Premixer and device for preparing phenylglycine through continuous acidification

Abstract

The utility model provides a premixer and a device for preparing phenylglycine through continuous acidification, and belongs to the technical field of chemical equipment, the premixer comprises a premixer shell, one end of the premixer shell is provided with a first liquid inlet and a second liquid inlet, and the other end of the premixer shell is provided with a mixed liquid outlet; and a mixing structure is arranged in the premixer shell. The device comprises a premixer, an acidification kettle and an external heat exchanger which are connected in sequence. According to the device for preparing phenylglycine through continuous acidification provided by the utility model, the premixer is adopted to pre-mix a decolorizing solution and sulfuric acid, and the decolorizing solution and sulfuric acid are continuously stirred and temperature is controlled in the acidification kettle, so that the purposes of reducing acidification retention time, reducing temperature control time and achieving continuous operation can be achieved, the acidification effect and stability are improved, the operation steps are reduced, and the production cost is reduced. The use quantity and the land area of the acidification kettle are reduced, stable and continuous acidification production of phenylglycine can be realized, the production stability and the production efficiency are improved, the product quality is improved, and the product production cost is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of chemical equipment, and specifically relates to a premixer and a device for preparing phenylglycine by continuous acidification using the premixer for pretreatment. Background Art

[0002] Phenylglycine is an important intermediate in drug synthesis. It is optically active. Since phenylglycine is optically active, the left-handed and right-handed products have different effects. Most of the products used in the production of medicines and pesticides are left-handed phenylglycine. As a drug intermediate, left-handed phenylglycine is often used in the preparation of antibiotics such as ampicillin and cefotaxime. Right-handed phenylglycine is often used as a resolving agent in many organic reactions. It is also an important intermediate in the synthesis of some pesticides. Due to the wide range of uses of phenylglycine, the synthesized pharmaceutical products can also be made into a variety of dosage forms, which are conducive to human absorption and have broad prospects in the field of medicine.

[0003] The existing conventional phenylglycine acidification process is to directly add decolorized clear liquid and sulfuric acid into the acidification kettle. The reaction process is cumbersome, and the subsequent separation operation requires manual operation. A large number of acidification kettles are required, which occupy a large area, take a long preparation time, and have low production efficiency. Utility Model Content

[0004] The utility model provides a premixer and a device for preparing phenylglycine by continuous acidification, aiming to solve the problems of the existing phenylglycine acidification process using a large number of acidification kettles, complicated operation process, large occupied area, long preparation time and low production efficiency.

[0005] In the first aspect, in order to achieve the above-mentioned purpose, the technical solution adopted by the utility model is: to provide a premixer, including: a premixer shell, one end of which is provided with a first liquid inlet and a second liquid inlet, and the other end of which is provided with a mixed liquid outlet; a mixing structure is provided in the premixer shell.

[0006] In a first aspect, in an achievable manner, a sprayer is disposed at both the first liquid inlet and the second liquid inlet.

[0007] In a first aspect, in one achievable manner, the nozzles of the two sprayers are arranged vertically and crosswise.

[0008] In a first aspect, in one achievable manner, the sprayer includes a baffle installed at each liquid inlet, and a plurality of spray holes are provided on the baffle.

[0009] In a first aspect, in an achievable manner, the mixing structure includes a plurality of first baffles and second baffles arranged in the premixer housing along the direction of fluid flow, the first baffles are arranged in two rows along the direction of fluid flow, the second baffles are arranged in one row along the direction of fluid flow, two rows of the first baffles and one row of the second baffles are evenly distributed along the circumference of the inner wall of the premixer housing, and the second baffles are staggered with the first baffles.

[0010] In a first aspect, in an achievable manner, the second baffle plate and the first baffle plate are both arc-shaped plates, and the first baffle plate is arched in a direction of fluid flow, and the second baffle plate is arched in an opposite direction of fluid flow.

