Solid compositions

a technology of solid compositions and compounds, which is applied in the field of solid compositions comprising antihcv compounds, can solve the problems of insufficient viral elimination from the body, substantial limitations in efficacy and tolerability, etc., and achieve the effect of reducing the blood or tissue level of hcv virus in the patien

Active Publication Date: 2015-03-24
ABBVIE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019]The present invention further features methods of using a solid composition of the present invention to treat HCV infection. The methods comprise administering a solid composition of the present invention to a patient in need thereof, thereby reducing the blood or tissue level of HCV virus in the patient.

Problems solved by technology

Substantial limitations to efficacy and tolerability remain as many users suffer from side effects, and viral elimination from the body is often inadequate.

Method used

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Examples

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Embodiment Construction

[0021]The present invention features solid compositions comprising (1) a selected HCV inhibitor, (2) a pharmaceutically acceptable hydrophilic polymer, and optionally (3) a pharmaceutically acceptable surfactant, wherein the selected inhibitor is telaprevir (VX-950), BI-201335, TMC-435 (TMC-435350), vaniprevir (MK-7009), MK-5172, asunaprevir (BMS-650032), daclatasvir (BMS-790052), danoprevir, setrobuvir (ANA-598), tegobuvir (GS-333126 or GS-9190), GS-9451, mericitabine (R-4048), IDX-184, filibuvir (PF-00868554), PSI-7977, PSI-352938, BIT-225, boceprevir, GS-5885 or GS-9256. Formulating the selected HCV inhibitor in an amorphous form can increase the inherent drug solubility and dissolution rate, thereby enhancing the bioavailability of the compound.

[0022]Telaprevir (VX-950), BI-201335, TMC-435 (TMC-435350), vaniprevir (MK-7009), MK-5172, asunaprevir (BMS-650032), danoprevir, GS-9451, boceprevir and GS-9256 are HCV protease inhibitors; daclatasvir (BMS-790052) and GS-5885 are HCV NS5...

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Abstract

The present invention features solid compositions comprising a selected HCV inhibitor in an amorphous form. In one embodiment, the selected HCV inhibitor is formulated in an amorphous solid dispersion which comprises a pharmaceutically acceptable hydrophilic polymer and preferably a pharmaceutically acceptable surfactant.

Description

[0001]This application is a continuation-in-part of U.S. patent application Ser. No. 13 / 717,993, filed Dec. 18, 2012, which claims priority from U.S. Provisional Patent Application Ser. No. 61 / 581,146, filed Dec. 29, 2011, and U.S. Provisional Patent Application Ser. No. 61 / 645,696, filed May 11, 2012. This application incorporates by reference the entire content of U.S. Patent Application Publication No. 2013 / 0172239.FIELD OF THE INVENTION[0002]The present invention relates to solid compositions comprising anti-HCV compounds and methods of using the same to treat HCV infection.BACKGROUND[0003]The hepatitis C virus (HCV) is an RNA virus belonging to the Hepacivirus genus in the Flaviviridae family. The enveloped HCV virion contains a positive stranded RNA genome encoding all known virus-specific proteins in a single, uninterrupted, open reading frame. The open reading frame comprises approximately 9500 nucleotides and encodes a single large polyprotein of about 3000 amino acids. The...

Claims

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Application Information

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Patent Type & AuthorityPatents(United States)
IPC IPC(8): A61K31/4184A61K38/06A61K47/32A61K9/10A61K38/05A61K38/07A61K45/06A61K9/14A61K9/16A61K31/403A61K31/4178A61K31/439A61K31/4709A61K31/497A61K31/501A61K31/519A61K31/549A61K31/55A61K31/7068A61K31/708
CPCA61K9/10A61K31/4184A61K47/32A61K38/06A61K38/05A61K38/07A61K45/06A61K9/146A61K9/1635A61K31/403A61K31/4178A61K31/439A61K31/4709A61K31/497A61K31/501A61K31/519A61K31/549A61K31/55A61K31/7068A61K31/708
InventorGAO, YIZHANG, GEOFF
OwnerABBVIE INC