A Chinese medicine composition for preventing postoperative recurrence of condyloma acuminatum and its preparation method and application
Through the extraction and extraction of Chinese medicine compositions such as Sophora ginseng and preparation of extracts, Anbu Yixuan Decoction was formed, which solved the problems of high recurrence rates and obvious side effects in the treatment of genital warts, and achieved more effective and safe treatment effects.
Patent Information
- Application Number
- CN202310511683.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-05-09
- Publication Date
- 2024-12-06
- Estimated Expiration
- 2043-05-09
AI Technical Summary
The existing treatment methods for genital warts have problems such as high recurrence rate, long treatment time, obvious side effects, poor targeting, and lack of effective antiviral drugs. They are often accompanied by complications and frequent recurrences after surgical treatment.
Using Chinese medicine compositions such as Sophora cinnabarium, gentian, gardenia, rhubarb, Glauber's salt, schizonepeta, snake bed, syringae, and black plum, the active ingredient extraction solution is obtained by adding water to form a drug extract for sitting bath or local Use, combined with hydroxyethyl ethyl hydroxyphenyl ester auxiliary materials, to prepare Anbu Yiyi Decoction, which is used to treat genital warts and postoperative itching.
It significantly reduces the recurrence rate and complication rate of genital warts, reduces side effects, and improves postoperative healing effect. It shows better efficacy and safety compared with Western medicine and commercially available Chinese medicine lotions.
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Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating condyloma acuminata, a preparation method thereof and an application thereof. Background Art
[0002] Condyloma acuminata (CA), also known as anogenital warts, is a sexually transmitted disease mainly caused by human papillomavirus (HPV) infection, which is characterized by verrucous hyperplastic lesions of the skin and mucosa. The main symptoms are discomfort and itching in the anus, or no symptoms. It mostly occurs on the skin and mucosa of the genital organs, anus or perianal area, and can also involve areas such as the groin or perineum. Anogenital HPV infection is common. From cervical cytology samples, the corrected infection rate of the global cytologically normal population is 11.7%. Most are subclinical infections and latent infections. The reported incidence of condyloma acuminata in China is 0.025% - 0.029%, of which 0.026% - 0.029% are males and 0.023% - 0.030% are females.
[0003] Perianal condyloma acuminata is called "sao you" in traditional Chinese medicine, which is caused by damp-heat pouring downward or heat-toxin accumulating in the perianal area. It often shows moist itching and foreign body sensation in the vulva and perianal skin, accompanied by dry mouth and bitter taste, fullness and distension in the chest and hypochondrium, poor appetite, yellow urine, red tongue with yellow and greasy coating, and slippery and rapid pulse. It is often caused by damp-heat pouring downward and heat-toxin accumulating in the perianal skin and mucosa. According to relevant guideline documents [1][2] , it belongs to the accumulation of damp-heat and toxic pathogens.
[0004] For the treatment of genital warts, the "Guidelines for Clinical Diagnosis and Treatment of Genital Warts in China (2021 Full Version)" points out that there is currently no definite evidence that one regimen is superior to another, and no regimen is suitable for all patients and all warts. There is currently no effective antiviral drug for HPV, and HPV infection cannot be eradicated by systemic application of antiviral drugs. Non-surgical and operational drug treatments are mostly toxic to eliminate warts, and the treatment time is long to eliminate warts, and the long-term efficacy is uncertain, especially for slightly larger warts. Therefore, surgical treatment has become a trend. After surgical treatment, there will be certain complications around the surgical incision, such as local irritation, redness, swelling, ulcers, erosion, scars, etc. In addition, genital warts have a very high recurrence rate, and all therapies are likely to relapse, requiring long-term repeated treatment, which seriously affects the patient's quality of life. Data from large samples show that the incidence of recurrent pathology in the male population is (47-163) / 100,000, and in the female population it is (23-110) / 100,000. The recurrence rate is highest in 3-6 months, and the recurrence rate gradually decreases with time. At present, local medication is generally used to treat recurrence, mainly to improve symptoms. Imiquimod and local interferon treatment (such as external application of α2b interferon gel) are used, but they cannot effectively reduce recurrence. Patients often suffer from frequent recurrences, itching, dampness and other clinical symptoms. Although the use of compound phellodendron liquid coating has a certain effect, it has a wide range of indications and poor targeting, and cannot obtain a definite and accurate effect.
