary of the invention

[0004] The purpose of the present invention is to solve the problems in the prior art of using membrane technology for filtration, such as insufficient penetration of the slurry, difficulty in achieving a good separation effect, and reduced plasma collection effect; and the problem that the collection environment temperature is too high, which easily leads to plasma inactivation, and to propose a plasma collection system and a collection method.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions: A plasma collection system includes an equipment box, and also includes: a separation box fixed on the top of the equipment box, wherein the separation box is provided with a filter part for separating blood and plasma, wherein a liquid storage ring is provided on the top of the separation box, and a dripping part for adding an anticoagulant into the separation box is provided on the liquid storage ring; a refrigerator fixed on the equipment box, wherein a cold storage chamber is provided on the side wall of the equipment box, and the output end of the refrigerator is connected to the inner cavity of the cold storage chamber, wherein the equipment box is provided with a guide part for promoting the circulation of cold air in the cold storage chamber.

[0006] In order to facilitate blood transfusion, preferably, a mounting groove is provided on the top of the equipment box, and a blood collection groove and a plasma collection groove are provided on the upper and lower parts of the side walls of the mounting groove respectively, a return tube is fixedly connected to the bottom of the mounting groove, the separation box is plugged and fixed in the mounting groove, and the input end of the return tube is plugged into the bottom of the inner cavity of the separation box, a return pump is fixedly connected to the outer wall of the equipment box, and the return tube is communicated with the return pump, a blood collection tube and a plasma collection tube are fixedly connected to the upper and lower parts of the side walls of the separation box respectively, the blood collection tube and the plasma collection tube respectively pass through the blood collection groove and the plasma collection groove to the outside of the equipment box, and the output end of the plasma collection tube is fixedly connected to a vacuum blood collection bag.

[0007] In order to facilitate plasma separation, preferably, the filtration part includes a filter bucket, which is rotatably connected to the inner cavity of the separation box, the filter bucket is arranged in an inverted "eight" shape, and a filter membrane is fixedly connected to the filtration surface of the filter bucket, the filter bucket and the separation box are fitted and slid, and a filter slurry bin is formed between the filter bucket and the separation box, the input end of the slurry collection tube is connected to the inner cavity of the slurry bin, the output end of the blood collection tube is connected to the upper part of the inner cavity of the separation box, and the input end of the return tube is connected to the inner cavity of the filter bucket.

[0008] In order to improve the efficiency of plasma separation, preferably, the top of the separation box is fixedly connected to a power compartment, the power compartment is communicated with the top of the inner cavity of the separation box, the top of the power compartment is fixedly connected to a driving motor, a rotating shaft is rotatably connected in the power compartment, the top of the rotating shaft is fixedly connected to the output end of the driving motor, a magnetic plate is fixedly connected to the outer wall of the rotating shaft, four groups of piston tubes are fixed at equal intervals on the outer wall of the power compartment, a piston plate is slidably connected in the piston tube, a return spring is fixedly connected between the side wall of the piston plate and the inner wall of the piston tube, the top of the piston tube is fixed and connected to a negative pressure tube, and a one-way valve is arranged in the negative pressure tube, the other end of the negative pressure tube is communicated with the inner cavity of the power compartment, and the piston plate and the magnetic plate are magnetically repelled, the end of the piston tube away from the power compartment is communicated with the outside world, and a one-way valve is arranged in the channel.

[0009] Furthermore, the rotating shaft extends downward into the cavity of the filter bucket, and the outer wall of the bottom end of the rotating shaft is fixedly connected to the side wall of the filter bucket through a guide rod.

[0010] In order to improve the quality of plasma collection, preferably, the dripping part includes four groups of cross plates, and the four groups of cross plates are fixed at equal intervals on the top of the separation box, the liquid storage ring is fixed on the top of the cross plate, the liquid storage ring is connected with the inner cavity of the input end of the cross plate, the output end of the cross plate is connected with the top of the inner cavity of the separation box, an intermittent groove is provided in the cross plate, the intermittent groove is connected with the input end and the output end of the cross plate, a sealing plate is slidably connected in the intermittent groove, a push rod is fixedly connected to the side wall of the piston plate, the other end of the push rod passes through the piston tube, extends into the intermittent groove and is fixedly connected to the side wall of the sealing plate, and a guide groove is provided on the sealing plate.

[0011] Furthermore, the repulsive force between the piston plate and the magnetic plate is greater than the sum of the thrusts required for the retraction of the return spring and the sliding of the blocking plate.

