Composite mass spectrometry ion source device

Abstract

The present invention discloses a composite mass spectrometry ion source device, comprising: an ion source, an auxiliary heating device, an ion source bracket, an adjusting device and a cavity; the ion source bracket is installed on the cavity; the ion source comprises an electrospray ion source and an atmospheric pressure chemical ionization source, the electrospray ion source and the atmospheric pressure chemical ionization source are installed on the cavity by replacing each other through the ion source bracket, and the auxiliary heating device and the adjusting device are installed on the cavity; the interior of the cavity is hollow, the interior of the cavity has an ionization region, and the ion source bracket and the auxiliary heating device are both oriented toward the ionization region. The technical problem to be solved by the present invention is that the electrospray ion source and the atmospheric pressure chemical ionization source can be compatible and installed on the same cavity by replacing each other. In the process of equipment procurement, enterprises only need to purchase one type of equipment to have the two functions of the electrospray ion source and the atmospheric pressure chemical ionization source, which greatly reduces the purchase cost of the enterprise.

Description

Technical Field

[0001] The invention belongs to the technical field of mass spectrometer equipment, and in particular relates to a composite mass spectrometer ion source device. Background Art

[0002] The triple quadrupole mass spectrometer is a chemical analysis instrument with a very large market demand. It has the characteristics of high precision, high difficulty in R&D and manufacturing, broad market demand, high instrument value, and mainly relying on imports. It is mainly used in the fields of food, medicine and health, precision medicine, forensic identification, industrial analysis, etc. In the triple quadrupole mass spectrometer, the function of the ion source equipment is to convert the detection sample from neutral molecules into charged ions. The ion source has a great influence on the signal sensitivity and signal stability of the mass spectrometer.

[0003] There are two types of ion source equipment for commonly used triple quadrupole mass spectrometers, namely electrospray ionization source (ESI) equipment and atmospheric pressure chemical ionization source (APCI) equipment. When purchasing equipment, enterprises need to purchase both electrospray ionization source and atmospheric pressure chemical ionization source at the same time. The ion source is two different split devices, which increases the purchase cost of enterprises. The spray direction and interface of the traditional ion source are designed to be vertically orthogonal. The disadvantage of this design is that there is a lot of ion loss and a low rate of ion conversion to the interface. Summary of the invention

[0004] The technical problem to be solved by the present invention is that the electrospray ion source and the atmospheric pressure chemical ionization source can be compatible and interchangeably installed on the same cavity. During the equipment procurement process, the enterprise only needs to purchase one type of equipment to have both the functions of the electrospray ion source and the atmospheric pressure chemical ionization source, which greatly reduces the enterprise's purchase cost.

[0005] The technical solution is as follows:

[0006] A composite mass spectrometer ion source device, comprising: an ion source, an auxiliary heating device, an ion source bracket, an adjustment device and a cavity;

[0007] An ion source is used to eject neutral molecules from a liquid sample and release electric charge to the heated and vaporized neutral molecules, so that the heated and vaporized neutral molecules are charged and then converted into charged ions;

[0008] An auxiliary heating device, used to heat and vaporize the ejected neutral molecules;

[0009] An ion source bracket, wherein the ion source is mounted on the ion source bracket;

[0010] The adjusting device is used to adjust the installation position and direction of the ion source bracket, and the ion source bracket is installed on the cavity;

[0011] The ion source includes an electrospray ion source and an atmospheric pressure chemical ionization source, the electrospray ion source and the atmospheric pressure chemical ionization source are installed on the cavity by replacing each other through an ion source bracket, and an auxiliary heating device and an adjusting device are installed on the cavity;

[0012] The interior of the cavity is hollow, and an ionization region is provided inside the cavity. The ion source support and the auxiliary heating device are both oriented toward the ionization region.

[0013] Furthermore, both the electrospray ion source and the atmospheric pressure chemical ionization source are provided with a spray needle for spraying mist droplets, and the atmospheric pressure chemical ionization source is provided with a high-voltage discharge needle for releasing electric charge.

[0014] Further, the cavity includes a top and a bottom, the top and the bottom are opposite to each other, the adjustment device is installed on the top, and the ionization area is located above the bottom;

[0015] The bottom includes a flat plate and two inclined plates, the inclined plates are respectively located on both sides of the flat plate, the cross-sections of the flat plate and the inclined plates in the vertical direction are gradually concave along the direction from the inclined plate to the flat plate, and the inclined plate is located above the flat plate.

