Chemiluminescent Immunoassay Analyzer

Abstract

The present invention discloses a chemiluminescent immunoassay analyzer, which includes a frame and a manipulator device, an incubation device, a cleaning device, and a reading device arranged thereon; the reading device includes a first shell, a second shell, a photon counter, a first platform, and a first driving mechanism; the second shell is movably inserted on the first shell and is provided with a first cup placement hole for a reaction cup to be placed therein and a photometric hole connected thereto; the first shell is provided with a photometric connecting hole and is connected with the photon counter; the first driving mechanism is drivingly connected to the first shell and / or the first platform; the first platform can move relative to the second shell and can shield the upper end of the second shell; the second shell can move relative to the first shell; the photometric hole and the photometric connecting hole can be connected; the photon counter can detect the luminescence of the reaction cup in the photometric hole; and the second shell can shield the photometric connecting hole. The present invention has a good light shielding effect for reading detection and a high detection accuracy.

Description

Technical Field

[0001] The invention relates to the field of medical detection, and in particular to a chemiluminescent immunoassay analyzer. Background Art

[0002] Chemiluminescent immunoassay is an instrument that uses chemiluminescent immunoassay technology and reaction principles to qualitatively or quantitatively detect analytes in human serum, plasma or other body fluid samples, and is used to assist in the diagnosis of related diseases. Chemiluminescent immunoassay consists of two parts, namely the immune response system and the chemiluminescent analysis system. The immune response system marks the marker substance on the antigen or antibody, and after a specific immune reaction, an antigen-antibody complex is formed, and then the marker is detected to determine the analyte. The chemiluminescent analysis system uses the catalysis of the chemiluminescent substance or the oxidation of the oxidant to form an excited intermediate. When this excited intermediate returns to the stable ground state, it will emit photons at the same time, which are detected by the optical signal detector and converted into the concentration of the analyte by the computer data processing system.

[0003] The existing chemiluminescence immunoassay analyzer generally includes a cup placement mechanism, a manipulator device, a refrigeration chamber device, an incubation device, a cleaning device and a reading device, etc. The cup placement mechanism is used to place the reaction cup and the sample cup containing the liquid to be detected, etc. The manipulator device is used to grab and transport the reaction cup and add the liquid to be detected and reagents, etc. into it, the refrigeration chamber device is used to store the reagent at low temperature, the incubation device is used to simulate the human body to incubate and shake the test object in the reaction cup, so that it undergoes a specific immune reaction to produce immune complexes, the cleaning device is used to separate and clean the immune complexes after the reaction, and the reading device is used to detect the luminescence of the immune complex to analyze its immune reaction. The existing chemiluminescence analyzer has a problem of high noise when incubating and shaking the reaction cup, and the reading device has a complex structure. The effect of using a shading structure to shading the part of the photon reading is poor, resulting in low luminescence detection accuracy. The overall structure is complex and the volume is large, and the detection and analysis effect is poor, which is not convenient for promotion and application. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a chemiluminescent immunoassay analyzer, which has a good light shielding effect for reading detection, a high detection accuracy, and can achieve a good detection and analysis effect.

[0005] The chemiluminescent immunoassay analyzer according to an embodiment of the present invention comprises a frame and a manipulator device, an incubation device, a cleaning device, and a reading device respectively arranged on the frame; the manipulator device is used to grab and transport a reaction cup and add a detection material into the reaction cup; the incubation device can generate heat to incubate the test object in the reaction cup and can shake the reaction cup; the cleaning device can separate the immune complex and waste liquid in the reaction cup and can clean the immune complex in the reaction cup; the reading device comprises a first shell, a second shell, a photon counter, a first platform and a first driving mechanism, the second shell is movably inserted on the first shell, and the second shell is respectively A first cup placing hole for placing the reaction cup and a photometric hole connected to the lower end of the first cup placing hole are provided, a photometric connecting hole is provided on the first shell, the photon counter is connected to the photometric connecting hole, the first driving mechanism is arranged on the frame, the first driving mechanism is drivingly connected to the first shell and / or the first platform, the first platform can move relative to the second shell and can cover the upper end of the second shell, the second shell can move up and down relative to the first shell, the photometric hole and the photometric connecting hole can be connected, the photon counter can detect the luminescence of the reaction cup in the photometric hole through the photometric connecting hole, and the second shell can cover the photometric connecting hole.

[0006] The chemiluminescent immunoassay analyzer according to the embodiment of the present invention has at least the following beneficial effects: when performing detection and analysis, the robot device adds the test object and the reagent into the reaction cup, and then transports it to the incubation device for incubation and shaking, so that it undergoes a specific immune reaction to produce immune complexes, the robot device transports the reaction cup mixed with the immune complexes and waste liquid to the cleaning device, the cleaning device separates the immune complexes and waste liquid in the reaction cup and cleans the immune complexes, and then the robot device transports the reaction cup to the reading device and places it in the first cup placement hole, before reading. Luminescent liquid is added to the reaction cup, and under the drive of the first driving mechanism, the first platform is moved relative to the second shell and shields the upper end of the second shell, and at the same time, the second shell is moved relative to the first shell to connect the photometric hole and the photometric connecting hole, and the photon counter detects the luminescence of the reaction cup in the photometric hole through the photometric connecting hole; after completing the luminescence analysis detection, the second shell is moved and reset so that the photometric hole and the photometric connecting hole can be completely staggered, and the second shell shields the photometric connecting hole, which can avoid the detection end of the photon counter from being exposed, thereby avoiding affecting the detection reading effect of the photon counter. The present invention sets a double-layer shell structure of the first shell and the second shell, so that the first platform can cooperate with the two to form a double-layer dark box structure, which has a good light shielding effect, can improve the detection accuracy of the present invention, and achieve a good detection and analysis effect.

[0007] According to some embodiments of the present invention, the first platform is provided with a first sealing portion and a second sealing portion, respectively, the upper end of the first shell is provided with a sealing groove for the first sealing portion to be inserted, the upper end of the second shell is provided with a sealing step for the second sealing portion to abut, and an elastic member is connected between the lower end of the first shell and the lower end of the second shell. By providing the sealing groove and the sealing step, when the first sealing portion is connected to the upper end of the first shell and the second sealing portion is connected to the upper end of the second shell, a multi-layer structure is formed at the connection, which can enhance the light-shielding sealing effect, so that the reading device obtains a better detection reading effect; and the provision of the elastic member can facilitate the movement and reset after the relative movement between the first shell and the second shell, and at the same time can achieve the complete staggering of the photometric hole and the photometric connection hole, so that the second shell can shield the photometric connection hole, and its structure is simple and can reduce the volume of the reading device.