[0012] In order to improve the plasma refrigeration effect, preferably, the guide part includes a guide ring, the guide ring is fixed on four groups of cross plates, and the intermittent groove is connected with the inner cavity of the guide ring, the outer wall of the guide ring is fixed and connected with an air guide pipe, a circulation bin is opened on the equipment box, a circulation pipe is fixedly connected in the circulation bin, the input end and output end of the circulation pipe are both connected with the inner cavity of the refrigeration bin, and a one-way valve is arranged in the input end and the output end of the circulation pipe, and the other end of the circulation pipe is connected with the middle inner cavity of the circulation pipe.

[0013] Furthermore, a sealing cover is rotatably connected to the outer wall of the cold storage compartment, a hook is fixedly connected to the side wall of the equipment box, the hook is located above the closed sealing cover, and the vacuum blood collection bag is inserted into the hook and fits against the outer wall of the closed sealing cover.

[0014] A plasma collection method, comprising the following steps: Step 1: Connect the blood collection tube and the return tube to the blood collection needle and insert them into the blood vessel of the blood donor; Step 2: Collecting blood into a separation box for separation and collection; Step 3, adding anticoagulant to the blood entering the separation box; Step 4: Refrigerate the collected plasma.

[0015] Compared with the prior art, the present invention provides a plasma collection system and a collection method thereof, which have the following beneficial effects: 1. The plasma collection system, through the repulsive action of the piston plate and the magnetic plate, makes the air pressure in the separation box continuously reduce, so that the blood moves into the separation box more quickly, effectively improving the blood collection efficiency; and cooperates with the rotating shaft to drive the filter bucket to rotate, so that the filter bucket generates centrifugal force, so that the plasma components in the blood pass through the filter membrane more quickly and effectively, effectively improving the separation effect.

[0016] 2. In the plasma collection system, when the piston plate and the magnetic plate repel each other, the sealing plate will be pushed to slide in the intermittent groove, so that the guide groove and the inner cavity of the cross plate are connected. At this time, the anticoagulant will drip into the separation box and mix with the blood, effectively preventing the blood from coagulating during the collection process, ensuring the fluidity of the blood, avoiding the blockage of the pipeline, and at the same time preventing the activation of coagulation factors in the blood, thereby improving the blood quality.

[0017] 3. The plasma collection system, through the setting of the cold storage chamber and the sealing cover plate, lowers the temperature in the area where the vacuum blood collection bag is located to ensure the quality of plasma collection, and cooperates with the sealing plate to slide back and forth in the intermittent groove, which will make the cold air flow in the cold storage chamber circulate, can maintain the uniform temperature in the cold storage chamber, improve the cooling efficiency and ensure the preservation quality of the vacuum blood collection bag.

[0018] 4. The plasma collection system, by returning the blood from which the plasma has been filtered out to the donor, avoids the anemia symptoms of the donor due to the loss of too many red blood cells, reduces the donor's discomfort, promotes the donor's physical recovery, and ensures the donor's safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The overall structure of a plasma collection system proposed by the present invention is shown in FIG. Figure 1 ; Figure 2 The overall structure of a plasma collection system proposed by the present invention is shown in FIG. Figure 2 ; Figure 3 The overall structure of a plasma collection system proposed by the present invention is shown in FIG. Figure 3 ; Figure 4 A schematic diagram of a side view and half section structure of a plasma collection system proposed by the present invention; Figure 5 A plasma collection system proposed by the present invention Figure 4 A schematic diagram of the enlarged structure of the middle A area; Figure 6 A plasma collection system proposed by the present invention Figure 4 Schematic diagram of the enlarged structure of the middle B area; Figure 7 A plasma collection system proposed by the present invention Figure 4 Schematic diagram of the enlarged structure of the middle C area; Figure 8 This is a schematic diagram of the internal structure of a power chamber of a plasma collection system proposed by the present invention.

