Liver clearing medicine formula and preparation process thereof

Abstract

The invention provides a liver-clearing medicine formula and a preparation process thereof, and relates to the technical field of liver and gall disease treatment, liver-clearing soup is prepared from dandelion, patrinia, fructus forsythiae, polygonum cuspidatum and oriental wormwood, the proportion of the medicines can be increased and decreased along with symptoms, and during the taking period of the liver-clearing soup, eating of greasy fried food is forbidden, so that the liver-clearing soup is free of toxic and side effects. The taking method of the liver-clearing decoction adopts a low-temperature frequent taking mode. The preparation process of the liver-clearing medicine formula comprises the following steps: A, selecting raw materials; b, weighing the raw materials; c, decocting the raw materials with water; d, taking at low temperature. The traditional Chinese medicine composition has the advantages of being capable of rapidly benefiting gallbladder, relieving jaundice, improving liver functions and reducing the number of hepatitis B viruses, superior to other traditional Chinese medicine prescriptions, simple in using method, convenient to collect, low in price and remarkable in curative effect.

Description

Technical Field

[0001] The present invention relates to the technical field of liver and gallbladder disease treatment, and particularly to a liver-clearing drug formula and a preparation process thereof. Background Art

[0002] Hepatobiliary disease is a general term for liver and gallbladder diseases, including chronic hepatitis, cirrhosis, liver tumors, etc. These diseases still use liver-protecting treatment methods during the treatment process, mainly to reduce liver cell damage and promote liver cell repair and regeneration.

[0003] The usage of existing liver-clearing drugs is relatively complicated and requires professionals to handle and use them. At the same time, the raw materials of existing liver-clearing drugs are relatively difficult to collect, which leads to high drug prices, is not conducive to patient use, and easily causes a large family burden. Summary of the invention

[0004] The purpose of the present invention is to solve the shortcomings of the prior art and propose a liver-clearing drug formulation and its preparation process. The technical solution adopted by the present invention is:

[0005] A liver-clearing medicine formula and a preparation process thereof include raw materials of liver-clearing soup including dandelion, Patrinia suspensa, Forsythia suspensa, Polygonum cuspidatum and Artemisia capillaris, and the proportion of the medicines can be increased or decreased according to symptoms.

[0006] As an improvement, during the period of taking the Qinggan Decoction, it is forbidden to eat greasy fried foods.

[0007] As an improvement, the Qinggan Decoction is taken at low temperature and frequently.

[0008] A preparation process of a liver-clearing drug formula, which is applicable to the above-mentioned liver-clearing drug formula, and is characterized in that the preparation process of the liver-clearing drug formula includes A. selecting raw materials; B. weighing raw materials; C. decocting raw materials in water; and D. taking at low temperature.

[0009] As an improvement, the preparation process of the liver-clearing drug formula, wherein A, the specific method of selecting raw materials is:

[0010] First, different raw materials are selected according to the formula. During the selection process, the raw materials need to be selected based on the age of the medicinal materials, the dryness and wetness of the medicinal materials, etc., so as to select the medicinal materials of the quality required for Qinggan Decoction.

[0011] As an improvement, the preparation process of the liver-clearing drug formula, wherein B, the specific method of weighing the raw materials is:

[0012] Then weigh the selected medicinal materials. When weighing, first use an object of fixed weight to test the weighing tool to ensure the accuracy of the weighing tool data.

[0013] As an improvement, the preparation process of the liver-clearing drug formula, wherein C, the specific method of decocting the raw materials in water is:

[0014] The weighed medicinal materials are then decocted in water. During the decocting process, the medicinal materials need to be decocted in water twice. After two decoctions, the remaining amount of the medicine needs to be ensured to be 800 ml. The dosage form of the medicine is not limited to aqueous solution, and it can also be made into tablets or granules.

[0015] As an improvement, the specific method of preparing the liver-clearing drug formula D and taking it at low temperature is:

[0016] The boiled medicine is then cooled to lower the temperature of the liquid medicine, and the patient then takes the liquid medicine frequently at low temperature.

