A sample analysis device and cleaning method thereof, and computer readable storage medium

Abstract

The present application discloses a sample analysis device and a cleaning method thereof, and a computer-readable storage medium, wherein the cleaning method of the sample analysis device comprises: obtaining the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particle; determining the corresponding dirt contribution according to the concentration value; accumulating the dirt contribution; and when the accumulated dirt contribution meets the preset condition, performing a cleaning operation on the sample analysis device. By the above method, the sample test rate of the sample analysis device can be improved.

Description

Technical Field

[0001] The present application relates to the technical field of analysis and detection, and in particular to a sample analysis device and a cleaning method thereof, and a computer-readable storage medium. Background Art

[0002] In order to meet the testing needs of a large number of samples, it is necessary to speed up the speed of sample testing by the testing instrument. However, as the speed of sample testing increases, the original cleaning strategy of the testing instrument cannot adapt to the cleaning needs of the testing instrument after the speed increase. The testing instrument is still cleaned after a fixed time or a fixed number of tests, but at this time the testing instrument may not have reached the standard for cleaning, and each cleaning takes a long time. If cleaning is frequent, the number of samples that can be tested per unit time will not increase or even decrease, thus failing to achieve the goal of improving the sample rate of the testing instrument.

[0003] Therefore, the original cleaning strategy needs to be optimized to speed up the rate at which the detection instrument performs sample detection. Summary of the invention

[0004] To solve the above problems, the present application provides a sample analysis device and a cleaning method thereof, and a computer-readable storage medium, which can effectively reduce the cleaning frequency of the sample analysis device and improve the sample testing rate of the sample analysis device.

[0005] A technical solution adopted in the present application is: to provide a cleaning method for a sample analysis device, the method comprising: obtaining the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particles; determining the corresponding dirt contribution according to the concentration value; accumulating the dirt contribution; and when the accumulated dirt contribution meets a preset condition, performing a cleaning operation on the sample analysis device.

[0006] The method of determining the corresponding dirty contribution according to the concentration value includes: obtaining a correspondence between a predetermined concentration value and the dirty contribution; and determining the dirty contribution corresponding to the concentration value according to the correspondence.

[0007] Among them, the concentration value is directly proportional to the dirt contribution.

[0008] Among them, obtaining the correspondence between the predetermined concentration value and the dirt contribution includes: when the concentration value is greater than a preset concentration threshold, obtaining a first correspondence between the predetermined concentration value and the dirt contribution; or when the concentration value is less than or equal to the preset concentration threshold, obtaining a second correspondence between the predetermined concentration value and the dirt contribution; wherein the first correspondence is obtained by obtaining user input, and the second correspondence is obtained by testing the test sample.

[0009] The method also includes: obtaining multiple test sample groups corresponding to different concentration value intervals; testing a test sample group corresponding to each concentration value interval respectively; determining the number of test samples that need to be cleaned when the sample analysis device needs to complete the test during the test of a test sample group corresponding to each concentration value interval; and determining the dirt contribution corresponding to each concentration value interval based on the number of test samples to determine the second corresponding relationship.

[0010] Among them, each test sample group contains multiple test sample sub-groups; each test sample group corresponding to each concentration value interval is tested respectively, including: using multiple sample analysis devices to test the multiple test sample sub-groups respectively; determining the number of test samples that have been tested when the sample analysis device needs to be cleaned during the detection of a test sample group corresponding to each concentration value interval, including: determining the number of test samples that have been tested when the corresponding sample analysis device needs to be cleaned during the detection of multiple test sample sub-groups corresponding to each concentration value interval; taking the minimum value of the multiple test sample numbers as the final test sample number.

[0011] Among them, according to the number of test samples, the dirt contribution corresponding to each concentration value interval is determined, including: determining the dirt contribution corresponding to each concentration value interval according to the following formula: z = f(y); wherein z is the dirt contribution, and y is the number of test samples; when the accumulated dirt contribution meets the preset conditions, the sample analysis device is cleaned, including: when the accumulated dirt contribution is greater than the preset value, the sample analysis device is cleaned.

