Tissue section sealing device

Abstract

The present invention discloses a tissue slice sealing device, belonging to the technical field of medical devices. It includes: a support frame; a slide placement plate for placing a slide with a tissue slice, which is linearly slidably mounted on the support frame; a sealing glue dripping device for dripping a quantitative sealing glue on the tissue slice, and a plurality of sealing glue dripping devices are provided, and a plurality of sealing glue dripping devices are installed at intervals on the support frame; a cover glass placing device for covering the tissue slice with a cover glass, and a plurality of cover glass placing devices are provided, and a plurality of cover glass placing devices are installed at intervals on the support frame; an intermittent driving device for driving the slide placement plate to slide intermittently on the support frame; a microprocessor, and the sealing glue dripping device, the cover glass placing device and the intermittent driving device are electrically connected to the microprocessor respectively. The tissue slice sealing device in the present invention can drip a quantitative sealing glue and can place a cover glass on the tissue slice.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a tissue section sealing device. Background Art

[0002] Sealing is to seal the tissue slices and store them between the slide and the cover glass, drip a small amount of sealing glue to prevent them from contacting with the air, prevent them from oxidation and fading, and facilitate microscopic observation and preservation. Sealing glue usually uses neutral gum; but currently, sealing mainly relies on manual sealing. In the actual sealing process, there is a problem of uneven glue dripping, which is easy to cause excessive overflow of sealing glue to produce odor with certain toxicity, and too little sealing glue makes the tissue on the tissue slice not fully covered or easily produce bubbles. Technical problems. In addition, after dripping a small amount of sealing glue on the tissue slice, it is necessary to place a cover glass on the tissue slice dripped with sealing glue, and cover the tissue slice with the cover glass, but in the actual sealing process, the operator needs to pick up the cover glass and place it on the tissue slice. Because the cover glass is thin and has sharp edges, it is not easy to be picked up and it is easy to scratch the operator during the picking process, which poses a safety hazard. Therefore, there is an urgent need for a sealing device that can drip a quantitative sealing glue and can place a cover glass on the tissue slice. Summary of the invention

[0003] The object of the present invention is to overcome at least one of the above-mentioned shortcomings of the prior art and to provide a tissue section sealing device capable of dripping a quantitative sealing glue and placing a cover glass on a tissue section.

[0004] The technical solution of the present invention to solve the above technical problem is as follows: a tissue section sealing device, comprising:

[0005] Support frame;

[0006] A slide placement plate, used for placing slides with tissue sections, and linearly slidably mounted on the support frame;

[0007] A sealing glue dripping device, used for dripping a quantitative amount of sealing glue onto the tissue slices placed on the glass slide, wherein a plurality of sealing glue dripping devices are provided, and the plurality of sealing glue dripping devices are installed on the support frame at intervals and are located above the glass slide placement plate;

[0008] A cover glass placing device, used for placing a cover glass on the tissue slice placed on the slide after a certain amount of sealing glue is dripped, wherein a plurality of cover glass placing devices are provided, and the plurality of cover glass placing devices are installed on the support frame at intervals and are located above the slide placing plate;

[0009] An intermittent driving device is used to drive the glass slide placement plate to intermittently slide on the support frame, and the intermittent driving device is provided with a plurality of them. The plurality of intermittent driving devices cooperate to sequentially slide the plurality of glass slide placement plates to the bottom of the sealing glue dripping device to drip the sealing glue, and slide the glass slide placement plate to the bottom of the cover glass placing device to cover the cover glass;

[0010] The microprocessor, the sealing glue dripping device, the cover glass placing device and the intermittent driving device are electrically connected to the microprocessor respectively.

[0011] The beneficial effects of the present invention are as follows: in the present invention, a plurality of sealing glue dripping devices for dripping a quantitative amount of sealing glue onto tissue sections placed on a glass slide are arranged on a support frame, and the sealing glue dripping devices are electrically connected to the microprocessor, so as to facilitate dripping a quantitative amount of sealing glue onto multiple tissue sections, which is beneficial to reducing the influence of human factors on the dripped sealing glue, is beneficial to accurately dripping a certain amount of sealing glue, avoids dripping too much or too little sealing glue, and is beneficial to improving the quality of the sealing. In addition, a plurality of coverslip placing devices are provided for covering tissue sections placed on glass slides with coverslips after a certain amount of coverslip glue is dripped on them. The coverslip placing devices are electrically connected to the microprocessor. The coverslips are placed on the coverslip glue on the tissue sections by the coverslip placing devices, which helps to avoid the safety hazard of scratching the operators when they pick up the coverslips. Furthermore, the glass slide placing plates in this embodiment are driven by an intermittent driving device electrically connected to the microprocessor to slide the plurality of glass slide placing plates to directly below the coverslip glue dripping device to drip the coverslip glue, and slide the glass slide placing plates to directly below the coverslip placing device to cover them with coverslips, which helps to automatically drip the coverslip glue and automatically cover the tissue sections placed on the glass slides. Therefore, the tissue section sealing device in the present invention can drip a certain amount of sealing glue and place a cover glass on the tissue section, avoiding dripping too much or too little sealing glue, improving the sealing quality and sealing efficiency, and facilitating the automation of tissue section sealing.

[0012] In addition, based on the above technical solution, the present invention can also make the following improvements and can also have the following additional technical features.

[0013] According to one embodiment of the present invention, the sealing glue dripping device comprises:

[0014] A housing, wherein a sealing glue storage cavity for storing sealing glue is provided in the housing;

[0015] A sealing adhesive delivery tube, wherein two ends of the sealing adhesive delivery tube are respectively an input end and an output end, the input end extends into the sealing adhesive storage cavity and is communicated with the sealing adhesive storage cavity, and the output end passes through the housing;

[0016] a sealing glue suction and discharge device, used for sucking the sealing glue stored in the sealing glue storage chamber into the sealing glue delivery tube and outputting the sealing glue sucked into the sealing glue delivery tube from the sealing glue delivery tube, the sealing glue suction and discharge device is connected to the sealing glue delivery tube and communicated with the sealing glue delivery tube, and the sealing glue suction and discharge device is electrically connected to the microprocessor;

[0017] a first one-way valve connected to the sealing glue delivery pipe and located between the input end and the connection between the sealing glue suction and discharge device and the sealing glue delivery pipe, wherein the one-way conduction direction of the first one-way valve is from the input end to the connection between the sealing glue suction and discharge device and the sealing glue delivery pipe;

[0018] The second one-way valve is connected to the sealing glue delivery tube and is located between the output end and the connection point between the sealing glue suction and discharge device and the sealing glue delivery tube. The one-way conduction direction of the second one-way valve is from the connection point between the sealing glue suction and discharge device and the sealing glue delivery tube to the output end. The first one-way valve and the second one-way valve are alternately turned on and off under the action of the sealing glue suction and discharge device, and a certain amount of sealing glue is output from the output end of the sealing glue delivery tube after completing one alternating process of turning on and off.

[0019] In this embodiment, a sealing glue storage chamber for storing sealing glue is provided in the shell body, so that sealing glue is stored in the shell body. A first one-way valve and a second one-way valve are connected to the sealing glue delivery pipe, and a sealing glue suction and discharge device is connected between the first one-way valve and the second one-way valve. The sealing glue stored in the sealing glue storage chamber is sucked into the sealing glue delivery pipe and the sealing glue is delivered by the sealing glue suction and discharge device. The first one-way valve and the second one-way valve are alternately turned on and off under the action of the sealing glue suction and discharge device, and a certain amount of sealing glue is output from the output end of the sealing glue delivery pipe after completing an alternating process of turning on and off. Therefore, the driving mechanism can be driven once or several times to realize that an appropriate amount of sealing glue is output and dripped on the tissue slice, and the tissue slice is dripped with glue, so that a cover glass is placed on the tissue slice for sealing, so that the amount of sealing glue dripped on the tissue slice is appropriate and the amount added can be controlled, so as to avoid excessive or insufficient dripping of sealing glue, which is beneficial to improving the quality of sealing and at the same time, improving the consistency of sealing of tissue slices.

