Synergistic drug delivery device for natural orifice

Abstract

A natural orifice synergistic dosing device comprises a slender hard rod-shaped body and a soft body wrapping the rod-shaped body, the rod-shaped body is provided with a rod-shaped body head portion entering a natural orifice opening during use, a rod-shaped body middle portion and a rod-shaped body tail portion located outside the natural orifice opening during use, and the dosing device is provided with a liquid injection opening, a liquid passage and a radial liquid outlet. The head area of the soft body is provided with a hollow flexible wrapping part and / or a suction cup part, the internal space of the flexible wrapping part can at least contain one part of the tail of the solid suppository, the solid suppository is firstly inserted into the flexible wrapping part and / or adsorbed on the suction cup part during use, and then the administration device is slowly inserted into the natural cavity through the opening of the natural cavity. And then a liquid medicament is injected through the liquid injection port, the dosing device is pulled out of the opening of the natural cavity, and the solid suppository is retained in the natural cavity.

Description

Technical Field

[0001] The utility model relates to a natural cavity cooperative drug delivery device, belonging to the technical field of medical device products. Background Art

[0002] Drug administration through natural cavities is a commonly used medical method, such as anal canal, rectal administration, vaginal administration, etc. When administering drugs, solid suppositories and liquid medicines are usually used successively. The drug ingredients in solid suppositories are gradually released, while liquid medicines can take effect quickly and have a cleaning effect at the same time. When treating hemorrhoids and other diseases around the anal canal, solid suppositories are usually clamped with tweezers and placed into the dilated part of the rectum through the anal canal, and then a flushing tube is inserted to release the liquid medicine. It needs to enter the anus twice, which causes great damage to the mucosa and is time-consuming and labor-intensive. In order to prevent local stenosis after anal canal surgery, it is usually necessary to dilate the anal canal every day and insert corresponding dilator devices. Vaginal administration also usually uses liquid medicine to flush the vagina first and then inserts solid suppositories into the vaginal vault. The drug administration steps are all two-step operations, with low medical efficiency and significant patient discomfort. Summary of the invention

[0003] The utility model provides a natural cavity coordinated drug delivery device, which can complete the two operations of inserting a solid suppository and releasing a liquid medicine in a process of entering the natural cavity once, and can avoid the hard part of the drug delivery device from damaging the mucosa. When encountering a natural cavity that needs to be expanded, the expansion is completed by filling an expandable capsule attached to the drug delivery device.

[0004] The purpose of the utility model is achieved in this way:

[0005] A natural cavity coordinated drug delivery device comprises: a slender hard rod-shaped body, a soft body wrapped outside the rod-shaped body, the rod-shaped body having a head portion entering the opening of the natural cavity when in use, a middle portion and a tail portion located outside the opening of the natural cavity when in use, the drug delivery device is provided with a liquid injection port, a liquid passage and a liquid radial outlet, a hollow flexible wrapping portion and / or a suction cup portion is provided in the head region of the soft body, the internal space of the flexible wrapping portion can accommodate at least a part of the tail of a solid suppository, when in use, the solid suppository is first inserted into the flexible wrapping portion and / or adsorbed on the suction cup portion, and then the drug delivery device is slowly inserted into the natural cavity through the opening of the natural cavity, and then the liquid medicine is injected through the liquid injection port, and then the drug delivery device is pulled out of the natural cavity opening, and the solid suppository is retained in the natural cavity.

[0006] The soft body includes a soft body head, a flexible wrapping part at the distal end of the soft body head, a soft body middle part, and a soft body tail; a radial liquid outlet is provided in the area below the flexible wrapping part, and the utility model realizes the coordinated administration of solid suppositories and liquid medicines, shortens the operation time, improves the operation efficiency, and avoids mucosal damage to the greatest extent; the injection port of the drug delivery device is arranged at the tail of the rod-shaped body, and the external liquid medicine or pure water enters the liquid passage of the drug delivery device through the injection cavity at the tail of the rod-shaped body.