[0016] Furthermore, the auxiliary heating device includes a first heater and a second heater, the first heater is installed at the bottom of the cavity, and the second heater is installed on the ion source bracket.

[0017] Furthermore, the top is provided with a socket, the ion source bracket is hingedly mounted on the socket through an adjustment device, and the ion source bracket passes through the socket; the flat plate and the inclined plate are both provided with mounting holes, the number of the first heaters is two, and the two first heaters respectively cooperate with the mounting holes of the corresponding inclined plates.

[0018] Furthermore, a waste discharge device is included, and the waste discharge device cooperates with the mounting hole of the flat plate.

[0019] Further, in the direction of the cross section of the flat plate and the inclined plate, the two first heaters are symmetrical to each other with the longitudinal center axis perpendicular to the flat plate as the symmetry axis.

[0020] Furthermore, the cavity also includes a side plate, and the side plate is equipped with an observation window, and the observation window corresponds to the ionization area.

[0021] Furthermore, the ion source bracket is installed at an angle on the top, the first heater is matched with the mounting hole at an angle, and the inclination direction of the second heater is consistent with the inclination direction of the ion source bracket.

[0022] Furthermore, the inclination direction of the ion source support is inclined downward in the vertical direction, and the orientation direction of the first heater is inclined upward in the vertical direction, and the inclination directions of the ion source support and the first heater are both toward the ionization region.

[0023] It should be noted that:

[0024] 1. The English abbreviation of the aforementioned electrospray ion source is ESI; the English abbreviation of the aforementioned atmospheric pressure chemical ionization source is APCI.

[0025] 2. The auxiliary heating device sprays out high-temperature hot air.

[0026] 3. The aforementioned “first” and “second” do not represent specific quantities and orders, but are only used to distinguish names.

[0027] 4. The aforementioned “installation” should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meaning of the above terms in the present invention can be understood according to specific circumstances.

[0028] The advantages or principles of the present invention are described below:

[0029] A composite mass spectrometry ion source device, in which the electrospray ion source and the atmospheric pressure chemical ionization source of the ion source bracket are installed on the cavity by replacing each other through the ion source bracket. When the electrospray ion source is needed, the electrospray ion source is installed on the ion source bracket, and the ion source bracket is hingedly installed on the cavity through the adjustment device, so that the electrospray ion source is sprayed inside the cavity and converted into charged ions; when the atmospheric pressure chemical ionization source is needed, the electrospray ion source and the ion source bracket are removed from the cavity, and then the ion source bracket equipped with the atmospheric pressure chemical ionization source is replaced and installed on the cavity, and the electrospray ion source is sprayed inside the cavity and converted into charged ions. When purchasing equipment, the enterprise only needs to purchase one ion source device to use two different functions, and there is no need to purchase two different devices at the same time, which greatly reduces the equipment investment cost of the enterprise. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of the physical structure of a composite mass spectrometry ion source device according to an embodiment of the present invention;

[0031] Figure 2 is a cross-sectional view of a composite mass spectrometry ion source device according to an embodiment of the present invention;

[0032] Figure 3 2. It is a front view of a composite mass spectrometer ion source device according to an embodiment of the present invention;

[0033] Figure 4is a front view of an electrospray ion source according to an embodiment of the present invention installed on an ion source support;

[0034] Figure 5 yes Figure 4 A partial cross-sectional view of

[0035] Figure 6 is a front view of an ion source support according to an embodiment of the present invention;

[0036] Figure 7 is a front view of an electrospray ion source according to an embodiment of the present invention;

[0037] Figure 8 is a front view of an atmospheric pressure chemical ionization source according to an embodiment of the present invention installed on an ion source support;

[0038] Fig. 9 is a front view of an atmospheric pressure chemical ionization source according to an embodiment of the present invention;

[0039] Description of reference numerals:

[0040] 10. Cavity, 11. Ionization region, 12. Side panel, 13. Observation window, 20. Top, 21. Socket, 30. Bottom, 31. Flat plate, 32. Inclined plate, 33. Mounting hole, 40. Ion source bracket, 41. Ion source, 42. Electrospray ion source, 43. Atmospheric pressure chemical ionization source, 44. Spray needle, 45. Discharge needle, 50. Auxiliary heating device, 51. First heater, 52. Second heater, 60. Adjustment device, 70. Waste discharge device, 80. Ion channel. DETAILED DESCRIPTION

[0041] The embodiments of the present invention are described in detail below.