[0020] In the figure: 1. Equipment box; 2. Separation box; 3. Liquid storage ring; 4. Refrigerator; 41. Refrigeration chamber; 42. Sealing cover plate; 5. Mounting groove; 51. Blood collection groove; 52. Slurry collection groove; 53. Return pipe; 54. Return pump; 55. Blood collection tube; 56. Slurry collection tube; 57. Vacuum blood collection bag; 6. Filter bucket; 61. Slurry filter chamber; 62. Power chamber; 63. Drive motor; 64. Rotating shaft; 641. Magnetic plate; 642. Guide rod; 65. Piston tube; 651. Piston plate; 652. Reset spring; 653. Negative pressure tube; 7. Cross plate; 71. Intermittent groove; 72. Blocking plate; 721. Push rod; 722. Guide groove; 8. Guide ring; 81. Air guide tube; 82. Circulation chamber; 83. Circulation pipe; 9. Hook. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0022] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. Example

[0023] Reference Figure 1-Figure 8 A plasma collection system includes an equipment box 1, and also includes: a separation box 2 fixed on the top of the equipment box 1, the separation box 2 is provided with a filtering part for separating blood and plasma, wherein a liquid storage ring 3 is provided on the top of the separation box 2, and a dripping part for adding an anticoagulant to the separation box 2 is provided on the liquid storage ring 3; a refrigerator 4 fixed on the equipment box 1, the refrigerator 4 adopts the existing mature technology, a refrigeration chamber 41 is opened on the side wall of the equipment box 1, and the output end of the refrigerator 4 is connected to the inner cavity of the refrigeration chamber 41, wherein the equipment box 1 is provided with a guide part for promoting the circulation of cold air flow in the refrigeration chamber 41.

[0024] Reference Figure 1-Figure 4 A mounting groove 5 is provided on the top of the equipment box 1, and a blood collection groove 51 and a plasma collection groove 52 are respectively provided on the upper and lower parts of the side walls of the mounting groove 5, a return pipe 53 is fixedly connected to the bottom of the mounting groove 5, the separation box 2 is plugged and fixed in the mounting groove 5, and the input end of the return pipe 53 is plugged into the bottom of the inner cavity of the separation box 2, a return pump 54 is fixedly connected to the outer wall of the equipment box 1, and the return pipe 53 is communicated with the return pump 54, a blood collection blood vessel 55 and a plasma collection pipe 56 are respectively fixedly connected to the upper and lower parts of the side walls of the separation box 2, the blood collection blood vessel 55 and the plasma collection pipe 56 respectively pass through the blood collection groove 51 and the plasma collection groove 52 to the outside of the equipment box 1, and a vacuum blood collection bag 57 is fixedly connected to the output end of the plasma collection pipe 56.

[0025] It should be noted that the ends of the blood collection tube 55 and the return tube 53 can be detachably connected to an existing disposable blood collection needle to improve the convenience of use.

[0026] Through the arrangement of the above structure, the blood collection tube 55 and the return tube 53 are connected to the blood collection needle and inserted into the blood vessel of the blood donor: the disposable blood collection needle is installed at the ends of the blood collection tube 55 and the return tube 53, and the blood collection needle at the end of the blood collection tube 55 is first inserted into the blood vessel of the blood donor. Under the action of blood pressure, the blood will flow into the separation box 2 along the blood collection tube 55; at the same time, the return pump 54 is turned on to extract the blood, and after the residual air in the return tube 53 is emptied, the blood collection needle at the end of the return tube 53 is inserted into the blood vessel of the blood donor, so that the blood is returned to the body of the blood donor, avoiding the anemia symptoms caused by the loss of too many red blood cells, reducing the discomfort of the blood donor, promoting the physical recovery of the blood donor, and ensuring the safety of the blood donor.

[0027] Reference Figure 4 , Figure 5 , Figure 7 and Figure 8 , wherein the filtering part includes a filter bucket 6, which is rotatably connected to the inner cavity of the separation box 2, the filter bucket 6 is set in an inverted "eight" shape, and a filter membrane is fixedly connected to the filtering surface of the filter bucket 6, the filter bucket 6 and the separation box 2 fit and slide, and a filter slurry bin 61 is formed between the filter bucket 6 and the separation box 2, the input end of the slurry collection tube 56 is connected to the inner cavity of the filter slurry bin 61, the output end of the blood collection tube 55 is connected to the upper part of the inner cavity of the separation box 2, and the input end of the return tube 53 is connected to the inner cavity of the filter bucket 6; a power bin 62 is fixedly connected to the top of the separation box 2, the power bin 62 is connected to the top of the inner cavity of the separation box 2, a drive motor 63 is fixedly connected to the top of the power bin 62, a rotating shaft 64 is rotatably connected in the power bin 62, and the top of the rotating shaft 64 is fixedly connected to the output end of the drive motor 63 Then, a magnetic plate 641 is fixedly connected to the outer wall of the rotating shaft 64, four groups of piston tubes 65 are fixed at equal intervals on the outer wall of the power chamber 62, a piston plate 651 is slidably connected inside the piston tube 65, a return spring 652 is fixedly connected between the side wall of the piston plate 651 and the inner wall of the piston tube 65, the top of the piston tube 65 is fixed and connected to a negative pressure tube 653, and a one-way valve is arranged in the negative pressure tube 653, the other end of the negative pressure tube 653 is connected to the inner cavity of the power chamber 62, and the piston plate 651 and the magnetic plate 641 repel each other, one end of the piston tube 65 away from the power chamber 62 is connected to the outside world, and a one-way valve is arranged in the channel; the rotating shaft 64 extends downward into the cavity of the filter bucket 6, and the outer wall of the bottom end of the rotating shaft 64 is fixedly connected to the side wall of the filter bucket 6 through the guide rod 642.