[0007] One structure is that the liquid injection port of the drug delivery device is arranged at the tail of the rod-shaped body, and the hollow part inside the rod-shaped body constitutes a liquid passage.

[0008] Another structure is that the liquid injection port of the drug delivery device is arranged at the tail of the rod-shaped body or the tail of the soft body, and the gap between the outer surface of the rod-shaped body and the inner surface of the soft body constitutes a liquid passage.

[0009] In order to exert the driving effect of the liquid, the hollow part inside the rod-shaped body constitutes a liquid passage, and the liquid passage has multiple liquid radial outlets in the head area of ​​the applicator. The hollow part inside the rod-shaped body penetrates the head of the rod-shaped body to form a top opening of the liquid passage, and the top opening of the liquid passage is connected to the liquid passage.

[0010] A structure of a flexible wrapping portion is that the flexible wrapping portion at the distal end of the soft body head is folded toward the tail of the rod-shaped body, the inner surface of the flexible wrapping portion is turned outward, and the free end of the flexible wrapping portion faces the tail of the rod-shaped body; when used, the tail of the solid suppository can be wrapped by pushing it upward, and the inner surface of the flexible wrapping portion contacts and constrains the outer surface of the tail of the solid suppository.

[0011] A comprehensive solution is that the top of the rod-shaped body head is covered with a soft body membrane part or a soft body suction cup part, and the top of the rod-shaped body head does not directly contact the tail end surface of the solid suppository; the soft body suction cup part can be used in combination with the wrapping part, and can also be used alone to absorb and fix the tail end surface of the solid suppository.

[0012] In order to enhance the restraining ability of the solid suppository, the rod-shaped body head is connected with a rod-shaped body covering portion for covering the solid suppository.

[0013] A solution for forming a liquid passage is that the rod-shaped body is provided with at least one longitudinal rib, and the gaps between the longitudinal rib and the rod-shaped body and / or between the longitudinal ribs are wrapped by a soft body to form a liquid passage together; the liquid injection port is connected to the liquid passage through an outwardly open connecting hole on the tail of the rod-shaped body; the outwardly open connecting hole is located at the starting part of the longitudinal rib, the longitudinal rib starts at the distal end of the tail of the rod-shaped body, and the connecting hole is between the longitudinal ribs; under this solution, the drug delivery device has multiple liquid passages to ensure the circumferential uniformity of the drug solution when it is released; the "distal end" described in the utility model refers to the direction away from the liquid injection port of the drug delivery device and toward the head of the rod-shaped body.

[0014] Furthermore, an expandable sac is provided between the liquid injection port and the liquid outlet of the drug delivery device. When the inner cavity of the expandable sac is filled with fluid, the radial supporting force generated by the expansion of the outer boundary expands the natural cavity.

[0015] In order to make the solid suppository easily detach from the flexible wrapping portion, the applicator may also be provided with a push rod, which contacts the rear end surface of the solid suppository after entering through the liquid passage, thereby generating a thrust to push the solid suppository detach from the flexible wrapping portion.

[0016] The beneficial effects of the utility model are:

[0017] 1. When the applicator passes through the opening of the natural cavity, the hard rod-shaped body does not directly contact the mucosal tissue, but the soft body covering it contacts the mucosa, reducing the damage to the mucosa.

[0018] 2. The flexible wrapping part on the soft body of the applicator wraps the tail of the solid suppository, protecting the mucosal tissue while allowing it to move forward stably, preventing the solid suppository from falling off when inserted into the natural cavity, and ensuring that the solid suppository is placed in the target position.

[0019] 3. The suction cup on the soft body of the applicator can absorb the tail end of the solid suppository and fix it axially without increasing the maximum external dimension of the applicator. When the solid suppository passes through the opening of the natural cavity and moves forward in the natural cavity, it prevents the solid suppository from falling off while minimizing the damage to the mucosa.

[0020] 4. The suction cup part and the flexible wrapping part on the soft body of the applicator are used in combination, so that the solid suppository can move forward more stably in the natural cavity.