[0008] According to some embodiments of the present invention, a drip connection seat, a drip assembly and a liquid extraction joint assembly are provided on the first platform, a drip connection hole for the reaction cup to be inserted into is provided on the first platform, the drip connection seat is connected to the drip connection hole, the drip assembly is detachably arranged on the drip connection seat, the drip assembly can be connected to an external luminescent liquid delivery device and can drip luminescent liquid into the reaction cup, the liquid extraction joint assembly includes a liquid extraction tube that can be inserted into the reaction cup and a cup removal piece sleeved on the liquid extraction tube, the liquid extraction joint assembly can be connected to an external suction device, and the cup removal piece can lift the reaction cup on the second shell from the first cup placement hole. By setting a drip connection seat and a drip assembly, after the first platform is covered and shielded on the upper end of the second shell, the luminescent chemical liquid can be dripped into the reaction cup through the drip assembly to realize the detection of instant chemiluminescence in the detection cup, so that the present invention can be applied to detection in different drip modes, thereby improving its applicability; and the setting of the liquid extraction joint assembly facilitates the external suction equipment to suck and discharge the waste liquid in the reaction cup after the detection is completed through the liquid extraction tube, thereby avoiding pollution caused by leakage of waste liquid. At the same time, the cup removal component lifts the reaction cup on the second shell from the first cup placement hole, thereby facilitating the next cup placement for detection, thereby reducing manual labor and improving the degree of automation.

[0009] According to some embodiments of the present invention, the incubation device includes a fixed seat assembly, an incubation mechanism and a second driving mechanism; the fixed seat assembly includes a first guide member fixedly connected to the frame; the incubation mechanism includes an incubation chamber, a heating component and a heat conductor, the upper end of the incubation chamber is provided with a second cup placement hole for the reaction cup to be clamped, the heating component is arranged at the lower end of the incubation chamber, the heat conductor is arranged at the upper part of the heating component, and the heat conductor is provided with a heat conductive groove for the reaction cup to be inserted corresponding to the second cup placement hole; the second driving mechanism includes a first driving component and a moving component drivingly connected to the first driving component, the moving component includes a first connecting seat and a first rolling wheel rotatably arranged on the first connecting seat, the first connecting seat is fixedly connected to the incubation chamber, the first rolling wheel is connected to the first guide member and can roll along the guide direction of the first guide member, and the first driving component can drive the moving component to reciprocate along the guide direction of the first guide member. During incubation, the reaction cup is clamped at the second cup placement hole, the heating component generates heat and conducts heat through the heat conductive member, the heat conductive groove on the heat conductive member can make the reaction cup placed therein obtain a better heating effect, and by setting a first driving component to drive the first connecting seat to move back and forth along the first guide member, the first connecting seat drives the incubation mechanism to move back and forth, so as to shake the reaction cup placed therein, so that the test object and the reagent in the reaction cup are fully mixed to form an immune complex better, and when the first rolling wheel rolls and guides on the first guide member, the interaction force between the first rolling wheel and the first guide member is small, so that the reaction force of the fixed seat assembly when the moving assembly moves is small, thereby reducing the vibration of the fixed seat assembly, reducing the generation of noise, and improving the comfort of the working environment.

[0010] According to some embodiments of the present invention, the fixed seat assembly further includes a second guide member that is consistent with the guide direction of the first guide member, the second driving mechanism further includes a balancing assembly, the balancing assembly includes a second connecting seat and a second rolling wheel that is rotatably arranged on the second connecting seat, the second rolling wheel is connected to the second guiding member and can roll along the guiding direction of the second guiding member, the first driving assembly is drivingly connected to the second connecting seat and can drive the balancing assembly to move along the guiding direction of the second guiding member, and the movement direction of the balancing assembly is opposite to the movement direction of the moving assembly. By setting the balancing assembly, the movement direction of the balancing assembly is opposite to the movement direction of the moving assembly, when the moving assembly moves to the left, the first guide member is subjected to the rightward reaction force of the first rolling wheel, and the balancing assembly moves to the right, so that the second guide member is subjected to the leftward reaction force of the second rolling wheel, and the fixed seat assembly is simultaneously subjected to the rightward reaction force of the first rolling wheel and the leftward reaction force of the second rolling wheel, and the two oppositely directed forces offset each other, so that the fixed seat assembly can achieve a better force balance effect, can avoid the vibration of the fixed seat assembly, reduce vibration leakage, and further achieve the reduction of noise generation.

[0011] According to some embodiments of the present invention, two groups of first rolling wheels are provided and are respectively located at the upper part and the lower part of the first connecting seat, each group of the first rolling wheels is provided with at least one, and the first guide is clamped between the two groups of the first rolling wheels; two groups of second rolling wheels are provided and are respectively located at the upper part and the lower part of the second connecting seat, each group of the second rolling wheels is provided with at least one, and the second guide is clamped between the two groups of the second rolling wheels. By providing two groups of first rolling wheels that clamp the first guide up and down on the first connecting seat, the movement stability of the moving component when moving along the first guide can be improved, and the upward and downward deviation between the moving component and the first guide can be avoided; and by providing two groups of second rolling wheels that clamp the second guide up and down on the second connecting seat, the movement stability of the balancing component when moving along the second guide can be improved, and the upward and downward deviation between the balancing component and the second guide can be avoided, thereby improving the stability and reliability of the moving guide.

[0012] According to some embodiments of the present invention, the cleaning device includes a main frame, a conveying mechanism, a cleaning needle mechanism and a magnet mechanism; the main frame is provided with a liquid aspiration station and a liquid injection station; the conveying mechanism is arranged on the main frame, the conveying mechanism includes a turntable and a second driving component capable of driving the turntable to rotate, the turntable is provided with a third cup placement hole for placing the reaction cup, the conveying mechanism can transport the reaction cup placed in the third cup placement hole to different stations, and the turntable can rotate reciprocatingly; the cleaning needle mechanism is arranged on the main frame and corresponds to the liquid aspiration station and the liquid injection station, the cleaning needle mechanism can absorb waste liquid from the reaction cup and can inject cleaning liquid into the reaction cup; the magnet mechanism is arranged on the main frame and distributed on at least one side of the running path of the reaction cup on the turntable, the magnet mechanism includes at least one active magnet component arranged corresponding to the liquid aspiration station, the active magnet component can adsorb the immune complex in the reaction cup and can drive the immune complex to move upward. When the immune complex is washed and separated, the turntable rotates to transport the reaction cup to the liquid aspiration station, the movable magnet assembly adsorbs the immune complex in the reaction cup to the bottom of the cup wall and drives it to move upward to a position at a preset height from the bottom of the cup, the cleaning needle mechanism absorbs waste liquid from the reaction cup, and the immune complex adsorbed on the cup wall can avoid being affected by the cleaning needle mechanism. After the cleaning needle mechanism completes the waste liquid absorption, the conveying mechanism transports the reaction cup to the liquid injection station, the cleaning needle mechanism injects cleaning liquid into the reaction cup, and then the turntable rotates back and forth, so that the immune complex adsorbed on the cup wall is shaken and dispersed, which facilitates the immune complex and the injected cleaning liquid to be fully mixed for cleaning, so that the immune complex in the reaction cup obtains a better cleaning effect, and achieves a better washing and separation effect. At the same time, it can reduce the washing and separation time of the immune complex, and improve the working efficiency of the present invention.

