Virus inactivation tank

Abstract

The utility model relates to a virus inactivation tank, which belongs to the technical field of biological medicine equipment and comprises an inactivation tank body, a temperature control component, a control unit and a power supply unit for supplying power to the whole inactivation tank, the inactivation tank body comprises an inner tank, an outer tank is arranged on the outer side of the inner tank, a partition plate is arranged between the inner tank and the outer tank, and a heat insulation layer is arranged between the outer tank and the partition plate. The temperature control assembly comprises a temperature control medium source, an upper medium coil pipe and a lower medium coil pipe, the lower medium coil pipe is coiled at the bottom of the outer wall of the inner tank, the upper medium coil pipe is coiled on the outer wall of the inner tank above the lower medium coil pipe, and the two ends of the upper medium coil pipe and the two ends of the lower medium coil pipe are connected to the medium source; the upper medium coil pipe and the lower medium coil pipe are arranged on the upper portion and the lower portion of the outer wall of the inner tank respectively, two temperature control loops are formed, and accurate control over the temperatures of different parts of the inner tank can be achieved. The layout ensures that the temperature distribution in the inner tank is more uniform, so that the inactivation efficiency of viruses and bacteria is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of biomedical equipment, and particularly relates to a virus inactivation tank. Background Art

[0002] In the field of biomedicine, the inactivation of viruses and bacteria is an important step in the process of vaccine preparation and biological product production. In the field of biopharmaceutical production technology, virus inactivation is a decisive process and step related to product safety. As the process is scaled up, the volume of the product to be virus-inactivated increases, so the volume of the inactivation tank increases accordingly. At the same time, because biological products are sensitive to temperature, there are strict requirements for the heating temperature (for example, pasteurization requires a temperature of 60.0℃±0.5℃, but the heating temperature is often required to be no higher than 62.0℃). This results in the original design (the jacket temperature control layer has only one set of coil channels) having a very long heating time, which actually increases the time that the product to be inactivated withstands higher temperatures, seriously affecting the activity or potency of the biological product. Summary of the Invention

[0003] The purpose of this utility model is to provide a virus inactivation tank designed to solve the problems existing in the prior art.

[0004] In order to achieve the above purpose, the present invention provides the following technical solutions:

[0005] A virus inactivation tank comprises an inactivation tank body, a temperature control component, a control unit and a power supply unit for supplying power to the entire inactivation tank. The inactivation tank body comprises an inner tank, an outer tank is arranged on the outside of the inner tank, a partition is arranged between the inner tank and the outer tank, and an insulation layer is arranged between the outer tank and the partition. The temperature control component comprises a temperature control medium source, an upper medium coil and a lower medium coil. The lower medium coil is coiled on the bottom of the outer wall of the inner tank, and the upper medium coil is coiled on the outer wall of the inner tank above the lower medium coil. Both ends of the upper medium coil and both ends of the lower medium coil are connected to the medium source to form two temperature control loops. A pump body is provided on the coil at the medium inlet of the temperature control loop. The temperature control medium source and the pump body are both connected to the control unit.

[0006] A further improvement of the present technical solution is that the temperature control component includes a temperature sensor arranged on the outer wall of the inner tank.

[0007] A further improvement of the technical solution is that the temperature control component also includes a conditioning circuit, and the temperature sensor is connected to the control unit via the conditioning circuit.

[0008] A further improvement of the technical solution is that the conditioning circuit includes a resistor R1, a resistor R2, an amplifier U1, a resistor R3, a reference source, a capacitor C1, a capacitor C2, a resistor R4, a capacitor C3, a resistor R5, a resistor R6, an amplifier U2, a capacitor C4, a capacitor C5, a resistor R7 and a capacitor C6;

[0009] The first end of the resistor R1 is connected to the temperature sensor, the second end of the resistor R1 is connected to the non-inverting input terminal of the amplifier U1 and the first end of the resistor R2, the second end of the resistor R2 is grounded, the inverting input terminal of the amplifier U1 is connected to the reference source through the resistor R3, the first external capacitor terminal of the amplifier U1 is connected to the external capacitor common terminal of the amplifier U1 through the capacitor C1, the second external capacitor terminal of the amplifier U1 is connected to the external capacitor common terminal of the amplifier U1 through the capacitor C2, the output terminal of the amplifier U1 is connected to the inverting input terminal of the amplifier U1 through the parallel resistor R4 and capacitor C3; the output terminal of the amplifier U1 is connected to the non-inverting input terminal of the amplifier U2 through the resistor R5, the inverting input terminal of the amplifier U1 is grounded through the resistor R6, the first external capacitor terminal of the amplifier U1 is connected to the external capacitor common terminal of the amplifier U2 through the capacitor C4, the second external capacitor terminal of the amplifier U2 is connected to the external capacitor common terminal of the amplifier U2 through the capacitor C5, the output terminal of the amplifier U2 is connected to the inverting input terminal of the amplifier U2 through the parallel resistor R7 and capacitor C6, and the output terminal of the amplifier U2 is also connected to the input terminal of the control unit.