[0021] 5. The multiple radial liquid outlets on the suction cup part or below the flexible wrapping part of the applicator can release liquid medicine to the natural cavity mucosal tissue at any time, achieving the purpose of coordinated administration of solid suppositories and liquid medicines in one operation.

[0022] 6. Before, during and after administration, the expandable capsule can be filled according to the needs of the disease to radially expand the natural cavity, thereby improving local blood supply, promoting lymphatic return, promoting drug absorption, preventing stenosis, evenly coating liquid medicines, and promoting mucosal absorption of liquid medicines.

[0023] 7. The top opening of the liquid passage can exert the hydraulic force of the liquid medicine, which helps to separate the solid suppository from the applicator when it reaches the target position.

[0024] 8. The flexible wrapping part that is easy to deform and expand is suitable for solid suppositories with various outer diameters, and the everted flexible wrapping part is easier to fully combine with the solid suppository.

[0025] The operation steps are significantly simplified, reducing the two-step drug administration operation to a coordinated one step, and the three-step operation of joint expansion to one step, avoiding secondary and tertiary mucosal tissue damage when medical devices enter the natural cavity opening, significantly saving medical operation time, protecting the fragile mucosa of the affected area, and reducing treatment costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings which do not limit the present invention are as follows:

[0027] Figure 1A : Schematic diagram of the structure of Example 1

[0028] Figure 1B: Cross-sectional view of Example 1, arrows indicate the flow direction of liquid medicine

[0029] Figure 1C : Example 1 Schematic diagram of the cross section of entering the anal canal C and the rectal cavity R

[0030] Figure 1D : Schematic diagram of the cross section of the solid suppository retained in the rectal cavity R of Example 1

[0031] Figure 1E : Cross-sectional view of Example 1

[0032] Figure 2A : Schematic cross-section of Example 2

[0033] Figure 2B : Schematic diagram of embodiment 2

[0034] Figure 3A : Schematic cross-section of Example 3

[0035] Figure 3B : Schematic diagram of the rod-shaped body of Example 3

[0036] Figure 3C : Schematic cross-sectional view of the push rod of Example 3

[0037] Figure 4A : Schematic diagram of the rod-shaped body of Example 4

[0038] Figure 4B : Partial cross-sectional view of the applicator of Example 4

[0039] Figure 5A : Schematic cross-section of Example 5

[0040] Figure 5B : Partial cross-sectional view of Example 5

[0041] Fig. 6A : Partial cross-sectional view of embodiment 6

[0042] Figure 6B : Partial stereoscopic schematic diagram of Example 6

[0043] Fig. 7A : Partial cross-sectional view of Example 7

[0044] Figure 7B : Partial cross-sectional schematic diagram of Example 7

[0045] Figure 7C : A partial cross-sectional schematic diagram of a new structure of Example 7

[0046] Fig. 8A : Schematic diagram of a partial cross-section of the inflatable bladder 13 and the surrounding parts of Example 8

[0047] Figure 8B : Schematic diagram of embodiment 8 DETAILED DESCRIPTION

[0048] The embodiments of the present invention are not limited to the following:

[0049] Embodiment 1:

[0050] like Figures 1A-1E As shown, a natural cavity coordinated drug delivery device (hereinafter referred to as the drug delivery device) includes: a slender hard rod-shaped body 11, which can be molded from medical polymer materials such as polypropylene and polyamide, and a soft body 12 wrapped outside the rod-shaped body 11, and the soft body 12 includes a soft body head 121, a flexible wrapping part 125 at the distal end of the soft body head 121, a soft body middle part 122, and a soft body tail 123; the soft body 12 can be made of flexible materials such as silicone rubber, latex, and thermoplastic elastomer; Figure 1B The rod-shaped body 11 has a rod-shaped head 111 that enters the natural cavity when in use, a rod-shaped middle part 112 and a rod-shaped tail 113 that is located outside the opening of the natural cavity when in use. The applicator 1 is provided with a liquid injection port 101, a liquid passage 10 and a radial liquid outlet 102. The radial liquid outlet 102 is opened in the area below the flexible wrapping part 125. In this example, the liquid injection port 101 is arranged in the hollow rod-shaped tail 113, which is the hollow tail opening to the outside; multiple radial liquid outlets 102 are formed by connecting the radial openings on the rod-shaped head 111 and the flexible body head 121. The radial liquid outlet 102 refers to the liquid medicine or flushing water that can directly contact the natural cavity mucosa radially after flowing out of the liquid outlet 102; the hollow part inside the rod-shaped body 11 constitutes the liquid passage 10 of the applicator 1.