[0020] According to one embodiment of the present invention, the sealing glue suction and discharge device includes a suction and discharge pipe and a driving mechanism for enabling the suction and discharge pipe to suction and discharge the sealing glue, one end of the suction and discharge pipe is connected to the sealing glue delivery pipe and communicates with the sealing glue delivery pipe, one end of the suction and discharge pipe is connected to the sealing glue delivery pipe and communicates with the sealing glue delivery pipe, the driving mechanism drives the suction and discharge pipe to suction and discharge the sealing glue, and the driving mechanism is electrically connected to the microprocessor. The sealing glue suction and discharge device in this embodiment includes a suction and discharge pipe and a driving mechanism for enabling the suction and discharge pipe to suction and discharge the sealing glue, so that the suction and discharge pipe is driven by the driving mechanism to suction and discharge the sealing glue.

[0021] According to one embodiment of the present invention, a sealing glue suction and discharge chamber is provided in the suction and discharge pipe, and the volume of the sealing glue suction and discharge chamber is equal to the volume of the sealing glue required for one sealing, or the volume of the sealing glue suction and discharge chamber multiple times is equal to the volume of the sealing glue required for one sealing; the driving mechanism includes:

[0022] A piston adapted to be slidably mounted in the sealing glue suction and discharge cavity of the suction and discharge pipe;

[0023] A push rod, one end of which is connected to the piston and the other end of which extends outwardly through the housing to form an extended end;

[0024] An electric push rod is fixedly connected to the support frame. A telescopic rod is provided on the electric push rod. The telescopic rod is fixedly connected to the extended end of the push rod. The electric push rod is electrically connected to the microprocessor.

[0025] The driving mechanism in this embodiment includes a piston, a push rod and an electric push rod. The piston is adapted to be installed in the sealing glue suction and discharge chamber. One end of the push rod is connected to the piston, and the other end passes through the housing. The piston is driven to move by the electric push rod by pushing and pulling the push rod. The electric push rod pulls the push rod outward from the housing, and the piston moves outward by a certain displacement. The sealing glue between the first one-way valve and the second one-way valve is adsorbed, and the second one-way valve is closed, the first one-way valve is opened, and a certain amount of sealing glue enters the sealing glue output tube between the first one-way valve and the second one-way valve; when the electric push rod pushes the push rod into the housing, the piston moves forward to restore the original position, the sealing glue between the first one-way valve and the second one-way valve is squeezed, and the first one-way valve is closed, the second one-way valve is opened, and a certain amount of sealing glue is output from the output end of the sealing glue output tube; thus, by pushing and pulling the push rod, the amount of sealing glue dripped on the tissue section is appropriate and the amount added can be controlled to avoid dripping too much or too little sealing glue.

[0026] According to one embodiment of the present invention, a stop plate is provided on the push rod, a spring 1 is installed between the stop plate and the sealing glue delivery tube, a set of the spring is arranged on the stop plate, and one end of the spring 1 is stopped on the stop plate, and the other end is stopped on the suction and discharge tube or the sealing glue delivery tube. In this embodiment, a spring 1 is installed between the stop plate and the sealing glue delivery tube, and a set of the spring is arranged on the push rod. The electric push rod applies pressure to the push rod to push the push rod into the shell. The spring 1 is elastically deformed by the pressure, the piston moves forward and squeezes the sealing glue, the electric push rod pulls the push rod out of the shell, the spring 1 restores its elasticity, the telescopic rod on the electric push rod is reset, the piston is reset and a certain amount of sealing glue is sucked into the sealing glue delivery tube, which is convenient for the next push rod operation, so that the piston squeezes the sealing glue next time and outputs a certain amount of sealing glue. In addition, the spring 1 of this embodiment can buffer the thrust and tension of the electric push rod, which is conducive to improving the uniformity of dripping the sealing glue.

[0027] According to one embodiment of the present invention, the cover glass placing device comprises:

[0028] A body, wherein a cover glass storage cavity for storing cover glasses is provided in the body, and a cover glass push-out channel for sequentially passing a single cover glass is provided in the body, wherein one end of the cover glass push-out channel is connected to the cover glass storage cavity, and the other end extends out of the body;

[0029] A cover glass pushing device, used for pushing the cover glass stored in the cover glass storage cavity out of the cover glass pushing channel, the cover glass pushing device comprising a cover glass pushing plate and a driving mechanism for driving the cover glass pushing plate to move linearly, one end of the cover glass pushing plate is connected to the driving mechanism, and the other end can be extended into and withdrawn from the cover glass pushing channel and the cover glass storage cavity under the drive of the driving mechanism;

[0030] The cover glass pressing device is used to pressurize the cover glass stored in the cover glass storage cavity to flatten the cover glass and make multiple cover glasses close together. The cover glass pressing device is provided with a pressure rod, and the pressure rod can extend into the cover glass storage cavity.

[0031] The present embodiment provides a coverslip storage cavity in the body, so as to facilitate the storage of coverslips in the body; a coverslip pushing device is provided to push the coverslips stored in the coverslip storage cavity from the coverslip pushing channel, the coverslip pushing device includes a coverslip pushing plate and a driving mechanism for driving the coverslip pushing plate to move linearly, and under the drive of the driving mechanism, the coverslip pushing plate can push out the coverslips stored in the coverslip storage cavity in sequence, so as to facilitate pushing the coverslips from the coverslip pushing channel and placing the coverslips on the sealing glue on the tissue section, which helps to avoid the safety hazard of scratching the operator when picking up the coverslip. In addition, by providing a coverslip pressing device for applying pressure to the coverslips stored in the coverslip storage cavity to flatten the coverslips and make multiple coverslips fit tightly together, it is beneficial for multiple coverslips to fit tightly together and ensure that the coverslip pushing plate only pushes out one coverslip in the process of pushing the coverslips at a time, and avoids confusion of the coverslips placed in the coverslip storage cavity and affecting the smoothness of the pushing. Furthermore, after the coverslip pushing plate is withdrawn from the coverslip storage cavity, the coverslips stored in the coverslip storage cavity move downward under the pressure of the coverslip pressing device, which makes it easier for the coverslip pushing plate to push out the next coverslip.

[0032] According to one embodiment of the present invention, the cover glass push-out channel is horizontally arranged and flush with the bottom of the cover glass storage cavity, and a through groove for fitting the cover glass push plate is provided on the body opposite to the cover glass push-out channel. The cover glass push plate is horizontally arranged and one end of the cover glass push plate can pass through the through groove and extend into the cover glass storage cavity and the cover glass push-out channel. The cover glass push-out channel in this embodiment is horizontally arranged and flush with the bottom of the cover glass storage cavity. After the cover glass push plate is withdrawn from the cover glass storage cavity, the cover glass stored in the cover glass storage cavity moves downward under the pressure of the cover glass pressure device and makes the cover glass at the bottom flush with the cover glass push-out channel, so that the cover glass push plate can be pushed out of the body under the drive of the driving mechanism.

[0033] According to one embodiment of the present invention, the cover glass pressure applying device comprises:

[0034] A support seat is vertically slidably mounted on the body and extends upward, the pressure rod is vertically slidably mounted on the support seat and is located directly above the cover glass storage cavity, the upper end of the pressure rod passes through the support seat, and the lower end can extend into the cover glass storage cavity;

[0035] Spring 2 is sleeved on the pressure rod, the upper end of the pressure rod is provided with a stop plate, the lower end of the pressure rod is provided with a pressure plate, the upper end of the spring 2 is stopped against the lower side of the support seat, and the lower end of the spring 2 is stopped against the upper side of the pressure plate;

[0036] The locking member is used to lock the support base and the main body to fix the support base at different heights, so that the spring 2 installed on the pressure rod produces elastic deformation to apply pressure to the cover glass stored in the cover glass storage cavity.

[0037] The support seat of the present embodiment is vertically slidably mounted on the main body, and the pressure rod is vertically slidably mounted on the support seat and is located directly above the cover glass storage cavity. The upper end of the pressure rod passes through the support seat, and the lower end can be extended into the cover glass storage cavity, and the support seat is locked with the main body by a locking member to fix the support seat at different heights, which is convenient for sliding the support seat upward or adding a cover glass into the cover glass storage cavity after removing the support seat; in addition, a spring is sleeved on the pressure rod, and the fixed height of the support seat is adjusted in the vertical direction, thereby adjusting the degree of compression of the spring two on the cover glass stored in the cover glass storage cavity, so that the degree of compression of the spring two on the cover glass is suitable, which is convenient for the cover glass push plate to push out the cover glass in the cover glass storage cavity, and avoids excessive pressure of the spring two on the slide glass causing the cover glass to break.