[0010] A further improvement of the technical solution is that both amplifier U1 and amplifier U2 use operational amplifiers of model ICL7650.

[0011] A further improvement of the technical solution is that the control unit includes a single chip microcomputer of model AT89C51.

[0012] Further improvements of this technical solution include: a stirring assembly is provided on the top of the inactivation tank body, a filling port is provided on the inactivation tank body on one side of the stirring assembly, a tank bottom valve is provided at the bottom end of the inactivation tank body, and tank legs are provided at the bottom end of the inactivation tank body around the tank bottom valve.

[0013] The beneficial effects of the present invention are:

[0014] Uniform and stable temperature control: By placing upper and lower dielectric coils on the outer wall of the inner tank, forming two temperature control circuits, the temperature of different parts of the inner tank can be precisely controlled. This layout ensures a more uniform temperature distribution inside the inner tank, thereby improving the inactivation efficiency of viruses and bacteria.

[0015] Efficient energy utilization: The insulation layer between the outer tank and the partition effectively reduces heat loss and improves energy efficiency. This not only reduces the energy consumption of equipment operation, but also reduces long-term operating costs.

[0016] Optimized temperature control performance: A pump is installed at the medium inlet of the temperature control loop to precisely control the flow rate and flow of the temperature control medium, thereby achieving rapid response and precise adjustment of the internal tank temperature. This ensures the high efficiency and stability of the virus inactivation process.

[0017] In addition, the utility model has a reliable design principle, a simple structure and a very broad application prospect.

[0018] It can be seen that compared with the prior art, the present invention has outstanding substantial features and significant progress, and the beneficial effects of its implementation are also obvious. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the structure of the virus inactivation tank.

[0020] Figure 2 This is the schematic diagram of the conditioning circuit.

[0021] 111 is the inner tank, 112 is the outer tank, 113 is the partition, 114 is the stirring assembly, 115 is the filling port, 116 is the tank bottom valve, 117 is the tank leg, 121 is the temperature control medium source, 122 is the upper medium coil, 123 is the lower medium coil, 130 is the control unit, 140 is the power supply unit, 150 is the solenoid valve, and 160 is the pump body. DETAILED DESCRIPTION

[0022] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the following will be combined with the drawings of the embodiments of the present invention to clearly and completely describe the technical solutions of the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0024] like Figure 1As shown, the utility model provides a virus inactivation tank, including an inactivation tank body, a temperature control assembly, a control unit, and a power supply unit for powering the entire inactivation tank. The inactivation tank body includes an inner tank, an outer tank is provided on the outside of the inner tank, a partition is provided between the inner and outer tanks, and an insulation layer is provided between the outer tank and the partition. The temperature control assembly includes a temperature control medium source, an upper medium coil, and a lower medium coil. The lower medium coil is coiled at the bottom of the outer wall of the inner tank, and the upper medium coil is coiled on the outer wall of the inner tank above the lower medium coil. Both ends of the upper medium coil and the lower medium coil are connected to the medium source, forming two temperature control circuits. A pump body is provided on the coil at the medium inlet of the temperature control circuit. The temperature control medium source and the pump body are both connected to the control unit. The control unit includes a single-chip microcomputer model AT89C51. To ensure safety, solenoid valves are provided on both the medium coil and the lower medium coil. A connecting pipe is provided between the medium coil and the lower medium coil. The connecting pipe is also provided with a solenoid valve. Both solenoid valves are connected to the output end of the control unit.

[0025] Wherein, the temperature control component includes a temperature sensor arranged on the outer wall of the inner tank, and the temperature control component also includes a conditioning circuit, and the temperature sensor is connected to the control unit through the conditioning circuit; Figure 2 As shown, the conditioning circuit includes a resistor R1, a resistor R2, an amplifier U1, a resistor R3, a reference source, a capacitor C1, a capacitor C2, a resistor R4, a capacitor C3, a resistor R5, a resistor R6, an amplifier U2, a capacitor C4, a capacitor C5, a resistor R7 and a capacitor C6; a first end of the resistor R1 is connected to the temperature sensor, a second end of the resistor R1 is connected to the non-inverting input terminal of the amplifier U1 and the first end of the resistor R2, a second end of the resistor R2 is grounded, an inverting input terminal of the amplifier U1 is connected to the reference source through the resistor R3, a first external capacitor terminal of the amplifier U1 is connected to the external capacitor common terminal of the amplifier U1 through the capacitor C1, and a second external capacitor terminal of the amplifier U1 is connected to the amplifier common terminal through the capacitor C2 The output of amplifier U1 is connected to the inverting input of amplifier U1 via a parallel resistor R4 and capacitor C3. The output of amplifier U1 is connected to the non-inverting input of amplifier U2 via resistor R5. The inverting input of amplifier U1 is grounded via resistor R6. The first external capacitor of amplifier U1 is connected to the external capacitor common of amplifier U2 via capacitor C4. The second external capacitor of amplifier U2 is connected to the external capacitor common of amplifier U2 via capacitor C5. The output of amplifier U2 is connected to the inverting input of amplifier U2 via a parallel resistor R7 and capacitor C6. The output of amplifier U2 is also connected to the input of the control unit. Both amplifiers U1 and U2 use ICL7650 operational amplifiers.

