8 results about "Mycotoxin contamination" patented technology

Methods, compositions, and systems for steeping, propagation and fermentation, particularly large-scale operations for production of starch and ethanol and fermentation product streams are provided. Addition of mycotoxin mitigating enzymes or microorganisms expressing mycotoxin mitigating enzymes to steeping, propagation, and / or fermentation tanks, and / or to post-fermentation product streams, mitigates mycotoxin levels in fermentation co-products obtained from mycotoxin contaminated feedstocks.

The present disclosure relates to compositions and methods comprising a yeast cell wall extract and a clay material admixed to a proteinaceous and / or cell wall extract(s) from bacterial or fungal fermentation from amino acid production. In another embodiment, the present compositions comprise a yeast cell wall extract, a clay material, and an algal material admixed to a proteinaceous and / or cell wall extract(s) from bacterial or fungal fermentation from amino acid production. This disclosure also relates to methods of utilizing the same to sequester and / or adsorb mycotoxins internal or external to an animal, thereby reducing and / or preventing the toxic and harmful effects of mycotoxin contamination and / or infection in animals. Specifically, application of the present methods and compositions are found in the dietary administration and / or co-administration of the present compositions to animals in animal feed and / or animal production systems, as well as in therapeutic, prophylactic, and research applications.

This invention relates to a formulation and method of application of a multicomponent mycotoxin detoxifier for poultry feed, particularly female broiler chickens, which aims to provide protection to the Bursa Fabricius due to exposure to mycotoxins in the form of aflatoxin and ochratoxin. The mycotoxin detoxifier formulation according to this invention consists of an inorganic mycotoxin binder in the form of bentonite and / or zeolite, an organic mycotoxin binder in the form of pectin and / or esterified cellulose, and a natural antioxidant in the form of vitamin E and / or antioxidant herbal extracts. The formulation is applied to poultry feed at a dose of 2 to 2.5 g per kg of feed and is able to bind aflatoxin and ochratoxin simultaneously in the digestive tract, thereby reducing the bioavailability of mycotoxins.The application of this formulation has been proven to reduce histopathological damage to the Bursa of Fabricius, including lymphoid follicle depletion, cyst formation, cell necrosis, inflammatory cell infiltration, and tissue fibrosis, while also supporting the immune system function of female broiler chickens. This invention provides an effective, efficient, and easily applicable technical solution in the poultry farming industry to address mixed mycotoxin contamination in feed.

This invention concerns a mycotoxin detoxification-based feed additive for poultry, particularly broiler chickens, aimed at addressing the decline in feed nutrient utilization and performance due to aflatoxin B1 and ochratoxin A contamination. This invention relates to the use of a multicomponent feed additive formulation that combines inorganic mycotoxin binders, mycotoxin modifying components in the form of biological agents and / or detoxification enzymes, and supporting components in the form of natural antioxidants that work synergistically through adsorption and biotransformation mechanisms in the digestive tract. This formulation functions to reduce the toxicity of aflatoxin B1 and ochratoxin A thereby optimizing the utilization of feed nutrients. The application of this feed additive at an effective dose allows for increased feed utilization efficiency and performance of broiler chickens consuming mycotoxin-contaminated feed, as well as supporting livestock health and productivity in a practical and efficient manner.This invention can be applied in poultry feed management, especially in conditions with a high risk of mycotoxin contamination.

The present disclosure relates to compositions and methods comprising a yeast cell wall extract and a clay material admixed to a proteinaceous and / or cell wall extract(s) from bacterial or fungal fermentation from amino acid production. In another embodiment, the present compositions comprise a yeast cell wall extract, a clay material, and an algal material admixed to a proteinaceous and / or cell wall extract(s) from bacterial or fungal fermentation from amino acid production. This disclosure also relates to methods of utilizing the same to sequester and / or adsorb mycotoxins internal or external to an animal, thereby reducing and / or preventing the toxic and harmful effects of mycotoxin contamination and / or infection in animals. Specifically, application of the present methods and compositions are found in the dietary administration and / or co-administration of the present compositions to animals in animal feed and / or animal production systems, as well as in therapeutic, prophylactic, and research applications.

The application discloses a mycotoxin attenuant for improving mitochondrial function and application, and has the following components: 10-20 parts by weight of L-malic acid, 3-5 parts by weight of alpha-ketoglutaric acid (salt), 15-25 parts by weight of itaconic acid and 1-3 parts by weight of 5-norwongenin. In mycotoxin contaminated feed, the addition of L-malic acid, alpha-ketoglutaric acid (salt), itaconic acid or 5-norwongenin alone cannot improve mitochondrial function or relieve mycotoxin toxicity. Compared with the combination of any one of the four components, the complete addition of the four components can significantly enhance mitochondrial oxidative phosphorylation, weaken glycolysis, obviously improve mitochondrial energy metabolism, effectively relieve mycotoxin-induced mitochondrial damage in the intestines and liver of livestock and poultry, and thus improve the production performance and health status of livestock and poultry. The application can significantly reduce the toxic effect of mycotoxin on livestock and poultry through the synergistic effect of the components.

The invention discloses a corn mycotoxin pollution prediction method and system based on microbial fingerprints. The method comprises the following steps: collecting a corn sample, and obtaining microbial fingerprint information and mycotoxin pollution information; constructing a training set and a test set based on the microbial fingerprint information and the mycotoxin pollution information; inputting the training set into a random forest learning framework, performing training by taking the fungaltoxin pollution level as a prediction target and the microbial fingerprint data as input variables to generate a random forest prediction model, and verifying the performance of the random forest prediction model by using the test set; calculating the importance score of each microorganism characteristic based on a random forest prediction model, and screening the microorganism characteristic with high importance as the corn mycotoxin pollution key microorganism marker; training a corn fungaltoxin pollution prediction model by using the key microbial markers and verifying the performance of the model on an independent test set; and acquiring microbial fingerprint information of to-be-detected corn, and inputting the microbial fingerprint information into the corn mycotoxin pollution prediction model to obtain a mycotoxin pollution prediction result.

The application discloses a mycotoxin attenuant for improving mitochondrial function and application, and has the following components: 10-20 parts by weight of L-malic acid, 3-5 parts by weight of alpha-ketoglutaric acid (salt), 15-25 parts by weight of itaconic acid and 1-3 parts by weight of 5-norwongenin. In mycotoxin contaminated feed, the addition of L-malic acid, alpha-ketoglutaric acid (salt), itaconic acid or 5-norwongenin alone cannot improve mitochondrial function or relieve mycotoxin toxicity. Compared with the combination of any one of the four components, the complete addition of the four components can significantly enhance mitochondrial oxidative phosphorylation, weaken glycolysis, obviously improve mitochondrial energy metabolism, effectively relieve mycotoxin-induced mitochondrial damage in the intestines and liver of livestock and poultry, and thus improve the production performance and health status of livestock and poultry. The application can significantly reduce the toxic effect of mycotoxin on livestock and poultry through the synergistic effect of the components.