[0012] Wherein, determining the dirty contribution corresponding to each concentration value interval according to the number of test samples includes: determining the dirty contribution corresponding to each concentration value interval according to the following formula: ; Among them, z is the dirty contribution, y is the number of test samples, and a, b, and k are all constants.

[0013] When the accumulated dirt contribution is greater than a preset value, a cleaning operation is performed on the sample analysis device, including: when the accumulated dirt contribution is greater than 1, a cleaning operation is performed on the sample analysis device.

[0014] Wherein, determining the dirty contribution corresponding to each concentration value interval according to the number of test samples includes: determining the dirty contribution corresponding to each concentration value interval according to the following formula: ;

[0015] Wherein, z is the dirt contribution, y is the number of test samples; when the accumulated dirt contribution meets the preset conditions, the sample analysis device is cleaned, including: when the accumulated dirt contribution is greater than 1, the sample analysis device is cleaned.

[0016] Among them, the target particle is a specific protein.

[0017] Among them, the specific protein is C-reactive protein.

[0018] Another technical solution adopted in the present application is: to provide a sample analysis device, which includes: a reaction pool for accommodating samples for reaction; a detection pool for accommodating samples for detection; a cleaning component connecting the reaction pool and the detection pool; and a controller connected to the cleaning component for executing the above method.

[0019] Another technical solution adopted by the present application is: providing a computer-readable storage medium, in which program data is stored, and when the program data is executed by a processor, it is used to implement the above method.

[0020] The cleaning method of the sample analysis device provided in the present application includes: obtaining the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particle; determining the corresponding dirty contribution according to the concentration value; accumulating the dirty contribution; and performing a cleaning operation on the sample analysis device when the accumulated dirty contribution meets a preset condition. In the above manner, by corresponding the obtained concentration value of the target ion to the dirty contribution, and performing a cleaning operation on the sample analysis device after the accumulation of the dirty contribution reaches a certain condition, the cleaning operation is optimized, and the cleaning frequency of the sample analysis device can be effectively reduced on the basis of shortening the detection time of a single sample, thereby improving the sample test rate of the sample analysis device as a whole, and allowing the sample analysis device to be cleaned before it becomes dirty, thereby avoiding the detection sample from being contaminated in the sample analysis device and affecting the accuracy of the detection result. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. Among them:

[0022] Figure 1 It is a schematic flow chart of a first embodiment of a cleaning method for a sample analysis device provided by the present application;

[0023] Figure 2 is a flow chart of a specific embodiment of step 12;

[0024] Figure 3 It is a flow chart of a second embodiment of a cleaning method for a sample analysis device provided by the present application;

[0025] Figure 4 is a flowchart of a first specific embodiment for determining a second corresponding relationship;

[0026] Figure 5 is a graph of concentration values ​​versus the number of samples tested;

[0027] Figure 6 is a flowchart of a second specific embodiment for determining a second corresponding relationship;

[0028] Figure 7 It is a structural schematic diagram of an embodiment of a sample analysis device provided by the present application;

[0029] Figure 8 It is a structural schematic diagram of an embodiment of a computer-readable storage medium provided by the present application. DETAILED DESCRIPTION

[0030] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. It will be appreciated that the specific embodiments described herein are only used to explain the present application, rather than to limit the present application. It should also be noted that, for ease of description, only some but not all structures related to the present application are shown in the drawings. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the art without making creative work are within the scope of protection of the present application.

[0031] The terms "first", "second", etc. in this application are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0032] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0033] See also Figure 1 , Figure 1 1 is a flow chart of a first embodiment of a cleaning method for a sample analysis device provided by the present application, the method comprising:

[0034] Step 11: Obtain the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particles.

[0035] It is understandable that the detection result includes at least the concentration value of the target particles, which means that the target particles are included in the current sample or generated when the current sample is detected, which is not limited here. When obtaining the detection result of the current sample, the concentration value of the current particle is also obtained.

[0036] Specifically, the target particle may be a certain protein or a certain type of protein, or may be other non-protein particles.