[0042] like Figures 1 to 3As shown, the composite mass spectrometer ion source device includes: an ion source 41, an auxiliary heating device 50, an ion source bracket 40, an adjustment device 60 and a cavity 10; the ion source 41 is used to eject the neutral molecules of the liquid sample and release the charge to the heated and vaporized neutral molecules so that the heated and vaporized neutral molecules are charged and converted into charged ions; the auxiliary heating device 50 is used to heat and vaporize the ejected neutral molecules; the ion source bracket 40, the ion source 41 is installed on the ion source bracket 40; the adjustment device 60 is used to adjust the ion source bracket 40 The installation position and direction of the cavity 10 are as follows: the ion source bracket 40 is installed on the cavity 10; the ion source 41 includes an electrospray ion source 42 and an atmospheric pressure chemical ionization source 43, and the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are installed on the cavity 10 by replacing each other through the ion source bracket 40, and the auxiliary heating device 50 and the adjustment device 60 are installed on the cavity 10; the interior of the cavity 10 is hollow, and the interior of the cavity 10 has an ionization region 11, and the ion source bracket 40 and the auxiliary heating device 50 are both oriented toward the ionization region 11.

[0043] See also Figures 4 to 9 , wherein the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are both provided with a spray needle 44 for spraying mist droplets, and the atmospheric pressure chemical ionization source 43 is provided with a high-voltage discharge needle 45 for releasing electric charge; the auxiliary heating device 50 includes a first heater 51 and a second heater 52, the first heater 51 is installed on the bottom 30 of the cavity 10, and the second heater 52 is installed on the ion source bracket 40.

[0044] See also Figure 2 , Figure 3 , wherein the chamber 10 includes a top 20 and a bottom 30, the top 20 and the bottom 30 are opposite to each other, the adjustment device 60 is installed on the top 20, and the ionization area 11 is located above the bottom 30; the bottom 30 includes a flat plate 31 and two inclined plates 32, the inclined plates 32 are respectively located on both sides of the flat plate 31, and the cross-sections of the flat plate 31 and the inclined plates 32 in the vertical direction are gradually concave along the direction from the inclined plate 32 to the flat plate 31, and the inclined plate 32 is located above the flat plate 31; the top 20 is provided with a socket 21, and the ion source bracket 40 is hingedly installed on the socket 21 through the adjustment device 60, and the ion source bracket 40 passes through the socket 21; the flat plate 31 and the inclined plate 32 are both provided with mounting holes 33, the number of the first heaters 51 is two, and the two first heaters 51 are respectively matched with the mounting holes 33 of the corresponding inclined plates 32; in the direction of the cross-sections of the flat plate 31 and the inclined plates 32, the two first heaters 51 are symmetrical to each other with the longitudinal center axis of the flat plate 31 as the symmetry axis.

[0045] See also Figure 1, wherein the composite mass spectrometry ion source device also includes a waste discharge device 70, which cooperates with the mounting hole 33 of the flat plate 31; the cavity 10 also includes a side plate 12, and the side plate 12 is equipped with an observation window 13, and the observation window 13 corresponds to the ionization area 11.

[0046] See also Figure 1 , Figure 2 , Figure 3 , wherein the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are both installed at an angle on the top 20, the first heater 51 is matched with the mounting hole 33 at an angle, and the inclination direction of the second heater 52 is consistent with the inclination direction of the atmospheric pressure chemical ionization source 43; the inclination direction of the ion source bracket 40 is inclined downward in the vertical direction, and the orientation direction of the first heater 51 is inclined upward in the vertical direction, and the inclination directions of the ion source bracket 40 and the first heater 51 are both toward the ionization region 11; in this embodiment, the temperature range of the high-temperature hot gas ejected by the auxiliary heating device 50 is 640 degrees to 660 degrees.

[0047] The method for using the composite mass spectrometry ion source of this embodiment includes the following steps:

[0048] When the composite mass spectrometer ion source device ionizes molecules of medium to strong polar compounds, an electrospray ion source 42 device is used, the electrospray ion source 42 is installed on the ion source bracket 40, and then the ion source bracket 40 is installed on the socket 21, and the installation position and orientation of the electrospray ion source 42 on the socket 21 are adjusted by the adjustment device 60, and the electrospray ion source 42 is fixed after being adjusted to the specified position and direction;

