A detection device and reagent card for detecting blood coagulation items

Abstract

The present application discloses a detection device and a reagent card for detecting a coagulation project, the detection device includes: a reagent storage module, including a multi-person reagent storage module and a single-person reagent storage module, the multi-person reagent storage module is used to store reagent bottles; the single-person reagent storage module includes at least one reagent card storage channel to store reagent cards, and the reagent card includes at least one reagent storage position to store a single-person detection reagent; a distribution module, used to inject the collected sample into the detection cup, and inject the detection reagent in the reagent bottle or the single-person detection reagent in the reagent card into the detection cup; an incubation detection module, used to incubate the sample in the detection cup and detect the sample in the detection cup to obtain a coagulation detection result. Through the above method, the detection device can meet the detection of single-person samples and avoid the waste of large bottles of reagents.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a detection device and a reagent card for detecting blood coagulation items. Background Art

[0002] The existing detection device for detecting coagulation items is used to detect the coagulation ability of the sample, including a sample storage module and a reagent storage module, wherein the sample storage module is used to store multiple test tubes, and the reagent storage module stores multiple reagent bottles. The reagent bottles are used to load a large number of reagents, which can meet the use of dozens of test samples and are suitable for scenes with large sample quantities. In scenes with a small sample quantity (such as only a few test samples), after the reagent bottles with an expiration date are opened, they will be wasted because they cannot be used up. Therefore, the existing detection device has the problem that it cannot be well used for single-person sample detection. Summary of the invention

[0003] In order to solve the above problems, the present application provides a detection device for detecting coagulation items, comprising:

[0004] The reagent storage module includes a multi-person reagent storage module and a single-person reagent storage module, wherein the multi-person reagent storage module is used to store reagent bottles to perform multi-person coagulation tests; the single-person reagent storage module includes at least one reagent card storage channel to store reagent cards, wherein the reagent card includes at least one reagent storage position to store single-person detection reagents to perform single-person coagulation tests;

[0005] A dispensing module, used to inject the collected sample into the test cup, and inject the test reagent in the reagent bottle or the single-portion test reagent in the reagent card into the test cup;

[0006] The incubation detection module is used to incubate the sample in the detection cup and detect the sample in the detection cup to obtain the coagulation detection result.

[0007] Optionally, it further includes a sample storage module and a scanning module, the sample storage module is used to store test tubes, the distribution module is used to inject samples in the test tubes into the detection cups; the scanning module is used to scan the identification information of the test tubes so that the detection device binds the identification information with the coagulation detection results.

[0008] Optionally, it further includes a test cup storage module for storing test cups, and the distribution module is used to inject the collected samples into the test cups in the test cup storage module, and inject the test reagents in the reagent bottles or the single-person test reagents in the reagent cards into the test cups in the test cup storage module.

[0009] Optionally, it further comprises a grabbing module, which is used to move the detection cup from the detection cup storage module to the incubation detection module.

[0010] Optionally, the reagent card includes a first reagent card, the first reagent card only includes at least one reagent storage position for storing a single-person detection reagent; the at least one reagent card storage channel includes a first reagent card storage channel for storing the first reagent card;

[0011] And / or, the reagent card includes a second reagent card, the second reagent card only includes at least one reagent storage position and at least one detection position, the reagent storage position is used to store a single-portion detection reagent, and the detection position is used as a detection cup; the distribution module is used to inject the sample into the detection position, and inject the detection reagent in the reagent bottle or the single-portion detection reagent in the reagent card into the detection position; at least one reagent card storage channel includes a second reagent card storage channel, which is used to store the second reagent card.

[0012] Optionally, the reagent card includes a third reagent card, the third reagent card includes at least one reagent storage position and a sample storage position, the reagent storage position is used to store a single-person detection reagent, and the sample storage position is used to store a sample; at least one reagent card storage channel includes a third reagent card storage channel for storing the third reagent card;

[0013] And / or, the reagent card includes a fourth reagent card, the fourth reagent card only includes at least one reagent storage position, at least one detection position and a sample storage position, the reagent storage position is used to store a single-portion detection reagent, the sample storage position is used to store the sample, and the detection position is used as a detection cup; the distribution module is used to inject the sample into the detection position, and inject the detection reagent in the reagent bottle or the single-portion detection reagent in the reagent card into the detection position; at least one reagent card storage channel includes a fourth reagent card storage channel, which is used to store the fourth reagent card.

[0014] Optionally, the incubation detection module includes a first incubation detection channel. When the first reagent card storage channel stores the first reagent card or the third reagent card storage channel stores the third reagent card to perform a single-person coagulation test, or the detection device performs a multi-person coagulation test, the distribution module injects the sample and the single-person detection reagent into the detection cup respectively; or, the distribution module injects the sample and the detection reagent in the reagent bottle into the detection cup respectively, and the detection cup is transferred to the first incubation detection channel; and / or

[0015] The incubation detection module includes a second incubation detection channel, and the second incubation detection channel is arranged corresponding to the second reagent card storage channel and / or the fourth reagent card storage channel. When the second reagent card is placed in the second reagent card storage channel or the fourth reagent card is placed in the fourth reagent card storage channel, at least one detection position in the second reagent card or the fourth reagent card is placed in the second incubation detection channel, so that at least one detection position is used as a detection cup, and the distribution module injects the sample and the single-person detection reagent into the detection position respectively; or, the distribution module injects the sample and the detection reagent in the reagent bottle into the detection position respectively.

