Gallbladder wood leaf composition containing strictosamide and preparation thereof

Abstract

The invention relates to a gallbladder wood leaf composition containing strictosamide and a preparation thereof. The gallbladder wood leaf composition containing the strictosamide is characterized in that the composition is applied in the preparation of medicament for clearing heat and eliminating phlegm and relieving cough and asthma, and or is applied in the preparation of medicines used for treating expectoration, cough with dyspnea and irritability asthma; the composition is composed of alkaloid and flavonoid extracted from gallbladder wood leaf through combination, and the alkaloid contains strictosamide, 10-hydroxy-strictosamide and short snakeroot glucoside; and the flavonoid contains kaempferol-3-O-rutinoside and rutin. The invention also discloses a preparation of the composition. The gallbladder wood leaf composition provided by the invention has the advantages that the active ingredient is definite, and the gallbladder wood leaf composition has notable curative effects.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition, in particular to a bile leaf composition containing isovinblastam. The present invention also relates to the preparation of the above-mentioned composition of the leaves of B. japonica. Background technique

[0002] Gall wood, also known as ebony, medicinal ebony, and yellow sheep wood, is a plant of the Rubiaceae ebony ebony ( Nauclea officinalis Pierre ex Pitard) dry stems, branches, bark and roots. Born in miscellaneous forests near the top of mountains or in shaded and humid areas on the mountainside, distributed in Guangdong (west and southwest), Guangxi and Hainan and other provinces and regions. Gallwood nature and flavor are bitter, cold, have the effect of heat-clearing and toxic substances removing, reducing swelling and relieving pain. my country's Guangxi, Guangdong and Hainan folks are commonly used in the treatment of colds, fever, pneumonia, enteritis, dysentery, ec...

Examples

Embodiment 1

[0113] Example 1. A composition containing isovinblastam birch leaves, the application of the composition in the preparation of medicines for clearing away heat and reducing phlegm, relieving cough and relieving asthma; The application in medicines for expectoration, asthma and allergic asthma caused by diseases; the composition is composed of alkaloids and flavonoids extracted from the leaves of B. Lactam, 10-hydroxyl-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned three alkaloids The total weight of the flavonoids accounts for 50% of the composition, and the total weight ratio of the aforementioned three alkaloids to the total weight of the flavonoids is 10:0.5.

Embodiment 2

[0114]Example 2. A composition containing isovinblastam birch leaves, the application of the composition in the preparation of medicines for clearing away heat and resolving phlegm, relieving cough and relieving asthma; The application in medicines for expectoration, asthma and allergic asthma caused by diseases; the composition is composed of alkaloids and flavonoids extracted from the leaves of B. Lactam, 10-hydroxyl-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned three alkaloids The total weight of the flavonoids accounts for 98% of the composition, and the total weight of the aforementioned 3 alkaloids and the total weight of the flavonoids is 0.7:10.

Embodiment 3

[0115] Example 3. A composition containing isovinblastam birch leaves, the application of the composition in the preparation of medicines for clearing away heat and resolving phlegm, relieving cough and relieving asthma; The application in medicines for expectoration, asthma and allergic asthma caused by diseases; the composition is composed of alkaloids and flavonoids extracted from the leaves of B. Lactam, 10-hydroxyl-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned three alkaloids The total weight of the flavonoids and the flavonoids accounts for 80% by weight of the composition, and the ratio of the total weight of the aforementioned three alkaloids to the total weight of the flavonoids is 10-0.7:0.5-10.

technical field

[0001] The invention relates to a traditional Chinese medicine composition, in particular to a bile leaf composition containing isovinblastam. The present invention also relates to the preparation of the above-mentioned composition of the leaves of B. japonica. Background technique

[0002] Gall wood, also known as ebony, medicinal ebony, and yellow sheep wood, is a plant of the Rubiaceae ebony ebony ( Nauclea officinalis Pierre ex Pitard) dry stems, branches, bark and roots. Born in miscellaneous forests near the top of mountains or in shaded and humid areas on the mountainside, distributed in Guangdong (west and southwest), Guangxi and Hainan and other provinces and regions. Gallwood nature and flavor are bitter, cold, have the effect of heat-clearing and toxic substances removing, reducing swelling and relieving pain. my country's Guangxi, Guangdong and Hainan folks are commonly used in the treatment of colds, fever, pneumonia, enteritis, dysentery, ec...

Examples

Embodiment 1

[0113] Example 1. A composition containing isovinblastam birch leaves, the application of the composition in the preparation of medicines for clearing away heat and reducing phlegm, relieving cough and relieving asthma; The application in medicines for expectoration, asthma and allergic asthma caused by diseases; the composition is composed of alkaloids and flavonoids extracted from the leaves of B. Lactam, 10-hydroxyl-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned three alkaloids The total weight of the flavonoids accounts for 50% of the composition, and the total weight ratio of the aforementioned three alkaloids to the total weight of the flavonoids is 10:0.5.

Embodiment 2

[0114]Example 2. A composition containing isovinblastam birch leaves, the application of the composition in the preparation of medicines for clearing away heat and resolving phlegm, relieving cough and relieving asthma; The application in medicines for expectoration, asthma and allergic asthma caused by diseases; the composition is composed of alkaloids and flavonoids extracted from the leaves of B. Lactam, 10-hydroxyl-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned three alkaloids The total weight of the flavonoids accounts for 98% of the composition, and the total weight of the aforementioned 3 alkaloids and the total weight of the flavonoids is 0.7:10.

Embodiment 3

[0115] Example 3. A composition containing isovinblastam birch leaves, the application of the composition in the preparation of medicines for clearing away heat and resolving phlegm, relieving cough and relieving asthma; The application in medicines for expectoration, asthma and allergic asthma caused by diseases; the composition is composed of alkaloids and flavonoids extracted from the leaves of B. Lactam, 10-hydroxyl-vinblastam and brevis sergoside; the flavonoids contain kaempferol-3-O-rutinoside and rutin; in the composition, the aforementioned three alkaloids The total weight of the flavonoids and the flavonoids accounts for 80% by weight of the composition, and the ratio of the total weight of the aforementioned three alkaloids to the total weight of the flavonoids is 10-0.7:0.5-10.

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