Virus concentration device

Abstract

The utility model relates to the technical field of pseudovirus concentration devices, and discloses a virus concentration device. The feed inlets are divided into two groups, are symmetrically arranged at the top end of the shell and are communicated with the shell; the filtering mechanism is arranged in the shell; the shaking mechanism is arranged in the shell and is positioned below the filtering mechanism; the top end of the concentration equipment is connected with the shaking mechanism. Under the centrifugal acting force, viruses can be rapidly screened, large solid viruses can be rapidly guided and recycled under the cooperation of the guide pipe, the viruses continue to be screened after being recycled, the screening efficiency is effectively improved, and blocking during equipment screening is effectively avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of pseudovirus concentration devices, in particular to a virus concentration device. Background Art

[0002] HPV (human papillomavirus) is a non-enveloped double-stranded circular DNA virus, whose infection may cause a variety of skin diseases, especially malignant tumors such as cervical cancer. Therefore, the development and production of HPV vaccines have great social significance.

[0003] In the process of research, development and production of HPV virus, it needs to be purified to improve the accuracy of research data. However, during the purification operation, the existing equipment can extract the sample by filtering and adsorption, and concentrate it with the cooperation of the equipment. However, the equipment is prone to blockage at the filter point during filtration, thus affecting the filtration effect. Utility Model Content

[0004] In order to solve the technical problem that when existing equipment is used to filter pseudoviruses, solids in the virus easily cause blockage at the sieve plate, thereby affecting the filtering effect of the equipment, the utility model provides a virus concentration device.

[0005] The utility model is implemented by the following technical solutions: a virus concentration device, comprising a shell;

[0006] Also includes:

[0007] Feed inlets, which are in two groups and symmetrically arranged at the top of the shell, and are connected to the shell;

[0008] A filter mechanism, wherein the filter mechanism is disposed in the housing;

[0009] A shaking mechanism, wherein the shaking mechanism is disposed in the housing and below the filtering mechanism;

[0010] A concentration device, wherein the top of the concentration device is connected to a shaking mechanism.

[0011] Through the above technical solution, it can be ensured that the equipment can avoid clogging during screening during operation, and larger viruses can be automatically recovered and screened again; rapid virus filtering is carried out with the cooperation of the filtering mechanism and the shaking mechanism.

[0012] As a further improvement of the above scheme, the filtering mechanism includes a motor installed on the top of the shell, and a rotating shaft is connected to the output shaft direction of the motor. The rotating shaft passes through the shell and a separation plate is fixedly connected to the bottom end. The separation plate is a bowl-shaped structure with an inward folded top.

[0013] As a further improvement of the above solution, multiple groups of partitions are evenly and fixedly connected to the inner wall of the separation plate, and sieve holes are provided at the connection between the two sides of the multiple groups of partitions and the separation plate to achieve equipment guidance and filtering operations.

[0014] As a further improvement of the above solution, guide tubes are fixedly connected to both sides of the separation plate, and the bottom ends of the guide tubes are connected to the separation plate for recovering the virus under centrifugation.

[0015] Through the above technical solution, the inner fold set at the top can be used to avoid virus splashing under the action of centrifugal force, and the larger solid virus can be recovered in cooperation with the guide tube.

[0016] As a further improvement of the above scheme, the shaking mechanism includes a rotating rod symmetrically connected to the shell, and a material receiving plate is fixedly connected to the inner side of the two groups of rotating rods. The material receiving plate is arranged as a funnel, and a material discharge hole is opened in the middle of the material receiving plate. A collecting plate is arranged at the bottom of the material receiving plate, and a concentration device is connected to the bottom of the collecting plate.

[0017] As a further improvement of the above solution, the top ends of the rotating rods are fixedly connected with vertical plates, and the two groups of vertical plates can intermittently abut against side plates. The side plates are in two groups and are installed on both sides of the separation plate.

[0018] Two groups of sleeve plates are symmetrically fixedly connected on both sides of the receiving plate, and the outer sides of the two groups of sleeve plates are rotatably connected with rotating blocks, the outer ends of the two groups of rotating blocks are fixedly connected with side slides, the outer sides of the two groups of side slides are slidably connected with sleeve blocks, the two groups of sleeve blocks are vertically slidably connected to the inner wall of the shell, and the bottom ends of the two groups of sleeve blocks are welded with springs, the bottom ends of the two groups of springs are fixedly connected with fixed plates, and the two groups of fixed plates are installed on the inner wall of the shell.

[0019] Through the above technical scheme, the side plates and the vertical plates are intermittently pushed and abutted, and the rotating rod is used as the rotation fulcrum to shake in the corresponding direction. The side slide plates are pushed to slide accordingly under the rotation of the sleeve plates and the rotating blocks on both sides, and the sleeve blocks can be driven to perform adaptive displacement on the inner wall of the shell to achieve the rapid falling of the internal viruses.