[0038] According to one embodiment of the present invention, the intermittent driving device comprises:

[0039] A rack fixedly connected to the lower side of the slide placement plate;

[0040] An incomplete gear, used for matching and meshing with the rack, and corresponding to the rack, arranged just below the slide placement plate;

[0041] A drive motor is fixedly connected to the support frame and is located directly below the slide placement plate. The end face of the output shaft of the drive motor is connected to the incomplete gear. The drive motor is electrically connected to the microprocessor.

[0042] The intermittent driving device in this embodiment includes a rack, a non-complete gear meshing with the rack, and a driving motor that drives the non-complete gear to rotate, the rack being fixedly connected to the lower side of the slide placement plate, and under the drive of the driving motor, the non-complete gear intermittently meshes with the rack, so that when the slide placement plate is intermittently driven to slide to the bottom of the sealing glue dripping device, the non-complete gear rotates to the non-gear part, the non-complete gear disengages from the rack, the slide placement plate pauses and drips sealing glue on the tissue sections placed on the slide, and when the slide placement plate is slid to the bottom of the cover glass placement device, the non-complete gear rotates to the non-gear part, the non-complete gear disengages from the rack, the slide placement plate pauses and covers the tissue sections placed on the slide with a cover glass, which is conducive to automatically dripping sealing glue and automatically covering the tissue sections placed on the slide.

[0043] According to one embodiment of the present invention, the tissue section sealing device further comprises:

[0044] The suspension beam comprises a first suspension beam and a second suspension beam, the first suspension beam and the second suspension beam are arranged in parallel, the two ends of the first suspension beam and the second suspension beam are respectively slidably mounted on the left and right ends of the support frame, and can slide in the front and rear directions relative to the slide placement plate, a plurality of the sealing glue dripping devices are installed on the first suspension beam at intervals, and a plurality of the cover glass placing devices are installed on the first suspension beam at intervals.

[0045] This embodiment is provided with a suspension beam, and the suspension beam is slidably installed on the support frame, so that the position of the suspension beam can be adjusted by sliding the suspension beam in the front-to-back direction, and the position of the sealing glue dripping device and the cover glass placing device can be adjusted in the front-to-back direction.

[0046] According to one embodiment of the present invention, the support frame comprises:

[0047] Bottom support plate;

[0048] A plurality of vertical support rods are provided, wherein the plurality of vertical support rods are vertically connected to the rear end of the bottom support plate and extend upward to form an extension end;

[0049] A crossbeam connected to the extended ends of the plurality of vertical support rods;

[0050] Two supporting longitudinal beams are provided, the two supporting longitudinal beams are connected to the left and right ends of the cross beam and extend forward to form extended ends, and the two ends of the suspension beam are slidably mounted on the supporting longitudinal beams;

[0051] The placement plate mounting seat is located at the front part of the vertical support rod, and the slide placement plate is detachably mounted on the placement plate mounting seat.

[0052] The support frame of this embodiment includes two supporting longitudinal beams connected to the left and right ends of the horizontal beam, which is convenient for the sliding installation of the suspension beam and the longitudinal sliding of the suspension beam; in addition, the support frame also includes a placement plate mounting seat, which is convenient for installing the slide placement plate under the suspension beam, and is conducive to the sealing glue dripping device installed on the suspension beam to drip glue on the tissue section, so as to place a cover glass on the tissue section for sealing. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] In order to more clearly illustrate the technical solutions in the present invention, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0054] Figure 1 It is a structural schematic diagram of a tissue section sealing device according to an embodiment of the present invention;

[0055] Figure 2 for Figure 1 Front view after straightening;

[0056] Figure 3 for Figure 2 A top view of

[0057] Figure 4 for Figure 2 Right view of;

[0058] Figure 5 for Figure 2 Left view of

[0059] Figure 6 This is a schematic structural diagram of a sealing glue dripping device according to an embodiment of the present invention;

[0060] Figure 7 A cross-sectional view of a sealing glue dispensing device according to an embodiment of the present invention;

[0061] Figure 8 It is a structural schematic diagram of a cover glass placing device according to an embodiment of the present invention;

[0062] Fig. 9 4 is a cross-sectional view of a cover glass placing device according to an embodiment of the present invention.

[0063] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0064] 1. Support frame, 2. Sealing glue dripping device, 3. Cover glass placing device, 4. Locking piece 1, 5. Locking piece 2, 6. Slide placement plate, 7. Locking piece 3, 8. Electric push rod 1, 9. Intermittent drive device, 10. Bottom support plate, 11. Vertical support rod, 12. Crossbeam, 13. Support longitudinal beam, 14. Sliding mounting seat, 15. First suspension beam, 16. Second suspension beam, 17. Placement plate mounting seat, 18. Horizontal support beam, 20. Upper shell, 21. Lower shell, 22. Sealing glue conveyor tube, 23, sealing glue suction and discharge device, 30, body, 31, cover glass push device, 32, cover glass pressure device, 33, locking member 4, 34, spring 2, 35, connecting structure, 36, cover glass, 60, slide mounting groove, 61, slider, 62, rack, 90, drive motor, 91, output shaft, 92, non-complete gear, 131, slide rail, 171, bottom plate, 172, support rod, 173, placement plate mounting plate, 174, guide rail, 175, motor mounting plate, 201, vertical connecting rod, 202, locking hole, 203, horizontal connecting plate, 204, sealing glue adding port plug, 205, sealing glue storage chamber, 221, input pipe, 222, connecting elbow, 223, first one-way valve, 224, three-way connecting pipe, 225, second one-way valve, 226, output nozzle, 231, suction and discharge pipe, 232, piston, 233, sealing glue suction and discharge chamber, 234, limit connecting pipe, 235, stop plate, 236, spring 1, 237, push-pull rod, 238, limit plate, 239 , connecting plate one, 301, extension plate, 302, cover glass storage cavity, 303, cover glass delivery nozzle, 304, cover glass push-out channel, 305, slide groove, 306, protective cover, 311, electric push rod two, 312, push rod, 313, cover glass push plate, 321, support slide plate, 322, limit guide rail, 323, horizontal support plate, 324, pressure rod, 325, stop plate, 326, pressure plate, 351, horizontal connecting plate one, 352, vertical connecting plate, 353, horizontal connecting plate two. DETAILED DESCRIPTION

[0065] In order to make the objectives, technical solutions and advantages of the present application clearer, the implementation methods of the present application will be further described in detail below with reference to the accompanying drawings.

[0066] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0067] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited to the specific embodiments disclosed below.

[0068] The present disclosure provides a tissue section sealing device, such as Figures 1 to 5 As shown, it includes: a support frame 1; a slide placement plate 6, which is used to place a slide with a tissue section, and is linearly slidably installed on the support frame 1; a sealing glue dripping device 2, which is used to drip a certain amount of sealing glue on the tissue section placed on the slide, and a plurality of sealing glue dripping devices 2 are provided, and the plurality of sealing glue dripping devices 2 are installed on the support frame 1 at intervals and are located above the slide placement plate 6; a cover glass placing device 3, which is used to cover the tissue section placed on the slide with a certain amount of sealing glue dripped, and the cover glass placing device 3 is provided with a plurality of cover glass placing devices. 3 are installed on the support frame 1 and are located above the slide placement plate 6; an intermittent driving device 9 is used to drive the slide placement plate 6 to slide intermittently on the support frame 1, and a plurality of intermittent driving devices 9 are provided. The plurality of intermittent driving devices 9 cooperate to sequentially slide the plurality of slide placement plates 6 to the bottom of the sealing glue dripping device 2 to drip the sealing glue, and slide the slide placement plate 6 to the bottom of the cover glass placing device 3 to cover the cover glass 36; a microprocessor, the sealing glue dripping device 2, the cover glass placing device 3 and the intermittent driving device are electrically connected to the microprocessor respectively.