[0049] The composite mass spectrometer ion source device is started, and the electrospray ion source 42 sprays the charged neutral molecules of the liquid sample to the ionization region 11 through the charged spray needle 44. The first heater 51 of the auxiliary heating device 50 sprays high-temperature hot air to the ionization region 11. The high-temperature hot air heats the neutral molecules in the ionization region 11 to vaporize the charged neutral molecules, thereby generating charged ions. The generated charged ions enter the ion channel 80, and the uncharged neutral ions or other impurities after the neutral molecules are heated are drawn away and discharged together with the high-temperature hot air through the exhaust device 70;

[0050] When the composite mass spectrometer ion source device ionizes macromolecules with less charge or poor polarity, the atmospheric pressure chemical ionization source 43 device is used, the electrospray ion source 42 and the ion source bracket 40 are disassembled from the socket 21, and then the ion source bracket 40 with the atmospheric pressure chemical ionization source 43 installed is replaced and installed on the socket 21, and the installation position and orientation direction of the atmospheric pressure chemical ionization source 43 are adjusted by the adjustment device 60. After adjusting to the specified installation position and orientation direction, the atmospheric pressure chemical ionization source 43 is fixed, and the discharge needle 45 is rotated so that the discharge direction of the discharge needle 45 is toward the position direction of the spray needle 44;

[0051] The composite mass spectrometry ion source device is started, the atmospheric pressure chemical ionization source 43 sprays out the neutral molecules of the liquid sample through the spray needle 44, and the second heater 52 of the auxiliary heating device 50 sprays out high-temperature hot air. The high-temperature hot air heats the neutral molecules inside the atmospheric pressure chemical ionization source 43, vaporizes the mist droplets inside the atmospheric pressure chemical ionization source 43, and blows the vaporized neutral molecules from the atmospheric pressure chemical ionization source 43 to the ionization region 11 through the high-temperature hot air. The discharge needle 45 releases the charge, so that the nitrogen or oxygen in the ionization region 11 is charged, and the charged nitrogen or oxygen transfers the charge to the gaseous solvent molecules, and the charged gaseous solvent molecules transfer the charge to the vaporized neutral molecules, thereby generating charged ions. The generated charged ions enter the ion channel 80, and the uncharged neutral ions or other impurities are drawn away and discharged together with the high-temperature hot air through the exhaust device 70.

[0052] The above embodiment has the following advantages:

[0053] 1. A composite mass spectrometry ion source device, wherein the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 of the ion source bracket 40 are installed on the cavity 10 by replacing each other through the ion source bracket 40. When the electrospray ion source 42 is needed, the electrospray ion source 42 is installed on the ion source bracket 40, and the ion source bracket 40 is hingedly installed on the cavity 10 through the adjustment device 60, so that the electrospray ion source 42 is sprayed inside the cavity 10 and converted into charged ions; when the atmospheric pressure chemical ionization source 43 is needed, the electrospray ion source 42 and the ion source bracket 40 are disassembled from the cavity 10, and then the ion source bracket 40 equipped with the atmospheric pressure chemical ionization source 43 is replaced and installed on the cavity 10, and the electrospray ion source 42 is sprayed inside the cavity 10 and converted into charged ions. When purchasing equipment, the enterprise only needs to purchase one ion source device to use two different functions, and there is no need to purchase two different devices at the same time, which greatly reduces the equipment investment cost of the enterprise.

[0054] 2. The adjusting device 60 can adjust the installation position and direction of the ion source bracket 40, and has good flexibility. After adjusting the installation position and direction, the ion source bracket 40 is equipped with the ion source 41 to eject the neutral molecules of the liquid sample. The auxiliary heating device 50 heats and vaporizes the neutral molecules to generate charged ions. After the heating and vaporization is completed, the waste gas is separated in the ionization area 11, so that most of the charged ions in the ionization area 11 enter the ion channel 80, and the waste gas and unconverted impurities are prevented from entering the ion channel 80. This can not only improve the anti-pollution ability and durability of the mass spectrometer, but also improve the transmission efficiency of the charged ions, thereby ensuring the performance of the composite mass spectrometer ion source device in the mass spectrometer.

[0055] 3. The angle positions of the flat plate 31 and the inclined plate 32 are set to fix the installation position and orientation of the first heater 51 and the waste discharge device 70 when they are installed, so that the first heater 51 has a better and more obvious vaporization effect on the ejected mist droplets, can convert more charged ions, and further improve the conversion rate of charged ions.

[0056] 4. The two mutually symmetrical first heaters 51 can jointly heat and vaporize the sprayed mist droplets, further improving the efficiency of heating and vaporization.