[0037] For example, the target particle may be a specific protein. Specific proteins are proteins with specific functions that are derived from tissue cells and widely present in serum, plasma, urine, and cerebrospinal fluid, and perform various important biological functions. Taking serum as an example, the specific protein test of serum may include CRP (C-reactive protein), SAA (serum amyloid protein A), and PCT (procalcitonin), etc. In a specific embodiment, the target particle may be C-reactive protein (CRP). The blood analysis device is used to detect a blood sample to determine the concentration value of C-reactive protein in the blood sample. Specifically, the sample analysis device first samples the sample to be detected, and then reacts the sample to be detected with a reagent in a reaction pool so that the C-reactive protein in the sample reacts with the reagent to form a complex, and finally detects the content of the complex by, for example, optical detection to further determine the concentration value of the C-reactive protein.

[0038] Step 12: Determine the corresponding dirt contribution according to the concentration value.

[0039] The dirt contribution is the contribution of the target particles to the dirt, and is related to whether the sample analysis device needs to be cleaned.

[0040] Further, see Figure 2 , Figure 2 is a flow chart of a specific embodiment of step 12, which specifically includes:

[0041] Step 21: Obtain the correspondence between the predetermined concentration value and the dirt contribution.

[0042] In other embodiments, the concentration value and the dirty contribution may also be positively correlated, that is, the dirty contribution increases as the concentration value increases, and the dirty contribution decreases as the concentration value decreases.

[0043] Step 22: According to the corresponding relationship, determine the dirt contribution corresponding to the concentration value.

[0044] After obtaining the predetermined correspondence between the concentration value and the dirt contribution, the corresponding dirt contribution is determined in the correspondence by the concentration value.

[0045] Step 13: Accumulate the dirty contribution.

[0046] The multiple dirty contributions are accumulated and summed to obtain the accumulated dirty contribution, and then proceed to the next step.

[0047] Step 14: When the accumulated dirt contribution meets the preset condition, the sample analysis device is cleaned.

[0048] When the accumulated dirt contribution meets the preset condition, that is, the condition for cleaning the sample analysis device is met, the cleaning operation is performed on it. The accumulated dirt contribution meets the preset condition, which can be specifically that the accumulated dirt contribution is greater than a preset value, and the preset value is a threshold, such as 0.5, 0.8 or 1.

[0049] Optionally, the cleaning operation may specifically include cleaning the sampling needle, the reaction pool, the detection pool and the liquid path, or may be cleaning part of them, which is not limited here.

[0050] Different from the prior art, the cleaning method of the sample analysis device provided in this embodiment includes: obtaining the detection result of the current sample; wherein the detection result includes at least the concentration value of the target particle; determining the corresponding dirty contribution according to the concentration value; accumulating the dirty contribution; when the accumulated dirty contribution meets the preset conditions, performing a cleaning operation on the sample analysis device. In the above manner, by corresponding the obtained concentration value of the target ion to the dirty contribution, and performing a cleaning operation on the sample analysis device after the accumulation of the dirty contribution reaches a certain condition, the cleaning operation is optimized, and the cleaning frequency of the sample analysis device can be effectively reduced on the basis of shortening the detection time of a single sample, thereby improving the sample test rate of the sample analysis device as a whole, and the sample analysis device is cleaned before it becomes dirty, thereby avoiding the detection sample from being contaminated in the sample analysis device and affecting the accuracy of the detection result.

[0051] See also Figure 3 , Figure 3 1 is a flow chart of a second embodiment of a cleaning method for a sample analysis device provided by the present application, the method comprising:

[0052] Step 31: Obtain the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particles.

[0053] This step is similar to the above step 11 and will not be repeated here.

[0054] Step 32: When the concentration value is greater than a preset concentration threshold, obtain a first correspondence between a predetermined concentration value and a dirt contribution; or when the concentration value is less than or equal to a preset concentration threshold, obtain a second correspondence between a predetermined concentration value and a dirt contribution; wherein the first correspondence is obtained by obtaining user input, and the second correspondence is obtained by testing a test sample.