[0069] In this embodiment, if Figures 1 to 5As shown, a plurality of sealing glue dripping devices 2 for dripping a certain amount of sealing glue to tissue sections placed on glass slides are provided on the support frame 1, and the sealing glue dripping devices 2 are electrically connected to the microprocessor, so as to facilitate dripping a certain amount of sealing glue to multiple tissue sections, reduce the influence of human factors on the dripped sealing glue, accurately drip a certain amount of sealing glue, avoid dripping too much or too little sealing glue, and improve the quality of sealing. In addition, by providing a plurality of cover glass placing devices 3 for adding cover glass 36 to the tissue sections placed on the slide after the quantitative cover glass glue is dripped, the cover glass placing devices 3 are electrically connected to the microprocessor, and the cover glass 36 is placed on the cover glass glue on the tissue section through the cover glass placing devices 3, which is conducive to avoiding the safety hazard of scratching the operator by picking up the cover glass 36; further, the slide placement plates 6 in this embodiment are driven by the intermittent driving device 9 electrically connected to the microprocessor to slide the plurality of slide placement plates 6 to the right below the cover glass glue dripping device 2 to drip the cover glass glue, and slide the slide placement plates 6 to the right below the cover glass placing device 3 to cover the cover glass 36, which is conducive to realizing the automatic dripping of cover glass glue and automatic covering of cover glass 36 on the tissue sections placed on the slide. Further, the cover glass glue dripping device 2 and the cover glass placing device 3 in this embodiment can work simultaneously, which is conducive to improving the sealing efficiency.

[0070] In this embodiment, if Figures 1 to 5 As shown, the slide placement plate 6 is linearly slidably mounted on the support frame 1, and can slide to the position directly below the sealing glue dripping device 2 and the cover glass placing device 3. In this embodiment, the slide placement plate 6 is linearly slidably mounted on the support frame 1, so that the slides and tissue sections mounted on the slide placement plate 6 are moved to the position directly below the sealing glue dripping device 2 and the cover glass placing device 3 by moving the slide placement plate 6, so that it is convenient to drip sealing glue on the tissue sections and cover the tissue sections with the cover glass 36.

[0071] In this embodiment, the support frame 1 of this embodiment includes a placement plate mounting seat 17, the placement plate mounting seat 17 is located at the front of the vertical support rod 11, and a plurality of guide rails 174 are provided on the placement plate mounting seat 17. The bottom of the slide placement plate 6 is provided with a plurality of sliders 61 corresponding to the guide rails 174 and adapted to slide with the guide rails 174. The slide placement plate 6 is mounted on the plurality of sliders 61. The guide rails 174 in this embodiment are in a T-shaped structure. The placement plate mounting seat 17 in this embodiment passes through the support frame 1 in the front-to-back direction, so as to facilitate moving the slide placement plate 6 forward from the rear end of the placement plate mounting seat 17, so as to drip the sealing glue on the tissue slices and cover the tissue slices with the cover glass 36.

[0072] One embodiment of the present invention, as Figure 6 and Figure 7As shown, the sealing glue dripping device 2 includes: a shell, a sealing glue storage chamber 205 for storing sealing glue is provided in the shell; a sealing glue delivery tube 22, the two ends of the sealing glue delivery tube 22 are respectively an input end and an output end, the input end extends into the sealing glue storage chamber 205 and is communicated with the sealing glue storage chamber 205, and the output end passes through the shell; a sealing glue suction and discharge device 23, used to suck the sealing glue stored in the sealing glue storage chamber 205 into the sealing glue delivery tube 22 and output the sealing glue sucked into the sealing glue tube from the sealing glue delivery tube 22, the sealing glue suction and discharge device 23 is connected to the sealing glue delivery tube 22 and is communicated with the sealing glue delivery tube 22, and the sealing glue suction and discharge device 23 is electrically connected to the microprocessor; a first one-way valve 223, connected to the sealing glue delivery tube 22, and located at the output The one-way valve 223 is between the input end and the connection between the sealing glue suction and discharge device 23 and the sealing glue delivery tube 22, and the one-way conduction direction of the first one-way valve 223 is from the input end to the connection between the sealing glue suction and discharge device 23 and the sealing glue delivery tube 22; the second one-way valve 225 is connected to the sealing glue delivery tube 22, and is located between the output end and the connection between the sealing glue suction and discharge device 23 and the sealing glue delivery tube 22, and the one-way conduction direction of the second one-way valve 225 is from the connection between the sealing glue suction and discharge device 23 and the sealing glue delivery tube 22 to the output end; the first one-way valve 223 and the second one-way valve 225 are alternately turned on and off under the action of the sealing glue suction and discharge device 23, and a certain amount of sealing glue is output from the output end of the sealing glue delivery tube 22 after completing an alternating process of turning on and off.

[0073] In this embodiment, if Figure 7 As shown, a sealing glue storage chamber 205 for storing sealing glue is provided in the housing, so that the sealing glue is stored in the housing. A first one-way valve 223 and a second one-way valve 225 are connected to the sealing glue delivery pipe, and a sealing glue suction and discharge device 23 is connected between the first one-way valve 223 and the second one-way valve 225. The sealing glue stored in the sealing glue storage chamber 205 is sucked into the sealing glue delivery pipe 22 and the sealing glue is delivered through the sealing glue suction and discharge device 23. The first one-way valve 223 and the second one-way valve 225 are alternately operated under the action of the sealing glue suction and discharge device 23. The sealing glue delivery tube 22 is turned on and off, and after completing an alternating process of turning on and off, a certain amount of sealing glue is output from the output end of the sealing glue delivery tube 22, so that the driving mechanism can be driven once or several times to output an appropriate amount of sealing glue and drip it on the tissue slices, so as to place a cover glass 36 on the tissue slices for sealing, so that the amount of sealing glue dripped on the tissue slices is appropriate and the added amount can be controlled, avoiding excessive or insufficient dripping of sealing glue, which is beneficial to improving the quality of sealing and, at the same time, improving the consistency of sealing of tissue slices.

[0074] In this embodiment, if Figure 7As shown, the input end of the sealing glue delivery tube 22 is specifically an input tube 221, the rear end of the input tube 221 is connected to a connecting elbow 222, the rear end of the connecting elbow 222 is connected to a first one-way valve 223, the rear end of the first one-way valve 223 is connected to a three-way connecting tube 224, the sealing glue suction and discharge device 23 is connected to one branch of the three-way connecting tube 224, the rear end of the other branch of the three-way connecting tube 224 is connected to a second one-way valve 225, the rear end of the second one-way valve 225 is connected to an output nozzle 226, and the output nozzle 226 in this embodiment serves as the output end.

[0075] In this embodiment, if Figure 7 As shown, in order to facilitate adding sealing glue into the sealing glue storage cavity 205, a sealing glue adding port is provided on the upper side of the upper shell 20, and the sealing glue adding port is blocked by a sealing glue adding port plug 204.

[0076] One embodiment of the present invention, as Figure 7 As shown, the sealing glue suction and discharge device 23 includes a suction and discharge pipe 231 and a driving mechanism for enabling the suction and discharge pipe 231 to suction and discharge the sealing glue, one end of the suction and discharge pipe 231 is connected to the sealing glue delivery pipe and communicates with the sealing glue delivery pipe 22, one end of the suction and discharge pipe 231 is connected to the sealing glue delivery pipe 22 and communicates with the sealing glue delivery pipe 22, and the driving mechanism drives the suction and discharge pipe 231 to suction and discharge the sealing glue. The sealing glue suction and discharge device 23 in this embodiment includes a suction and discharge pipe 231 and a driving mechanism for enabling the suction and discharge pipe 231 to suction and discharge the sealing glue, so that the suction and discharge pipe 231 is driven by the driving mechanism to suction and discharge the sealing glue.

[0077] One embodiment of the present invention, as Figure 7 As shown, a sealing glue suction and discharge chamber 233 is provided in the suction and discharge pipe 231, and the volume of the sealing glue suction and discharge chamber 233 is equal to the volume of the sealing glue required for one sealing or several times the volume of the sealing glue suction and discharge chamber 233 is equal to the volume of the sealing glue required for one sealing; the driving mechanism includes: a piston 232, which is adapted to be slidably installed in the sealing glue suction and discharge chamber 233 of the suction and discharge pipe 231; a push-pull rod 237, one end of which is connected to the piston 232, and the other end extends outwardly through the shell to form an extended end.