[0005] [1] Li Yuanwen, Li Nan. Expert consensus on TCM treatment of pruritus[J]. Chinese Journal of Integrated Traditional and Western Medicine Dermatology and Venereology, 2017, 16(02): 189-190.
[0006] [2] Hu Xiangdang, Condyloma acuminatum of perianal skin and anorectal canal[M]. Chinese Journal of Anorectal Medicine, 2012, 10: 378-382. Summary of the invention
[0007] To solve the above problems, the present invention provides a Chinese medicine composition for treating condyloma acuminatum, and a preparation method and application thereof. The Chinese medicine composition of the present invention is consistent with the pathogenesis of condyloma acuminatum and pruritus, can effectively reduce the recurrence rate of condyloma acuminatum, and has a significant effect on common perianal diseases and pruritus caused by disease surgery, can promote healing, and reduce the occurrence of side effects. The Chinese medicine composition of the present invention is non-toxic and has no obvious drug toxic and side effects.
[0008] The invention provides a traditional Chinese medicine composition for treating condyloma acuminatum, comprising the following raw materials in parts by weight: 40-50 parts of sophora flavescens, 15-25 parts of gentiana, 15-25 parts of gardenia, 10-18 parts of rhubarb, 35-60 parts of sodium sulfate, 10-19 parts of schizonepeta tenuifolia, 15-25 parts of cnidium monnieri, 15-20 parts of kochia scoparia and 9-15 parts of ebony.
[0009] Preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 43-47 parts of Sophora flavescens, 18-22 parts of Gentiana scabra, 16-20 parts of Gardenia jasminoides, 11-15 parts of Rhubarb, 40-55 parts of Sodium sulfate, 11-15 parts of Schizonepeta tenuifolia, 16-20 parts of Cnidium monnieri, 16-19 parts of Kochia scoparia, and 11-13 parts of Prunus mume.
[0010] The present invention also provides a method for extracting effective ingredients of a traditional Chinese medicine composition for treating condyloma acuminatum, comprising the following steps:
[0011] The raw materials of the traditional Chinese medicine composition are crushed, and the crushed raw materials are extracted with water to obtain an effective component extract.
[0012] Preferably, the extraction is performed multiple times, and the extracts obtained from each extraction are mixed.
[0013] Preferably, after obtaining the active ingredient extract, the process further comprises filtering and concentrating to obtain a medicinal extract.
[0014] Preferably, the volume mass ratio of the drug extract to the raw material is 1L:2-4kg.
[0015] The invention also provides an effective component of a traditional Chinese medicine composition for treating condyloma acuminatum.
[0016] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition or the effective ingredients of the above-mentioned traditional Chinese medicine composition for treating condyloma acuminatum in preparing a medicine for treating condyloma acuminatum.
[0017] Preferably, the medicine comprises the above-mentioned traditional Chinese medicine composition or the above-mentioned traditional Chinese medicine composition for treating condyloma acuminatum and active ingredients and pharmaceutically permitted excipients.
[0018] Preferably, the auxiliary material includes ethylparaben.