[0055] In this embodiment, there may be two correspondences between the predetermined concentration value and the dirty contribution, which are divided into a first correspondence and a second correspondence according to the magnitude relationship between the concentration value and the preset concentration threshold. When the concentration value is greater than the preset concentration threshold, the dirty contribution corresponding to the concentration value is determined according to the acquired user input value. When the concentration value is less than or equal to the preset concentration value, the second correspondence between the predetermined concentration value and the dirty contribution is obtained by testing the test sample, that is, the test sample is tested to obtain the second correspondence between the concentration value and the dirty contribution.

[0056] Optionally, in other embodiments, there may be only a first corresponding relationship, or only a second corresponding relationship, wherein the first corresponding relationship is obtained by obtaining user input, and the second corresponding relationship is obtained by testing a test sample.

[0057] In this embodiment, since the target particles with high concentration values ​​have strong anti-interference ability to the dirtiness of the sample analysis device, in order to avoid the target particles with high concentration values ​​having a greater impact on the dirtiness contribution of the target ions with medium and low concentration values, the correspondence between the high concentration value and the dirtiness contribution and the correspondence between the medium and low concentration values ​​and the dirtiness contribution are respectively corresponded to the first correspondence and the second correspondence. Among them, the high concentration value means that the concentration value is greater than the preset concentration threshold, and the medium and low concentration values ​​are the concentration values ​​less than or equal to the preset concentration threshold. The preset concentration threshold can be specifically set according to the type of target particle or the type of sample analysis device. For example, when the target particle is CRP, the CRP concentration is generally greater than 90 mg / L, which is a high concentration. At this time, the preset concentration threshold is 90 mg / L. In this case, when the concentration value of CRP is greater than 90 mg / L, the concentration value and the dirtiness contribution are in a first correspondence, and the first correspondence is obtained by obtaining user input.

[0058] The first correspondence is obtained by obtaining user input. Specifically, in the first correspondence, the concentration value can be divided into segments, and the dirty contribution corresponding to each concentration value segment is fixed. For example, when the concentration value is in the range of 100-120 mg / L, the dirty contribution is 0.2 ( ).

[0059] Further, the step of determining the second corresponding relationship may be specifically referred to in Figure 4 , Figure 4 It is a flowchart of a first specific embodiment for determining a second corresponding relationship. Specifically, it includes:

[0060] Step 41: Obtain multiple test sample groups corresponding to different concentration value intervals.

[0061] The obtained multiple test sample groups correspond to different concentration value intervals. Among them, the different concentration value intervals can be intervals with fixed interval values, for example, multiple concentration value intervals such as 0-10, 11-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90 mg / L, or multiple concentration value intervals such as 0-30, 31-60, 61-90 mg / L. Each concentration value interval corresponds to a test sample group, and further, compared with a higher concentration value interval, the number of samples in the test sample group corresponding to a lower concentration value interval is greater.

[0062] Step 42: Detect a test sample group corresponding to each concentration value interval respectively.

[0063] In this embodiment, a test sample group corresponding to each concentration value interval is tested in the sample analysis device.

[0064] Specifically, the cleaning function of the sample analysis device can be turned off, and a test sample group corresponding to each concentration value interval can be tested one by one. When each test sample group is tested, it is determined whether the sample analysis device needs to be cleaned, that is, the sample analysis device reaches the dirty standard.

[0065] Step 43: Determine the number of test samples that have been tested when the sample analysis device needs to be cleaned during the testing process of a test sample group corresponding to each concentration value interval.

[0066] During the testing of the test sample group, when it is determined that the sample analyzer needs to be cleaned, the number of test samples that have been tested is completed, or the number of tests performed on the test samples in the time period from when the sample analyzer starts testing to when the sample analyzer needs to be cleaned.

[0067] Specifically, in conjunction with Table 1, each of the multiple concentration value intervals of 0-10, 11-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90 mg / L corresponds to a test sample group, and the concentration mean x of each test sample group is obtained, which is x1, x2, ..., x9. During the detection process of a test sample group corresponding to each concentration value interval, the number y of test samples that have been detected when the sample analysis device needs to be cleaned is y1, y2, ..., y9.