[0051] like Figure 1A As shown, the solid suppository 2 to be delivered by the applicator 1 is in the shape of a bullet head, and is composed of a rounded blunt head 21, a middle part 22, and a tail 23 that are connected as a whole. The tail end surface 231 of the solid suppository 2 is in contact with the top end 1111 of the head of the rod-shaped body 11 when used. The solid suppository can carry antibiotics such as metronidazole, Chinese medicine ingredients, various hormones, non-steroidal anti-inflammatory drugs, hemostatic drugs, interferon, etc.; the head area of ​​the soft body 12 is provided with a hollow flexible wrapping part 125, and the internal space 1250 of the flexible wrapping part 125 can at least accommodate a part of the tail 23 of the solid suppository, such as Figure 1B When in use, first insert the solid suppository 2 into the flexible wrapping portion 125, so that the top end 1111 of the rod-shaped body head abuts against the tail end surface 231 of the solid suppository 2, and the flexible wrapping portion 125 circumferentially constrains the tail end 23 of the solid suppository 2 to prevent the solid suppository 2 from swinging left and right and falling; Figure 1CThen, the applicator 1 is slowly inserted into the natural cavity (i.e., the anal canal C and the rectal cavity R) through the natural cavity opening A (the anus in this example), and then a syringe or the like (not shown) is used to inject external liquid medicine or pure water into the liquid passage 10 of the applicator 1 through the injection port 101 through the injection cavity 1130 of the rod-shaped body tail 113. The liquid medicine enters the anal canal C through the radial liquid outlet 102 and is coated on the anal canal mucosa to play a corresponding role. Then, the applicator 1 is pulled out of the natural cavity opening, and the stretched anal canal C is closed to prevent the solid suppository 2 from following the applicator 1. The medicine device 1 is withdrawn, and the solid suppository 2 is retained in the rectal cavity R, and the corresponding medicine is gradually released; in addition, because the flexible wrapping portion 125 of the flexible body 12 only covers the tail portion 23 of the solid suppository, a large area of ​​the solid suppository 2 is partially located outside the medicine device 1, and the solid suppository 2 is difficult to be taken out when the medicine device 1 is withdrawn; in specific applications, the inner surface 1251 of the flexible wrapping portion may also not be in interference contact with the outer surface of the solid suppository 2, and when the medicine device 1 is withdrawn, the inner surface of the flexible wrapping portion and the outer surface of the solid suppository will not generate significant friction resistance, and the solid suppository 2 will not be taken out.

[0052] The utility model realizes the coordinated administration of the solid suppository 2 and the liquid medicine, shortens the operation time, improves the operation efficiency and avoids the mucosal damage to the greatest extent.

[0053] Embodiment 2:

[0054] like Figure 2A , Figure 2B As shown, the soft body 12 of this example does not completely cover the rod-shaped body 11, and only covers the part of the rod-shaped body 11 that may enter the natural cavity when used, that is, the rod-shaped body head 111 and the rod-shaped body middle part 112 are all or partially covered, and the rod-shaped body tail 113 is not covered, which saves material costs. At the same time, the hard rod-shaped body head top 1111 does not directly contact the solid suppository 2, but is isolated by the flexible wrapping part 125 of the soft body 12 outside, that is, the rod-shaped body head top 1111 is covered with a soft body membrane part 126, so as to avoid the hard rod-shaped body head top 1111 from damaging the relatively fragile solid suppository 2, thereby ensuring the integrity of the solid suppository 2 after entering the natural cavity.