[0011] In the second aspect, the utility model also provides a device for preparing phenylglycine by continuous acidification, comprising the premixer, the acidification kettle and the external heat exchanger, wherein the premixer, the acidification kettle and the external heat exchanger are connected in sequence; the mixed liquid outlet of the premixer is connected to the upper reaction liquid inlet of the acidification kettle through a pipeline, the lower inlet of the external heat exchanger is connected to the bottom outlet of the acidification kettle through a pipeline, and the upper outlet of the external heat exchanger is connected to the upper liquid return port of the acidification kettle through a pipeline; the bottom outlet of the acidification kettle is also connected to the finished product extraction pipe; a stirring mechanism is arranged in the acidification kettle.

[0012] In a second aspect, in an achievable manner, the stirring mechanism includes a stirring motor disposed on the top of the acidification kettle and a stirring shaft extending into the acidification kettle, and the stirring shaft is provided with a spirally wound cyclone stirring blade along its axial direction.

[0013] In a second aspect, in one achievable manner, a liquid level monitoring sensor and a pH value detector are provided on the acidification kettle.

[0014] In a second aspect, in one achievable manner, a tail gas discharge pipe is disposed on the top of the acidification kettle.

[0015] Compared with the prior art, the premixer and the device for preparing phenylglycine by continuous acidification provided by the utility model have the following beneficial effects: after the decolorizing liquid and sulfuric acid are mixed in a certain proportion in advance through the premixer, they are introduced into the acidification kettle for reaction, and the temperature in the acidification kettle is circulated and regulated by the external heat exchanger to keep the pH in the acidification kettle stable and continuously extracted; the premixer can effectively increase the mixing area and improve the acidification effect; the stirring mechanism of the acidification kettle makes the material reaction more sufficient, rapid and uniform, and can accelerate the gas emission, so that there is no volume expansion in the whole acidification process; the external heat exchanger can maintain the balance of the reaction temperature in the acidification kettle, improve the uniformity of the reaction, the sufficiency of the reaction, the reaction rate and the quality of the product.

[0016] Therefore, the device adopts temperature-controlled mixing of the decolorizing liquid and sulfuric acid at the same time, and continuously stirs and controls the temperature in the acidification kettle, which can reduce the acidification residence time, reduce the temperature control time, achieve the purpose of continuous operation, increase the acidification effect and stability, reduce the operation steps, reduce the number of acidification kettles used and the land area, and can achieve smooth and continuous phenylglycine acidification, thereby greatly improving production stability and production efficiency, improving product quality, and reducing product production costs. It has great social environmental benefits and economic benefits, and has a certain effect on increasing enterprise output value, enhancing enterprise brand, promoting the development of the pharmaceutical intermediates industry, and expanding the pharmaceutical intermediates sales market. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the structure of a device for preparing phenylglycine by continuous acidification provided in an embodiment of the utility model;

[0018] Figure 2 A schematic diagram of the structure of a premixer provided in an embodiment of the utility model;

[0019] Figure 3 A schematic diagram of the structure of an external heat exchanger provided in an embodiment of the utility model;

[0020] Figure 4 A schematic diagram of the structure of a stirring mechanism provided in an embodiment of the utility model;

[0021] Description of reference numerals:

[0022] 1. Decolorizing liquid inlet pipe; 2. Sulfuric acid inlet pipe; 3. Premixer; 31. First liquid inlet; 32. Second liquid inlet; 33. Premixer shell; 34. Mixed liquid outlet; 35. First baffle plate; 36. Second baffle plate; 37. Sprinkler; 4. Acidification kettle; 5. Liquid level monitoring sensor; 6. PH value detector; 7. Cyclone stirring blade; 8. Stirring motor; 9. Tail gas discharge pipe; 10. External heat exchanger; 11. Circulation pump; 12. Finished product extraction pipe; 13. Extraction pump; 14. Stirring shaft. DETAILED DESCRIPTION

[0023] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0024] Please also read Figure 1 and Figure 2The premixer provided by the utility model is now described. The premixer comprises a premixer housing 33, one end of which is provided with a first liquid inlet 31 and a second liquid inlet 32, and the other end of which is provided with a mixed liquid outlet 34; a mixing structure is provided in the premixer housing 33.

