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Medicine composition containing alpha-pinene and 1,8-eucalyptol fever-tree oil and use thereof

A technology of eucalyptus globulus oil and composition, applied in the field of pharmaceutical composition of eucalyptus globulus oil to achieve the effect of less toxicity

Inactive Publication Date: 2005-11-23
SHENZHEN SALUBRIS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports at home and abroad that the preparations made from the composition containing α-pinene and 1,8-cineole prepared from Eucalyptus blue oil are used in expectorant and antitussive medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Pharmaceutical Research

[0020] 1. Production process research Steam distillation method to extract volatile oil. Under normal pressure, fractionate and collect the effective fraction of Eucalyptus globulus oil (called Eucalyptus globulus oil) in fractions of 60-80°C. Eucalyptus eucalyptus oil is a colorless or slightly yellow oily liquid with a specific aroma, pungent and cool taste. The relative density is 0.890-0.910, and the refractive index is 1.455-1.465. Determined by GC method, the content limits of α-pinene should not be less than 20.0%, and eucalyptol should not be less than 55.0%. Soft capsule preparation: the content limit of α-pinene should not be less than 12.0%, and eucalyptol should not be less than 28.0%.

[0021] 2. Chemical composition analysis

[0022] (1) Chemical composition analysis of eucalyptus eucalyptus volatile oil

[0023] Determined by GC-MS, the chemical composition analysis mainly contains α-pinene (α-pinene) 7.9-13.05%, p...

Embodiment 2

[0026] Embodiment 2 pharmacodynamic research:

[0027] 1. Effect of eucalyptus oil on airway phenol red excretion in mice

[0028] Using the characteristics of phenol red excreted from the airway after intraperitoneal injection in mice, the airway phenol red excretion of mice was measured to judge the effect of the test drug on the amount of airway secretion and to understand the expectorant effect of the test drug.

[0029] Methods: Mice were starved for 16-18 hours before the experiment. Eucalyptus eucalyptus oil was administered by intragastric administration 30 minutes before the injection of phenol red, and then 0.2ml / 10g of 1% phenol red normal saline solution was injected intraperitoneally. Cut the neck skin, separate the trachea, insert the trachea with a thin plastic tube, and gently lavage the bronchi with 0.8ml of 5% sodium bicarbonate three times, totaling 2.4ml. Use a wavelength of 546nm for colorimetry and compare it with the phenol red standard curve to calcul...

Embodiment 3

[0164] Example 3 Toxicology Research

[0165] Eucalyptus oil mouse LD 50 It was 1.716±0.148g / kg, and the 95% credible limit was 1.5746~1.8707g / kg. According to the WHO acute toxicity classification, mice were orally administered LD 50 501-5000mg / kg belongs to low toxicity, and Eucalyptus oil belongs to low toxicity drugs, and the possible lethal dose for people with low toxicity drugs is 250g.

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PUM

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Abstract

The composite medicine of the present invention contains tasmanian bluegum oil with alpha-pinene and 1,8-cineole as main components, medicinal diluent and medicinal additives. It may be administrated in solid form, semi-solid form or liquid form, and its preparation may be taken orally, intravenous injected or locally administrated. It is used in treating diseases of respiratory system, such as upper respiratory tract infection, acute and chronic bronchitis, chronic obstructive pneumonia, pulmonary tuberculosis, pneumosilicosis, etc.

Description

Technical field [0001] The invention relates to a pharmaceutical composition of eucalyptus oil, in particular to a pharmaceutical composition of eucalyptus oil containing α-pinene and 1,8-cineol and its use, preferably for the treatment of respiratory diseases for eliminating phlegm and relieving cough. Background technique [0002] Eucalyptus oil is primarily used as a fragrance. Pharmacopoeia [1] The eucalyptus oil contained is derived from the volatile oil obtained by steam distillation of Eucalyptus globulus Labill, a plant of the family Myrtaceae, Eucalyptus globulus Labill. 10 h 18 O) content shall not be less than 70.0%. It has the effect of expelling wind and relieving pain, and is used for skin itching and neuralgia. Foods containing eucalyptus oil, such as eucalyptus sugar, and Chinese patent medicine compound containing eucalyptus oil. The patent (publication number CN1298699A) "Pharmaceutical Composition Containing Eucalyptus Oil and Orange Oil" is a pharmac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K9/20A61K9/48A61K31/335A61P11/00A61P11/10A61P11/14
Inventor 唐法娣孙静芸
Owner SHENZHEN SALUBRIS PHARMA CO LTD
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