[0055] Embodiment 3:

[0056] like Figure 3A , Figure 3BAs shown, the biggest difference from Example 1 is that the hollow portion in the rod-shaped body 11 constitutes a liquid passage 10, and the liquid passage 10 is provided with a plurality of radial liquid outlets 102 in the head region of the applicator. The hollow portion in the rod-shaped body 11 penetrates the rod-shaped body head 111 to form a top opening 1110 of the liquid passage, and the top opening 1110 of the liquid passage is connected to the liquid passage 10. When in use, in addition to the resistance effect of the annular top 1111 of the rod-shaped body head on the tail end surface 231 of the solid suppository 2, the liquid medicine can also actively push the solid suppository 2 to separate from the inner cavity 1250 of the flexible wrapping portion and enter the natural cavity through the top opening 1110 of the liquid passage.

[0057] like Figure 3C As shown, the push rod G also includes a push rod G entering the liquid passage 10 through the liquid injection port 101, the top end of the push rod G contacts the rear end surface 231 of the solid suppository 2 through the top opening 1110 of the liquid passage, and the external force drives the push rod G to push the solid suppository 2 out of the inner cavity 1250 of the flexible wrapping part and into the natural cavity; the push rod G can be provided with a push rod handle G1 for the user to hold, and the push rod handle G1 with a larger area can also prevent the push rod G from entering the liquid passage 10 completely.

[0058] Embodiment 4:

[0059] like Figure 4A , Figure 4B As shown, the rod-shaped body 11 of this example does not have a liquid passage 10 inside, and a plurality of longitudinal ribs 1120 are provided in the rod-shaped body head 111 and the rod-shaped body middle part 112. The gaps between the longitudinal ribs 1120 and the rod-shaped body 1 and between the longitudinal ribs 1120 are wrapped by the soft body 12 to form the liquid passage 10 together; the liquid injection port 101 is connected to the liquid passage 10 through the outwardly open communication hole 1121 on the rod-shaped body tail 113; the outwardly open communication hole 1121 is located at the longitudinal rib 1120 The starting part, the longitudinal ribs 1120 start at the distal end of the rod-shaped body tail 113, and the connecting hole 1121 is between the longitudinal ribs 1120; under this scheme, the applicator 1 has multiple liquid passages 10, and the cross-sectional area of ​​the liquid passages 10 is increased to ensure the patency and circumferential uniformity of the drug solution during release; the longitudinal ribs 1120 can increase the strength of the applicator 1, and it is not easy to bend during use; the "distal end" described in the utility model refers to the direction away from the applicator injection port 101 and toward the rod-shaped body head 111.

[0060] Embodiment 5:

[0061] like Figure 5A , Figure 5BAs shown, considering that a solid suppository 2 with a heavy weight or a long axial length is used clinically, although the flexible wrapping portion 125 can flexibly contact the mucosa to avoid mucosal damage to the greatest extent, the restraining effect on the above-mentioned specific solid suppository 2 is insufficient. In this example, a hard rod-shaped body covering portion 1112 is provided at the distal end of the hard rod-shaped body head 111, and the rod-shaped body covering portion 1112 is connected to the rod-shaped body head 111 as a whole to cover the solid suppository 2. Compared with the flexible wrapping portion 125 sleeved thereon, the rod-shaped body covering portion 1112 has greater strength, and has sufficient restraining effect on the specific solid suppository 2, ensuring that the solid suppository 2 is delivered to the target position and preventing the solid suppository 2 from falling off when being pushed into the natural cavity.