[0017] The beneficial effects of the present invention are:

[0018] The liver-clearing drug formula and the preparation process thereof are suitable for liver and gallbladder diseases such as chronic hepatitis, liver cirrhosis, liver tumors, etc., can quickly promote bile secretion and reduce jaundice, improve liver function, and reduce the number of hepatitis B viruses. The formula is superior to other traditional Chinese medicine prescriptions, is simple to use, is convenient to collect, is low in price, and has significant curative effect. DETAILED DESCRIPTION

[0019] In order to make the contents of the present invention more clearly understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0020] The ingredients of Qinggan Decoction include dandelion, Patrinia suspensa, Forsythia suspensa, Polygonum cuspidatum and Artemisia capillaris. The proportion of the medicines can be increased or decreased according to the symptoms.

[0021] Dandelion: It has antiviral and antibacterial effects, protects the liver and promotes bile secretion, helps bile to enter the intestines, and improves the body's immunity. According to the Compendium of Materia Medica, dandelion can clear away heat and detoxify, eliminate food poisons, and reduce swelling. It has been highly praised in medical monographs of all dynasties, such as Tang Materia Medica, Shennong Materia Medica, and Chinese Medicine Dictionary.

[0022] Patrinia salsa: It has antiviral, anti-tumor, choleretic, diuretic, and liver cell regeneration-promoting effects. According to the "National Compilation of Chinese Herbal Medicines", it is mainly used to treat sudden heat sores, red qi, scabies, itching, carbuncle, hemorrhoids and other diseases. Because it is a commonly used heat-clearing and detoxifying medicine, it has the functions of clearing heat and detoxifying, relieving pain and discharging pus, removing blood stasis and relieving pain, it is listed as a top-grade product in the "Shennong's Herbal Classic".

[0023] Forsythia: It has the functions of clearing away heat, detoxifying, dispersing nodules, reducing swelling, and entering the heart, liver, and gallbladder meridians. It is mainly used to treat warmness, erysipelas, rashes, carbuncles, swelling and toxins, and urinary retention.

[0024] Polygonum cuspidatum: It has the effects of promoting dampness and relieving jaundice, clearing away heat and detoxifying, dispersing blood stasis and relieving pain, relieving cough and resolving phlegm. It is used for jaundice caused by damp heat, turbid stranguria, rheumatism and pain, carbuncles, ulcers, burns caused by water or fire, amenorrhea, abdominal masses, injuries from falls, and cough caused by lung heat.

[0025] Artemisia capillaris: clears away heat and dampness, relieves jaundice. Indications: jaundice, dysuria, itching of eczema, has liver protection, antibacterial, and blood lipid lowering effects.

[0026] During the period of taking Qinggan Decoction, it is forbidden to eat greasy fried foods. Qinggan Decoction should be taken at low temperature and frequently.

[0027] A preparation process of a liver-clearing drug formula, which is applicable to the above-mentioned liver-clearing drug formula, is characterized in that the preparation process of the liver-clearing drug formula includes A. raw material selection:

[0028] First, different raw materials are selected according to the formula. During the selection process, the raw materials need to be selected based on the age of the medicinal materials, the dryness and wetness of the medicinal materials, etc., so as to select the medicinal materials of the quality that meet the requirements of Qinggan Decoction;

[0029] B. Raw material weighing:

[0030] Then, the selected medicinal materials are weighed. When weighing, the weighing tool is first tested with an object of fixed weight to ensure the accuracy of the weighing tool data;

[0031] C. Decoction of raw materials:

[0032] Then, the weighed medicinal materials are decocted in water. During the decocting process, the medicinal materials need to be decocted in water twice. After the two decoctings, the remaining amount of the medicine needs to be ensured to be 800 ml. The dosage form of the medicine is not limited to aqueous solution, and can also be made into tablets or granules;

[0034] D. Use at low temperature:

[0035] The boiled medicine is then cooled to lower the temperature of the liquid medicine, and the patient then takes the liquid medicine frequently at low temperature.

[0036] It is suitable for liver and gallbladder diseases such as chronic hepatitis, cirrhosis, liver tumors, etc. It can quickly promote bile secretion and reduce jaundice, improve liver function, and reduce the number of hepatitis B viruses. It is superior to other Chinese medicine prescriptions, is simple to use, easy to collect, low in price, and has significant therapeutic effects.