[0028] It should be noted that the one-way valve at the inner and outer connection of the piston tube 65 can only allow the gas in the piston tube 65 to be discharged; the one-way valve in the negative pressure tube 653 can only allow the gas in the separation box 2 to be sucked into the piston tube 65.

[0029] By setting the above structure, the driving motor 63 is turned on to drive the rotating shaft 64 to rotate, so that the piston plate 651 and the magnetic plate 641 move to the repulsive area. Under the repulsive effect of the two, the piston plate 651 will be pushed to slide in the piston tube 65, thereby compressing the gas in the piston tube 65 and opening the one-way valve connected to the outside of the piston tube 65, so that the gas in the piston tube 65 is discharged. Then the piston plate 651 and the magnetic plate 641 are separated from the repulsive area. At this time, under the rebound effect of the reset spring 652, the piston plate 651 will be reset, thereby generating a suction effect in the piston tube 65, and the one-way valve in the negative pressure tube 653 is opened, so that The gas in the separation box 2 is sucked out, thereby reducing the air pressure in the separation box 2, allowing the blood to move more quickly into the separation box 2, effectively improving the blood collection efficiency; and when the blood enters the separation box 2, it will fall onto the filter bucket 6, and then slide down the filter bucket 6. During this process, the plasma part with a better particle size in the blood will pass through the filter membrane and enter the filter slurry chamber 61, and then flow along the slurry collection tube 56 to the vacuum blood collection bag 57, and the rotating shaft 64 will also drive the filter bucket 6 to rotate at a low speed in the separation box 2. At this time, centrifugal force will be generated, causing the plasma components in the blood to pass through the filter membrane more quickly and effectively, effectively improving the separation effect.

[0030] Reference Figure 1 , Figure 4 and Figure 6 , wherein the dripping part includes four groups of cross plates 7, which are fixed on the top of the separation box 2 at equal intervals, and the liquid storage ring 3 is fixed on the top of the cross plate 7. The liquid storage ring 3 is connected to the inner cavity of the input end of the cross plate 7, and the output end of the cross plate 7 is connected to the top of the inner cavity of the separation box 2. An intermittent groove 71 is provided in the cross plate 7, and the intermittent groove 71 is connected to the input end and the output end of the cross plate 7. A blocking plate 72 is slidably connected in the intermittent groove 71, and a push rod 721 is fixedly connected to the side wall of the piston plate 651. The other end of the push rod 721 penetrates the piston tube 65 and extends into the intermittent groove 71 and is fixedly connected to the side wall of the blocking plate 72. A guide groove 722 is provided on the blocking plate 72; the repulsive force between the piston plate 651 and the magnetic plate 641 is greater than the sum of the thrusts required for the retraction of the reset spring 652 and the sliding of the blocking plate 72.

[0031] Through the arrangement of the above-mentioned structure, when the piston plate 651 and the magnetic plate 641 repel each other, the piston plate 651 will also push the sealing plate 72 to slide in the intermittent groove 71 through the push rod 721, so that the guide groove 722 is connected with the input end and the output end of the cross plate 7. At this time, the anticoagulant in the liquid storage ring 3 will drip into the separation box 2 and mix with the blood, effectively avoiding the coagulation of blood during the collection process, ensuring the fluidity of the blood, avoiding the blockage of the pipeline, and at the same time preventing the activation of coagulation factors in the blood, thereby improving the blood quality.