[0062] In this example, Figure 5A The liquid injection port 101 of the drug delivery device 1 is shown to be arranged at the rod-shaped body tail 113 or the soft body tail 123. The gap between the rod-shaped outer surface 114 and the soft body inner surface 124 constitutes a liquid passage 10. The gap can be in a closed state and is only opened when the liquid medicine enters. Figure 5A The liquid passage is in a closed state, that is, the outer surface 114 of the rod-shaped body is in close contact with the inner surface 124 of the soft body; similar to the above-mentioned embodiment, the liquid injection port 101 is connected to the liquid passage 10 through the outwardly open communication hole 1121 on the tail 113 of the rod-shaped body (the figure is omitted in this embodiment); Figure 5B The middle rod-shaped body 11 is hollow inside to form a hollow liquid passage 10, and a push rod G (not shown) can enter through the liquid passage 10 to push the solid suppository 2 out of the inner cavity 1250 of the flexible wrapping portion; the liquid medicine can also actively push the solid suppository 2 out of the inner cavity 1250 of the flexible wrapping portion through the top opening 1110 of the liquid passage.

[0063] Embodiment 6:

[0064] like Fig. 6A , Figure 6B As shown, considering that the solid suppository 2 is difficult to insert into the flexible wrapping part 125 when a thin-walled flexible wrapping part 125 is used, the flexible wrapping part 125 at the distal end of the soft body head 121 of this example is folded toward the rod-shaped body tail 113, the inner surface 1251 of the flexible wrapping part 125 is turned outward, and the free end 1252 of the flexible wrapping part 125 faces the rod-shaped body tail 113; when in use, the solid suppository 2 is first placed on the bottom end 1253 of the flexible wrapping part, and then the turned-out flexible wrapping part 125 is pushed toward the solid suppository 2, and folded to the wrapped state described in the drawings of the aforementioned embodiment. The outer diameter of the thin-walled flexible wrapping part 125 will not increase significantly after wrapping the solid suppository 2, and it is easier to enter through the natural cavity opening; in addition, the material of the flexible wrapping part 125 is easy to deform and expand, and solid suppositories 2 with different outer diameters within a certain range can be wrapped therein.

[0065] This example Fig. 6AA plurality of top openings 1110 of the applicator 1 are shown. When the solid suppository 2 is delivered to a certain position, the liquid medicine can actively push the solid suppository 2 out of the inner cavity of the flexible wrapping part and into the natural cavity through the plurality of top openings 1110 of the liquid passage.

[0066] Embodiment 7:

[0067] like Fig. 7A , Figure 7B As shown, a downwardly concave suction cup portion 127 is provided at the distal center area of ​​the soft body head 121, and a circumferentially distributed suction cup lower gap 128 is left below the suction cup portion 127; Figure 7B , the solid suppository 2 is placed in the flexible wrapping portion 125 so that the rear end surface 231 of the solid suppository 2 is pressed against the suction cup portion 127, so that the air in the suction cup portion 127 is partially or completely squeezed out, and the solid suppository 2 is adsorbed on the suction cup portion 127, and the solid suppository 2 is kept stable during the natural cavity advancement process; the gap 128 under the suction cup can make the suction cup portion 127 easy to deform downward, which is helpful to discharge the air in the suction cup portion 127 to form a negative pressure; the adsorption force generated by the negative pressure is only to stabilize the solid suppository 2 and prevent it from swinging left and right. After the solid suppository 2 is transported to the target position and exits the applicator 1, the stretched mucosal tissue retracts, and the resistance effect of the retracted mucosal tissue on the solid suppository 2 with a larger diameter is greater than the adsorption effect of the suction cup portion 127, so that the solid suppository 2 is separated from the suction cup portion 127 of the applicator 1.

[0068] A variation of this approach is Figure 7C In order to facilitate the release of the continuous adsorption of the solid suppository 2 after the solid suppository 2 is delivered to the target position, a suction cup hole 1270 is opened in the central area of ​​the suction cup portion 127, and the bottom of the suction cup hole 1270 is blocked by the top end 1111 of the rod-shaped body head. When it is necessary to release the adsorption of the solid suppository 2, the rod-shaped body 11 can be pulled outside the body to make the top end 1111 of the rod-shaped body head and the suction cup portion 127 of the soft body 12 relatively displaced, that is, the top end 1111 of the rod-shaped body head moves downward, the blockage of the suction cup hole 1270 is released, and the gas or liquid enters the depression of the suction cup portion 127 through the suction cup hole 1270, thereby releasing the adsorption of the solid suppository 2.