[0037] Case 1: The patient, Mr. Yu, male, 18 years old, had yellow body and eyes, poor appetite, fatigue, red and yellow urine, and bleeding gums for half a month, which worsened for a week. He was diagnosed with chronic hepatitis B upon admission. Biochemical examination showed: ALT320U / L, AST175U / L, TBIL21.3umol / L, HBV-DNA4.28E+06IU / ml, and abnormal electrocardiogram. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, his liver function returned to normal, HBV-DNA dropped to 2.03E+04IU / ml, and the electrocardiogram was normal. He was discharged from the hospital after his condition improved.

[0038] Case 2: The patient, Ms. Xiong, female, 41 years old, suffered from abdominal distension, pain in the liver area, yellow urine and fatigue for half a year, which worsened for three months. She was diagnosed with liver cancer, post-hepatitis B cirrhosis (decompensated stage), and pleural effusion at Shanghai Oriental Hepatobiliary Hospital and the First Affiliated Hospital of Nanchang University. She needed nursing care when she was admitted to the hospital and had difficulty taking care of herself. After treatment with Qinggan Decoction, the ascites disappeared, her condition improved, she could take care of herself, and her liver function and liver fibrosis tests were all better than when she was admitted to the hospital.

[0039] Case 3: Mr. Yu, male, 49 years old, was admitted to the hospital for yellow eyes and body, distended abdomen, poor appetite, fatigue, and yellow urine for half a month. B-ultrasound showed a large amount of ascites. Abnormal liver function, hepatitis B two-to-half: "small three positive", HBV-DNA1.57E+06IU / ml, abnormal liver fibrosis, abnormal blood cell analysis. After treatment with Qinggan Decoction, it turned into small two positive (HBsAg(+), HBcAb(+)), HBV-DNA8.93 E+03IU / ml / ml, ascites completely disappeared, four indicators of liver fibrosis decreased, and the condition improved.

[0040] Case 4: Patient Mr. Tang, male, 33 years old, had yellow body and eyes, poor appetite, fatigue, abdominal distension, nausea, and red and yellow urine for one week, which worsened for three days. He was diagnosed with chronic hepatitis B (severe) upon admission. Biochemical examination showed: liver function: ALT172.4U / L, AST178.1U / L, TBIL135.1umol / L, DBIL66.3umol / L, GGT220U / L, A / G1.1, five hepatitis B tests: HBsAg(+), HBsAb(-), HBeAg(-), HBeAb(+), HBcAb(+), HBV-DNA3.77E+04IU / ML, AFP203.8ng / ml, ferritin562.6ng / ml. B-ultrasound showed: cirrhosis, rough and thickened gallbladder wall, and splenomegaly. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, liver function was rechecked: TBIL25.9umol / L, DBIL7.9umol / L, HBV-DNA6.43E+02IU / ML, AFP19.211ng / ml, the patient's condition improved and he was discharged from the hospital.

[0041] Case 5: Mr. Yu, male, 31 years old, had fullness in the right upper abdomen, nausea, aversion to oil, cough, poor appetite, fatigue, and yellow urine for seven days, which worsened for two days. He was diagnosed with chronic hepatitis B (severe) upon admission. Biochemical examination showed: liver function: ALT600U / L, AST248U / L, TBIL25.5umol / L, five hepatitis B items: HBsAg(+), HBsAb(-), HBeAg(+), HBeAb(-), HBcAb(+), HBV-DNA1.97E+08IU / ML. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, liver function was rechecked: ALT24U / L, AST29.4U / L, TBIL17.7umol / L, HBV-DNA1.83E+05IU / ML, and his condition improved and he was discharged from the hospital.

[0042] Case 6: Mr. Gao, male, 49 years old, had yellow eyes and body, poor appetite, fatigue, distended abdomen, chest tightness, cough, and yellow urine for one month, which worsened for one week. He was admitted to the hospital and diagnosed with post-hepatitis cirrhosis (decompensated stage). Ultrasound: color ultrasound showed: cirrhosis, peritoneal effusion, small kidney stones, possible gallstones, and splenomegaly. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, reexamination of ultrasound showed: cirrhosis, splenomegaly, and kidney stones. He was discharged from the hospital after his condition improved.

[0043] Case 7: Mr. Zhang, male, 31 years old, had poor appetite, fatigue, red and yellow urine for half a month, which worsened for two days. He was admitted to the hospital and diagnosed with chronic hepatitis B (severe). Biochemical examination showed: liver function: ALT919U / L, AST69U / L. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, liver function was rechecked: ALT36U / L, AST23U / L. He was discharged from the hospital after his condition improved.