[0019] Beneficial effects: The present invention provides a Chinese medicine composition for treating condyloma acuminatum, comprising the following raw materials in parts by weight: 40-50 parts of Sophora flavescens, 15-25 parts of Gentiana scabra, 15-25 parts of Gardenia jasminoides, 10-18 parts of Rhubarb, 35-60 parts of Glauber's salt, 10-19 parts of Nepeta tenuifolia, 15-25 parts of Cnidium monnieri, 15-20 parts of Kochia scoparia, and 9-15 parts of Prunus mume. The drugs in the composition are relatively common and inexpensive. Among them, Sophora flavescens and Gentiana radix are used to clear away heat and dampness, and are the main drugs; Gardenia jasminoides, Rhubarb, and Glauber's salt help the main drugs to clear away heat and dampness, and have the function of cooling blood and detoxifying, and are more in line with the pathogenesis of this disease with the main drugs, and are the minister drugs; Cnidium monnieri and Kochia scoparia are good at clearing damp heat in the lower part of the body, killing insects and relieving itching, and Schizonepeta tenuifolia is good at relieving damp heat on the skin surface, killing insects and relieving itching. The three drugs play the role of clearing heat and dampness, killing insects and relieving itching, and are adjuvant drugs; Prunus mume is the messenger, and its sour and astringent nature can absorb moisture, stop bleeding, reduce exudation, and inhibit a variety of pathogenic bacteria and skin fungi, and promote healing. At the same time, the external use of Prunus mume decoction enhances the adhesion of the drug and makes the drug effect more lasting. The whole prescription plays the role of clearing heat and dampness, killing insects and relieving itching, without obvious toxic and side effects. It is suitable for the treatment of condyloma acuminatum and common perianal diseases and itching symptoms caused by postoperative diseases, and can effectively reduce the recurrence rate of the disease and complications. Experiments show that the therapeutic effect of the present invention is remarkable. Compared with western medicine and commercially available Chinese medicine lotions, the recurrence rate is greatly reduced, and the incidence of complications is also greatly reduced. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] Figure 1 This is the diagnosis case sheet of Li XX (female);
[0021] Figure 2 This is the medical record of Li Moumou (female)'s follow-up visit 15 days after the operation;
[0022] Figure 3 This is the medical record of Li Moumou (female)'s follow-up visit 2 months after surgery;
[0023] Figure 4 This is the medical record of Mr. Li (male);
[0024] Figure 5 This is the medication medical record of Li Moumou (male);
[0025] Figure 6 This is Du's medical record sheet;
[0026] Figure 7 This is Du's follow-up medical record one week after surgery;
[0027] Figure 8 This is Du's follow-up medical record 3 weeks after surgery;
[0028] Fig. 9 This is Du's follow-up medical record 4 weeks after surgery;
[0029] Fig.10This is Du's follow-up medical record 2 months after surgery;
[0030] Fig.11 This is Qiu's medical record sheet;
[0031] Fig.12 This is Qiu's follow-up medical record 6 days after surgery;
[0032] Fig.13 This is Qiu's follow-up medical record 13 days after the operation;
[0033] Fig.14 Medication case list for Zhao Moumou;
[0034] Fig.15 This is Zhao Moumou’s medical record for his follow-up visit 2 weeks after the operation. DETAILED DESCRIPTION
[0035] The invention provides a traditional Chinese medicine composition for treating condyloma acuminatum, comprising the following raw materials in parts by weight: 40-50 parts of sophora flavescens, 15-25 parts of gentiana, 15-25 parts of gardenia, 10-18 parts of rhubarb, 35-60 parts of sodium sulfate, 10-19 parts of schizonepeta tenuifolia, 15-25 parts of cnidium monnieri, 15-20 parts of kochia scoparia and 9-15 parts of ebony.
[0036] The sources of the raw materials of the Chinese medicine composition of the present invention are as follows: Sophora flavescens Ait., a perennial shrub of the Leguminosae family, is selected as the dried root. Gentiana manshurica Kitag., Gentiana scabra Bge., Gentiana triflora Pall., or Gentiana rigescens Franch., a perennial herb of the Gentianaceae family, is selected as the dried root and rhizome. Gardenia jasminoides Ellis, an evergreen shrub of the Rubiaceae family, is selected as the dried mature fruit. Sodium sulfate (Xuanming powder) is selected as a crystal formed by refining natural minerals containing sodium sulfate, which is weathered to lose crystal water and become a white powder called Xuanming powder or Yuanming powder. Nepeta tenuifolia Briq., an annual herb of the Lamiaceae family, is selected as the dried above-ground part of Schizonepeta tenuifolia Briq. Cnidium monnieri (L.) Cuss., an annual herbaceous plant of the Umbelliferae family, is selected from the dried mature fruit. Kochia scoparia (L.) Schrad., an annual herbaceous plant of the Chenopodiaceae family, is selected from the dried mature fruit. Rhubarb is selected from the dried root and rhizome of Rheumpalmatum L., a perennial herbaceous plant of the Polygonaceae family. Black plum is selected from the dried nearly mature fruit of Prunus mume (sieb.) Sieb.EtZucc., a perennial deciduous tree of the Rosaceae family.