[0013] According to some embodiments of the present invention, the movable magnet assembly includes a movable magnet and a magnet driver connected to the movable magnet, one end of the magnetic pole of the movable magnet is located on one side of the reaction cup running path on the turntable, and the magnet driver can drive the movable magnet to move up and down along the cup wall of the reaction cup. By setting the movable magnet and the magnet driver, the movable magnet adsorbs the immune complex in the reaction cup, and the magnet driver drives the movable magnet to move, driving the immune complex adsorbed on the cup wall to move. It has a simple structure and a small size, and can better achieve the purpose of adsorbing the immune complex in the reaction cup and driving it to move, which can improve the reliability of the present invention.

[0014] According to some embodiments of the present invention, the cleaning needle mechanism includes a second platform and a third driving assembly driven and connected to the second platform; the second platform is provided with a liquid aspiration needle assembly that can be connected to an external suction device, an injection needle assembly that can be connected to an external cleaning liquid delivery device, and a liquid dripping needle assembly that can be connected to an external luminescent liquid delivery device; the liquid aspiration needle assembly is arranged corresponding to the liquid aspiration station and can aspirate waste liquid from the reaction cup; the liquid injection needle assembly is arranged corresponding to the liquid injection station and can inject cleaning liquid into the reaction cup; a liquid dripping station is also provided on the main frame; the liquid dripping needle assembly is arranged corresponding to the liquid dripping station and can drip luminescent liquid into the reaction cup; and the third driving assembly can drive the second platform to move up and down. By setting up the second platform, the aspiration needle assembly and the injection needle assembly, the structure is simple and the volume is small, which can reduce the production cost and facilitate the production and manufacturing, and can better realize the functions of absorbing waste liquid and injecting cleaning liquid of the cleaning needle mechanism; and the setting of the dripping needle assembly, after the immune complex in the reaction cup is completed by washing and separating, the luminescent liquid can be dripped to the immune complex in the reaction cup through the dripping needle assembly, which is convenient for the subsequent chemiluminescent immunoassay detection of the immune complex in the reaction cup, avoids the trouble of setting up an additional dripping device, and improves the convenience and functionality of the present invention.

[0015] According to some embodiments of the present invention, a refrigeration bin device is further provided on the rack, and the refrigeration bin device includes a bin body, a reagent strip, a refrigeration mechanism and a shaking mechanism; a placement hole for placing a reagent bottle is provided on the reagent strip, a placement cavity for placing the reagent strip is provided in the bin body, a take-in and put-out opening connected to the placement cavity is provided on the side of the bin body, and the reagent strip can enter or leave the placement cavity through the take-in and put-out opening, a liquid collection hole connected to the placement cavity is provided on the upper part of the bin body, and the distribution position of the liquid collection hole corresponds to the position of the placement hole when the reagent strip is placed in the placement cavity; the refrigeration mechanism is fixedly connected to the bin body and is used to cool the placement cavity; the shaking mechanism includes a rack movably arranged on the bin body and a fourth drive assembly drivingly connected to the rack, a gear portion capable of meshing with the rack is provided on the reagent strip, the fourth drive assembly can drive the rack to move, and the gear portion can drive the reagent bottle located at the placement hole to rotate. By setting up a warehouse body with a side opening structure, when replacing the reagent strip, the reagent strip can be taken out from the placement cavity through the pick-and-place opening by horizontal pulling, which is convenient for replacing the reagent strip and can avoid accidentally touching the manipulator when manually replacing the reagent strip, and avoid the trouble of stopping the manipulator when replacing the reagent strip. At the same time, a pick-and-place opening is provided on the side, and its opening area is small, which can reduce the leakage of cold air and achieve better refrigeration and heat preservation effects; by providing a liquid collection hole on the upper part of the warehouse body, it is convenient for the manipulator to take the liquid from the reagent bottle on the reagent strip placed in the placement cavity, thereby improving ease of use; and the arrangement of the rack and gear part, the fourth drive assembly drives the rack to move and drives the gear part to rotate through the gear meshing transmission, thereby driving the reagent bottle at the placement hole to rotate, so as to realize the rotation and shaking of the reagent bottle. It has a simple structure and good transmission stability, and is convenient for the extraction and replacement of the reagent strip. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0017] Figure 1 This is a schematic diagram of the structure of a chemiluminescent immunoassay analyzer according to an embodiment of the present invention;

[0018] Figure 2 for Figure 1 A schematic diagram of a front view of a chemiluminescent immunoassay analyzer;

[0019] Figure 3 for Figure 1 Schematic diagram of the exploded structure of the reading device;

[0020] Figure 4 for Figure 3 A schematic diagram of the cross-sectional structure of the middle reading device in a non-reading state;

[0021] Figure 5 for Figure 3 A schematic diagram of the cross-sectional structure of the middle reading device in a reading state;

[0022] Figure 6 for Figure 1 Schematic diagram of the exploded structure of the incubation device;

[0023] Figure 7 for Figure 6 A schematic diagram of the cross-sectional structure of the incubation device;

[0024] Figure 8 for Figure 6 A schematic diagram of a part of the structure of the incubation device;

[0025] Fig. 9 for Figure 1 Schematic diagram of the exploded structure of the cleaning device;

[0026] Fig.10 for Fig. 9 A schematic diagram of the cross-sectional structure of the cleaning device;

[0027] Fig.11 for Figure 1 Schematic diagram of the exploded structure of the cold storage device;

[0028] Fig.12 for Fig.11 Schematic diagram of the partial structure of the refrigeration warehouse device.

[0029] Reference numerals:

[0030] Rack 100, cup placement mechanism 110, reaction cup 1, reagent bottle 2;

[0031] Manipulator device 200, gripper assembly 210, sampling pump assembly 220, mobile drive assembly 230;

[0032] Incubation device 300, fixed seat assembly 310, first guide member 311, second guide member 312, incubation mechanism 320, incubation chamber 321, heating assembly 322, heat conducting member 323, second cup placement hole 324, heat conducting groove 325, second driving mechanism 330, first driving assembly 331, moving assembly 332, first connecting seat 332a, first rolling wheel 332b, balancing assembly 333, second connecting seat 333a, second rolling wheel 333b;

[0033] Cleaning device 400, main frame 410, conveying mechanism 420, turntable 421, second driving assembly 422, third cup placement hole 423, cleaning needle mechanism 430, second platform 431, third driving assembly 432, aspiration needle assembly 433, injection needle assembly 434, dripping needle assembly 435, magnet mechanism 440, active magnet assembly 441, active magnet 441a, magnet driver 441b;

[0034] Reading device 500, first shell 510, photometric connecting hole 511, sealing groove 512, elastic member 513, second shell 520, first cup placing hole 521, photometric hole 522, sealing step 523, photon counter 530, first platform 540, first sealing part 541, second sealing part 542, dripping connecting seat 543, dripping connecting hole 544, first driving mechanism 550, dripping assembly 560, liquid extraction joint assembly 570, liquid extraction tube 571, cup removing member 572;

[0035] Refrigeration bin device 600 , bin body 610 , placement cavity 611 , access opening 612 , liquid extraction hole 613 , reagent strip 620 , placement hole 621 , refrigeration mechanism 630 , shaking mechanism 640 , rack 641 , fourth driving assembly 642 . DETAILED DESCRIPTION

[0036] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0037] In the description of the present invention, it is necessary to understand that if it involves orientation description, the orientation or position relationship indicated by, for example, up, down, front, back, left, right, etc. is based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0038] In the description of the present invention, if the words such as several, greater than, less than, exceed, above, below, within, etc. appear, among which, several means one or more, more means more than two, greater than, less than, exceed, etc. are understood as not including the number itself, and above, below, within, etc. are understood as including the number itself.