[0020] Compared with the prior art, the beneficial effects of the present invention are:

[0021] (I) The utility model utilizes centrifugal force to quickly screen viruses, and with the cooperation of the guide tube, quickly guides and recovers larger solid viruses, and continues to screen them after recovery, effectively improving the screening efficiency and effectively avoiding clogging of the equipment during screening.

[0022] (ii) The utility model utilizes the cooperation of the filtering mechanism and the shaking mechanism to intermittently shake the screened viruses and make them fall quickly to the concentration device for concentration. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the overall structure of a virus concentration device provided in Example 1 of the utility model;

[0024] Figure 2 For this utility model Figure 1 A schematic diagram of a three-dimensional cross-sectional structure;

[0025] Figure 3 For this utility model Figure 2 A schematic diagram of the enlarged structure at point A in the middle.

[0026] Description of main symbols:

[0027] 1. Shell; 2. Feed inlet; 3. Motor; 4. Rotating shaft; 5. Separation plate; 6. Partition plate; 7. Screen hole; 8. Guide pipe; 9. Side plate; 10. Receiving plate; 11. Rotating rod; 12. Vertical plate; 13. Feeding hole; 14. Collecting plate; 15. Concentration equipment; 16. Sleeve plate; 17. Rotating block; 18. Side slide plate; 19. Sleeve block; 20. Spring; 21. Fixed plate. DETAILED DESCRIPTION

[0028] The present invention is further described below in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0029] Embodiment 1:

[0030] Please combine Figure 1 and Figure 2 , a virus concentration device of this embodiment includes a housing 1;

[0031] Also includes:

[0032] Feed inlet 2, the feed inlet 2 is in two groups and symmetrically arranged at the top of the shell 1, and the feed inlet 2 is connected to the shell 1;

[0033] A filtering mechanism, the filtering mechanism is arranged in the housing 1;

[0034] A shaking mechanism, which is arranged in the housing 1 and below the filtering mechanism;

[0035] The concentrating device 15 has a top connected to the shaking mechanism.

[0036] The filtering mechanism includes a motor 3 installed on the top of the shell 1. The motor 3 is connected to a rotating shaft 4 at the output shaft direction. The rotating shaft 4 passes through the shell 1 and is fixedly connected to a separation plate 5 at the bottom. The separation plate 5 is a bowl-shaped structure with an inward folded top.

[0037] A plurality of partition plates 6 are evenly and fixedly connected to the inner wall of the separation plate 5, and sieve holes 7 are provided at the connection between the plurality of partition plates 6 and the separation plate 5 on both sides to realize equipment guidance and filtering operation.

[0038] Guide tubes 8 are fixedly connected to both sides of the separation plate 5, and the bottom ends of the guide tubes 8 are connected to the separation plate 5 for recovering the virus by centrifugation.

[0039] The implementation principle of a virus concentration device in the embodiment of the present application is:

[0040] The viruses to be concentrated are put in from the feed port 2 respectively, and the motor 3 is started to drive the rotating shaft 4 to rotate with the separation plate 5. As the viruses fall to the upper end of the separation plate 5, the centrifugal force generated by the rotation will drive the viruses to slide along the partition 6 to the outside of both ends, so that the viruses quickly pass through the sieve holes 7 and enter the receiving plate 10 for collection; when there are viruses in a solid state, they will enter the separation plate 5 again along the guide tube 8 during rotation, and rotate and screen again under the centrifugal force.

[0041] Embodiment 2:

[0042] Combination Figure 2 and Figure 3 Based on Example 1, this embodiment is further improved in that:

[0043] The shaking mechanism includes a rotating rod 11 symmetrically connected to the shell 1, and a receiving plate 10 is fixedly connected to the inner side of two groups of rotating rods 11. The receiving plate 10 is arranged as a funnel, and a discharge hole 13 is opened in the middle of the receiving plate 10. A collecting plate 14 is arranged at the bottom of the receiving plate 10, and a concentration device 15 is connected to the bottom of the collecting plate 14.

[0044] The top of the rotating rod 11 is fixedly connected with a vertical plate 12 , and two groups of vertical plates 12 can intermittently abut against the side plates 9 . The side plates 9 are in two groups and are installed on both sides of the separation plate 5 .

[0045] Two sets of sleeve plates 16 are symmetrically fixedly connected on both sides of the receiving plate 10, and the outer sides of the two sets of sleeve plates 16 are rotatably connected with rotating blocks 17, the outer ends of the two sets of rotating blocks 17 are fixedly connected with side slides 18, the outer sides of the two sets of side slides 18 are slidably connected with sleeve blocks 19, the two sets of sleeve blocks 19 are vertically slidably connected to the inner wall of the shell 1, and the bottom ends of the two sets of sleeve blocks 19 are welded with springs 20, the bottom ends of the two sets of springs 20 are fixedly connected with fixed plates 21, and the two sets of fixed plates 21 are installed on the inner wall of the shell 1.

