Compound celery seed tablet assisting gout treatment and preparation method thereof

Abstract

The invention belongs to the field of a medicine treating gout diseases, and particularly relates to a compound celery seed tablet assisting gout treatment and a preparation method thereof. The compound celery seed tablet comprises celery seed, lobed kudzuvine root, pericarpium citri reticulatae, artemisia argyi and folium perillae with the weight ratio being 24:5:5:5:5. The preparation method comprises the following steps: (1), weighing raw materials, crushing, and sieving the raw materials with a 100-mesh sieve; (2), performing ethanol extraction, and performing ultrasonic-assisted extraction; (3), performing filtrate decompression and ethanol removal, so as to obtain primary extract, and performing low temperature sterilization, so as to obtain compound celery seed thick extract; (4), adding beta-cyclodextrin, starch and microcrystalline cellulose, then spraying ethanol, and performing spray drying, so as to obtain powder particles; adding sodium carboxymethyl starch and magnesium stearate into the powder particles, and performing tabletting, so as to obtain the target product compound celery seed tablet. The compound celery seed tablet can effectively reduce a uric acid index,resist gout treatment, reduce gout relapse and relieve gout symptoms, and does not have any toxic and side effect.

Description

technical field

[0001] The invention belongs to the field of drugs for treating gout-like diseases, and in particular relates to a compound celery seed tablet for auxiliary treatment of gout and a preparation method thereof. Background technique

[0002] Gout is a disease caused by purine metabolism disorder, and its clinical features are hyperuricemia and recurrent arthritis. Acute gouty arthritis has a sudden onset, often at night, with joint redness, swelling, heat, pain and restricted movement as the main manifestations, and belongs to the category of "heat arthralgia" in traditional Chinese medicine. In recent years, with the improvement of living standards and changes in dietary structure, the incidence of gouty arthritis has increased significantly. The main patients are middle-aged and elderly men, and they tend to become younger. It is one of the clinically intractable diseases. At present, the mode of oral administration of Western medicine is mostly used to treat...

Examples

Embodiment 1

[0026] The invention provides a compound celery seed tablet for the auxiliary treatment of gout. The weight ratios are: 24:5:5:5:5.

[0027] The preparation method of above-mentioned compound celery seed tablet, comprises the steps:

[0028] (1) Weigh the raw material, pulverize it with a traditional Chinese medicine pulverizer, and pass through a 100-mesh sieve;

[0029] (2) Extract the crushed and sieved raw materials with 70% ethanol for 24 hours, the amount of ethanol added is 5 times the total weight of the raw materials after crushed and sieved in the step (1), assisted by ultrasonic method Extraction; ultrasonic power 200W; ultrasonic frequency 40kHz; extraction for 30min, repeated three times, combined filtrate filtration;

[0030] (3) Use a rotary evaporator for the filtrate to remove ethanol under reduced pressure to obtain the primary extract. After the primary extract is sterilized at low temperature, the finished compound celery seed thick extract is obtained; ...

Embodiment 2

[0033] The invention provides a compound celery seed tablet for the auxiliary treatment of gout. The weight ratios are: 24:5:5:5:5.

[0034] The preparation method of above-mentioned compound celery seed tablet, comprises the steps:

[0035] (1) Weigh the raw material, pulverize it with a traditional Chinese medicine pulverizer, and pass through a 100-mesh sieve;

[0036] (2) Extract the crushed and sieved raw materials with 70% ethanol for 48 hours, the amount of ethanol added is 8 times the total weight of the raw materials after crushed and sieved in the step (1), and ultrasonic method is used to assist Extraction; ultrasonic power 200W; ultrasonic frequency 40kHz; extraction for 30min, repeated three times, combined filtrate filtration;

[0037] (3) Use a rotary evaporator for the filtrate to remove ethanol under reduced pressure to obtain the primary extract. After the primary extract is sterilized at low temperature, the finished compound celery seed thick extract is o...

technical field

[0001] The invention belongs to the field of drugs for treating gout-like diseases, and in particular relates to a compound celery seed tablet for auxiliary treatment of gout and a preparation method thereof. Background technique

[0002] Gout is a disease caused by purine metabolism disorder, and its clinical features are hyperuricemia and recurrent arthritis. Acute gouty arthritis has a sudden onset, often at night, with joint redness, swelling, heat, pain and restricted movement as the main manifestations, and belongs to the category of "heat arthralgia" in traditional Chinese medicine. In recent years, with the improvement of living standards and changes in dietary structure, the incidence of gouty arthritis has increased significantly. The main patients are middle-aged and elderly men, and they tend to become younger. It is one of the clinically intractable diseases. At present, the mode of oral administration of Western medicine is mostly used to treat...

Examples

Embodiment 1

[0026] The invention provides a compound celery seed tablet for the auxiliary treatment of gout. The weight ratios are: 24:5:5:5:5.

[0027] The preparation method of above-mentioned compound celery seed tablet, comprises the steps:

[0028] (1) Weigh the raw material, pulverize it with a traditional Chinese medicine pulverizer, and pass through a 100-mesh sieve;

[0029] (2) Extract the crushed and sieved raw materials with 70% ethanol for 24 hours, the amount of ethanol added is 5 times the total weight of the raw materials after crushed and sieved in the step (1), assisted by ultrasonic method Extraction; ultrasonic power 200W; ultrasonic frequency 40kHz; extraction for 30min, repeated three times, combined filtrate filtration;

[0030] (3) Use a rotary evaporator for the filtrate to remove ethanol under reduced pressure to obtain the primary extract. After the primary extract is sterilized at low temperature, the finished compound celery seed thick extract is obtained; ...

Embodiment 2

[0033] The invention provides a compound celery seed tablet for the auxiliary treatment of gout. The weight ratios are: 24:5:5:5:5.

[0034] The preparation method of above-mentioned compound celery seed tablet, comprises the steps:

[0035] (1) Weigh the raw material, pulverize it with a traditional Chinese medicine pulverizer, and pass through a 100-mesh sieve;

[0036] (2) Extract the crushed and sieved raw materials with 70% ethanol for 48 hours, the amount of ethanol added is 8 times the total weight of the raw materials after crushed and sieved in the step (1), and ultrasonic method is used to assist Extraction; ultrasonic power 200W; ultrasonic frequency 40kHz; extraction for 30min, repeated three times, combined filtrate filtration;

[0037] (3) Use a rotary evaporator for the filtrate to remove ethanol under reduced pressure to obtain the primary extract. After the primary extract is sterilized at low temperature, the finished compound celery seed thick extract is o...