[0039] If the first and second are described, they are only used to distinguish the technical features and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the sequence of the indicated technical features.

[0040] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0041] Reference Figure 1 , Figure 2 and Figure 3 A chemiluminescent immunoassay analyzer includes a frame 100 and a manipulator device 200, an incubation device 300, a cleaning device 400, and a reading device 500 respectively arranged on the frame 100; the manipulator device 200 is used to grab and transport a reaction cup 1 and add a detection material to the reaction cup 1; the incubation device 300 can generate heat to incubate the object to be tested in the reaction cup 1, and can shake the reaction cup 1; the cleaning device 400 can separate the immune complex and waste liquid in the reaction cup 1 and can clean the immune complex in the reaction cup 1; the reading device 500 includes a first shell 510, a second shell 520, a photon counter 530, a first platform 540 and a first driving mechanism 550, the second shell 520 is movably inserted in the first shell 510, and the second shell 520 is respectively provided with There is a first cup placing hole 521 for placing a reaction cup 1 and a photometric hole 522 connected to the lower end of the first cup placing hole 521. A photometric connecting hole 511 is provided on the first shell 510. The photon counter 530 is connected to the photometric connecting hole 511. The first driving mechanism 550 is arranged on the frame 100. The first driving mechanism 550 is drivingly connected to the first shell 510 and / or the first platform 540. The first platform 540 can move relative to the second shell 520 and can cover the upper end of the second shell 520. The second shell 520 can move up and down relative to the first shell 510. The photometric hole 522 and the photometric connecting hole 511 can be connected. The photon counter 530 can detect the luminescence of the reaction cup 1 in the photometric hole 522 through the photometric connecting hole 511. The second shell 520 can cover the photometric connecting hole 511.

[0042] When performing detection and analysis, the robot device 200 adds the test object and reagent to the reaction cup 1, and then transports it to the incubation device 300 for incubation and shaking, so that it undergoes a specific immune reaction to produce immune complexes. The robot device 200 transports the reaction cup 1 mixed with the immune complex and waste liquid to the cleaning device 400, and the cleaning device 400 separates the immune complex and waste liquid in the reaction cup 1 and cleans the immune complex. Then the robot device 200 transports the reaction cup 1 to the reading device 500 and places it in the first cup placement hole 521. Before reading, add luminescent liquid to the reaction cup 1. Figure 3 , Figure 4 and Figure 5As shown, when the reading device 500 is in a non-detection reading state, the photometric hole 522 and the photometric connecting hole 511 are in a completely staggered state, and the outer wall of the second shell 520 blocks the photometric connecting hole 511, so that the detection head of the photon counter 530 is in a dark environment. When performing detection reading, under the drive of the first driving mechanism 550, the first platform 540 is moved relative to the second shell 520 and blocks the upper end of the second shell 520, and at the same time, the second shell 520 is moved relative to the first shell 510 to connect the photometric hole 522 with the photometric connecting hole 511. Since the first platform 540 is covered and shielded in The upper end of the second shell 520 makes the photometric hole 522 connected with the photometric connection hole 511, and the detection head of the photon counter 530 is still in a dark environment. The photon counter 530 detects the luminescence of the reaction cup 1 in the photometric hole 522 through the photometric connection hole 511; after the luminescence analysis detection is completed, the second shell 520 moves and resets so that the photometric hole 522 and the photometric connection hole 511 can be completely staggered. The second shell 520 blocks the photometric connection hole 511, which can prevent the detection end of the photon counter 530 from being exposed, thereby avoiding affecting the detection reading effect of the photon counter 530. The present invention sets a double-layer shell structure of the first shell 510 and the second shell 520, so that the first platform 540 can cooperate with the two to form a double-layer dark box structure, which has a good light shielding effect, can improve the detection accuracy of the present invention, and achieve a good detection and analysis effect.

[0043] In this embodiment, if Figure 1 and Figure 2 As shown, the frame 100 is also provided with a cup placement mechanism 110 for placing the reaction cup 1, the TIP head and the reagent cup containing the object to be tested, etc. The manipulator device 200 includes a clamping jaw assembly 210, a sampling pump assembly 220 and a mobile drive assembly 230, etc. The clamping jaw assembly 210 is used to clamp the reaction cup 1, and can be a pneumatic finger or other clamping mechanism. The sampling pump assembly 220 is used to be used with the TIP head to perform sampling and adding of the object to be tested and the reagent sampling and adding, etc. The mobile drive assembly 230 can be composed of three groups of linear motors or screw drive mechanisms or synchronous belt drive mechanisms with different drive axes. Since the other structures of the cup placement mechanism 110 and the manipulator device 200 are known to ordinary technicians in this field, they are not described in detail here. The first driving mechanism 550 can be a linear motor, a screw driving mechanism, a synchronous belt driving mechanism, etc., which can be configured to independently drive the first platform 540 to move, independently drive the first shell 510 to move, or drive the two to move relative to each other. The specific structures of the incubation device 300, the cleaning device 400, and the reading device 500 are not described in detail here, but will be described in detail below.

[0044] In some embodiments, the first platform 540 is provided with a first sealing portion 541 and a second sealing portion 542, respectively; the upper end of the first shell 510 is provided with a sealing groove 512 for inserting the first sealing portion 541, the upper end of the second shell 520 is provided with a sealing step portion 523 for abutting the second sealing portion 542, and an elastic member 513 is connected between the lower end of the first shell 510 and the lower end of the second shell 520. By providing the sealing groove 512 and the sealing step portion 523, as shown in FIG. Figure 4 and Figure 5 As shown, the first platform 540 moves downward to first make the second sealing portion 542 abut against the sealing step portion 523 at the upper end of the second shell 520, and then continues to move downward, pushing the second shell 520 to move relative to the first shell 510, compressing the elastic member 513 and making the first sealing portion 541 insert into the sealing groove 512 at the upper end of the first shell 510. The connection between the first platform 540 and the first shell 510 and the second shell 520 forms a multi-layer structure, which can enhance the light-shielding sealing effect, so that the reading device 500 obtains a better detection and reading effect; and the setting of the elastic member 513 can facilitate the movement and reset after the relative movement between the first shell 510 and the second shell 520, and at the same time can achieve complete offset of the photometric hole 522 and the photometric connecting hole 511, so that the second shell 520 can cover the photometric connecting hole 511. It has a simple structure and can reduce the volume of the reading device 500. In actual application, the elastic member 513 may be a spring or other elastic material, and the specific structure of the connection between the first platform 540 and the first shell 510 and the second shell 520 may also be changed according to actual use needs, which is not limited here.