[0069] The soft body suction cup portion 127 can be used in combination with the flexible wrapping portion 125, or can be used alone to absorb and fix the tail end surface 231 of the solid suppository.

[0070] Embodiment 8:

[0071] like Fig. 8A , Figure 8BAs shown, in order to simultaneously meet the need for expanding the natural cavity in clinical practice, an expandable bladder 13 is provided between the injection port 101 and the liquid outlet 102 of the applicator 1. After the inner cavity 130 of the expandable bladder is filled with fluid, the radial supporting force generated by the expansion of the outer boundary expands the natural cavity; the expandable bladder 13 can be made of compliant materials such as silicone rubber, latex, thermoplastic elastomer, etc., and can also be made of semi-compliant or non-compliant materials such as polyamide, block polyether amide, etc. The inflatable bladder 13 is sleeved on the outside of the soft body 12, and is composed of a bladder connecting part 131 and a bladder expansion part 132. The bladder connecting parts 131 located at both ends of the inflatable bladder 13 are sealed and connected to the outer surface of the soft body 12. The annular gap between the inner surface of the bladder expansion part 132 located in the middle of the inflatable bladder 13 and the outer surface of the soft body 12 wrapped therein is the inflatable bladder inner cavity 130. When in use, a syringe (not shown) is inserted into the one-way valve 134, and the fluid in the syringe enters the inflatable bladder inner cavity 130 through the bladder connecting tube 133, the bladder connecting tube opening 1330, and the bladder passage 1220 and the bladder passage opening 1221 located in the soft body 12. The bladder expansion part 132 expands and deforms outward under the internal fluid pressure, and the natural cavity expands radially; the bladder passage 1220 can also be located in the rod-shaped body 11.

[0072] When the drug delivery device 1 of the present invention passes through the opening of a natural cavity, the hard rod-shaped body 11 does not directly contact the mucosal tissue, but the soft body covering it contacts the mucosa, thereby reducing damage to the mucosa; the flexible wrapping portion 125 on the soft body of the drug delivery device wraps the tail 23 of the solid suppository, protecting the mucosal tissue while allowing it to move forward stably, thereby preventing the solid suppository 2 from falling off when inserted into the natural cavity, and ensuring that the solid suppository 2 is inserted into the target position.

[0073] The suction cup portion 127 on the soft body of the applicator can absorb the tail end surface 231 of the solid suppository and fix it axially without increasing the maximum external dimension of the applicator. When the solid suppository 2 passes through the opening of the natural cavity and moves forward in the natural cavity, it can prevent the solid suppository 2 from falling off and cause minimal damage to the mucosa. The suction cup portion 127 on the soft body of the applicator is used in combination with the flexible wrapping portion 125, so that the solid suppository 2 moves forward in the natural cavity more stably.

[0074] The suction cup portion 127 on the soft body 12 of the applicator or the multiple radial liquid outlets 102 below the flexible wrapping portion 125 can release liquid medicine to the natural cavity mucosal tissue at any time, achieving the purpose of coordinated administration of the solid suppository 2 and the liquid medicine in one operation.

[0075] Before, during and after administration, the expandable capsule can be filled according to the needs of the disease to radially expand the natural cavity, thereby improving local blood supply, promoting lymphatic return, promoting drug absorption, preventing stenosis, evenly coating liquid medicines, and promoting mucosal absorption of liquid medicines.

[0076] The utility model significantly simplifies the clinical operation steps, reduces the two-step drug administration operation to a coordinated one step, and reduces the three-step operation of joint expansion to one step, thereby avoiding secondary and tertiary mucosal tissue damage when medical instruments enter the natural cavity opening, significantly saving medical operation time, protecting the fragile mucosa of the affected area, and reducing treatment costs.

[0077] One parameter setting is: the outer diameter of the main body of the drug delivery device 1 for the rectum, excluding the flexible wrapping portion 125 and part of the injection port 101, is between 2mm-8mm, and the length is between 35mm-180mm; the outer diameter of the main body of the drug delivery device 1 for the vagina is between 5mm-38mm, and the length is between 65mm-280mm; the size-related parameters can be individually customized according to the concept of the present utility model.