[0037] The Chinese medicine composition provided by the present invention comprises 40 to 50 parts of Sophora flavescens, preferably 43 to 47 parts, and most preferably 45 parts. The Sophora flavescens described in the present invention is bitter in taste, cold in nature, enters the heart, liver, stomach, large intestine, and bladder meridians, and has the function of clearing away heat and drying dampness.
[0038] The Chinese medicine composition provided by the present invention comprises 15 to 25 parts of gentian, preferably 18 to 22 parts, and most preferably 18 parts. The gentian of the present invention is bitter in taste, cold in nature, enters the liver and gallbladder meridians, and has the function of clearing away heat and drying dampness.
[0039] The Chinese medicine composition provided by the present invention comprises 15 to 25 parts of gardenia, preferably 16 to 20 parts, and most preferably 18 parts. The gardenia of the present invention is bitter in taste, cold in nature, enters the heart, lung and triple burner meridians, and has the functions of clearing away heat and dampness, cooling blood and detoxifying.
[0040] The Chinese medicine composition provided by the present invention comprises 10 to 18 parts of rhubarb, preferably 11 to 15 parts, and most preferably 12 parts. The rhubarb of the present invention is bitter in taste, cold in nature, enters the spleen, stomach and large intestine meridians, and has the functions of clearing away diarrhea, promoting facilitation, cooling blood and stopping bleeding.
[0041] The Chinese medicine composition provided by the present invention comprises 35 to 60 parts of mirabilite, preferably 40 to 55 parts, and most preferably 45 parts. The mirabilite of the present invention is salty and bitter, cold in nature, enters the stomach and large intestine meridians, and has the functions of moistening dryness, softening hard masses, clearing heat and reducing swelling.
[0042] The Chinese medicine composition provided by the present invention comprises 10 to 19 parts of Schizonepeta, preferably 11 to 15 parts, and most preferably 12 parts. The Schizonepeta of the present invention is pungent in taste, slightly warm in nature, enters the lung and liver meridians, has the functions of dispelling wind, clearing rashes and eliminating sores, and can also relieve itching.
[0043] The Chinese medicine composition provided by the present invention comprises 15 to 25 parts of Cnidium monnieri, preferably 16 to 20 parts, and most preferably 18 parts. The Cnidium monnieri of the present invention is pungent and bitter in taste, warm in nature, enters the kidney meridian, and has the effects of drying dampness and dispelling wind, killing insects and relieving itching, and warming the kidney and strengthening yang.
[0044] The Chinese medicine composition provided by the present invention comprises 15 to 20 parts of Kochia scoparia, preferably 16 to 19 parts, and most preferably 18 parts. The Kochia scoparia of the present invention is pungent and bitter in taste, cold in nature, enters the kidney and bladder meridians, and has the effects of clearing away heat and dampness, dispelling wind and relieving itching.
[0045] The Chinese medicine composition provided by the present invention comprises 9 to 15 parts of Kochia scoparia, preferably 11 to 13 parts, and most preferably 12 parts. The black plum of the present invention is sour and astringent, neutral in nature, and enters the liver, spleen, lung, and large intestine meridians, and has the effects of astringing the lungs, astringing the intestines, promoting the production of body fluids, and calming ascaris.
