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Sesquiterpene component with nerve calming soporific function and its medicinal use

A technology of sesquiterpenoids and hypnotic effects, applied in the field of sesquiterpenoids and medicinal uses

Inactive Publication Date: 2002-10-23
CHINESE MEDICINE & NATURAL MEDICINE RES CENT SHENZHEN
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  • Abstract
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Problems solved by technology

Has strong sedative activity

Method used

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  • Sesquiterpene component with nerve calming soporific function and its medicinal use
  • Sesquiterpene component with nerve calming soporific function and its medicinal use

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Embodiment Construction

[0013] After repeated silica gel column chromatography, three new sesquiterpene compounds were isolated from the n-hexane elution fraction of the methanolic extract of Valeriana officinalis: valerianin z (VFE-12), valerianin x (VFH-3) and valeriaini E (VFV -1).

[0014] In the sedative activity test, the new compounds VFH-3, VFE-12 and valeriaini E (VFV-1) had strong sedative activity under the condition of equal concentration.

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Abstract

The present invention relating to a sesquiterpene composition which includes two new geamacrane susquiterpene compositions of valerianin X, valerianin Z and a new quaiane susquiterpene composition ofvalerianin E with effects of sedation and sleep in peace can be used in preparation of sedative medicine to be new type of sedative medicine. Three compositions of valerianin X, Z and E obtained fromnorth radix valerianae, all of which can prolong immovable time of mouse in swimming due to their quite strong sedative activity so that it effect strength is nearly as strong as the Western medicineof tranquilizer.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a sesquiterpene component with sedative and hypnotic effects and its medical application. The structures of two new gemane-type sesquiterpene components, valerianin X and valerianin Z, and a new guaiacane-type sesquiterpene component, valeriaini E, which both have sedative activity, are as follows: Background technique: [0002] Valerian is a wild perennial herb of the family Valerianaceae (Valeriana). There are about 200 species in the world, most of which are distributed in temperate regions. There are about 24 species in my country, mainly distributed in the southwest, northeast and northwest, and about 7 species in the northeast (Valeriana faurieiBriq. is one of them). Flat in nature and pungent in taste, it has the effects of calming the nerves, relieving spasm and relieving pain. The rhizome has long been used in folk as a sedative. The ancient Greeks and Romans hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/215A61K31/343A61K31/435A61P25/20
Inventor 姚新生张振学
Owner CHINESE MEDICINE & NATURAL MEDICINE RES CENT SHENZHEN
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