[0025] The premixer 3 provided by the utility model is applied to a device for preparing phenylglycine by continuous acidification. By mixing the decolorizing liquid and sulfuric acid in a certain proportion in advance through the premixer 3, the mixing area can be effectively increased, the acidification effect can be improved, and the uniformity, sufficiency, reaction rate and product quality of the reaction can be improved.

[0026] In some embodiments, Figure 2 As shown, a sprayer 37 is provided at both the first liquid inlet 31 and the second liquid inlet 32. The spraying of the sprayer 37 can improve the uniformity of mixing the two liquids. The premixer 3 has two liquid inlets and one outlet, wherein the first liquid inlet 31 is directly opposite to the mixed liquid outlet 34, and the premixer housing 33 is a tubular structure. Therefore, the first liquid inlet 31 as the main inlet is the inlet of the phenylglycine decolorant, which flows into the premixer housing 33 through the sprayer 37; the second liquid inlet 32 ​​is a branch pipe, which is perpendicular to the premixer housing 33, and serves as the branch pipe inlet of sulfuric acid, and enters the premixer 3 through the sprayer 37 similar to a shower head and is mixed with the phenylglycine decolorant.

[0027] In some embodiments, Figure 2 As shown, the nozzles of the two sprayers 37 are arranged vertically and crosswise, so that the incoming decolorizing liquid and sulfuric acid meet vertically, thereby improving the uniformity of mixing the decolorizing liquid and sulfuric acid.

[0028] In some embodiments, Figure 2 As shown, the sprayer 37 includes a baffle installed at each liquid inlet, and a plurality of spray holes are arranged on the baffle. The decolorizing liquid and sulfuric acid are dispersed after passing through the spray holes on the baffle, thereby improving the mixing effect.

[0029] Preferably, the baffle plate is an arc-shaped plate. The surface area of ​​the arc-shaped plate is increased, more spray holes can be arranged, and the spray area can be increased, thereby improving the uniformity of mixing of the two liquids.

[0030] It should be noted that the shapes, sizes and structures of the sprayers 37 on the liquid inlets may be the same or different.

[0031] In some embodiments, Figure 2As shown, the mixing structure includes a plurality of first baffles 35 and second baffles 36 arranged in the premixer housing 33 along the direction of fluid flow, the first baffles 35 are arranged in two rows along the direction of fluid flow, the second baffles 36 are arranged in one row along the direction of fluid flow, the two rows of first baffles 35 and one row of second baffles 36 are evenly distributed along the circumference of the inner wall of the premixer housing 33, and the second baffles 36 are arranged alternately with the first baffles 35. The use of baffles can greatly increase the mixing area, reduce the acidification time and temperature control time, and improve production efficiency.

[0032] Optionally, the mixing structure includes two rows of symmetrically arranged first baffles 35 , and the two rows of first baffles 35 are staggered.

[0033] In some embodiments, Figure 2 As shown, the second baffle plate 36 and the first baffle plate 35 are both arc-shaped plates, and the first baffle plate 35 is arched in the direction of fluid flow, and the second baffle plate 36 is arched in the opposite direction of fluid flow. Through the arc design of each baffle plate, the contact area between the liquid and the baffle plate is increased, and the uniformity of liquid dispersion and mixing is improved.

[0034] Optionally, each baffle is elliptical, and the arrangement of each baffle can increase the mixing time of the liquid in the premixer 3, increase the contact area between the two, thereby improving the uniformity of mixing, and can improve the quality of subsequent acidified products.

[0035] Optionally, each baffle is semicircular in shape, and the baffles in each row are staggered.

[0036] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described or recorded in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0037] Based on the same inventive concept, the present application also provides a device for preparing phenylglycine by continuous acidification, such as Figures 1 to 4 As shown, it includes the premixer 3, the acidification kettle 4 and the external heat exchanger 10, which are connected in sequence; the mixed liquid outlet 34 of the premixer 3 is connected to the upper reaction liquid inlet of the acidification kettle 4 through a pipeline, the lower inlet of the external heat exchanger 10 is connected to the bottom outlet of the acidification kettle 4 through a pipeline, and the upper outlet of the external heat exchanger 10 is connected to the upper liquid return port of the acidification kettle 4 through a pipeline; the bottom outlet of the acidification kettle 4 is also connected to the finished product extraction pipe 12; a stirring mechanism is arranged in the acidification kettle 4.

