Dual-wavelength excitation type feedback phototherapeutic instrument

A photothermal therapy and feedback technology, which is applied in the cross field of optics and medicine, can solve the problems of non-invasive temperature feedback function, damage to normal cells, long treatment cycle, etc., and achieve the goal of shortening the course of treatment, low biological toxicity and high signal-to-noise ratio Effect

CN107440795AActive Publication Date: 2017-12-08哈尔滨凯美斯科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2017-12-08

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Abstract

The invention relates to phototherapeutic instruments, in particular to a dual-wavelength excitation type feedback phototherapeutic instrument and aims to solve technical problems of harms to normal cells, lack of a noninvasive temperature feedback function and long treatment period of an existing phototherapeutic instrument. The phototherapeutic instrument comprises a double-channel signal generator, a heating laser, a refrigerating laser, an optical fiber transmission system, an up-conversion thermotherapy probe, a spectrograph and a computer. The optical fiber transmission system comprises a coupler, an annular and a focus mirror in sequential connection through optical fibers. Two pulse laser beams in different wavelengths are used for heating and refrigerating respectively; by up-conversion fluorescence signal resolution of the probe temperature, temperature feedback in a phototherapeutic process is realized, and input laser parameters are further adjusted according to feedback temperature to realize online intervention. The dual-wavelength excitation type feedback phototherapeutic instrument is simple in operation and capable of inhibiting overheating and shortening treatment cycle.
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Description

technical field

[0001] The invention relates to a photothermal therapy instrument, which belongs to the intersection field of optics and medicine. Background technique

[0002] There are currently three mainstream methods of cancer treatment: surgery, radiation therapy, and chemotherapy. Among them, surgical therapy has defects such as complicated operation, high risk, large trauma to human body, reduced human immunity, and prone to complications; radiotherapy and chemotherapy have brought great side effects to patients: these methods are effective in suppressing cancer cells. While developing, it also causes great damage to normal cells.

[0003] Hyperthermia is a low-cost, easy-to-operate, and less side-effect cancer treatment method that kills tumors by raising the body temperature. On the one hand, hyperthermia can inhibit the synthesis of deoxyribonucleic acid, ribonucleic acid, and protein, thereby promoting the death of tumor cells; Changes in chromatin structure l...

Examples

Embodiment 1

[0040] Embodiment 1: The dual-wavelength excitation feedback photothermal therapy instrument of this embodiment consists of a dual-channel signal generator 1, a heating laser 2, a cooling laser 3, an optical fiber transmission system 4, an up-conversion thermotherapy probe 5, and a spectrometer 6 and computer 7; wherein the optical fiber transmission system 4 is composed of a coupler 4-1, a circulator 4-2 and a focusing mirror 4-3 and is sequentially connected by optical fibers;

[0041] After the heating laser 2 and the cooling laser 3 are connected in parallel, one end is connected to the output end of the dual-channel signal generator 1, and the other end is connected to the coupler 4-1 of the optical fiber transmission system 4, and the focusing mirror 4-3 of the optical fiber transmission system 4 generates The laser light is irradiated on the up-conversion thermotherapy probe 5;

[0042] The circulator 4-2 of the optical fiber transmission system 4 is connected with the ...