[0044] Case 8: Mr. Zhang, male, 35 years old, had yellow body and eyes, poor appetite, fatigue, red and yellow urine, nausea and aversion to oil for half a month, which worsened for two days. He was diagnosed with chronic hepatitis B (severe) upon admission. Biochemical examination showed: liver function: ALT1085U / L, AST1095U / L, TBIL58.6umol / L, DBIL29.8umol / L, liver fibrosis four items: HA359ug / L. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, liver function was rechecked: ALT37U / L, AST48U / L, liver fibrosis four items: HA196ug / L. He was discharged from the hospital after his condition improved.

[0045] Case 9: Mr. Luo, male, 29 years old, had yellow body and eyes, poor appetite, fatigue, abdominal distension, aversion to oil, nausea, and red and yellow urine for half a month, which worsened for two days. He was admitted to the hospital and diagnosed with chronic hepatitis B (severe). Biochemical examination showed: liver function: ALT1256.7U / L, AST658.1U / L, TBIL176.4umol / L, DBIL96.2umol / L, ferritin 1747.0ng / ml. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, liver function was rechecked: ALT46.3U / L, TBIL24.1umol / L, DBIL6.2umol / L, ferritin 480ng / ml. He was discharged from the hospital after his condition improved.

[0046] Case 10: Patient Mr. Yin, male, 31 years old, had yellow body and eyes, chest tightness, cough, abdominal distension, poor appetite, fatigue, and red and yellow urine for one month, which worsened for two days. He was admitted to the hospital and diagnosed with chronic hepatitis B (severe). Biochemical examination showed: liver function: ALT1188U / L, AST405U / L. After symptomatic supportive treatment with Chinese medicine Qinggan Decoction, liver function was rechecked: ALT19U / L, AST20U / L. His condition improved and he was discharged from the hospital.

[0047] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A liver-clearing drug formulation, characterized in that: The raw materials of the liver-clearing soup include dandelion, Patrinia suspensa, Forsythia suspensa, Polygonum cuspidatum and Artemisia capillaris, and the proportion of the medicines can be increased or decreased according to the symptoms.

2. A liver-clearing drug formulation according to claim 1, characterized in that: During the period of taking the Qinggan Decoction, it is forbidden to eat greasy fried foods.

3. A liver-clearing drug formulation according to claim 1, characterized in that: The method for taking the Qinggan Decoction is to take it frequently at low temperature.

4. A preparation process of a liver-clearing drug formulation, the preparation process being applicable to a liver-clearing drug formulation according to any one of claims 1 to 3, characterized in that: The preparation process of the liver-clearing drug formula comprises A. selecting raw materials; B. weighing raw materials; C. decocting raw materials; D. Take at low temperature.

5. The preparation process of a liver-clearing drug formulation according to claim 4, characterized in that: The preparation process of the liver-clearing drug formula, wherein A, the specific method of selecting raw materials is: First, different raw materials are selected according to the formula. During the selection process, the raw materials need to be selected based on the age of the medicinal materials, the dryness and wetness of the medicinal materials, etc., so as to select the medicinal materials of the quality required for Qinggan Decoction.

6. The preparation process of a liver-clearing drug formulation according to claim 5, characterized in that: The preparation process of the liver-clearing drug formula, wherein B, the specific method of weighing the raw materials is: Then weigh the selected medicinal materials. When weighing, first use an object of fixed weight to test the weighing tool to ensure the accuracy of the weighing tool data.

7. The preparation process of a liver-clearing drug formulation according to claim 6, characterized in that: The preparation process of the liver-clearing drug formula, wherein C, the specific method of decocting the raw materials in water is: The weighed medicinal materials are then decocted in water. During the decocting process, the medicinal materials need to be decocted in water twice. After two decoctions, the remaining amount of the medicine needs to be ensured to be 800 ml. The dosage form of the medicine is not limited to aqueous solution, and it can also be made into tablets or granules.

8. The preparation process of a liver-clearing drug formulation according to claim 7, characterized in that The specific method of D, taking at low temperature in the preparation process of the liver-clearing drug formula is as follows: cooling the decocted medicine to lower the temperature of the medicine liquid, and then the patient takes the medicine liquid frequently at low temperature.