[0045] In some embodiments, a first platform 540 is provided with a drip connection seat 543, a drip assembly 560 and a liquid extraction joint assembly 570. The first platform 540 is provided with a drip connection hole 544 for the reaction cup 1 to extend into. The drip connection seat 543 is connected to the drip connection hole 544. The drip assembly 560 is detachably arranged on the drip connection seat 543. The drip assembly 560 can be connected to an external luminescent liquid delivery device and can drip luminescent liquid into the reaction cup 1. The liquid extraction joint assembly 570 includes a liquid extraction tube 571 that can extend into the reaction cup 1 and a cup removal member 572 sleeved on the liquid extraction tube 571. The liquid extraction joint assembly 570 can be connected to an external suction device, and the cup removal member 572 can lift the reaction cup 1 on the second shell 520 from the first cup placement hole 521. By providing the drip connection seat 543 and the drip assembly 560, as Figure 3 , Figure 4 and Figure 5As shown, after the first platform 540 is covered and shielded on the upper end of the second shell 520, the luminescent chemical liquid can be dripped into the reaction cup 1 through the drip assembly 560 to detect the instant chemiluminescence in the detection cup, so that the present invention can be applied to detection in different drip modes, thereby improving its applicability; and the arrangement of the liquid extraction joint assembly 570 facilitates the external suction equipment to extract and discharge the waste liquid in the reaction cup 1 after the detection is completed through the liquid extraction tube 571, thereby avoiding pollution caused by leakage of the waste liquid. At the same time, the cup removal component 572 lifts the reaction cup 1 on the second shell 520 from the first cup placement hole 521, thereby facilitating the next cup placement for detection, thereby reducing manual labor and improving the degree of automation.

[0046] In actual application, the specific structure of the drip assembly 560 and the liquid extraction joint assembly 570 can be set accordingly according to actual use needs. It is mainly used to connect with corresponding external equipment to realize the functions of dripping luminous liquid and extracting waste liquid. Technical personnel in this field should be able to understand it, and the specific structure of the cup-removing member 572, which can be a clamping cup-removing structure or a tapered cup-removing structure, can be set accordingly according to actual use needs and is not limited here.

[0047] In some embodiments, the incubation device 300 includes a fixed seat assembly 310, an incubation mechanism 320 and a second driving mechanism 330; the fixed seat assembly 310 includes a first guide member 311 fixedly connected to the frame 100; the incubation mechanism 320 includes an incubation chamber 321, a heating component 322 and a heat conductor 323, the upper end of the incubation chamber 321 is provided with a second cup placement hole 324 for the reaction cup 1 to be clamped, the heating component 322 is arranged at the lower end of the incubation chamber 321, the heat conductor 323 is arranged at the upper part of the heating component 322, and the heat conductor 323 is provided with a second cup placement hole 324 corresponding to the second cup placement hole 324 for the reaction cup 1 to be inserted The heat conducting groove 325; the second driving mechanism 330 includes a first driving component 331 and a moving component 332 drivingly connected to the first driving component 331, the moving component 332 includes a first connecting seat 332a and a first rolling wheel 332b rotatably arranged on the first connecting seat 332a, the first connecting seat 332a is fixedly connected to the incubation chamber 321, the first rolling wheel 332b is connected to the first guide member 311 and can roll along the guiding direction of the first guide member 311, and the first driving component 331 can drive the moving component 332 to reciprocate along the guiding direction of the first guide member 311. When incubating, as Figure 6 , Figure 7 and Figure 8As shown, the reaction cup 1 is clamped at the second cup placement hole 324, the heating component 322 generates heat and conducts heat through the heat conductive member 323, and the heat conductive groove 325 on the heat conductive member 323 can make the reaction cup 1 placed therein obtain a better heating effect, and by setting the first driving component 331 to drive the first connecting seat 332a to reciprocate along the first guide member 311, the first connecting seat 332a drives the incubation mechanism 320 to reciprocate, so as to shake the reaction cup 1 placed therein, so that the analyte and the reagent in the reaction cup 1 are fully mixed to form an immune complex well, and when the first rolling wheel 332b rolls and guides on the first guide member 311, the interaction force between the first rolling wheel 332b and the first guide member 311 is small, so that the reaction force of the fixed seat component 310 when the moving component 332 moves is small, thereby reducing the vibration of the fixed seat component 310, reducing the generation of noise, and improving the comfort of the working environment. In this embodiment, the first drive component 331 is a synchronous belt drive mechanism, the first connecting seat 332a is fixedly connected to the synchronous belt, and the driving motor drives the first connecting seat 332a to move through the synchronous belt. In actual application, the specific structures of the first guide member 311, the first drive component 331, the moving component 332 and the incubation mechanism 320 can be changed accordingly according to actual use needs, and are not limited here.

[0048] In some embodiments, the fixed seat assembly 310 further includes a second guide member 312 that is consistent with the guiding direction of the first guide member 311, and the second driving mechanism 330 further includes a balancing assembly 333, the balancing assembly 333 includes a second connecting seat 333a and a second rolling wheel 333b rotatably disposed on the second connecting seat 333a, the second rolling wheel 333b is connected to the second guide member 312 and can roll along the guiding direction of the second guide member 312, the first driving assembly 331 is drivingly connected to the second connecting seat 333a and can drive the balancing assembly 333 to move along the guiding direction of the second guide member 312, and the movement direction of the balancing assembly 333 is opposite to the movement direction of the moving assembly 332. Figure 7 and Figure 8As shown, by setting a balancing component 333, the movement direction of the balancing component 333 is opposite to the movement direction of the moving component 332. In this embodiment, when the synchronous belt drives the moving component 332 to move to the left, the first guide member 311 is subjected to the rightward reaction force of the first rolling wheel 332b, and at the same time, the synchronous belt also drives the balancing component 333 to move to the right, so that the second guide member 312 is subjected to the leftward reaction force of the second rolling wheel 333b, and the fixed seat component 310 is simultaneously subjected to the rightward reaction force of the first rolling wheel 332b and the leftward reaction force of the second rolling wheel 333b. The two forces in opposite directions offset each other, so that the fixed seat component 310 can achieve a better force balance effect, avoid vibration of the fixed seat component 310, reduce vibration leakage, and further reduce noise generation.

[0049] In some embodiments, two groups of first rolling wheels 332b are provided and are respectively located at the upper and lower parts of the first connecting seat 332a, each group of first rolling wheels 332b is provided with at least one, and the first guide member 311 is clamped between the two groups of first rolling wheels 332b; two groups of second rolling wheels 333b are provided and are respectively located at the upper and lower parts of the second connecting seat 333a, each group of second rolling wheels 333b is provided with at least one, and the second guide member 312 is clamped between the two groups of second rolling wheels 333b. By arranging two groups of first rolling wheels 332b for clamping the first guide member 311 on the first connection seat 332a, the moving stability of the moving assembly 332 when moving along the first guide member 311 can be improved, and the upward and downward offset between the moving assembly 332 and the first guide member 311 can be avoided. And by arranging two groups of second rolling wheels 333b for clamping the second guide member 312 on the second connection seat 333a, the moving stability of the balancing assembly 333 when moving along the second guide member 312 can be improved, and the upward and downward offset between the balancing assembly 333 and the second guide member 312 can be avoided, thereby improving the stability and reliability of the moving guide. In actual application, the specific number of the first guide member 311 and the second guide member 312 can be set accordingly according to actual use needs, such as one, two or more, and the number of each group of roller groups can also be adaptively changed accordingly, which is not limited here.