[0046] The sophora flavescens and gentiana scabra are used as the main drugs for clearing away heat and removing dampness; gardenia, rhubarb and sodium sulfate are used as the assistant drugs, which help the main drugs to clear away heat and remove dampness, and have the functions of cooling blood and detoxifying, and cooperate with the main drugs to better meet the pathogenesis; cnidium monnieri and kochia scoparia are good at clearing damp-heat in the lower part of the body, killing insects and relieving itching, and schizonepeta tenuifolia is good at relieving damp-heat on the skin surface, killing insects and relieving itching, and the three drugs together play the effects of clearing heat and drying dampness, killing insects and relieving itching, and are used as adjuvant drugs; black plum is used as the messenger, which has the properties of sourness, astringency, moisture absorption, sore hemostasis, and exudation reduction, can inhibit a variety of pathogenic bacteria and skin fungi, and promote healing, and at the same time, the external use of black plum decoction enhances the adhesion of the drug, so that the drug effect is more durable.
[0047] The present invention also provides a method for extracting effective ingredients of a traditional Chinese medicine composition for treating condyloma acuminatum, comprising the following steps:
[0048] The raw materials of the traditional Chinese medicine composition are crushed, and the crushed raw materials are extracted with water to obtain an effective component extract.
[0049] Before the pulverization of the present invention, the raw materials are firstly washed, impurities are removed and air-dried.
[0050] The extraction described in the present invention is multiple extractions, the extraction solvent is preferably water, and the number of extractions is preferably two extractions.
[0051] In the two extractions described in the present invention, in the first extraction, the mass volume ratio of the raw material to water is preferably 1kg:11-13L, more preferably 1kg:11-12L, the extraction time is preferably 1-2h, more preferably 1-1.5h, and the first filtrate and the residue are obtained by filtration; in the second extraction, the mass volume ratio of the residue to water is preferably 1kg:7-9L, more preferably 1kg:8-9L, the extraction time is preferably 0.5-2h, more preferably 1-1.5h, and the second filtrate is obtained by filtration.
[0052] After the extraction of the present invention, the first filtrate and the second filtrate are combined to obtain an extract, and the extract is concentrated to obtain a drug extract. In the present invention, the concentration preferably includes concentrating the volume mass ratio of the drug extract to the raw material to 1L:2-4kg, more preferably 1L:2.5-3.5kg.
[0053] The present invention also provides the effective components of the traditional Chinese medicine composition extracted by the extraction method.
[0054] The effective ingredients of the present invention can be obtained by extracting the raw materials together, or by extracting the raw materials separately and then mixing them.
[0055] The administration route of the composition of the present invention is preferably sitz bath administration. The dosage form is preferably granules or extracts, which are diluted or diluted with water before sitz bathing.
[0056] The present invention has no particular limitation on the preparation method of the granule preparation, and the granule preparation can be prepared by conventional preparation methods in the art.
[0057] The granules or extracts are called wart-relieving and itching-relieving soup by the present invention.
[0058] The Chinese medicine composition and the effective ingredients of the Chinese medicine composition provided by the present invention have long-lasting efficacy, strong pertinence to the pathogenesis, and no obvious toxic and side effects, are suitable for the treatment of condyloma acuminatum and common perianal diseases and itching symptoms caused by postoperative diseases, can effectively reduce the recurrence rate of the disease and complications, and can be used to prepare drugs for the treatment of condyloma acuminatum.
[0059] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition or the effective ingredients of the above-mentioned traditional Chinese medicine composition for treating condyloma acuminatum in preparing a medicine for treating condyloma acuminatum.
[0060] The medicine of the present invention comprises the effective ingredients of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine composition for treating condyloma acuminatum and pharmaceutically permitted auxiliary materials.
[0061] The amount of the auxiliary material added in the present invention is preferably 0.1% by weight of the drug extract.
[0062] The auxiliary material of the present invention preferably includes ethylparaben.
[0063] To further illustrate the present invention, the Chinese medicine composition for treating condyloma acuminatum provided by the present invention, its preparation method and application are described in detail below in conjunction with examples, but they should not be construed as limiting the scope of protection of the present invention.