[0038] The utility model provides a device for preparing phenylglycine by continuous acidification. The decolorant enters the premixer 3 from the decolorant inlet pipe 1 through the first liquid inlet 31, and the sulfuric acid enters the premixer 3 from the sulfuric acid inlet pipe 2 through the second liquid inlet 32. The decolorant and the sulfuric acid are mixed in the premixer 3 in a certain proportion in advance, and then enter the acidification kettle 4 for reaction. The temperature in the acidification kettle 4 is circulated and regulated by the external heat exchanger 10 to keep the pH in the acidification kettle 4 stable and continuously extracted. The premixer 3 can effectively increase the mixing area and improve the acidification effect. The stirring mechanism of the acidification kettle 4 makes the material reaction more sufficient, rapid and uniform, and can accelerate the gas emission, so that there is no volume expansion in the whole acidification process. The external heat exchanger 10 can maintain the balance of the reaction temperature in the acidification kettle 4, improve the heat exchange efficiency, reduce the use of equipment such as coils, reduce the corrosion risk, and improve the acidification efficiency, thereby improving the uniformity of the reaction of the mixed liquid in the acidification kettle 4, the sufficiency of the reaction, the reaction rate and the quality of the product.

[0039] Therefore, the device adopts the method of premixing the decolorizing liquid with sulfuric acid, and then continuously stirring and controlling the temperature in the acidification kettle 4, which can reduce the acidification residence time, reduce the temperature control time, achieve the purpose of continuous operation, increase the acidification effect and stability, reduce the operation steps, reduce the number of acidification kettles 4 used and the land area, and can achieve smooth and continuous phenylglycine acidification, thereby greatly improving production stability and production efficiency, improving product quality, and reducing product production costs. It has great social environmental benefits and economic benefits, and has a certain effect on increasing enterprise output value, enhancing enterprise brand, promoting the development of the pharmaceutical intermediates industry, and expanding the pharmaceutical intermediates sales market.

[0040] In some embodiments, Figure 4 As shown, the stirring mechanism includes a stirring motor 8 disposed on the top of the acidification kettle 4 and a stirring shaft 14 extending into the acidification kettle 4, and a spirally wound cyclone stirring blade 7 is disposed on the stirring shaft 14 along its axial direction. The motor is linked to the cyclone stirring blade to stir the mixed liquid in the acidification kettle 4, which greatly enhances the stirring intensity and the mixing effect compared with the traditional stirring, and at the same time, under the action of pressure, it can promote the production and discharge of carbon dioxide.

[0041] The cyclone stirring blade 7 is a spiral sheet structure, with a large contact area with the feed liquid, good stirring effect, higher efficiency and strong adaptability. At the same time, the cyclone stirring blade 7 is used for sufficient mixing, which is beneficial to the discharge of carbon dioxide, and is more beneficial to the acidification effect and the subsequent extraction.

[0042] In some embodiments, Figure 1As shown, the acidification kettle 4 is provided with a liquid level monitoring sensor 5 and a pH value detector 6. The continuous acidification process includes fully mixing the decolorizing liquid with sulfuric acid, controlling the temperature outside the kettle, and adjusting the pH to meet the requirements before extraction. The device is provided with a control valve on each pipeline, a circulation pump 11 is provided on the pipeline between the external heat exchanger 10 and the acidification kettle 4, and a production pump 13 is provided on the finished product extraction pipe 12, as well as the configured liquid level monitoring sensor 5 and pH value detector 6, which can be connected to the control system of the entire device and can be remotely connected to a terminal computer or display screen, so as to realize automatic control, continuous production and save personnel.