[0078] The utility model can be applied to drug administration and synchronous expansion of other natural cavities such as nasal cavity, ear canal, etc. in addition to the digestive tract and reproductive tract.

Claims

1. A natural cavity cooperative drug delivery device (1), comprising: The invention relates to a slender hard rod-shaped body (11), and a soft body (12) wrapped around the rod-shaped body (11). The rod-shaped body (11) has a rod-shaped body head (111) that enters the opening of the natural cavity when in use, a rod-shaped body middle part (112), and a rod-shaped body tail (113) that is located outside the opening of the natural cavity when in use. The invention is characterized in that the drug delivery device (1) is provided with a liquid injection port (101), a liquid passage (10) and a radial liquid outlet (102). The head area of ​​the soft body (12) is provided with a hollow flexible wrapping part (111). 25) and / or the suction cup portion (127), the internal space (1250) of the flexible wrapping portion (125) can at least accommodate a portion of the solid suppository tail (23), when in use, the solid suppository (2) is first inserted into the flexible wrapping portion (125) and / or adsorbed on the suction cup portion (127), and then the applicator (1) is slowly inserted into the natural cavity through the opening of the natural cavity, and then the liquid medicine is injected through the injection port (101), and then the applicator (1) is pulled out of the natural cavity opening, and the solid suppository (2) is retained in the natural cavity.

2. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The injection port (101) of the drug delivery device (1) is arranged at the rod-shaped body tail (113), and external liquid medicine or pure water enters the liquid passage (10) of the drug delivery device (1) through the injection cavity (1130) of the rod-shaped body tail (113).

3. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The liquid injection port (101) of the drug delivery device (1) is arranged at the tail portion (113) of the rod-shaped body, and the hollow portion inside the rod-shaped body (11) constitutes a liquid passage (10).

4. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The liquid injection port (101) of the drug delivery device (1) is arranged at the rod-shaped body tail (113) or the soft body tail (123), and the gap between the rod-shaped body outer surface (114) and the soft body inner surface (124) constitutes a liquid passage (10).

5. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The hollow portion in the rod-shaped body (11) constitutes a liquid passage (10), and the liquid passage (10) is provided with a plurality of radial liquid outlets (102) in the head region of the applicator. The hollow portion in the rod-shaped body (11) penetrates the rod-shaped body head (111) and forms a liquid passage top opening (1110) at the top of the rod-shaped body head (111), and the liquid passage top opening (1110) is communicated with the liquid passage (10).

6. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The flexible wrapping portion (125) at the distal end of the soft body head (121) is folded toward the rod-shaped body tail (113), the inner surface (1251) of the flexible wrapping portion is turned outward, and the free end (1252) of the flexible wrapping portion (125) faces the rod-shaped body tail (113).

7. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The top end (1111) of the rod-shaped body head (111) is covered with a soft body membrane portion (126) or a soft body suction cup portion (127), and the top end (1111) of the rod-shaped body head (111) does not directly contact the tail end surface (231) of the solid suppository (2).

8. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The rod-shaped body head (111) is connected to a rod-shaped body covering portion (1112) for covering the solid suppository (2).

9. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: The rod-shaped body (11) is provided with at least one longitudinal rib (1120); the gap between the longitudinal rib (1120) and the rod-shaped body (11) and / or the gap between the longitudinal rib (1120) and the longitudinal rib (1120) is wrapped by the soft body (12) to form a liquid passage (10); the liquid injection port (101) is connected to the liquid passage (10) through a connecting hole (1121) opened outward on the tail of the rod-shaped body (113).

10. The natural cavity coordinated drug delivery device (1) according to claim 1, characterized in that: An expandable sac (13) is provided between the liquid injection port (101) and the liquid outlet (102) of the drug delivery device (1). When the inner cavity (130) of the expandable sac (13) is filled with fluid, the radial supporting force generated by the expansion expands the natural cavity.

Images