Dynamic equilibrium separation, concentration, and mixing apparatus and methods

a technology of dispersion mixing and dispersion separation, applied in the field of combined fluid flow and particle motivating force methods, to achieve the effect of accelerating the particle transport process

Inactive Publication Date: 2011-03-31
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach enables efficient separation, concentration, and mixing of particles by creating dynamic trapping zones and controlling particle trajectories, improving the sensitivity and reliability of particle manipulation, particularly for small particles like cells and DNA, and allows for the detection and collection of particles with enhanced throughput.

Problems solved by technology

However, large electric field gradients may strongly interact with the background media creating, by several electro-hydrodynamic effects, flows whose drag perturbs the particle trajectories.

Method used

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  • Dynamic equilibrium separation, concentration, and mixing apparatus and methods
  • Dynamic equilibrium separation, concentration, and mixing apparatus and methods
  • Dynamic equilibrium separation, concentration, and mixing apparatus and methods

Examples

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Embodiment Construction

[0030]In the following description of the exemplary embodiments of the present invention, reference is made to the accompanying drawings that form a part hereof, and in which are shown by way of illustration the underlying principles of the present invention as well as specific embodiments in which the invention may be practiced. It is to be understood that other embodiments may be utilized and structural changes or modifications to the methods may be made without departing from the scope of the present invention.

[0031]Overview

[0032]In accordance with the teachings of the present invention, convective fluid motion induced by one or more particle motivating forces and the resultant dielectrophoretic manipulation of particles is disclosed herein in the exemplary context of electrical fields. For purposes of explanation, a simplified exemplary model, specifically, a microfluidic separation, concentration, or mixing apparatus comprises a channel. with a periodic array of microelectrodes...

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Abstract

Particles are separated, concentrated, or mixed within a fluid by means of a fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal axis, and at least one particle motivating force directionally interacting with at least one recurrent circulating fluid flow generally aligned with the longitudinal axis within the fluid containing cell.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit under 35 U.S.C. §119(e) of co-pending and commonly-assigned U.S. Provisional Patent Application Ser. No. 60 / 737,989, entitled “DYNAMIC EQUILIBRIUM SEPARATION AND CONCENTRATION APPARATUS AND METHOD” by Igor Mezic, which application is incorporated by reference herein.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT[0002]This invention was made with Government support under Grant No. 0086061 awarded by NFS / ITR. The Government has certain rights in this invention.BACKGROUND OF THE INVENTION[0003]1. Field of the Invention[0004]The present invention is related generally to combined fluid flow and particle motivating force methods for particle manipulation, and is related specifically to dynamic equilibrium separation, concentration, dispersion and mixing apparatus and methods.[0005]2. Description of the Related Art[0006](Note: This application references a number of different publications as ...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): B03C7/02B07B7/00
CPCB07B7/00B03C5/026
InventorMEZIC, IGORBOTTAUSCI, FREDERICTUVAL, IDAN
OwnerRGT UNIV OF CALIFORNIA