[0050] In some embodiments, the cleaning device 400 includes a main frame 410, a conveying mechanism 420, a cleaning needle mechanism 430 and a magnet mechanism 440; the main frame 410 is provided with a liquid aspiration station and a liquid injection station; the conveying mechanism 420 is arranged on the main frame 410, and the conveying mechanism 420 includes a turntable 421 and a second driving assembly 422 capable of driving the turntable 421 to rotate, and the turntable 421 is provided with a third cup placement hole 423 for placing the reaction cup 1, and the conveying mechanism 420 can transport the reaction cup 1 placed in the third cup placement hole 423 to different stations, and the turntable 421 can reciprocate. Rotation; the cleaning needle mechanism 430 is arranged on the main frame 410 and corresponds to the liquid aspiration station and the liquid injection station. The cleaning needle mechanism 430 can absorb waste liquid from the reaction cup 1 and can inject cleaning liquid into the reaction cup 1; the magnet mechanism 440 is arranged on the main frame 410 and distributed on at least one side of the running path of the reaction cup 1 on the turntable 421. The magnet mechanism 440 includes at least one active magnet 441a component 441 corresponding to the liquid aspiration station. The active magnet 441a component 441 can absorb the immune complex in the reaction cup 1 and can drive the immune complex to move upward. Fig. 9 and Fig.10 As shown, when the immune complex is washed and separated, the turntable 421 rotates to transport the reaction cup 1 to the liquid aspiration station, the active magnet 441a component 441 adsorbs the immune complex in the reaction cup 1 to the bottom of the cup wall and drives it to move upward, so that it is at a preset height from the bottom of the cup, and the cleaning needle mechanism 430 is activated to absorb the waste liquid from the reaction cup 1 at this station. The active magnet 441a component 441 adsorbs the immune complex on the cup wall of the reaction cup 1 to separate it from the waste liquid and avoid the influence of the cleaning needle mechanism 430 on it. After the cleaning needle mechanism 430 completes the waste liquid absorption, it leaves the reaction cup 1, and the conveying mechanism 420 conveys the reaction cup 1 to the liquid injection station. Due to the viscosity and the liquid in the reaction cup 1 being sucked away, the immune complex in the reaction cup 1 is still adsorbed at a preset height on the cup wall of the reaction cup 1. The cleaning needle mechanism 430 injects cleaning liquid into the reaction cup 1 and then leaves the reaction cup 1. Then the turntable 421 rotates back and forth. Since the cup is filled with cleaning liquid, the immune complex on the cup wall is shaken back and forth and dispersed under the reciprocating rotation of the turntable 421 and the action of gravity, which facilitates the immune complex and the injected cleaning liquid to be fully mixed for cleaning, so that the immune complex in the reaction cup 1 obtains a better cleaning effect and achieves a better washing and separation effect. At the same time, it can reduce the washing and separation time of the immune complex and improve the working efficiency of the present invention.

[0051] In actual application, three, four or more liquid aspiration stations and liquid injection stations can be set according to actual needs. There are many ways for the second drive component 422 to drive the turntable 421 and to achieve reciprocating rotation of the turntable 421, such as setting a synchronous belt drive mechanism or a dividing plate drive mechanism. The specific structures of the cleaning needle mechanism 430 and the active magnet 441a component 441 can also be set accordingly according to actual needs. They are not described in detail here and are explained in detail below.

[0052] In some embodiments, the movable magnet 441a assembly 441 includes a movable magnet 441a and a magnet driver 441b drivingly connected to the movable magnet 441a. One end of the magnetic pole of the movable magnet 441a is located on one side of the running path of the reaction cup 1 on the turntable 421. The magnet driver 441b can drive the movable magnet 441a to move up and down along the cup wall of the reaction cup 1. By setting the movable magnet 441a and the magnet driver 441b, as shown in FIG. Fig. 9 and Fig.10 As shown, the active magnet 441a adsorbs the immune complex in the reaction cup 1, and the magnet driver 441b drives the active magnet 441a to move, driving the immune complex adsorbed on the cup wall to move. It has a simple structure and a small volume, and can better achieve the purpose of adsorbing the immune complex in the reaction cup 1 and driving it to move, which can improve the reliability of the present invention. In practical application, the magnet driver 441b can be a linear motor, or a screw drive mechanism or a gear rack drive mechanism, and in addition to the active magnet 441a component 441, the main frame 410 can also be provided with fixed magnets at different liquid aspiration stations to be used in conjunction with the active magnet 441a component 441, thereby reducing the production cost of the present invention.

[0053] In some embodiments, the cleaning needle mechanism 430 includes a second platform 431 and a third driving assembly 432 drivingly connected to the second platform 431. The second platform 431 is provided with a liquid suction needle assembly 433 that can be connected to an external suction device, a liquid injection needle assembly 434 that can be connected to an external cleaning liquid delivery device, and a liquid dripping needle assembly 435 that can be connected to an external luminescent liquid delivery device. The liquid suction needle assembly 433 is arranged corresponding to the liquid suction station and can suck waste liquid from the reaction cup 1, and the liquid injection needle assembly 434 is arranged corresponding to the liquid injection station and can inject cleaning liquid into the reaction cup 1. The main frame 410 is also provided with a liquid dripping station, and the liquid dripping needle assembly 435 is arranged corresponding to the liquid dripping station and can drip luminescent liquid into the reaction cup 1. The third driving assembly 432 can drive the second platform 431 to move up and down. Fig. 9 and Fig.10As shown, by setting the second platform 431, the liquid suction needle assembly 433 and the liquid injection needle assembly 434, when used, the liquid suction needle assembly 433 and the liquid injection needle assembly 434 are respectively connected to the corresponding suction equipment and the cleaning liquid delivery equipment through pipelines, and the third driving assembly 432 drives the second platform 431 to move up and down, so that the liquid suction needle assembly 433 and the liquid injection needle assembly 434 can be extended into the reaction cup 1 to extract and inject liquid. It has a simple structure and a small volume, which can reduce the production cost and facilitate production and manufacturing, and can better realize the functions of absorbing waste liquid and injecting cleaning liquid of the cleaning needle mechanism 430; and the setting of the dripping needle assembly 435, after the immune complex in the reaction cup 1 is washed and separated, the luminescent liquid can be dripped to the immune complex in the reaction cup 1 through the dripping needle assembly 435, which is convenient for the subsequent chemiluminescent immunoassay detection of the immune complex in the reaction cup 1, avoiding the trouble of additionally setting up a dripping device, and improving the convenience and functionality of the present invention.

[0054] In actual application, the specific structural form of the cleaning needle mechanism 430 is not limited to this. For example, a robot can be set to individually control the movement of each aspiration needle assembly 433 or injection needle assembly 434. The third drive assembly 432 can be a linear motor or a screw drive structure. The specific structure of the aspiration needle assembly 433 or the injection needle assembly 434 can also be changed accordingly according to actual use needs, which can be understood by those skilled in the art.