[0078] In this embodiment, if Figure 7As shown, the driving mechanism includes a piston 232, a push rod 312 and an electric push rod. The piston 232 is adapted to be installed in the sealing glue suction and discharge chamber 233. One end of the push-pull rod 237 is connected to the piston 232, and the other end passes through the shell. The electric push rod pushes and pulls the push-pull rod 237 to drive the piston 232 to move. The electric push rod pulls the push-pull rod 237 outward from the shell, and the piston 232 moves outward by a certain displacement. The sealing glue between the first one-way valve 223 and the second one-way valve 225 is adsorbed, while the second one-way valve 225 is closed, the first one-way valve 223 is opened, and a certain amount of sealing glue enters the sealing glue output pipe between the first one-way valve 223 and the second one-way valve 225; when the electric push rod pushes the push rod 312 into the shell, the piston 232 moves forward to restore the original position, and the sealing glue between the first one-way valve 223 and the second one-way valve 225 is squeezed, while the first one-way valve 223 is closed, the second one-way valve 225 is opened, and a certain amount of sealing glue is output from the output end of the sealing glue output pipe; thereby, the amount of sealing glue dripped on the tissue section is appropriate and the amount added can be controlled by pushing and pulling the push rod 312 by the electric push rod, so as to avoid excessive or insufficient dripping of sealing glue. The electric push rod in this embodiment is an electric push rod 8, and the telescopic rod on the electric push rod 8 is coaxially arranged with the push rod 312. The electric push rod 8 in this embodiment is fixed to the front part of the support frame 1. Furthermore, the electric push rod 8 is specifically fixedly connected to the horizontal support beam 18. The two ends of the horizontal support beam 18 in this embodiment are respectively fixedly connected to the lower side of the supporting longitudinal beam 13 at the left and right ends of the support frame 1.

[0079] One embodiment of the present invention, as Figure 7 As shown, two limiting protrusions are provided in the suction and discharge pipe 231, and the limiting protrusions are connected to the inner wall of the suction and discharge pipe 231 and protrude into the suction and discharge pipe 231, and a sealing adhesive suction and discharge cavity 233 is defined between the two limiting protrusions. In this embodiment, a sealing adhesive suction and discharge cavity 233 is defined between the two limiting protrusions, and the piston 232 is adapted to be installed in the sealing adhesive suction and discharge cavity 233. The two limiting protrusions limit the piston 232, and limit the displacement of the piston 232, so that the amount of sealing adhesive discharged each time is the same.

[0080] One embodiment of the present invention, as Figure 7As shown, a limit plate 238 is provided on the push rod 312, and a spring 236 is installed between the limit plate 238 and the sealing glue delivery tube 22. The spring 236 is sleeved on the push-pull rod 237, and one end of the spring 236 is stopped on the push-pull rod 237, and the other end is stopped on the suction and discharge tube 231 or the sealing glue delivery tube 22. In this embodiment, a spring 236 is installed between the limit plate 238 and the sealing glue delivery tube 22. The spring 236 is sleeved on the push-pull rod 237, and the push-pull rod 237 is pressed to push the push-pull rod 237 into the shell. The spring 236 is subjected to pressure and elastically deforms, and the piston 232 moves forward and squeezes the sealing glue. When the push-pull rod 237 is released, the spring 236 recovers its elasticity, and the push rod 312 is reset. The piston 232 is reset and a certain amount of sealing glue is sucked into the sealing glue delivery tube 22, which is convenient for the next push rod 312 operation, so that the piston 232 squeezes the sealing glue and outputs a certain amount of sealing glue. Further, the spring 1 of this embodiment can buffer the thrust and tension of the electric push rod, which is conducive to improving the uniformity of dripping the sealing glue. Further, a connecting plate 1 239 is provided on the extended end of the push rod of this embodiment, and a connecting plate 2 is provided at the end of the telescopic rod of the electric push rod. The connecting plate 1 239 and the connecting plate 2 are fixedly connected by bolts.

[0081] In this embodiment, if Figure 7 As shown, the left end of the suction and discharge pipe 231 is connected to the three-way connecting pipe 224, and the right end is connected to the limit connecting pipe 234. The limit connecting pipe 234 of this embodiment is provided with a limit protrusion, and the left end of the suction and discharge pipe 231 is provided with a limit protrusion. The sealing glue suction and discharge cavity 233 is defined between the limit connecting pipe 234 and the suction and discharge pipe 231. Further, in this embodiment, a limit plate 238 is provided at the extended end of the push-pull rod 237, and a stop plate 235 is installed at the right end of the limit connecting pipe 234. One end of the spring 236 stops on the stop plate 235, and the other end stops on the limit plate 238. Further, the limit plate 238 in this embodiment is specifically a disc-shaped structure.

[0082] In this embodiment, if Figure 6 and Figure 7 As shown, the housing includes an upper housing 20 and a lower housing 21, the sealing glue storage chamber 205 is provided in the upper housing 20, the sealing glue delivery pipe 22 is installed in the lower housing 21, and the output end of the sealing glue delivery pipe 22 passes through the lower end of the lower housing 21. In this embodiment, the housing includes an upper housing 20 and a lower housing 21, which is convenient for installing the delivery pipe and the first one-way valve 223 and the second one-way valve 225 in the lower housing 21. Further, the lower housing 21 in this embodiment is detachably installed at the lower end of the upper housing 20.

[0083] One embodiment of the present invention, as Figure 8 and Fig. 9As shown, the cover glass placing device 3 comprises: a body 30, wherein a cover glass storage cavity 302 for storing cover glass 36 is provided in the body 30, and a cover glass pushing channel 304 for sequentially passing a single cover glass 36 is also provided in the body 30, wherein one end of the cover glass pushing channel 304 is connected to the cover glass storage cavity 302, and the other end extends out of the body 30; a cover glass pushing device 31 for pushing the cover glass 36 stored in the cover glass storage cavity 302 out of the cover glass pushing channel 304, and the cover glass pushing device 31 comprises a cover glass pushing plate 3 13 and a driving mechanism for driving the cover glass push plate 313 to move linearly, one end of the cover glass push plate 313 is connected to the driving mechanism, and the other end can be extended into and withdrawn from the cover glass push channel 304 and the cover glass storage cavity 302 under the drive of the driving mechanism; a cover glass pressing device 32 is used to pressurize the cover glass 36 stored in the cover glass storage cavity 302 to flatten the cover glass 36 and make multiple cover glasses 36 close together, and a pressing rod 324 is provided on the cover glass pressing device 32, and the pressing rod 324 can be extended into the cover glass storage cavity 302.

[0084] In this embodiment, if Figure 8 and Fig. 9 As shown, by providing a cover glass storage cavity 302 in the main body 30, it is convenient to store the cover glass 36 in the main body 30; by providing a cover glass pushing device 31, the cover glass 36 stored in the cover glass storage cavity 302 is pushed out from the cover glass pushing channel 304. The cover glass pushing device 31 includes a cover glass pushing plate 313 and a driving mechanism for driving the cover glass pushing plate 313 to move linearly. Driven by the driving mechanism, the cover glass pushing plate 313 can push out the cover glass 36 stored in the cover glass storage cavity 302 in turn, thereby facilitating the cover glass 36 to be pushed out from the cover glass pushing channel 304 and placed on the sealing glue on the tissue section, which is beneficial to avoid the safety hazard of scratching the operator when the operator picks up the cover glass 36. In addition, by providing a cover glass pressing device 32 for applying pressure to the cover glass 36 stored in the cover glass storage cavity 302 to flatten the cover glass 36 and make multiple cover glasses 36 fit tightly together, it is beneficial for multiple cover glasses 36 to fit tightly together and ensure that the cover glass pushing plate 313 only pushes out one cover glass 36 in the process of pushing the cover glass 36 at a time, and avoids the cover glasses 36 placed in the cover glass storage cavity 302 being in a mess and affecting the smoothness of the push. Furthermore, after the cover glass pushing plate 313 is withdrawn from the cover glass storage cavity 302, the cover glass 36 stored in the cover glass storage cavity 302 moves downward under the pressure of the cover glass pressing device 32, which facilitates the cover glass pushing plate 313 to push out the next cover glass 36.

[0085] In this embodiment, if Figure 8 and Fig. 9As shown, in order to facilitate the installation and fixation of the cover glass placing device 3, this embodiment provides a connection structure 35 on one side of the body 30, and the connection structure 35 is specifically connected to the upper end of the rear side of the body 30. The connection structure 35 in this embodiment includes a horizontal connection plate 1 351, a vertical connection plate 352 and a horizontal connection plate 2 353. One end of the horizontal connection plate 1 351 is horizontally fixedly connected to the rear side of the body 30, the vertical connection plate 352 is vertically fixedly connected to the upper side of the horizontal connection plate 1 351, and the horizontal connection plate 2 353 is horizontally connected to the upper end of the vertical connection plate 352; the horizontal connection plate 2 353 can be fixed to other mechanisms to fix and install the cover glass placing device 3; further, the connection structure 35 in this embodiment can also be other structures, and the cover glass placing device 3 can also be fixedly connected to other mechanisms in other ways.