[0068] Table 1:

[0069]

[0070] According to each determined concentration value interval and its corresponding number of test samples, we can get Figure 5 , Figure 5 It is a graph of the relationship between the concentration value and the number of test samples. The mean concentration (concentration value) x and the number of test samples y are similarly linearly positively correlated, satisfying the formula As the mean concentration (concentration value) x increases, the number of test samples y also increases.

[0071] Step 44: Determine the dirt contribution corresponding to each concentration value interval according to the number of test samples to determine the second corresponding relationship.

[0072] In this embodiment, the dirty contribution corresponding to each concentration value interval can be determined according to the following formula: z = f(y); wherein z is the dirty contribution and y is the number of test samples. That is, the dirty contribution is a function related to the number of test samples. Among them, the dirty contribution z is negatively correlated with the number of test samples x. That is, the dirty contribution z decreases as the number of test samples x increases.

[0073] In a specific embodiment, the dirt contribution corresponding to each concentration value interval can be determined according to the following formula: ; Where z is the dirty contribution, y is the number of test samples, and a, b, and k are all constants. When constant a is 1, constant b is 0, and constant k is 1, the dirty contribution corresponding to each concentration value interval is determined according to the following formula: ; Where z is the dirty contribution and y is the number of test samples.

[0074] In this embodiment, the dirty contribution corresponding to each concentration value interval can be determined by the number of test samples corresponding to each concentration value interval, for example, z1, z2, ..., z9, to determine the second corresponding relationship. In a specific embodiment, z1, z2, ..., z9 can correspond to , ,..., Of course, you can also use the formula of the concentration mean (concentration value) x and the number of test samples y determined in the previous step , determine the formula satisfied by the dirt contribution z and the concentration mean (concentration value) x, and also determine the second corresponding relationship.

[0075] In another specific embodiment, see Figure 6 , Figure 6 It is a flowchart of a second specific embodiment for determining a second corresponding relationship. Specifically, it includes:

[0076] Step 61: Acquire multiple test sample groups corresponding to different concentration value intervals, each test sample group comprising multiple test sample subgroups.

[0077] In this embodiment, the specific description of obtaining multiple test sample groups corresponding to different concentration value intervals can refer to the relevant description of step 41, which will not be repeated here. Each test sample group includes multiple test sample subgroups, each of which can be the same. For example, according to different concentration value intervals of 0-10, 11-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, and 81-90 mg / L, nine corresponding test sample groups are obtained, and among these nine test sample groups, a test sample group corresponding to the concentration value interval of 81-90 mg / L includes multiple test sample subgroups, and the test sample concentration values ​​included in the multiple test sample subgroups can all be the same. Specifically, multiple test sample subgroups can be obtained by dividing a test sample group into multiple parts.

[0078] Step 62: Use multiple sample analysis devices to test multiple test sample subgroups respectively.

[0079] Multiple sample analysis devices are used to detect multiple test sample subgroups in different concentration value intervals. Specifically, each sample analysis device detects a test sample subgroup corresponding to each concentration value interval, thereby realizing that multiple sample analysis devices detect multiple test sample subgroups corresponding to each concentration value interval.

[0080] Step 63: Determine the number of multiple test samples that need to be tested when the corresponding sample analysis device needs to be cleaned during the detection process of multiple test sample subgroups corresponding to each concentration value interval.

[0081] During the process of each sample analysis device detecting a test sample subgroup corresponding to each concentration value interval, the number of test samples detected by each sample analysis device that needs to be cleaned is determined respectively, so that it is possible to determine the number of test samples detected by the corresponding sample analysis devices that need to be cleaned when multiple sample analysis devices detect multiple test sample subgroups corresponding to each concentration value interval.

[0082] Step 64: Taking the minimum value among the multiple test sample quantities as the final test sample quantity.

[0083] Each concentration value interval corresponds to multiple test sample subgroups (a test sample group) in multiple sample analysis devices, and multiple test sample quantities are obtained, and the minimum value of the multiple test sample quantities is used as the final test sample quantity.

[0084] Step 65: According to the final number of test samples, determine the dirt contribution corresponding to each concentration value interval to determine the second corresponding relationship.

