Medicinal gel for chronic periodontitis as well as preparation method and application thereof

A technology for chronic periodontitis and gel, applied in the field of Jiawei Wudan powder drug gel and its preparation, can solve the problems of being easily affected by other factors, prone to errors in results, and poor in quantification, and achieves the goal of promoting scientific development, Affordable, non-toxic effects

CN111569004AActive Publication Date: 2020-08-25钟瑾 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2020-08-25

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Abstract

The invention discloses medicinal gel for chronic periodontitis as well as a preparation method and application thereof. The medicinal gel comprises a carrier, traditional Chinese medicine components,water and beta-sodium glycerophosphate; the carrier is formed by mixing N-methyl-2-pyrrolidone, glyceryl triacetate and a polylactic acid-glycolic acid copolymer; and the traditional Chinese medicinecomponents comprise salvia miltiorrhiza, gallnut, bletilla striata, astragalus membranaceus, coptis chinensis and cinnamon extract. The volume fraction of the traditional Chinese medicine componentsin the gel is 15%, the volume fraction of the sodium beta-glycerophosphate is 4%, the volume fraction of the water is 30%, the mass fraction of the polylactic acid-glycolic acid copolymer is 40%, andthe volume ratio of the N-methyl-2-pyrrolidone to the glyceryl triacetate is 5:5. The invention also provides the preparation method and application of the medicinal gel. The gel disclosed by the invention is relatively simple and convenient to prepare, has good biocompatibility and adhesiveness, is good in local administration absorption and less in adverse reaction, also has traditional Chinesemedicine components, and has the advantages of high efficiency, no toxic or side effect, convenience in use, moderate price and the like.
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Description

technical field

[0001] The present invention relates to a drug gel for auxiliary treatment of chronic periodontitis and its preparation method and application, in particular, to a modified Wudan powder drug gel for chronic periodontitis, its preparation method and application . Background technique

[0002] Chronic periodontitis is a chronic infectious disease. It is a multifactorial disease determined by bacteria, host and environment. The interaction between microorganisms and host determines the process and progress of the disease. The antigenic components of plaque bacteria and the toxins and enzymes they produce can directly cause damage to periodontal tissue, and can also trigger host immune and inflammatory responses, indirectly causing damage to periodontal tissue and other systemic lesions throughout the body. The host's immune response can protect the periodontal tissue in the early stage and prevent pathogenic bacteria from invading the periodontal tissue, but so...

Examples

Embodiment 1

[0042] Embodiment 1: Preparation of the modified Wudan powder drug gel for chronic periodontitis.

[0043] Preparation of drug gel for chronic periodontitis, which contains carrier, traditional Chinese medicine ingredients, water and sodium β-glycerophosphate; carrier consists of N-methyl-2-pyrrolidone, glycerol triacetate, polylactic acid-glycolic acid copolymer A blend of traditional Chinese medicine ingredients including Danshen, Galla, Bletilla striata, Astragalus, Coptis, and cinnamon extracts.

[0044] Preferably, the polylactic acid-glycolic acid copolymer in the drug gel is 40% by mass percentage, and the ratio of the polylactic acid-glycolic acid copolymer is 75 / 25, that is, PLGA75:25; N-methyl-2- The volume ratio of pyrrolidone and triacetin is 5:5.

[0045] The medicinal gel contains 15% of traditional Chinese medicine ingredients, 4% of beta-glycerophosphate sodium and 30% of water in volume percentage.

[0046] The extracts of Salvia Miltiorrhiza, Galla Chinensi...

Embodiment 2

[0063] Example 2: Verification of the modified Wudan powder drug gel for chronic periodontitis.

[0064] The treatment group Jiawei Wudansan gel group and the control group tetracycline gel group completed the following treatments on the basis of periodontal basic treatment. see figure 1 shown.

[0065] Subject grouping and treatment: Take 100 cases of chronic periodontitis as observation objects, aged 18-80 years old, male or female, they are randomly divided into Chinese medicine gel group A and western medicine gel group by random number table method on the basis of standardized SPR Group B had 50 cases in each group. Group A was treated with periodontal topical modified Wudan powder gel, and group B was treated with tetracycline sustained-release gel locally. Both drugs were administered once a week, and one week was a course of treatment. After 4 courses of treatment, comparisons were made. 2 groups of treatment effects.

[0066] Efficacy evaluation indicators: the fol...