[0043] This device continuously acidifies phenylglycine. After the decolorizing liquid and sulfuric acid are controlled to pass through the premixer 3 in a certain proportion in advance, they enter the acidification kettle 4 for stirring and mixing. The circulating pump 11 and the external heat exchanger 10 are used for circulating temperature control to keep the pH in the acidification kettle 4 stable, so that a qualified acidification product can be obtained and continuously produced. The baffle in the premixer 3 can effectively increase the mixing area and improve the acidification effect. The acidification kettle 4 uses a cyclone stirring blade 7 for higher stirring efficiency, stronger adaptability and more sufficient stirring. At the same time, the stirring by the cyclone stirring blade 7 can accelerate gas emission and make the acidification process without volume expansion. Through continuous feeding and production, stable and continuous phenylglycine acidification is achieved, thereby greatly improving production stability. Through continuous feeding and production, stable and continuous phenylglycine acidification is achieved, thereby greatly improving production capacity.

[0044] In some embodiments, Figure 1 As shown, a tail gas discharge pipe 9 is provided on the top of the acidification kettle 4 to facilitate timely discharge of the gas generated in the acidification kettle 4 and avoid the volume expansion phenomenon in the acidification kettle 4.

[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A premixer, characterized in that: include: A premixer housing (33), wherein one end of the premixer housing (33) is provided with a first liquid inlet (31) and a second liquid inlet (32), and the other end of the premixer housing (33) is provided with a mixed liquid outlet (34); a mixing structure is provided inside the premixer housing (33); The mixing structure comprises a plurality of first baffles (35) and second baffles (36) arranged in the premixer housing (33) along the direction of fluid flow, wherein the first baffles (35) are arranged in two rows along the direction of fluid flow, and the second baffles (36) are arranged in one row along the direction of fluid flow, and the two rows of the first baffles (35) and one row of the second baffles (36) are evenly distributed along the circumference of the inner wall of the premixer housing (33), and the second baffles (36) and the first baffles (35) are arranged alternately.

2. The premixer according to claim 1, characterized in that Sprinklers (37) are provided at both the first liquid inlet (31) and the second liquid inlet (32).

3. The premixer according to claim 2, characterized in that The nozzles of the two sprayers (37) are arranged vertically and crosswise.

4. The premixer according to claim 2, characterized in that The sprayer (37) comprises a baffle installed at each liquid inlet, and a plurality of spray holes are arranged on the baffle.

5. The premixer according to claim 1, characterized in that The second baffle plate (36) and the first baffle plate (35) are both arc-shaped plates, and the first baffle plate (35) is arched in the direction of fluid flow, while the second baffle plate (36) is arched in the opposite direction of fluid flow.

6. A device for preparing phenylglycine by continuous acidification, characterized in that: The invention comprises a premixer (3), an acidification kettle (4) and an external heat exchanger (10) as claimed in any one of claims 1 to 5, wherein the premixer (3), the acidification kettle (4) and the external heat exchanger (10) are connected in sequence; the mixed liquid outlet (34) of the premixer (3) is connected to the upper reaction liquid inlet of the acidification kettle (4) through a pipeline, the lower inlet of the external heat exchanger (10) is connected to the bottom outlet of the acidification kettle (4) through a pipeline, and the upper outlet of the external heat exchanger (10) is connected to the upper liquid return port of the acidification kettle (4) through a pipeline; the bottom outlet of the acidification kettle (4) is also connected to the finished product extraction pipe (12); and a stirring mechanism is arranged in the acidification kettle (4).

7. The device for preparing phenylglycine by continuous acidification according to claim 6, characterized in that: The stirring mechanism comprises a stirring motor (8) arranged on the top of the acidification kettle (4) and a stirring shaft (14) extending into the interior of the acidification kettle (4), wherein the stirring shaft (14) is provided with a spirally wound cyclone stirring blade (7) along its axial direction.

8. The device for preparing phenylglycine by continuous acidification according to claim 6, characterized in that: The acidification kettle (4) is provided with a liquid level monitoring sensor (5) and a pH value detector (6).

9. The device for preparing phenylglycine by continuous acidification according to claim 6, characterized in that: A tail gas discharge pipe (9) is provided on the top of the acidification kettle (4).

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