[0085] In this step, the step of determining the second corresponding relationship according to the final number of test samples may be specifically referred to step 44. The final number of test samples in this step is equivalent to the number of test samples in step 44.

[0086] In this embodiment, the second corresponding relationship is determined by taking the minimum value of multiple test sample numbers as the final test sample number and determining the dirt contribution corresponding to each concentration value interval by the final test sample number, so that the second corresponding relationship can satisfy multiple different sample analysis devices.

[0087] Step 33: According to the corresponding relationship, determine the dirt contribution corresponding to the concentration value.

[0088] After the first correspondence relationship and the second correspondence relationship between the concentration value and the dirty contribution are determined in advance, the dirty contribution corresponding to the concentration value of the target particle is determined based on the correspondence relationship during the actual sample detection. When multiple samples are detected, the dirty contribution corresponding to the concentration value of the target particle in the multiple samples is determined respectively.

[0089] Step 34: Accumulate the dirty contribution.

[0090] The multiple dirty contributions in the previous step are accumulated, for example, the dirty contributions are superimposed and summed one by one according to the sample detection order or time sequence. Specifically, the accumulation algorithm can be . When the dirty contribution satisfies When z is the dirty contribution, y is the number of test samples, a, b, k are all constants, the cumulative algorithm can be In one embodiment, the dirty contribution satisfies When z is the dirty contribution, y is the number of test samples, the cumulative algorithm can be .

[0091] Step 35: When the accumulated dirt contribution meets the preset condition, the sample analysis device is cleaned.

[0092] When the accumulated dirt contribution meets the preset condition, that is, when the accumulated dirt contribution reaches a certain dirtiness, the sample analysis device is cleaned. , When the accumulated dirt contribution is greater than a preset value, the preset condition is satisfied. The preset value may be set accordingly according to the specific situation, such as 0.5, 0.8 or 1. In a specific embodiment, when the accumulated dirt contribution is greater than 1, the sample analysis device is cleaned.

[0093] Different from the prior art, the cleaning method of the sample analysis device provided in this embodiment determines the corresponding relationship between the concentration value of the target particle and the dirty contribution by determining the first corresponding relationship or the second corresponding relationship, and makes the corresponding relationship more accurate and applicable to multiple sample analysis devices by setting different concentration value intervals and using different sample analysis devices. When the sample analysis device actually performs sample detection, the dirty contribution of each sample can be corresponded to the concentration value of the target ion in each sample through the pre-acquired corresponding relationship, and each dirty contribution is accumulated. When the accumulation meets the preset conditions, the sample analysis device is cleaned. In the above manner, the accumulated dirty contribution determines whether a cleaning operation is required, thereby optimizing the cleaning method and cleaning logic of the sample analysis device, which can effectively reduce the cleaning frequency of the sample analysis device, improve the sample test rate of the sample analysis device, and enable the sample analysis device to be cleaned before it becomes dirty, so as to avoid the detection sample being contaminated in the sample analysis device and affecting the accuracy of the detection result.

[0094] See also Figure 7 , Figure 7 : is a schematic diagram of the structure of an embodiment of a sample analysis device provided by the present application, wherein the sample analysis device 70 includes a reaction pool 71, a detection pool 72, a cleaning component 73 and a controller 74. The reaction pool 71 is used to accommodate samples for reaction, the detection pool 72 is used to accommodate samples for detection, and the cleaning component 73 connects the reaction pool 71 and the detection pool 72. The controller 74 is connected to the cleaning component 73 and is used to perform the following method:

[0095] Obtain the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particles; determine the corresponding dirt contribution according to the concentration value; accumulate the dirt contribution; when the accumulated dirt contribution meets the preset conditions, perform a cleaning operation on the sample analysis device 70.

[0096] Optionally, the controller 74 is further configured to execute: obtaining a predetermined correspondence between a concentration value and a dirt contribution; and determining a dirt contribution corresponding to the concentration value according to the correspondence.

[0097] Optionally, the controller 74 is also used to execute: when the concentration value is greater than a preset concentration threshold, obtain a first correspondence between a predetermined concentration value and a dirt contribution; or when the concentration value is less than or equal to a preset concentration threshold, obtain a second correspondence between a predetermined concentration value and a dirt contribution; wherein the first correspondence is obtained by obtaining user input, and the second correspondence is obtained by testing the test sample.