[0055] In some embodiments, the rack 100 is further provided with a refrigeration warehouse device 600, which includes a warehouse body 610, a reagent strip 620, a refrigeration mechanism 630 and a shaking mechanism 640; the reagent strip 620 is provided with a placement hole 621 for placing the reagent bottle 2, the warehouse body 610 is provided with a placement cavity 611 for placing the reagent strip 620, the side of the warehouse body 610 is provided with a take-in and put-out opening 612 connected to the placement cavity 611, and the reagent strip 620 can enter or leave the placement cavity 611 through the take-in and put-out opening 612, and the upper part of the warehouse body 610 is provided with a liquid taking hole 613 connected to the placement cavity 611, The distribution position of the liquid hole 613 corresponds to the position of the placement hole 621 when the reagent strip 620 is placed in the placement cavity 611; the refrigeration mechanism 630 is fixedly connected to the warehouse body 610 and is used to cool the placement cavity 611; the shaking mechanism 640 includes a rack 641 movably arranged on the warehouse body 610 and a fourth driving component 642 drivingly connected to the rack 641. The reagent strip 620 is provided with a gear part (not shown in the figure) that can mesh with the rack 641. The fourth driving component 642 can drive the rack 641 to move, and the gear part can drive the reagent bottle 2 located at the placement hole 621 to rotate. Fig.11 and Fig.12As shown, by providing a storage body 610 with a side opening structure, when replacing the reagent strip 620, the reagent strip 620 can be taken out from the placement cavity 611 through the access opening 612 by horizontally pulling, which is convenient for replacing the reagent strip 620, and can avoid the easy accidental touching of the manipulator when manually replacing the reagent strip 620, and avoid the trouble of stopping the manipulator when replacing the reagent strip 620. At the same time, the access opening 612 is provided on the side, and its opening area is small, which can reduce the leakage of cold air and achieve a better refrigeration and heat preservation effect; the storage body 6 By providing a liquid collection hole 613 on the upper part of 10, it is convenient for the manipulator to collect the reagent installed in the reagent bottle 2 on the reagent strip 620 placed in the placement cavity 611, thereby improving the convenience of use; and the arrangement of the rack 641 and the gear part, the fourth driving component 642 drives the rack 641 to move and drives the gear part to rotate through the gear meshing transmission, thereby driving the reagent bottle 2 at the placement hole 621 to rotate, so as to realize the rotation and shaking of the reagent bottle 2. It has a simple structure and good transmission stability, and is convenient for the extraction and replacement of the reagent strip 620.

[0056] In this embodiment, a plurality of partitions arranged in sequence are arranged in the placement cavity 611 to separate the placement cavity 611 into a plurality of receiving grooves for placing the reagent strip 620. A clamping column is provided at the rear end of the receiving groove, and a clamping notch that can be clamped and positioned with the clamping column is provided on the reagent strip 620 to facilitate the clamping, positioning and placement of the reagent strip 620. The refrigeration mechanism 630 includes a conduction plate, a semiconductor refrigeration chip and a heat sink (not shown in the figure). The conduction plate is in contact with the bottom of the warehouse body 610, the cold surface of the semiconductor refrigeration chip is in contact with the lower part of the conduction plate, and the hot surface of the semiconductor refrigeration chip is in contact with the upper part of the heat sink. The semiconductor refrigeration chip is sealed and wrapped with an insulation board all around. When the semiconductor refrigeration chip performs refrigeration work, the cold surface of the semiconductor refrigeration chip generates cold energy and conducts it to the bottom of the warehouse body 610 through the conduction plate, and the hot surface of the semiconductor refrigeration chip generates heat and conducts it to the heat sink for heat dissipation. The semiconductor refrigeration chip is sealed and wrapped with an insulation board all around to prevent the generated cold energy from being dissipated to the surroundings, thereby achieving a better refrigeration effect. It has a simple structure and can avoid the use of refrigerant. In actual application, the refrigeration mechanism 630 can also achieve refrigeration through commonly used refrigeration structures such as refrigerants, compressors and condensers. The fourth drive component 642 can be a linear motor, a cylinder, or a hydraulic cylinder that can drive the rack 641 to move, which can be understood by skilled technicians.

[0057] The embodiments of the present invention are described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present invention.