[0026] A stirring assembly is provided at the top of the inactivation tank body, a filling port is provided on the inactivation tank body on one side of the stirring assembly, a tank bottom valve is provided at the bottom end of the inactivation tank body, and tank legs are provided at the bottom end of the inactivation tank body around the tank bottom valve. The stirring assembly includes a drive motor provided at the top of the inactivation tank body, and a stirring rod provided in the inner tank and driven by the drive motor. In addition, in order to improve the uniformity of temperature control, the present invention can also provide a temperature control medium circulation pipe inside the stirring rod, both ends of the temperature control medium circulation pipe are connected to the temperature control medium source, and a pump body is provided at the medium inlet of the temperature control medium circulation pipe. The temperature control medium can be water, and the temperature control medium source is also provided with a heater and a refrigerator, and the heater and the refrigerator are both connected to the output end of the single-chip microcomputer.

[0027] The above disclosure is only a preferred embodiment of the present invention, but the present invention is not limited thereto. Any non-creative changes that can be thought of by technicians in this field, as well as several improvements and modifications made without departing from the principles of the present invention, should fall within the scope of protection of the present invention.

Claims

1. A virus inactivation tank, characterized in that: The invention comprises an inactivation tank body, a temperature control component, a control unit and a power supply unit for supplying power to the entire inactivation tank. The inactivation tank body comprises an inner tank, an outer tank is arranged on the outer side of the inner tank, a partition is arranged between the inner tank and the outer tank, and an insulation layer is arranged between the outer tank and the partition. The temperature control component comprises a temperature control medium source, an upper medium coil and a lower medium coil. The lower medium coil is coiled on the bottom of the outer wall of the inner tank, and the upper medium coil is coiled on the outer wall of the inner tank above the lower medium coil. Both ends of the upper medium coil and both ends of the lower medium coil are connected to the medium source to form two temperature control loops. A pump body is arranged on the coil at the medium inlet of the temperature control loop, and the temperature control medium source and the pump body are both connected to the control unit.

2. The virus inactivation tank according to claim 1, characterized in that: The temperature control component includes a temperature sensor arranged on the outer wall of the inner tank.

3. The virus inactivation tank according to claim 2, characterized in that: The temperature control component also includes a conditioning circuit, and the temperature sensor is connected to the control unit through the conditioning circuit.

4. The virus inactivation tank according to claim 3, characterized in that: The conditioning circuit includes a resistor R1, a resistor R2, an amplifier U1, a resistor R3, a reference source, a capacitor C1, a capacitor C2, a resistor R4, a capacitor C3, a resistor R5, a resistor R6, an amplifier U2, a capacitor C4, a capacitor C5, a resistor R7 and a capacitor C6; The first end of the resistor R1 is connected to the temperature sensor, the second end of the resistor R1 is connected to the non-inverting input end of the amplifier U1 and the first end of the resistor R2, the second end of the resistor R2 is grounded, the inverting input end of the amplifier U1 is connected to the reference source through the resistor R3, the first external capacitor end of the amplifier U1 is connected to the external capacitor common end of the amplifier U1 through the capacitor C1, the second external capacitor end of the amplifier U1 is connected to the external capacitor common end of the amplifier U1 through the capacitor C2, the output end of the amplifier U1 is connected to the inverting input end of the amplifier U1 through the parallel resistor R4 and the capacitor C3; the output end of the amplifier U1 is connected to the non-inverting input end of the amplifier U2 through the resistor R5, the inverting input end of the amplifier U1 is grounded through the resistor R6, the first external capacitor end of the amplifier U1 is connected to the external capacitor common end of the amplifier U2 through the capacitor C4, the second external capacitor end of the amplifier U2 is connected to the external capacitor common end of the amplifier U2 through the capacitor C5, the output end of the amplifier U2 is connected to the inverting input end of the amplifier U2 through the parallel resistor R7 and the capacitor C6, and the output end of the amplifier U2 is also connected to the input end of the control unit.

5. The virus inactivation tank according to claim 4, characterized in that: Amplifier U1 and amplifier U2 both use operational amplifier model ICL7650.

6. The virus inactivation tank according to claim 1, characterized in that: The control unit includes a single chip microcomputer of type AT89C51.

7. The virus inactivation tank according to claim 1, characterized in that: A stirring assembly is arranged on the top of the inactivation tank body, a filling port is arranged on the inactivation tank body on one side of the stirring assembly, a tank bottom valve is arranged at the bottom end of the inactivation tank body, and tank legs are arranged at the bottom end of the inactivation tank body around the tank bottom valve.

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