[0086] In this embodiment, if Figure 8 and Fig. 9 As shown, in order to better push the cover glass 36 onto the sealing glue of the tissue section on the slide, a cover glass delivery nozzle 303 is provided in the cover glass delivery channel 304 of this embodiment, and the cover glass delivery nozzle 303 protrudes from the main body 30.

[0087] One embodiment of the present invention, as Figure 8 and Fig. 9 As shown, the cover glass push-out channel 304 is horizontally arranged and flush with the bottom of the cover glass storage cavity 302, and a through slot for fitting the cover glass push plate 313 is provided on the body 30 opposite to the cover glass push-out channel 304. The cover glass push plate 313 is horizontally arranged and one end thereof can pass through the through slot and extend into the cover glass storage cavity 302 and the cover glass push-out channel 304. The cover glass push-out channel 304 in this embodiment is horizontally arranged and flush with the bottom of the cover glass storage cavity 302. After the cover glass push plate 313 is withdrawn from the cover glass storage cavity 302, the cover glass 36 stored in the cover glass storage cavity 302 moves downward under the pressure of the cover glass pressure device 32 and makes the cover glass 36 at the bottom flush with the cover glass push-out channel 304, so that the cover glass push plate 313 is driven by the driving mechanism to push out the body 30.

[0088] In this embodiment, the driving mechanism is the second electric push rod 311, and the cover glass push plate 313 is connected to the push rod 312 of the second electric push rod 311. This embodiment uses the second electric push rod 311 as the driving mechanism, which has a simple structure and is conducive to reliably driving the cover glass push plate 313 to extend into and withdraw from the cover glass storage cavity 302 and the cover glass push channel 304 to push out the cover glass 36. Furthermore, in order to protect the push rod 312 on the second electric push rod 311, this embodiment provides a protective cover 306 at the rear end of the body 30, and the protective cover 306 is provided on the push rod 312 on the second electric push rod 311.

[0089] One embodiment of the present invention, as Figure 8 and Fig. 9 As shown, the cover glass pressure applying device 32 includes:

[0090] The support seat is vertically slidably mounted on the main body 30 and extends upward. The pressure rod 324 is vertically slidably mounted on the support seat and is located directly above the cover glass storage cavity 302. The upper end of the pressure rod 324 passes through the support seat, and the lower end can extend into the cover glass storage cavity 302; the second spring 34 is sleeved on the pressure rod 324. The upper end of the pressure rod 324 is provided with a stop plate 325, and the lower end of the pressure rod 324 is provided with a pressure plate 326. The upper end of the second spring 34 stops at the lower side of the support seat, and the lower end of the second spring 34 stops at the upper side of the pressure plate 326; the locking piece is used to lock the support seat and the main body 30 to fix the support seat at different heights, so that the second spring 34 installed on the pressure rod 324 produces elastic deformation to apply pressure to the cover glass 36 stored in the cover glass storage cavity 302.

[0091] In this embodiment, if Figure 8 and Fig. 9 As shown, the support seat is vertically slidably installed on the main body 30, and the pressure rod 324 is vertically slidably installed on the support seat and is located directly above the cover glass storage cavity 302. The upper end of the pressure rod 324 passes through the support seat, and the lower end can extend into the cover glass storage cavity 302, and the support seat is locked with the main body 30 by a locking member to fix the support seat at different heights, which is convenient for sliding the support seat upward or removing the support seat to add a cover glass 36 into the cover glass storage cavity 302; in addition, a spring 2 34 is sleeved on the pressure rod 324, and the fixed height of the support seat is adjusted in the vertical direction, thereby adjusting the degree of compression of the spring 2 34 on the cover glass storage cavity 302, so that the compression degree of the spring 2 34 on the cover glass 36 is suitable, which is convenient for the cover glass push plate 313 to push out the cover glass 36 in the cover glass storage cavity 302, and avoid excessive pressure of the spring 2 34 on the slide glass to cause the cover glass 36 to break. In this embodiment, the locking member used to lock the support seat and the main body 30 is a locking member 33, and the locking member 33 is a tightening bolt.

[0092] In this embodiment, if Figures 1 to 5As shown, the support seat includes a support slide 321, a limiting guide rail 322 and a horizontal support plate 323. The support slide 321 is slidably mounted on the right side of the body 30. The limiting guide rail 322 is provided on the left side of the support slide 321. The limiting guide rail 322 is in a T-shaped structure. The right side of the body 30 is provided with a slide groove 305 for slidingly connecting with the limiting guide rail 322. The slide groove 305 is in a T-shaped structure and is opened downward from the upper surface of the body 30. Further, in this embodiment, a horizontal support plate 323 is horizontally connected to the left side of the limiting guide rail 322, and the upper end of the pressure rod 324 passes through the horizontal support plate 323.

[0093] In this embodiment, if Figures 1 to 5 As shown, the intermittent drive device includes: a rack 62, fixedly connected to the lower side of the slide placement plate 6; an incomplete gear, used to adapt and mesh with the rack 62, and the corresponding rack 62 is arranged directly below the slide placement plate 6; a drive motor 90, fixedly connected to the support frame 1 and located directly below the slide placement plate 6, the end face of the output shaft 91 of the drive motor 90 is connected to the incomplete gear 92, and the drive motor 90 is electrically connected to the microprocessor.

[0094] In this embodiment, Figures 1 to 5As shown, the intermittent drive device includes a rack 62, a non-complete gear 92 meshing with the rack 62, and a drive motor 90 for driving the non-complete gear 92 to rotate. The rack 62 is fixedly connected to the lower side of the slide placement plate 6. Under the drive of the drive motor 90, the non-complete gear 92 is intermittently meshed with the rack 62, so that the slide placement plate 6 is intermittently driven to slide to the bottom of the sealing glue dripping device 2. The non-complete gear 92 rotates to the non-gear part, and the non-complete gear 92 is disengaged from the rack 62, and the slide placement plate 6 is intermittently driven. The slide placement plate 6 stops moving and drips the sealing glue on the tissue slice placed on the slide; in addition, when the driving motor 90 slides the slide placement plate 6 to the right below the cover glass placement device 3, the incomplete gear 92 rotates to the non-gear part, the incomplete gear 92 is disengaged from the rack 62, the slide placement plate 6 stops moving and covers the tissue slice placed on the slide with the cover glass 36, which is conducive to automatically dripping the sealing glue and automatically covering the tissue slice placed on the slide. It should be noted that the number of teeth and size of the incomplete gear 92 shown in the figure in this embodiment are only for illustration purposes and do not represent the actual size. The spacing between the slide placement plates 6 shown in the figure in this embodiment is also only for illustration purposes and does not represent the actual spacing. The number of teeth and size of the incomplete gear 92 can be various, and the incomplete gear 92 can drive the slide placement plate 6 to intermittently add the sealing glue and cover the cover glass in sequence. Furthermore, the intermittent driving device in this embodiment can also be composed of a stepper motor, a gear and a rack structure. The controller controls the stepper motor to intermittently drive the gear to achieve intermittent driving of the slide placement plate, which is convenient for automatically adding sealing glue to the tissue sections and automatically covering the coverslip 36. In addition, the intermittent driving device can also be other intermittent driving mechanisms.

[0095] In this embodiment, if Figure 2 , Figure 3 As shown, the drive motor 90 is fixedly connected to the motor mounting plate 175, the upper end of the motor mounting plate 175 is fixedly connected to the placement plate mounting plate 173, and the lower end extends vertically downward. The drive motor 90 is fixedly connected to the lower part of the motor mounting plate 175, and the output shaft 91 of the drive motor 90 passes through the motor mounting plate 175; further, the motor mounting plate 175 in this embodiment is connected to the lower side surface of the placement plate mounting plate 173, thereby, an avoidance groove for avoiding the non-complete gear 92 is opened on the placement plate mounting plate 173, and the motor mounting plate 175 in this embodiment is connected to the middle position of the placement plate mounting plate 173, and the avoidance groove is arranged in the middle position of the placement plate mounting plate 173.