[0064] Example 1
[0065] Preparation of Chinese medicine lotion
[0066] Weigh 0.45kg of Sophora flavescens, 0.20kg of Gentiana scabra, 0.18kg of Gardenia jasminoides, 0.12kg of Rhubarb, 0.45kg of Glauber's salt, 0.12kg of Nepeta tenuifolia, 0.18kg of Cnidium monnieri, 0.18kg of Kochia scoparia and 0.12kg of Prunus mume, wash and remove impurities, dry, crush into particles, then add 12 times the weight of the medicinal materials and boil for 1 to 1.5 hours, filter, and collect the filtrate; then add 8 times the weight of the medicinal materials to the medicinal residue and boil for 1 hour, filter, collect the filtrate, combine the two filtrates, and concentrate to a medicinal extract of solution volume: medicinal materials weight = 1L: 3kg. Add 0.1% of ethyl hydroxybenzoate to the medicinal extract, mix well, dilute with water to 2L, and pack into bags with 100ml per bag to obtain a Chinese medicine lotion.
[0067] Example 2
[0068] Take 22.5g of Sophora flavescens, 10g of Gentiana scabra, 9g of Gardenia jasminoides, 6g of Rhubarb, 22.5g of Sophora japonica salt, 6g of Schizonepeta tenuifolia, 9g of Cnidium monnieri, 9g of Kochia scoparia and 6g of Prunus mume and mix them evenly.
[0069] Application Example 1
[0070] A total of 185 eligible patients with perianal condyloma acuminatum were collected, of which 35 patients (24 males and 11 females) used compound phellodendron liquid for sitting bath; 48 patients (36 males and 12 females) were treated with Anyou Zhiyang decoction for sitting bath and topical α2b interferon gel in the experimental group; 53 patients (40 males and 13 females) used topical α2b interferon gel; 49 patients (33 males and 16 females) used Anyou Zhiyang decoction for sitting bath. There was no statistically significant difference in gender and age between the two groups, and they were comparable.
[0071] Anyou Zhiyang Decoction + Gel Group: Patients were treated with the Chinese medicine lotion prepared in Example 1 or 2. Usage: Take 50 ml of the Chinese medicine lotion prepared in Example 1, add 2000 ml of boiled water and place in a bidet, or take the granules prepared in Example 2, add 2000 ml of water and dissolve in a bidet.
[0072] Place the sitz bath basin on the sitz bath stand, assist the patient to sit on the sitz bath stand, and use the medicinal solution vapor to fumigate the perianal area for 10 minutes while the steam is hot. When the temperature of the medicinal solution drops to 45-50℃, sit in the basin and immerse the perianal skin completely in the medicinal solution for 15 minutes.
[0073] From the first day after condyloma acuminatum resection (high-frequency electrocoagulation and resection), patients were fumigated and bathed every morning, evening and after defecation, and then α2b interferon gel was applied. A course of treatment was 14 days, and follow-up examinations were performed every two weeks.
[0074] Compound Phellodendron liquid group: take 50ml of commercially available compound Phellodendron liquid ointment and add 2000ml of boiling water into the bidet. Other procedures are the same as those of the Anyu Zhiyang Decoction + gel group.
[0075] α2b gel group: The anus was cleaned every morning, evening and after defecation, and then α2b interferon gel was applied. 14 days was a course of treatment, and reexamination was performed every two weeks.
[0076] Anyou Zhiyang Decoction group: except not applying interferon α2b gel, other operations were the same as those in the Anyou Zhiyang Decoction + gel group.
[0077] The recurrence of the above four groups of patients after treatment, the condition of perianal itching, and the incidence of complications such as delayed wound healing, infection, erosion, and ulcer were compared every two weeks. Delayed wound healing refers to the absence of wound healing after two weeks of follow-up, and complications refer to redness, swelling, erosion, purulent secretions, edema, etc.
[0078] The results are shown in Table 1:
[0079] Table 1 Comparison of postoperative follow-up between the two groups of patients
[0080]
[0081] It can be seen from the data in Table 1 that the Chinese medicine composition of the present invention can significantly reduce the recurrence probability, recurrence frequency, itching frequency and complication incidence rate compared with α2b gel, and has more significant treatment and recurrence prevention effects than Western medicine.