[0098] Optionally, the controller 74 is also used to execute: obtaining multiple test sample groups corresponding to different concentration value intervals; testing one test sample group corresponding to each concentration value interval respectively; determining the number of test samples that need to be cleaned during the detection of a test sample group corresponding to each concentration value interval; determining the dirt contribution corresponding to each concentration value interval based on the number of test samples to determine the second corresponding relationship.

[0099] Optionally, the controller 74 is also used to execute: each test sample group includes multiple test sample subgroups; each test sample group corresponding to each concentration value interval is tested separately, including: multiple sample analysis devices are used to test multiple test sample subgroups separately; determining the number of test samples that need to be cleaned when the sample analysis device needs to be cleaned during the detection of a test sample group corresponding to each concentration value interval, including: determining the number of test samples that need to be cleaned when the corresponding sample analysis device needs to be cleaned during the detection of multiple test sample subgroups corresponding to each concentration value interval; and taking the minimum value of the multiple test sample numbers as the final test sample number.

[0100] Optionally, the controller 74 is further configured to execute: determining the dirt contribution corresponding to each concentration value interval according to the following formula: z = f(y); wherein z is the dirt contribution, and y is the number of test samples; when the accumulated dirt contribution is greater than a preset value, performing a cleaning operation on the sample analysis device 70. Specifically, the dirt contribution corresponding to each concentration value interval can be determined according to the following formula: ; Where z is the dirty contribution, y is the number of test samples, a, b, k are all constants. The default value can be 1.

[0101] See also Figure 8 , Figure 8 8 is a schematic diagram of a computer-readable storage medium according to an embodiment of the present application. The computer-readable storage medium 80 stores program data 81. When the program data 81 is executed by a processor, the following method is implemented:

[0102] Obtain the detection result of the current sample; wherein the detection result at least includes the concentration value of the target particles; determine the corresponding dirt contribution according to the concentration value; accumulate the dirt contribution; when the accumulated dirt contribution meets the preset conditions, perform a cleaning operation on the sample analysis device.

[0103] Optionally, when the program data 81 is executed by the processor, it is also used to implement the following method: obtaining a predetermined correspondence between a concentration value and a dirt contribution; and determining a dirt contribution corresponding to the concentration value according to the correspondence.

[0104] Optionally, when the program data 81 is executed by the processor, it is also used to implement the following method: when the concentration value is greater than a preset concentration threshold, a first correspondence between a predetermined concentration value and a dirt contribution is obtained; or when the concentration value is less than or equal to a preset concentration threshold, a second correspondence between a predetermined concentration value and a dirt contribution is obtained; wherein the first correspondence is obtained by obtaining user input, and the second correspondence is obtained by testing a test sample.

[0105] Optionally, when the program data 81 is executed by the processor, it is also used to implement the following method: obtain multiple test sample groups corresponding to different concentration value intervals; test one test sample group corresponding to each concentration value interval respectively; determine the number of test samples that need to be cleaned during the detection process of a test sample group corresponding to each concentration value interval; determine the dirt contribution corresponding to each concentration value interval based on the number of test samples to determine the second corresponding relationship.

[0106] Optionally, when the program data 81 is executed by the processor, it is also used to implement the following method: each test sample group contains multiple test sample subgroups; each test sample group corresponding to each concentration value interval is tested separately, including: using multiple sample analysis devices to test the multiple test sample subgroups separately; determining the number of test samples that have been tested when the sample analysis device needs to be cleaned during the detection of a test sample group corresponding to each concentration value interval, including: determining the number of test samples that have been tested when the corresponding sample analysis device needs to be cleaned during the detection of multiple test sample subgroups corresponding to each concentration value interval; and taking the minimum value of the multiple test sample numbers as the final test sample number.