[0032] Reference Figure 1-Figure 4 , wherein the guide part includes a guide ring 8, which is fixed on four groups of cross plates 7, and the intermittent groove 71 is connected to the inner cavity of the guide ring 8, and an air guide pipe 81 is fixed and connected on the outer wall of the guide ring 8, and a circulation bin 82 is opened on the equipment box 1, and a circulation pipe 83 is fixedly connected in the circulation bin 82, and the input end and output end of the circulation pipe 83 are both connected to the inner cavity of the cold storage bin 41, and a one-way valve is arranged in the input end and the output end of the circulation pipe 83, and the other end of the circulation pipe 83 is connected to the middle inner cavity of the circulation pipe 83; the outer wall of the cold storage bin 41 is rotatably connected with a sealing cover plate 42, and the sealing cover plate 42 is made of metal material and has a certain ability to conduct temperature. A hook 9 is fixedly connected to the side wall of the equipment box 1, and the hook 9 is located above the closed sealing cover plate 42. The vacuum blood collection bag 57 is plugged into the hook 9 and fits with the outer wall of the closed sealing cover plate 42.

[0033] Through the arrangement of the above structure, the vacuum blood collection bag 57 is plugged into the hook 9 so that it fits with the outer wall of the sealing cover plate 42. At this time, the refrigerator 4 is turned on to cool the cold storage chamber 41, and the cooling effect in the cold storage chamber 41 will reduce the temperature around the sealing cover plate 42, thereby ensuring the quality of plasma collection; when the plasma collection is completed, the vacuum blood collection bag 57 is removed and placed in the cold storage chamber 41, and a new vacuum blood collection bag 57 is replaced to continue the blood collection operation, which is convenient for the vacuum blood collection bag 57 to be refrigerated, and the convenience of plasma collection is improved; and when the sealing plate 72 is pushed to slide in the intermittent groove 71, the intermittent groove 71 will be squeezed. The gas flows into the guide ring 8, moves along the air guide tube 81 to the circulation tube 83, and opens the one-way valve at the output end of the circulation tube 83, allowing the gas to enter the cold storage bin 41. Subsequently, the sealing plate 72 is pulled to reset, which will generate suction in the intermittent groove 71 and transmit it to the circulation tube 83, so that the one-way valve at the input end of the circulation tube 83 opens, allowing the airflow in the cold storage bin 41 to enter the circulation tube 83. This reciprocating process will cause the cold airflow in the cold storage bin 41 to circulate, thereby maintaining the uniform temperature in the cold storage bin 41, improving the cooling efficiency, and ensuring the preservation quality of the vacuum blood collection bag 57.

[0034] Reference Figure 1-Figure 8In the present invention, when in use, the disposable blood collection needle is installed at the ends of the blood collection tube 55 and the return tube 53. First, the blood collection needle at the end of the blood collection tube 55 is inserted into the blood vessel of the blood donor. Under the action of blood pressure, the blood will flow into the separation box 2 along the blood collection tube 55. At the same time, the driving motor 63 is turned on to drive the rotating shaft 64 to rotate, so that the piston plate 651 and the magnetic plate 641 move to the repulsive area. Under the repulsive action of the two, the piston plate 651 will be pushed to slide in the piston tube 65, thereby compressing the gas in the piston tube 65, and opening the one-way valve connected to the outside of the piston tube 65, so that the gas in the piston tube 65 is discharged, and then the piston plate 651 and the magnetic plate 641 are separated from the repulsive area. At this time, under the rebound action of the reset spring 652, the piston plate 6 51 is reset, thereby generating suction in the piston tube 65, and opening the one-way valve in the negative pressure tube 653, so that the gas in the separation box 2 is sucked out, thereby reducing the air pressure in the separation box 2, allowing the blood to move more quickly into the separation box 2, effectively improving the blood collection efficiency; and when the blood enters the separation box 2, it will fall onto the filter bucket 6, and then slide down the filter bucket 6, and in this process, the plasma part of the blood with a better particle size will pass through the filter membrane into the filter slurry chamber 61, and then flow along the slurry collection tube 56 to the vacuum blood collection bag 57, and the rotating shaft 64 will also drive the filter bucket 6 to rotate at a low speed in the separation box 2, and centrifugal force will be generated at this time, so that the plasma components in the blood can pass through the filter membrane more quickly and effectively, effectively improving the separation effect. Subsequently, the blood from which the plasma has been filtered out will enter the return tube 53 along the filter bucket 6. At this time, the return pump 54 is turned on to extract the blood. After the residual air in the return tube 53 is emptied, the blood collection needle at the end of the return tube 53 is inserted into the blood vessel of the blood donor, so that the blood is returned to the body of the blood donor, avoiding the anemia symptoms caused by the loss of too many red blood cells in the blood donor, reducing the discomfort of the blood donor, promoting the physical recovery of the blood donor, and ensuring the safety of the blood donor.