[0057] 5. The electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 are interchangeably installed on the socket 21 through the ion source bracket 40. The two spray modes of the electrospray ion source 42 device corresponding to the electrospray ion source 42 and the atmospheric pressure chemical ionization source 43 device corresponding to the atmospheric pressure chemical ionization source 43 are compatible and combined on the same cavity 10, and the disassembly and replacement process is convenient and fast. Two different functions can be completed by one device. The enterprise does not need to purchase two different devices, which greatly reduces the equipment investment cost of the enterprise.

[0058] 6. The second heater 52 is a spraying method different from that of the electrospray ion source 42 on the atmospheric pressure chemical ionization source 43. When the ion source bracket 40 is equipped with the atmospheric pressure chemical ionization source 43 for operation, the first heater 51 does not heat and vaporize the mist droplets, but the second heater 52 heats and vaporizes the droplets inside the ion source bracket 40, so that the same cavity 10 can be well compatible with the two spraying methods of the electrospray ion source 42 device of the first heater 51 and the atmospheric pressure chemical ionization source 43 device of the second heater 52.

[0059] 7. The installation position and orientation of the ion source bracket 40 are adjusted and fixed, so that the exhaust device 7070 can just extract and discharge the heated and atomized exhaust gas from the ionization area 11, thereby separating the exhaust gas from the charged ions and allowing most of the charged ions to pass through the ion channel 80, further preventing the ion channel 80 from being blocked and contaminating the mass spectrometer, thereby extending the service life of the equipment.

[0060] The above are only specific embodiments of the present invention, and the protection scope of the present invention is not limited thereto; any replacement and improvement made on the basis of not violating the concept of the present invention shall fall within the protection scope of the present invention.

Claims

1. A composite mass spectrometry ion source device, comprising: An ion source is used to eject neutral molecules from a liquid sample and release electric charge to the heated and vaporized neutral molecules, so that the heated and vaporized neutral molecules are charged and then converted into charged ions; An auxiliary heating device, used to heat and vaporize the ejected neutral molecules; An ion source bracket, wherein the ion source is mounted on the ion source bracket; It is characterized in that it comprises an adjusting device and a cavity, wherein the adjusting device is used to adjust the installation position and direction of the ion source bracket, and the ion source bracket is installed on the cavity; The ion source includes an electrospray ion source and an atmospheric pressure chemical ionization source, the electrospray ion source and the atmospheric pressure chemical ionization source are installed on the cavity by replacing each other through an ion source bracket, and an auxiliary heating device and an adjusting device are installed on the cavity; The interior of the cavity is hollow, and an ionization region is provided inside the cavity, and the ion source support and the auxiliary heating device are both oriented toward the ionization region; The electrospray ion source and the atmospheric pressure chemical ionization source are both provided with a spray needle for spraying out mist droplets, and the atmospheric pressure chemical ionization source is provided with a high-voltage discharge needle for releasing electric charge; The cavity includes a top and a bottom, the top and the bottom are opposite to each other, the adjustment device is installed on the top, and the ionization area is located above the bottom; The bottom comprises a flat plate and two inclined plates, the inclined plates are respectively located on both sides of the flat plate, the cross-sections of the flat plate and the inclined plates in the vertical direction are gradually concave along the direction from the inclined plate to the flat plate, and the inclined plate is located above the flat plate; The auxiliary heating device comprises a first heater and a second heater, wherein the first heater is installed at the bottom of the chamber, and the second heater is installed on the ion source support; The top is provided with a socket, the ion source bracket is hingedly mounted on the socket through an adjustment device, and the ion source bracket passes through the socket; the flat plate and the inclined plate are both provided with mounting holes, the number of the first heaters is two, and the two first heaters are respectively matched with the mounting holes of the corresponding inclined plates; Also included is a waste discharge device, the waste discharge device cooperates with the mounting hole of the flat plate; In the direction of the cross section of the flat plate and the inclined plate, the two first heaters are symmetrical to each other with the longitudinal center axis of the flat plate being perpendicular to the symmetry axis; The chamber also includes a side plate, the side plate is equipped with an observation window, and the observation window corresponds to the ionization area; The ion source bracket is installed at an angle on the top, the first heater is matched with the mounting hole at an angle, and the inclination direction of the second heater is consistent with the inclination direction of the ion source bracket; The inclination direction of the ion source support is inclined downward in the vertical direction, and the orientation direction of the first heater is inclined upward in the vertical direction. The inclination directions of the ion source support and the first heater are both toward the ionization region.

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