Valved intradermal delivery device and method of intradermally delivering a substance to a patient

a delivery device and intradermal technology, applied in the field of valved intradermal delivery device and intradermal delivery of substances to patients, can solve the problems of not reaching a uniform depth, affecting and prior methods and devices for intradermal administration of substances have shown limited success. , to achieve the effect of increasing the comfort level of patients

Inactive Publication Date: 2007-06-28
BECTON DICKINSON & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] Accordingly, it is an object of the invention to provide a sampling or delivery device having at least one skin penetrating member having a length that provides an increased comfort level to the patient.
[0011] A further object of the invention is to provide a method of penetrating the skin for sampling or delivering a substance through the skin substantially without pain to the patient.

Problems solved by technology

However, these needles and blades having a length of a few microns to a few hundred microns typically do not penetrate skin to a uniform depth.
The prior methods and devices for the intradermal administration of substances have exhibited limited success.

Method used

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  • Valved intradermal delivery device and method of intradermally delivering a substance to a patient
  • Valved intradermal delivery device and method of intradermally delivering a substance to a patient
  • Valved intradermal delivery device and method of intradermally delivering a substance to a patient

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first embodiment

[0045] Referring to FIGS. 1-7, the invention in a first embodiment is directed to a device 10 having a supporting body 12 with a skin penetrating device 14 and a valve assembly 16. Device 10 is constructed for penetrating one or more selected layers of the dermis of a patient to attain the desired depth of penetration. The desired depth of penetration is determined by the substance being delivered, the delivery rate and the absorption rate. Penetration to a depth of 1 mm results in a high uptake by the body. Penetration to a depth on the order of 5 mm would slow delivery. The device is provided with one or more penetrating members each having a length to pierce the stratum corneum substantially without penetrating the dermis, which is below the stratum corneum and below the other layers of the epidermis. By delivering a substance to just below the stratum corneum, the substance can be absorbed and utilized by the body substantially without pain or discomfort to the patient. The devi...

second embodiment

[0064] Referring to FIGS. 8-12, the invention is illustrated for delivering a substance intradermally to a patient. Device 90 includes a body 92, a skin penetrating device 94 and a valve assembly 96. As shown in FIG. 8, body 92 has a generally circular configuration with a substantially flat planar top surface 98 and a planar bottom surface 100.

[0065] Top surface 98 of body 92 includes a recess 102 defined by a bottom surface 104 and a side wall 106. A flexible closure member 108 is coupled to top face 98 to close recess 102. Closure member 108 defines a reservoir having a chamber 110 between bottom surface 104 and closure member 108. As shown in FIG. 9, closure member 108 has a generally hemispherical shape having a convex top surface 112 and a concave bottom surface 114. A movable dispensing member is in the form of a closure member 108, which is preferably made of a material having the same characteristics as the material of the movable dispensing member 52 of the embodiment of F...

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Abstract

An intradermal delivery device for delivery a substance into the skin of a patient has a fluid chamber for containing the substance, at least one micro skin penetrating member, and a valve controlling the flow of the substance from the fluid chamber to the micro skin penetrating member. An adhesive releasably attaches the device to the skin of the patient, the fluid chamber can be sized to hold a unit dose of the substance, and, in some embodiments, the fluid chamber can be releasably coupled to a housing of the device.

Description

REFERENCE TO RELATED APPLICATIONS [0001] This Application is a divisional of U.S. patent application Ser. No. 10 / 112,756, filed on Apr. 2, 2002, now U.S. Pat. No. X,XXX,XXX.FIELD OF THE INVENTION [0002] The present invention relates to an intradermal delivery device having a fluid chamber to contain a substance to be delivered intradermally to a patient in a target area of the skin. The present invention also relates to a method of delivering a substance into the skin of a patient. BACKGROUND OF THE INVENTION [0003] Drugs and pharmaceutical agents are delivered to patients by a variety of methods. A typical method delivers the drug or pharmaceutical agent subcutaneously by a stainless steel cannula. Although the subcutaneous sampling and delivery methods using a cannula are effective for many applications, the pain normally induced by the cannula has prompted the development of less painful delivery methods. [0004] The skin is made up of several layers, with the upper composite laye...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61B17/20A61M37/00A61M31/00A61K9/70A61M5/142A61M5/148A61M5/168A61M5/42
CPCA61B17/205A61M5/14248A61M5/148A61M5/16881A61M5/425A61M37/0015A61M2037/0023A61M2037/003
InventorWILKINSON, BRADLEYHWANG, CHARLES
OwnerBECTON DICKINSON & CO