[0035] When the piston plate 651 and the magnetic plate 641 repel each other, the piston plate 651 will also push the sealing plate 72 to slide in the intermittent groove 71 through the push rod 721, so that the guide groove 722 is connected with the input end and the output end of the cross plate 7. At this time, the anticoagulant in the liquid storage ring 3 will drip into the separation box 2 and mix with the blood, effectively avoiding the coagulation of blood during the collection process, ensuring the fluidity of the blood, avoiding the blockage of the pipeline, and at the same time preventing the activation of coagulation factors in the blood, improving the blood quality, and under the rotation of the filter bucket 6, it is fully mixed with the blood, effectively improving the mixing effect.

[0036] When collecting plasma, the vacuum blood collection bag 57 is plugged into the hook 9 so that it fits with the outer wall of the sealing cover plate 42. At this time, the refrigerator 4 is turned on to cool the cold storage chamber 41, and the cooling effect in the cold storage chamber 41 will reduce the temperature around the sealing cover plate 42, thereby ensuring the quality of plasma collection. When the plasma collection is completed, the vacuum blood collection bag 57 is removed and placed in the cold storage chamber 41, and a new vacuum blood collection bag 57 is replaced to continue the blood collection operation, which is convenient for the vacuum blood collection bag 57 to be refrigerated, thereby improving the convenience of plasma collection; and when the sealing plate 72 is pushed to slide in the intermittent groove 71, the intermittent groove 71 will be squeezed. The gas flows into the guide ring 8, moves along the air guide tube 81 to the circulation tube 83, and opens the one-way valve at the output end of the circulation tube 83, allowing the gas to enter the cold storage bin 41. Subsequently, the sealing plate 72 is pulled to reset, which will generate suction in the intermittent groove 71 and transmit it to the circulation tube 83, so that the one-way valve at the input end of the circulation tube 83 opens, allowing the airflow in the cold storage bin 41 to enter the circulation tube 83. This reciprocating process will cause the cold airflow in the cold storage bin 41 to circulate, thereby maintaining the uniform temperature in the cold storage bin 41, improving the cooling efficiency, and ensuring the preservation quality of the vacuum blood collection bag 57. Example

[0037] Reference Figure 1-Figure 8 , which is basically the same as Example 1, on the basis of Example 1, a plasma collection method is proposed, and the steps are as follows: Step 1, connect the blood collection tube 55 and the return tube 53 to the blood collection needle and then insert them into the blood vessel of the blood donor: install the disposable blood collection needle at the end of the blood collection tube 55 and the return tube 53, first insert the blood collection needle at the end of the blood collection tube 55 into the blood vessel of the blood donor, under the action of blood pressure, the blood will flow into the separation box 2 along the blood collection tube 55, and the plasma in the blood will pass through the filter membrane into the filter slurry chamber 61, then turn on the return pump 54 to extract the blood, after the residual air in the return tube 53 is emptied, insert the blood collection needle at the end of the return tube 53 into the blood vessel of the blood donor, so that the blood is returned to the body of the blood donor, avoiding anemia symptoms caused by the loss of too many red blood cells, reducing the discomfort of the blood donor, promoting the physical recovery of the blood donor, and ensuring the safety of the blood donor.

[0038] Step 2: Collect blood into the separation box 2 for separation and collection: turn on the driving motor 63 to drive the rotating shaft 64 to rotate, so that the piston plate 651 and the magnetic plate 641 move to the repulsive area. Under the repulsive effect of the two, the piston plate 651 will be pushed to slide in the piston tube 65, thereby compressing the gas in the piston tube 65, and opening the one-way valve connected to the outside of the piston tube 65, so that the gas in the piston tube 65 is discharged, and then the piston plate 651 and the magnetic plate 641 are separated from the repulsive area. At this time, under the rebound effect of the reset spring 652, the piston plate 651 will be reset, thereby generating a suction effect in the piston tube 65, and making the one-way valve in the negative pressure tube 653 The valve opens, allowing the gas in the separation box 2 to be sucked out, thereby reducing the air pressure in the separation box 2, allowing the blood to move more quickly into the separation box 2, effectively improving the blood collection efficiency; and when the blood enters the separation box 2, it will fall onto the filter bucket 6, and then slide down the filter bucket 6. During this process, the plasma part of the blood with a better particle size will pass through the filter membrane and enter the filter slurry chamber 61, and then flow along the slurry collection tube 56 to the vacuum blood collection bag 57, and the rotating shaft 64 will also drive the filter bucket 6 to rotate at a low speed in the separation box 2. At this time, centrifugal force will be generated, causing the plasma components in the blood to pass through the filter membrane more quickly and effectively, effectively improving the separation effect.

