Compound genticin-micronomicin injection, preparing method and use thereof

Abstract

The invention discloses an injection of compound micironomicin sulfate, its preparation method and application. the injection comprises (by weight part) micironomicin sulfate injection 1-20, chlorpheniramine maleate 0.1-1, and dexamethasone sodium phosphate 0.01-1. the preparation method comprises heating 50% water for injection to 40-50deg.C, dissolving each components, regulating pH to 3.5-6.5 with hydrochloric acid or sodium hydroxide, and adding water for injection to 1000. The invention has the advantages of rational formulation, reduced drugfastness, and shortened withholding period. It can enhance therapeutic effect, improve swinish immunity, increase swinish body weight; and can be used for treating mycoplasmal pneumonia of pig.

Description

technical field

[0001] The invention relates to a drug injection, a preparation method and use, in particular to a compound genta sulfate-minornomycin injection, a preparation method and a use. Background technique

[0002] Pig asthma (or swine panting), also known as mycoplasma hyopneumoniae, is a chronic respiratory infectious disease of pigs. It is one of the most common diseases in pigs. The main clinical symptoms of this disease are cough and wheezing. The pathological changes are mainly located in the chest cavity. The lung is the main organ of the disease. In acute cases, pulmonary edema and emphysema are the main diseases; And chronic cases see lung "shrimp meat" like consolidation, the growth rate of diseased pigs is slow, the feed utilization rate is low, and the fattening and rearing period is prolonged. It is easy to cause Pasteurella, pneumococcus, Actinobacillus pleuropneumoniae, Salmonella and various suppurative bacteria, Mycoplasma hyorhinophylla and Chlamy...

Examples

Embodiment 1

[0015] Embodiment 1 (every part is 500g):

[0016] Compound Qingda Sulfate-Micronomycin Injection: 3 parts of Qingda Sulfate-Micronomycin Injection, 0.2 part of Chlorpheniramine, and 0.05 part of Dexamethasone Sodium Phosphate.

[0017] Made in the following way:

[0018] (1) Take by weight 3 parts of genta sulfate-micronomycin injection, 0.2 part of chlorpheniramine, and 0.05 part of dexamethasone sodium phosphate;

[0019] (2) Take 1.65 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

Embodiment 2

[0020] Embodiment 2 (every portion is 1500g):

[0021] Compound Qingda Sulfate-Micronomycin Injection: 2 parts of Qingda Sulfate-Micronomycin Injection, 0.1 part of Chlorpheniramine, and 0.04 part of Dexamethasone Sodium Phosphate.

[0022] Made in the following way:

[0023] (1) Take 2 parts of genta sulfate-micronomycin injection, 0.1 part of chlorpheniramine, and 0.04 part of dexamethasone sodium phosphate by weight;

[0024] (2) Take 1.05 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

Embodiment 3

[0025] Embodiment 3 (every portion is 2500g):

[0026] Compound genta sulfate-minornomycin injection injection: 10 parts of genta sulfate-minornomycin injection, 0.8 parts of chlorpheniramine, and 0.5 parts of dexamethasone sodium phosphate.

[0027] Made in the following way:

[0028] (1) Take by weight 10 parts of genta sulfate-micronomycin injection, 0.8 part of chlorpheniramine, and 0.5 part of dexamethasone sodium phosphate;

[0029] (2) Take 5.45 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

technical field

[0001] The invention relates to a drug injection, a preparation method and use, in particular to a compound genta sulfate-minornomycin injection, a preparation method and a use. Background technique

[0002] Pig asthma (or swine panting), also known as mycoplasma hyopneumoniae, is a chronic respiratory infectious disease of pigs. It is one of the most common diseases in pigs. The main clinical symptoms of this disease are cough and wheezing. The pathological changes are mainly located in the chest cavity. The lung is the main organ of the disease. In acute cases, pulmonary edema and emphysema are the main diseases; And chronic cases see lung "shrimp meat" like consolidation, the growth rate of diseased pigs is slow, the feed utilization rate is low, and the fattening and rearing period is prolonged. It is easy to cause Pasteurella, pneumococcus, Actinobacillus pleuropneumoniae, Salmonella and various suppurative bacteria, Mycoplasma hyorhinophylla and Chlamy...

Examples

Embodiment 1

[0015] Embodiment 1 (every part is 500g):

[0016] Compound Qingda Sulfate-Micronomycin Injection: 3 parts of Qingda Sulfate-Micronomycin Injection, 0.2 part of Chlorpheniramine, and 0.05 part of Dexamethasone Sodium Phosphate.

[0017] Made in the following way:

[0018] (1) Take by weight 3 parts of genta sulfate-micronomycin injection, 0.2 part of chlorpheniramine, and 0.05 part of dexamethasone sodium phosphate;

[0019] (2) Take 1.65 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

Embodiment 2

[0020] Embodiment 2 (every portion is 1500g):

[0021] Compound Qingda Sulfate-Micronomycin Injection: 2 parts of Qingda Sulfate-Micronomycin Injection, 0.1 part of Chlorpheniramine, and 0.04 part of Dexamethasone Sodium Phosphate.

[0022] Made in the following way:

[0023] (1) Take 2 parts of genta sulfate-micronomycin injection, 0.1 part of chlorpheniramine, and 0.04 part of dexamethasone sodium phosphate by weight;

[0024] (2) Take 1.05 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

Embodiment 3

[0025] Embodiment 3 (every portion is 2500g):

[0026] Compound genta sulfate-minornomycin injection injection: 10 parts of genta sulfate-minornomycin injection, 0.8 parts of chlorpheniramine, and 0.5 parts of dexamethasone sodium phosphate.

[0027] Made in the following way:

[0028] (1) Take by weight 10 parts of genta sulfate-micronomycin injection, 0.8 part of chlorpheniramine, and 0.5 part of dexamethasone sodium phosphate;

[0029] (2) Take 5.45 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.