[0096] One embodiment of the present invention, as Figures 1 to 5As shown, the tissue section sealing device also includes: a suspension beam, the suspension beam includes a first suspension beam 15 and a second suspension beam 16, the first suspension beam 15 and the second suspension beam 16 are arranged in parallel, the two ends of the first suspension beam 15 and the second suspension beam 16 are slidably mounted on the left and right ends of the support frame 1 respectively, and can slide in the front and rear directions relative to the slide placement plate 6, a plurality of sealing glue dripping devices 2 are installed at intervals on the first suspension beam 15, and a plurality of cover glass placement devices 3 are installed at intervals on the second suspension beam 16. In this embodiment, a plurality of slide mounting grooves 60 for mounting multiple slides with tissue sections are arranged at intervals on the slide placement plate 6. It should be noted that the slides and tissue sections placed on the slide placement plate 6 in this embodiment are not shown in the figure.

[0097] In this embodiment, if Figures 1 to 5 As shown, by providing a first suspension beam 15 and a second suspension beam 16, and the first suspension beam 15 and the second suspension beam 16 are slidably installed on the support frame 1, it is convenient to slide the first suspension beam 15 and the second suspension beam 16 in the front-rear direction to adjust the position of the suspension beam, and it is convenient to adjust the position of the sealing glue dripping device 2 and the cover glass placing device 3 in the front-rear direction.

[0098] The first suspension beam 15 and the second suspension beam 16 are provided with a plurality of installation openings for installing the sealing glue dripping device 2 at intervals, and the installation openings are horizontally opened along the width direction of the first suspension beam 15 and the second suspension beam 16. In addition, in order to facilitate the installation of the sealing glue dripping device 2, the present embodiment provides a vertical connecting rod 201 on the sealing glue dripping device 2, the lower end of the vertical connecting rod 201 is fixedly connected to the upper shell 20 of the sealing glue dripping device 2, and the upper end of the vertical connecting rod 201 vertically extends upward to form an extended end; and a horizontal connecting plate 203 is connected to the extended end of the vertical connecting rod 201, one end of the horizontal connecting plate 203 is connected to the upper end of the vertical connecting rod 201, and the other end extends horizontally to form a free end, the shape of the free end of the horizontal connecting plate 203 is adapted to the installation opening, and the free end of the horizontal connecting plate 203 is adapted to be inserted in the installation opening. Furthermore, in order to facilitate the fixation of the sealing glue dripping device 2, the present embodiment locks the sealing glue dripping device 2 by means of a locking member 4, and a threaded hole 1 is provided on the upper side of the first suspension beam 15 and the second suspension beam 16, and the threaded hole 1 is connected to the installation port, and the locking member 4 in the present embodiment is a locking bolt. Furthermore, a locking hole 202 is provided on the horizontal connecting plate 203 corresponding to the threaded hole 1, and the locking member 4 is screwed and connected to the threaded hole 1 and extends into the locking hole 202, thereby fixing the sealing glue dripping device 2 on the first suspension beam 15 and the second suspension beam 16. It should be noted that the sealing glue dripping device 2 in the present embodiment can also be fixedly connected to the first suspension beam 15 and the second suspension beam 16 by other means, which will not be described in detail here.

[0099] One embodiment of the present invention, as Figures 1 to 5 As shown, the support frame 1 includes: a bottom support plate 10; a plurality of vertical support rods 11, which are vertically connected to the rear end of the bottom support plate 10 and extend upward to form an extended end; a cross beam 12, which is connected to the extended ends of the plurality of vertical support rods 11; a supporting longitudinal beam 13, which is two, which are connected to the left and right ends of the cross beam 12 and extend forward to form an extended end, and both ends of the suspension beam are slidably installed on the supporting longitudinal beams 13; a placing plate mounting seat 17, which is located at the front part of the vertical support rod 11, and the slide placing plate 6 is detachably installed on the placing plate mounting seat 17.

[0100] In this embodiment, if Figures 1 to 5 As shown, the support frame 1 includes two supporting longitudinal beams 13 connected to the left and right ends of the horizontal beam 12, which is convenient for the sliding installation of the suspension beam and the longitudinal sliding of the suspension beam; in addition, the support frame 1 also includes a placement plate mounting seat 17, which is convenient for installing the slide placement plate 6 under the suspension beam, and is conducive to the sealing glue dripping device 2 installed on the suspension beam to drip glue on the tissue section, so as to place a cover glass 36 on the tissue section for sealing.

[0101] In this embodiment, if Figures 1 to 5 As shown, the placement plate mounting seat 17 includes a base plate 171 and a support rod 172 vertically connected to the base plate 171, a plurality of support rods 172 are provided, and a placement plate mounting plate 173 is mounted on the upper ends of the plurality of support rods 172, and the slide placement plate 6 is mounted on the placement plate mounting plate 173.

[0102] In this embodiment, if Figures 1 to 5As shown, a slide rail 131 is provided on the upper side of the supporting longitudinal beam 13, and a slide mounting seat 14 is slidably mounted on the slide rail 131, and the two ends of the suspension beam are respectively mounted on the slide mounting seat 14. Further, the slide mounting seat 14 in this embodiment is provided with a mounting hole for fitting the suspension beam, and the two ends of the suspension beam are respectively fitted and inserted in the mounting holes. In addition, the suspension beam is locked on the slide mounting seat 14 by a locking member 5, and a threaded hole 2 connected to the mounting hole is provided on the upper side of the slide mounting seat 14, and the locking member 2 5 is threadedly connected in the threaded hole 2 and extends into the mounting hole, and the locking member 2 5 is a locking bolt. Furthermore, the lower end of the sliding mounting seat 14 of the present embodiment is a guide slot, and the guide slot is adapted to be slidably connected with the slide rail 131. In order to lock the sliding mounting seat 14 at different positions of the supporting longitudinal beam 13, a threaded hole three connected to the mounting hole is provided on the left or right side of the sliding mounting seat 14, and the sliding mounting seat 14 is connected to the slide rail 131 by threading the locking member three 7 with the threaded hole three. The locking member three 7 is connected to one side of the sliding mounting seat 14, and the locking member three 7 extends into the guide slot, and the locking member three 7 is tightened. The locking member three 7 squeezes the slide rail 131 to lock the sliding mounting seat 14 on the supporting longitudinal beam 13. It should be noted that the telescopic amount of the electric push rod one 8 in the present embodiment can be appropriately set according to the displacement of the piston to be moved and the distance between the first suspension beam 15 and the electric push rod one 8.

[0103] Specifically, in this embodiment, a plurality of sealing glue dripping devices 2 for dripping a certain amount of sealing glue to tissue sections placed on glass slides are provided on the support frame 1. The sealing glue dripping devices are electrically connected to the microprocessor, which is convenient for dripping a certain amount of sealing glue to multiple tissue sections. This is beneficial to reducing the influence of human factors on the dripped sealing glue, and is beneficial to accurately dripping a certain amount of sealing glue, avoiding dripping too much or too little sealing glue, and is beneficial to improving the quality of the sealing. In addition, a plurality of cover glass placing devices 3 are provided for covering the tissue sections placed on the slides with cover glass 36 after a certain amount of cover glass glue is dripped on them. The cover glass placing devices 3 are electrically connected to the microprocessor. The cover glass 36 is placed on the cover glass glue on the tissue sections by the cover glass placing devices 3, which helps to avoid the safety hazard of scratching the operator by picking up the cover glass 36. Furthermore, the slide placing plates in this embodiment are driven by an intermittent driving device electrically connected to the microprocessor to slide the plurality of slide placing plates to directly below the cover glass glue dripping device to drip the cover glass glue, and slide the slide placing plates to directly below the cover glass placing device to cover them with the cover glass 36, which helps to automatically drip the cover glass glue and automatically cover the cover glass 36 on the tissue sections placed on the slides. Therefore, the tissue section sealing device in the present invention can drip a certain amount of sealing glue and place the cover glass 36 on the tissue section, avoiding excessive or insufficient dripping of sealing glue, improving the sealing quality and sealing efficiency, and facilitating the automation of tissue section sealing.

[0104] In addition, in addition to the technical solutions disclosed in the embodiments of the present invention, the first one-way valve 223, the second one-way valve 225, the electric push rod, the microprocessor and their working principles in the present invention can refer to the conventional technical solutions in the technical field, and these conventional technical solutions are not the focus of the present invention, and the present invention will not describe them in detail here.