[0039] Step three, add anticoagulant to the blood entering the separation box 2: when the piston plate 651 and the magnetic plate 641 repel each other, the piston plate 651 will also push the sealing plate 72 to slide in the intermittent groove 71 through the push rod 721, so that the guide groove 722 is connected with the input and output ends of the cross plate 7. At this time, the anticoagulant in the liquid storage ring 3 will drip into the separation box 2 and mix with the blood, effectively avoiding the coagulation of blood during the collection process, ensuring the fluidity of the blood, avoiding the blockage of the pipeline, and at the same time preventing the activation of coagulation factors in the blood, thereby improving the blood quality.

[0040] Step 4, refrigerate the collected plasma: after the plasma collection is completed, the vacuum blood collection bag 57 is removed and placed in the cold storage chamber 41, and a new vacuum blood collection bag 57 is replaced to continue the blood collection operation, so that the vacuum blood collection bag 57 can be refrigerated conveniently, and the convenience of plasma collection is improved; and when the blocking plate 72 is pushed to slide in the intermittent groove 71, the gas in the intermittent groove 71 will be squeezed, and the gas will enter the guide ring 8, and then move along the air guide pipe 81 to the circulation pipe 83, and open the one-way valve at the output end of the circulation pipe 83, so that the gas enters the cold storage chamber 41, and then the blocking plate 72 is pulled to reset, which will generate suction in the intermittent groove 71 and transmit it to the circulation pipe 83, so that the one-way valve at the input end of the circulation pipe 83 is opened, so that the airflow in the cold storage chamber 41 enters the circulation pipe 83, and so on and so forth, which will make the cold airflow in the cold storage chamber 41 circulate, and can maintain the uniform temperature in the cold storage chamber 41, improve the cooling efficiency and ensure the preservation quality of the vacuum blood collection bag 57.

[0041] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A plasma collection system, comprising an equipment box (1), characterized in that: Also includes: A separation box (2) is fixed on the top of the equipment box (1), wherein a filter part for separating blood and plasma is arranged inside the separation box (2). Wherein, a liquid storage ring (3) is arranged on the top of the separation box (2), and a dripping portion for adding an anticoagulant into the separation box (2) is arranged on the liquid storage ring (3); A refrigerator (4) is fixed on the equipment box (1), wherein a refrigeration chamber (41) is provided on a side wall of the equipment box (1), and an output end of the refrigerator (4) is in communication with an inner cavity of the refrigeration chamber (41). Wherein, the equipment box (1) is provided with a guide portion for promoting the circulation of cold air flow in the cold storage compartment (41).

2. A plasma collection system according to claim 1, characterized in that: The top of the equipment box (1) is provided with a mounting groove (5), and the upper and lower parts of the side walls of the mounting groove (5) are respectively provided with a blood collection groove (51) and a plasma collection groove (52), and the bottom of the mounting groove (5) is fixedly connected with a return pipe (53), the separation box (2) is plugged and fixed in the mounting groove (5), and the input end of the return pipe (53) is plugged into the bottom of the inner cavity of the separation box (2), a return pump (54) is fixedly connected to the outer wall of the equipment box (1), and the return pipe (53) is connected to the return pump (54), and the upper and lower parts of the side walls of the separation box (2) are respectively fixedly connected with a blood collection blood tube (55) and a plasma collection pipe (56), and the blood collection blood tube (55) and the plasma collection pipe (56) respectively pass through the blood collection groove (51) and the plasma collection groove (52) to the outside of the equipment box (1), and the output end of the plasma collection pipe (56) is fixedly connected with a vacuum blood collection bag (57).

3. A plasma collection system according to claim 2, characterized in that: The filtering section comprises a filtering bucket (6), the filtering bucket (6) being rotatably connected to the inner cavity of the separation box (2), the filtering bucket (6) being arranged in an inverted "eight" shape, and a filtering membrane being fixedly connected to the filtering surface of the filtering bucket (6), the filtering bucket (6) and the separation box (2) being fitted and slidable, and a slurry filter bin (61) being formed between the filtering bucket (6) and the separation box (2), the input end of the slurry collection tube (56) being in communication with the inner cavity of the slurry filter bin (61), the output end of the blood collection tube (55) being in communication with the upper part of the inner cavity of the separation box (2), and the input end of the return tube (53) being in communication with the inner cavity of the filtering bucket (6).