Claims

1. A chemiluminescent immunoassay analyzer, characterized in that: include: Rack(100); A robot device (200) is arranged on the frame (100), and the robot device (200) is used to grab and transport the reaction cup (1) and add detection materials into the reaction cup (1); An incubation device (300) is arranged on the frame (100) and comprises a fixed seat assembly (310), an incubation mechanism (320) and a second driving mechanism (330), wherein the fixed seat assembly (310) comprises a first guide member (311) fixedly connected to the frame (100), the incubation mechanism (320) comprises an incubation chamber (321), a heating assembly (322) and a heat conducting member (323), the upper end of the incubation chamber (321) is provided with a second cup placement hole (324) for the reaction cup (1) to be clamped, the heating assembly (322) is arranged at the lower end of the incubation chamber (321), and the heat conducting member (323) is provided with a second cup placement hole (324) for the reaction cup (1) to be clamped. 3) is arranged on the upper part of the heating component (322), the heat conducting member (323) is provided with a heat conducting groove (325) for inserting the reaction cup (1) corresponding to the second cup placing hole (324), so as to be able to incubate the test object in the reaction cup (1), the second driving mechanism (330) comprises a first driving component (331) and a moving component (332) drivingly connected to the first driving component (331), the moving component (332) comprises a first connecting seat (332a) and a first rolling wheel (332b) rotatably arranged on the first connecting seat (332a), the first connecting seat (33 2a) is fixedly connected to the incubation chamber (321), the first rolling wheel (332b) is connected to the first guide member (311) and can roll along the guide direction of the first guide member (311), the first driving assembly (331) can drive the moving assembly (332) to move back and forth along the guide direction of the first guide member (311), and can shake the reaction cup (1), the fixed seat assembly (310) also includes a second guide member (312) which is consistent with the guide direction of the first guide member (311), and the second driving mechanism (330) also includes a balancing assembly (333), The balancing component (333) comprises a second connecting seat (333a) and a second rolling wheel (333b) rotatably arranged on the second connecting seat (333a); the second rolling wheel (333b) is connected to the second guide member (312) and is capable of rolling along the guide direction of the second guide member (312); the first driving component (331) is drivingly connected to the second connecting seat (333a) and is capable of driving the balancing component (333) to move along the guide direction of the second guide member (312); the movement direction of the balancing component (333) is opposite to the movement direction of the moving component (332); A cleaning device (400) is arranged on the frame (100) and comprises a main frame (410), a conveying mechanism (420), a cleaning needle mechanism (430) and a magnet mechanism (440); the main frame (410) is provided with a liquid aspiration station and a liquid injection station; the conveying mechanism (420) is arranged on the main frame (410) and comprises a turntable (421) and a second driving assembly (422) capable of driving the turntable (421) to rotate; the turntable (421) is provided with a third cup placement hole (423) for placing the reaction cup (1); the conveying mechanism (420) is capable of conveying the reaction cup (1) placed in the third cup placement hole (423) to different stations; the turntable (421) is capable of reciprocating rotation; the cleaning needle mechanism (430) is arranged on the main frame (410) and comprises a turntable (421) and a second driving assembly (422) capable of driving the turntable (421) to rotate; ) and corresponding to the aspiration station and the injection station, the cleaning needle mechanism (430) is capable of aspirating waste liquid from the reaction cup (1) and injecting cleaning liquid into the reaction cup (1), the magnet mechanism (440) is arranged on the main frame (410) and distributed on at least one side of the running path of the reaction cup (1) on the turntable (421), the magnet mechanism (440) comprises at least one movable magnet component (441) arranged corresponding to the aspiration station, the movable magnet component (441) is capable of adsorbing immune complexes in the reaction cup (1) and driving the immune complexes to move upward, and the cleaning device (400) is capable of separating the immune complexes and waste liquid in the reaction cup (1) and cleaning the immune complexes in the reaction cup (1); The reading device (500) comprises a first shell (510), a second shell (520), a photon counter (530), a first platform (540) and a first driving mechanism (550), wherein the second shell (520) is movably inserted into the first shell (510), the second shell (520) is respectively provided with a first cup placement hole (521) for placing the reaction cup (1) therein and a photometric hole (522) connected to the lower end of the first cup placement hole (521), the first shell (510) is provided with a photometric connection hole (511), the photon counter (530) is connected to the photometric connection hole (511), the first driving mechanism (550) is arranged on the frame (100), and the reaction cup (1) is placed in the reaction cup (1) by the first cup placement hole (521). The first driving mechanism (550) is drivingly connected to the first shell (510) and / or the first platform (540); the first platform (540) can move relative to the second shell (520) and can cover the upper end of the second shell (520); the second shell (520) can move up and down relative to the first shell (510); the photometric hole (522) and the photometric connecting hole (511) can be connected; the photon counter (530) can detect the luminescence of the reaction cup (1) in the photometric hole (522) through the photometric connecting hole (511); the second shell (520) can cover the photometric connecting hole (511); the first platform (540) can move relative to the second shell (520) and can cover the upper end of the second shell (520); the second shell (520) can move relative to the first shell (510) and can move relative to the first shell (510); the photometric hole (522) and the photometric connecting hole (511) can be connected; the photon counter (530) can detect the luminescence of the reaction cup (1) in the photometric hole (522) through the photometric connecting hole (511); the second shell (520) can cover the photometric connecting hole (511); and the first platform (540) can move relative to the second shell (520) and ... move relative to the first shell (510) and can move relative to the first shell (510). A first sealing portion (541) and a second sealing portion (542) are respectively provided on the first shell (510), a sealing groove (512) for the first sealing portion (541) to be inserted is provided on the upper end of the first shell (510), a sealing step portion (523) for the second sealing portion (542) to abut against is provided on the upper end of the second shell (520), an elastic member (513) is connected between the lower end of the first shell (510) and the lower end of the second shell (520), a drip connection seat (543), a drip assembly (560) and a liquid extraction joint assembly (570) are provided on the first platform (540), and a drip connection hole (544) for the reaction cup (1) to extend into is provided on the first platform (540), The liquid dripping connection seat (543) is connected to the liquid dripping connection hole (544); the liquid dripping assembly (560) is detachably arranged on the liquid dripping connection seat (543); the liquid dripping assembly (560) can be connected to an external luminescent liquid delivery device and can drip luminescent liquid into the reaction cup (1); the liquid extraction joint assembly (570) comprises a liquid extraction tube (571) that can be inserted into the reaction cup (1) and a cup removal member (572) sleeved on the liquid extraction tube (571); the liquid extraction joint assembly (570) can be connected to an external suction device; and the cup removal member (572) can lift the reaction cup (1) on the second shell (520) from the first cup placement hole (521).

2. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The first rolling wheels (332b) are provided in two groups and are respectively located at the upper part and the lower part of the first connecting seat (332a), each group of the first rolling wheels (332b) is provided with at least one first rolling wheel, and the first guide member (311) is sandwiched between the two groups of the first rolling wheels (332b); the second rolling wheels (333b) are provided in two groups and are respectively located at the upper part and the lower part of the second connecting seat (333a), each group of the second rolling wheels (333b) is provided with at least one second rolling wheel, and the second guide member (312) is sandwiched between the two groups of the second rolling wheels (333b).

3. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The movable magnet assembly (441) comprises a movable magnet (441a) and a magnet driver (441b) drivingly connected to the movable magnet (441a); a magnetic pole at one end of the movable magnet (441a) is located on one side of the running path of the reaction cup (1) on the turntable (421); and the magnet driver (441b) is capable of driving the movable magnet (441a) to move up and down along the cup wall of the reaction cup (1).

4. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The cleaning needle mechanism (430) comprises a second platform (431) and a third driving assembly (432) drivingly connected to the second platform (431); the second platform (431) is provided with a liquid suction needle assembly (433) that can be connected to an external suction device, an injection needle assembly (434) that can be connected to an external cleaning liquid delivery device, and a liquid dripping needle assembly (435) that can be connected to an external luminescent liquid delivery device; the liquid suction needle assembly (433) is arranged corresponding to the liquid suction station and can suck waste liquid from the reaction cup (1); the liquid injection needle assembly (434) is arranged corresponding to the liquid injection station and can inject cleaning liquid into the reaction cup (1); the main frame (410) is also provided with a liquid dripping station; the liquid dripping needle assembly (435) is arranged corresponding to the liquid dripping station and can drip luminescent liquid into the reaction cup (1); and the third driving assembly (432) can drive the second platform (431) to move up and down.

5. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The frame (100) is also provided with a refrigeration warehouse device (600), and the refrigeration warehouse device (600) comprises: Bin body (610); A reagent strip (620), wherein the reagent strip (620) is provided with a placement hole (621) for placing a reagent bottle (2), the chamber body (610) is provided with a placement cavity (611) for placing the reagent strip (620), a side edge of the chamber body (610) is provided with a take-in and put-out opening (612) in communication with the placement cavity (611), the reagent strip (620) can enter or leave the placement cavity (611) through the take-in and put-out opening (612), the upper portion of the chamber body (610) is provided with a liquid collection hole (613) in communication with the placement cavity (611), the distribution position of the liquid collection hole (613) corresponds to the position of the placement hole (621) when the reagent strip (620) is placed in the placement cavity (611); A refrigeration mechanism (630) fixedly connected to the warehouse body (610) and used to cool the placement cavity (611); The shaking mechanism (640) comprises a rack (641) movably arranged on the chamber body (610) and a fourth driving assembly (642) drivingly connected to the rack (641); the reagent strip (620) is provided with a gear portion capable of meshing with the rack (641); the fourth driving assembly (642) can drive the rack (641) to move, and the gear portion can drive the reagent bottle (2) located at the placement hole (621) to rotate.

Images