[0105] In the present invention, the term "plurality" refers to two or more than two, unless otherwise clearly defined. The terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; "connected" can be a direct connection or an indirect connection through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0106] In the description of the present invention, it is necessary to understand that the directions or positional relationships indicated by the terms "upper", "lower", "front", "rear", etc. are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or unit referred to must have a specific direction, be constructed and operated in a specific orientation, and therefore, cannot be understood as a limitation on the present application.

[0107] In the description of this specification, the description of the terms "one embodiment", "some embodiments", "specific embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0108] The above are only preferred embodiments of the present application and are not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A tissue section sealing device, characterized in that: include: Support frame; A slide placement plate, used for placing slides with tissue sections, and linearly slidably mounted on the support frame; A sealing glue dripping device, used for dripping a quantitative amount of sealing glue onto the tissue slices placed on the glass slide, wherein a plurality of sealing glue dripping devices are provided, and the plurality of sealing glue dripping devices are installed on the support frame at intervals and are located above the glass slide placement plate; A cover glass placing device, used for placing a cover glass on the tissue slice placed on the slide after a certain amount of sealing glue is dripped, wherein a plurality of cover glass placing devices are provided, and the plurality of cover glass placing devices are installed on the support frame at intervals and are located above the slide placing plate; An intermittent driving device is used to drive the glass slide placement plate to intermittently slide on the support frame, and the intermittent driving device is provided with a plurality of them. The plurality of intermittent driving devices cooperate to sequentially slide the plurality of glass slide placement plates to the bottom of the sealing glue dripping device to drip the sealing glue, and slide the glass slide placement plate to the bottom of the cover glass placing device to cover the cover glass; A microprocessor, wherein the sealing glue dispensing device, the cover glass placing device and the intermittent driving device are electrically connected to the microprocessor respectively; The sealing glue dripping device comprises: A housing, wherein a sealing glue storage cavity for storing sealing glue is provided in the housing; A sealing adhesive delivery tube, wherein two ends of the sealing adhesive delivery tube are respectively an input end and an output end, the input end extends into the sealing adhesive storage cavity and is communicated with the sealing adhesive storage cavity, and the output end passes through the housing; a sealing glue suction and discharge device, used for sucking the sealing glue stored in the sealing glue storage chamber into the sealing glue delivery tube and outputting the sealing glue sucked into the sealing glue delivery tube from the sealing glue delivery tube, the sealing glue suction and discharge device is connected to the sealing glue delivery tube and communicated with the sealing glue delivery tube, and the sealing glue suction and discharge device is electrically connected to the microprocessor; a first one-way valve connected to the sealing glue delivery pipe and located between the input end and the connection between the sealing glue suction and discharge device and the sealing glue delivery pipe, wherein the one-way conduction direction of the first one-way valve is from the input end to the connection between the sealing glue suction and discharge device and the sealing glue delivery pipe; A second one-way valve is connected to the sealing glue delivery tube and is located between the output end and the connection between the sealing glue suction and discharge device and the sealing glue delivery tube, wherein the one-way conduction direction of the second one-way valve is from the connection between the sealing glue suction and discharge device and the sealing glue delivery tube to the output end; the first one-way valve and the second one-way valve are alternately turned on and off under the action of the sealing glue suction and discharge device, and a fixed amount of sealing glue is output from the output end of the sealing glue delivery tube after completing one alternating process of turning on and off; The intermittent drive device comprises: A rack fixedly connected to the lower side of the slide placement plate; An incomplete gear, used for matching and meshing with the rack, and corresponding to the rack, arranged just below the slide placement plate; A drive motor is fixedly connected to the support frame and is located directly below the slide placement plate. The end face of the output shaft of the drive motor is connected to the incomplete gear. The drive motor is electrically connected to the microprocessor.

2. The tissue section sealing device according to claim 1, characterized in that: The sealing glue suction and discharge device includes a suction and discharge pipe and a driving mechanism for enabling the suction and discharge pipe to suction and discharge the sealing glue, one end of the suction and discharge pipe is connected to the sealing glue delivery pipe and communicated with the sealing glue delivery pipe, one end of the suction and discharge pipe is connected to the sealing glue delivery pipe and communicated with the sealing glue delivery pipe, the driving mechanism drives the suction and discharge pipe to suck in and output the sealing glue, and the driving mechanism is electrically connected to the microprocessor.

3. The tissue section sealing device according to claim 2, characterized in that: The suction and discharge pipe is provided with a sealing glue suction and discharge cavity, the volume of which is equal to the volume of sealing glue required for one sealing or a multiple of the volume of which is equal to the volume of sealing glue required for one sealing; the driving mechanism comprises: A piston adapted to be slidably mounted in the sealing glue suction and discharge cavity of the suction and discharge pipe; A push rod, one end of which is connected to the piston and the other end of which extends outwardly through the housing to form an extended end; An electric push rod is fixedly connected to the support frame. A telescopic rod is provided on the electric push rod. The telescopic rod is fixedly connected to the extended end of the push rod. The electric push rod is electrically connected to the microprocessor.

4. The tissue section sealing device according to claim 3, characterized in that: A limit plate is provided on the push rod, and a spring 1 is installed between the limit plate and the sealing glue delivery tube. The spring set is arranged on the push rod, and one end of the spring 1 stops on the limit plate, and the other end stops on the suction and discharge tube or the sealing glue delivery tube.

5. The tissue section sealing device according to claim 1, characterized in that: The cover glass placing device comprises: A body, wherein a cover glass storage cavity for storing cover glasses is provided in the body, and a cover glass push-out channel for sequentially passing a single cover glass is provided in the body, wherein one end of the cover glass push-out channel is connected to the cover glass storage cavity, and the other end extends out of the body; A cover glass pushing device, used for pushing the cover glass stored in the cover glass storage cavity out of the cover glass pushing channel, the cover glass pushing device comprising a cover glass pushing plate and a driving mechanism for driving the cover glass pushing plate to move linearly, one end of the cover glass pushing plate is connected to the driving mechanism, and the other end can be extended into and withdrawn from the cover glass pushing channel and the cover glass storage cavity under the drive of the driving mechanism; The cover glass pressing device is used to pressurize the cover glass stored in the cover glass storage cavity to flatten the cover glass and make multiple cover glasses close together. The cover glass pressing device is provided with a pressure rod, and the pressure rod can extend into the cover glass storage cavity.

6. The tissue section sealing device according to claim 5, characterized in that: The cover glass pressure applying device comprises: A support seat is vertically slidably mounted on the body and extends upward, the pressure rod is vertically slidably mounted on the support seat and is located directly above the cover glass storage cavity, the upper end of the pressure rod passes through the support seat, and the lower end can extend into the cover glass storage cavity; Spring 2 is sleeved on the pressure rod, the upper end of the pressure rod is provided with a stop plate, the lower end of the pressure rod is provided with a pressure plate, the upper end of the spring 2 is stopped against the lower side of the support seat, and the lower end of the spring 2 is stopped against the upper side of the pressure plate; The locking member is used to lock the support base and the main body to fix the support base at different heights, so that the spring 2 installed on the pressure rod produces elastic deformation to apply pressure to the cover glass stored in the cover glass storage cavity.

7. The tissue section sealing device according to any one of claims 1 to 6, characterized in that: Also includes: The suspension beam comprises a first suspension beam and a second suspension beam, the first suspension beam and the second suspension beam are arranged in parallel, the two ends of the first suspension beam and the second suspension beam are respectively slidably mounted on the left and right ends of the support frame, and can slide in the front and rear directions relative to the slide placement plate, a plurality of the sealing glue dripping devices are installed on the first suspension beam at intervals, and a plurality of the cover glass placing devices are installed on the first suspension beam at intervals.

8. The tissue section sealing device according to claim 7, characterized in that: The support frame comprises: Bottom support plate; A plurality of vertical support rods are provided, wherein the plurality of vertical support rods are vertically connected to the rear end of the bottom support plate and extend upward to form an extension end; A crossbeam connected to the extended ends of the plurality of vertical support rods; Two supporting longitudinal beams are provided, the two supporting longitudinal beams are connected to the left and right ends of the cross beam and extend forward to form extended ends, and the two ends of the suspension beam are slidably mounted on the supporting longitudinal beams; The placement plate mounting seat is located at the front part of the vertical support rod, and the slide placement plate is detachably mounted on the placement plate mounting seat.

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