4. A plasma collection system according to claim 3, characterized in that: The top of the separation box (2) is fixedly connected to a power bin (62), the power bin (62) is in communication with the top of the inner cavity of the separation box (2), the top of the power bin (62) is fixedly connected to a drive motor (63), a rotating shaft (64) is rotatably connected inside the power bin (62), the top of the rotating shaft (64) is fixedly connected to the output end of the drive motor (63), a magnetic plate (641) is fixedly connected to the outer wall of the rotating shaft (64), four groups of piston tubes (65) are fixedly arranged at equal intervals on the outer wall of the power bin (62), and the piston tubes (65) are provided with a plurality of pistons (65) disposed inside the piston tubes (65). A piston plate (651) is slidably connected, a return spring (652) is fixedly connected between the side wall of the piston plate (651) and the inner wall of the piston tube (65), the top of the piston tube (65) is fixed and connected to a negative pressure tube (653), and a one-way valve is arranged in the negative pressure tube (653), the other end of the negative pressure tube (653) is connected to the inner cavity of the power chamber (62), and the piston plate (651) and the magnetic plate (641) are magnetically repelled from each other, and the end of the piston tube (65) away from the power chamber (62) is connected to the outside, and a one-way valve is arranged in the channel.

5. A plasma collection system according to claim 4, characterized in that: The rotating shaft (64) extends downward into the cavity of the filter bucket (6), and the outer wall of the bottom end of the rotating shaft (64) is fixedly connected to the side wall of the filter bucket (6) via a guide rod (642).

6. A plasma collection system according to claim 4, characterized in that: The dripping part comprises four groups of cross plates (7), the four groups of cross plates (7) are fixed at equal intervals on the top of the separation box (2), the liquid storage ring (3) is fixed on the top of the cross plate (7), the liquid storage ring (3) is communicated with the inner cavity of the input end of the cross plate (7), the output end of the cross plate (7) is communicated with the top of the inner cavity of the separation box (2), an intermittent groove (71) is provided in the cross plate (7), the intermittent groove (71) is communicated with the input end and the output end of the cross plate (7), a blocking plate (72) is slidably connected in the intermittent groove (71), a push rod (721) is fixedly connected to the side wall of the piston plate (651), the other end of the push rod (721) passes through the piston tube (65) and extends into the intermittent groove (71) and is fixedly connected to the side wall of the blocking plate (72), and a guide groove (722) is provided on the blocking plate (72).

7. A plasma collection system according to claim 6, characterized in that: The repulsive force between the piston plate (651) and the magnetic plate (641) is greater than the sum of the thrusts required for the retraction of the return spring (652) and the sliding of the blocking plate (72).

8. A plasma collection system according to claim 6, characterized in that: The guide portion comprises a guide ring (8), the guide ring (8) being fixed on the four groups of cross plates (7), and the intermittent groove (71) being in communication with the inner cavity of the guide ring (8), and an air guide pipe (81) being fixed and in communication with the outer wall of the guide ring (8), and a circulation bin (82) being provided on the equipment box (1), and a circulation pipe (83) being fixedly connected in the circulation bin (82), the input end and the output end of the circulation pipe (83) being in communication with the inner cavity of the cold storage bin (41), and a one-way valve being provided in the input end and the output end of the circulation pipe (83), and the other end of the circulation pipe (83) being in communication with the inner cavity of the middle part of the circulation pipe (83).

9. A plasma collection system according to claim 8, characterized in that: The outer wall of the cold storage compartment (41) is rotatably connected to a sealing cover plate (42); a hook (9) is fixedly connected to the side wall of the equipment box (1); the hook (9) is located above the closed sealing cover plate (42); the vacuum blood collection bag (57) is plugged onto the hook (9) and fits against the outer wall of the closed sealing cover plate (42).

10. A plasma collection method, using a plasma collection system according to any one of claims 1 to 9, characterized in that: Here are the steps: Step 1: Connect the blood collection tube (55) and the return tube (53) to the blood collection needle and insert them into the blood vessel of the blood donor; Step 2: collecting blood into a separation box (2) for separation and collection; Step 3: adding an anticoagulant to the blood entering the separation box (2); Step 4: Refrigerate the collected plasma.

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