[0046] The implementation principle of this embodiment is:

[0047] As the separation plate 5 rotates, the side plate 9 will be driven to rotate, and under the rotation of the side plate 9 and the push and contact of the vertical plate 12, the receiving plate 10 will be intermittently pushed to shake in the corresponding direction with the rotating rod 11 as the rotating fulcrum, and the side slide plate 18 will be pushed to slide accordingly under the rotation of the sleeve plate 16 and the rotating block 17 on both sides. At the same time, the sleeve block 19 can be driven to adaptively displace on the inner wall of the shell 1 and return to its original position under the action of the spring 20, so that the screened virus can quickly enter the collecting plate 14 and be guided into the concentration device 15 for concentration operation.

[0048] Working principle:

[0049] The viruses to be concentrated are put in from the feed port 2 respectively, and the motor 3 is started to drive the rotating shaft 4 to rotate with the separation plate 5. As the viruses fall to the upper end of the separation plate 5, the centrifugal force generated by the rotation will drive the viruses to slide along the partition 6 to the outside of both ends, so that the viruses quickly pass through the sieve holes 7 and enter the receiving plate 10 for collection; when there are viruses in a solid state, they will enter the separation plate 5 again along the guide tube 8 during rotation, and rotate and screen again under the centrifugal force.

[0050] As the separation plate 5 rotates, the side plate 9 will be driven to rotate, and under the rotation of the side plate 9 and the push and contact of the vertical plate 12, the receiving plate 10 will be intermittently pushed to shake in the corresponding direction with the rotating rod 11 as the rotating fulcrum, and the side slide plate 18 will be pushed to slide accordingly under the rotation of the sleeve plate 16 and the rotating block 17 on both sides. At the same time, the sleeve block 19 can be driven to adaptively displace on the inner wall of the shell 1 and return to its original position under the action of the spring 20, so that the screened virus can quickly enter the collecting plate 14 and be guided into the concentration device 15 for concentration operation.

[0051] The above-mentioned implementation modes are only preferred implementation modes of the present invention, and cannot be used to limit the protection scope of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A virus concentration device, comprising a housing; It is characterized in that Also includes: Feed inlets, which are in two groups and symmetrically arranged at the top of the shell, and are connected to the shell; A filter mechanism, wherein the filter mechanism is disposed in the housing; A shaking mechanism, wherein the shaking mechanism is disposed in the housing and below the filtering mechanism; A concentration device, wherein the top of the concentration device is connected to a shaking mechanism.

2. A virus concentration device according to claim 1, characterized in that: The filtering mechanism comprises a motor installed at the top of the shell, a rotating shaft is connected to the output shaft direction of the motor, the rotating shaft passes through the shell and a separation plate is fixedly connected to the bottom end, and the separation plate is a bowl-shaped structure with an inward folded top.

3. A virus concentration device as claimed in claim 2, characterized in that: The inner wall of the separation plate is evenly and fixedly connected with a plurality of partitions, and sieve holes are provided at the connection between the two sides of the plurality of partitions and the separation plate to realize equipment guidance and filtering operation.

4. A virus concentration device as claimed in claim 3, characterized in that: Guide tubes are fixedly connected to both sides of the separation plate, and the bottom ends of the guide tubes are connected to the separation plate for recovering the virus under centrifugation.

5. A virus concentration device as claimed in claim 1, characterized in that: The shaking mechanism includes rotating rods symmetrically connected to the shell, and the inner sides of the two sets of rotating rods are fixedly connected with receiving plates, the receiving plates are arranged as funnels, and a discharge hole is opened in the middle of the receiving plates, a collecting plate is arranged at the bottom of the receiving plates, and the bottom of the collecting plate is connected to a concentration device.

6. A virus concentration device as claimed in claim 5, characterized in that: The top ends of the rotating rods are fixedly connected with vertical plates, and two groups of vertical plates can intermittently abut against side plates. The side plates are in two groups and are installed on both sides of the separation plate.

7. A virus concentration device as claimed in claim 5, characterized in that: Two groups of sleeve plates are symmetrically fixedly connected on both sides of the receiving plate, and the outer sides of the two groups of sleeve plates are rotatably connected with rotating blocks, the outer ends of the two groups of rotating blocks are fixedly connected with side slides, the outer sides of the two groups of side slides are slidably connected with sleeve blocks, the two groups of sleeve blocks are vertically slidably connected to the inner wall of the shell, and the bottom ends of the two groups of sleeve blocks are welded with springs, the bottom ends of the two groups of springs are fixedly connected with fixed plates, and the two groups of fixed plates are installed on the inner wall of the shell.

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