[0082] Compared with the compound phellodendron chinense solution, the Chinese medicine composition of the present invention can also significantly reduce the recurrence probability, recurrence frequency, itching frequency and complication incidence rate. Moreover, the Chinese medicine composition of the present invention and α2b gel are used simultaneously, and the effect is better than that of using the Chinese medicine composition of the present invention alone.
[0083] Application Example 2
[0084] Clinical effects:
[0085] Patient Li, female, complained of anal foreign body growth for 1 month and was diagnosed with anal genital condyloma acuminatum. After perianal condyloma acuminatum excision surgery, she used the anti-wart anti-itching soup of the present invention for sitz bathing, and no recurrence, no itching, no delayed wound healing, and the case example Figures 1 to 3 shown.
[0086] Patient Li, male, complained of anal foreign body growth for more than one month and was diagnosed with perianal condyloma acuminatum. After perianal condyloma acuminatum removal surgery, he used the anti-wart antipruritic decoction of the present invention for sitz bathing and no recurrence was observed. Figures 4-5 shown.
[0087] Patient Du, female, complained of anal discomfort for one week and was diagnosed with perianal condyloma acuminatum. After undergoing perianal condyloma acuminatum excision surgery, she used the anti-wart antipruritic decoction of the present invention for sitz bathing and no recurrence was observed. Figures 6 to 10 shown.
[0088] The patient, male, Qiu Moumou, complained of discomfort caused by foreign bodies in the anus for 3 months and was diagnosed with perianal condyloma acuminatum. After undergoing perianal condyloma acuminatum excision surgery, he used the anti-wart antipruritic decoction of the present invention for sitz bathing and had no recurrence. Figures 11 to 13 shown.
[0089] Patient Zhao, male, had condyloma acuminatum surgery two weeks ago. He used the anti-wart and itching decoction of the present invention after removing the gardenia. There was no recurrence, but the wound was not completely healed. Figures 14-15 shown.
[0090] Although the above embodiment describes the present invention in detail, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the protection scope of the present invention.
Claims
1. A Chinese medicine composition for preventing postoperative recurrence of condyloma acuminatum, characterized in that: The invention is prepared from the following raw materials in parts by weight: 40-50 parts of sophora flavescens, 15-25 parts of gentian, 15-25 parts of gardenia, 10-18 parts of rhubarb, 35-60 parts of sodium sulfate, 10-19 parts of schizonepeta, 15-25 parts of cnidium monnieri, 15-20 parts of kochia scoparia and 9-15 parts of ebony.
2. The Chinese medicine composition according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 43-47 parts of sophora flavescens, 18-22 parts of gentiana, 16-20 parts of gardenia, 11-15 parts of rhubarb, 40-55 parts of sodium sulfate, 11-15 parts of schizonepeta tenuifolia, 16-20 parts of cnidium monnieri, 16-19 parts of kochia scoparia and 11-13 parts of ebony.
3. The method for extracting the active ingredients of the Chinese medicine composition according to claim 1 or 2, characterized in that: The following steps are involved: The raw materials of the traditional Chinese medicine composition are crushed, and the crushed raw materials are extracted with water to obtain an effective component extract.
4. The extraction method according to claim 3, characterized in that The extraction is performed multiple times, and the extracts obtained from each extraction are mixed.
5. The extraction method according to claim 4, characterized in that After obtaining the active ingredient extract, the process further includes filtering and concentrating to obtain a drug extract.
6. The extraction method according to claim 3, wherein the volume mass ratio of the drug extract to the raw material is 1L:2~4kg.
7. The effective ingredient of the Chinese medicine composition obtained by extracting using any one of the extraction methods of claims 3 to 6.
8. Use of the effective ingredients of the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine composition according to claim 7 in the preparation of a medicament for preventing postoperative recurrence of condyloma acuminatum.
9. The use according to claim 8, characterized in that: The medicine is prepared from the effective ingredients of the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine composition according to claim 7 and pharmaceutically acceptable excipients.
10. The use according to claim 9, characterized in that: The auxiliary material is ethyl hydroxybenzoate.