[0107] Optionally, when the program data 81 is executed by the processor, it is also used to implement the following method: determine the dirt contribution corresponding to each concentration value interval according to the following formula: z= f(y); wherein z is the dirt contribution, and y is the number of test samples; when the accumulated dirt contribution is greater than a preset value, perform a cleaning operation on the sample analysis device 70. Specifically, the dirt contribution corresponding to each concentration value interval can be determined according to the following formula: ; Where z is the dirty contribution, y is the number of test samples, a, b, k are all constants. The default value can be 1.

[0108] In the several embodiments provided in this application, it should be understood that the disclosed methods and devices can be implemented in other ways. For example, the device implementation described above is only illustrative, for example, the division of the modules or units is only a logical function division, and there may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed.

[0109] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the present embodiment.

[0110] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units.

[0111] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made according to the description and drawings of the present application, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A method for cleaning a sample analysis device, characterized in that: The method comprises: Obtaining a test result of the current sample; wherein the test result at least includes a concentration value of the target particles; When the concentration value is greater than a preset concentration threshold, obtaining a predetermined first correspondence between the concentration value and the dirt contribution, and determining the dirt contribution corresponding to the concentration value according to the first correspondence, wherein the first correspondence is obtained by obtaining a user input; Or, when the concentration value is less than or equal to a preset concentration threshold, a second correspondence between a predetermined concentration value and a dirt contribution is obtained, and the dirt contribution corresponding to the concentration value is determined according to the second correspondence; the second correspondence is obtained by testing the test sample in the following manner: Obtaining multiple test sample groups corresponding to different concentration value intervals; A test sample group corresponding to each concentration value interval is tested respectively; Determine the number of test samples that have been tested when the sample analysis device needs to be cleaned during the test of a test sample group corresponding to each concentration value interval; Determine the dirt contribution corresponding to each concentration value interval according to the number of test samples to determine the second corresponding relationship; Accumulating the dirty contribution; When the accumulated dirt contribution meets a preset condition, the sample analysis device is cleaned.

2. The method according to claim 1, characterized in that The concentration value is directly proportional to the dirt contribution.

3. The method according to claim 1, characterized in that Each test sample group includes multiple test sample subgroups; The step of testing a test sample group corresponding to each concentration value interval includes: Using multiple sample analysis devices to test multiple test sample subgroups respectively; In the process of determining a test sample group corresponding to each concentration value interval, the number of test samples that have been tested when the sample analysis device needs to be cleaned includes: Determine, during the detection process of the multiple test sample subgroups corresponding to each concentration value interval, the number of the multiple test samples that have been detected when the corresponding sample analysis device needs to be cleaned; The minimum value among the multiple test sample quantities is taken as the final test sample quantity.

4. The method according to claim 1, characterized in that: Determining the dirt contribution corresponding to each concentration value interval according to the number of test samples includes: The dirty contribution corresponding to each concentration value interval is determined according to the following formula: z = f(y); Among them, z is the dirty contribution, y is the number of test samples, and z is negatively correlated with y; When the accumulated dirt contribution meets a preset condition, the sample analysis device is cleaned, including: When the accumulated dirt contribution is greater than a preset value, the sample analysis device is cleaned.

5. The method according to claim 4, characterized in that Determining the dirt contribution corresponding to each concentration value interval according to the number of test samples includes: The dirty contribution corresponding to each concentration value interval is determined according to the following formula: ； Among them, z is the dirty contribution, y is the number of test samples, and a, b, and k are all constants.

6. The method according to claim 4, characterized in that When the accumulated dirt contribution is greater than a preset value, the sample analysis device is cleaned, including: When the accumulated dirt contribution is greater than 1, the sample analysis device is cleaned.

7. The method according to any one of claims 1 to 6, characterized in that: The target particle is a specific protein.

8. The method according to claim 7, characterized in that The specific protein is C-reactive protein.

9. A sample analysis device, characterized in that: The sample analysis device comprises: A reaction pool, used to hold samples for reaction; A detection pool, used to contain samples for testing; A cleaning component, connecting the reaction pool and the detection pool; A controller, connected to the cleaning component, is used to execute the method as described in any one of claims 1-8.

10. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores program data, and when the program data is executed by a processor, it is used to implement the method according to any one of claims 1 to 8.

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