Sequential therapy comprising a 20(S)-camptothecian and a pyrimidine base analog
Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- SUPERGEN
- Publication Date
- 2006-03-09
- Estimated Expiration
- Not applicable · inactive patent
Abstract
Description
CROSS-REFERENCE
[0001] This application is a continuation application of application Ser. No. 10 / 081,974, filed Feb. 21, 2002, which is incorporated herein by reference in its entirety and to which application we claim priority under 35 USC § 120:BACKGROUND OF THE INVENTION
[0002] 1. Field of the Invention
[0003] This invention relates to a method for treating disease using a 20(S)-camptothecin and a pyrimidine base analog, and more specifically a method for treating disease using a 20(S)-camptothecin and pyrimidine base analog in a sequential therapy.
[0004] 2. Description of Related Art
[0005] A. 20(S)-Camptothecins
[0006] 20(S)-camptothecin, a plant alkaloid, was found to have anticancer activity in the late 1950's. Wall, M. et al., Plant anti-tumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata, J. Am. Chem. Soc. 88: 3888-3890, (1966); Monroe E. Wall et al., Camptothecin: Discovery to Clinic, 803...