[0016] To solve the above problems, the present application provides a reagent card, which is applied to the above-mentioned detection device. The reagent card includes a handle and a main body. The handle is arranged at one end of the main body. The main body includes at least one reagent storage position to store a single-person detection reagent so that the detection device can perform a single-person coagulation test.

[0017] Optionally, the reagent card includes a sample storage location, and the sample storage location is used to store the sample.

[0018] Optionally, the reagent card includes at least one detection position, and the detection position is used as a detection cup of the detection device.

[0019] The present application proposes a detection device for detecting coagulation items, including a reagent storage module, a distribution module and an incubation detection module; the reagent storage module includes a multi-person reagent storage module and a single-person reagent storage module, the multi-person reagent storage module is used to store reagent bottles to perform multi-person coagulation detection; the single-person reagent storage module includes at least one reagent card storage channel to store reagent cards, and the reagent card includes at least one reagent storage position to store single-person detection reagents to perform single-person coagulation detection; the distribution module is used to inject the collected sample into the detection cup, and inject the detection reagent in the reagent bottle or the single-person detection reagent in the reagent card into the detection cup; the incubation detection module is used to incubate the sample in the detection cup and detect the sample in the detection cup to obtain the coagulation detection result. Therefore, the detection device stores the reagent card through the single-person reagent storage module, and the reagent storage position of the reagent card is used to store the single-person detection reagent, so as to provide the detection device with a single-person detection reagent, without using the reagent bottle of the multi-person reagent storage module, so as to meet the detection of the single-person sample by the detection device, and also avoid the waste of large bottles of reagents. The detection device has various detection modes, which can meet the detection needs of users in different situations, and improve the user experience and detection convenience. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. Among them:

[0021] Figure 1 It is a schematic diagram of the framework of the first embodiment of the detection device of the present application;

[0022] Figure 2 It is a structural schematic diagram of the first embodiment of the reagent card of the present application;

[0023] Figure 3is a structural schematic diagram of the first embodiment of the optical detection module of the present application;

[0024] Figure 4 It is a structural schematic diagram of the first embodiment of the magnetic bead detection module of the present application;

[0025] Figure 5 It is a structural schematic diagram of the first embodiment of the optical detection module and the magnetic bead detection module of the present application;

[0026] Figure 6 is a schematic structural diagram of a second embodiment of the reagent card of the present application;

[0027] Figure 7 is a schematic structural diagram of a third embodiment of the reagent card of the present application;

[0028] Figure 8 is a schematic structural diagram of a fourth embodiment of the reagent card of the present application;

[0029] Figure numbers: reagent storage module 11, multi-person reagent storage module 111, single-person reagent storage module 112, reagent bottle 113, common reagent bottle 114, reagent card storage channel 115, reagent card 116, reagent storage position 117, handle 118, sample storage position 119, detection position 120; distribution module 12; incubation detection module 13, first incubation detection channel 131, second incubation detection channel 132; detection cup 14; sample storage module 15, test tube 151; scanning module 16; detection cup storage module 1 7; grabbing module 18; display screen 19; scanning gun 20; cleaning liquid module 21, cleaning liquid barrel 211, first pump body 212; waste liquid module 22, waste liquid barrel 221, second pump body 222; power supply 23; cleaning pool 24; printer 25; waste cup barrel 26; optical detection module 30, light source generator 31, light detector 32; magnetic bead detection module 40, alternating coil 41, detection coil 42; optical and magnetic bead mixed detection module 50, light source generator 51, light detector 52, alternating coil 53 and detection coil 54. DETAILED DESCRIPTION

[0030] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. It is to be understood that the specific embodiments described herein are only used to explain the present application, rather than to limit the present application. It should also be noted that, for ease of description, only some structures related to the present application are shown in the accompanying drawings, rather than all structures. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0031] The terms "first", "second", etc. in this application are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "provided with" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0032] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0033] See also Figure 1-2 As shown, Figure 1 It is a schematic diagram of the framework of the first embodiment of the detection device of the present application; Figure 2 The detection device of this embodiment is used to detect blood coagulation items, and the detection device includes a reagent storage module 11, a distribution module 12, an incubation detection module 13 and a detection cup 14.

[0034] The reagent storage module 11 includes a multi-person reagent storage module 111 and a single-person reagent storage module 112. The multi-person reagent storage module 111 is used to store reagent bottles 113 to perform multi-person coagulation tests; the reagent bottles 113 stored in the multi-person reagent storage module 111 include at least one of PT (Prothrombin time) reagent, APTT (Activated Partial Thromboplastin Time) reagent, TT (Thrombin Time) reagent and FIB (Fibrinogen) reagent.

[0035] Optionally, the multi-reagent storage module 111 is also used to store common reagent bottles 114, which are used to store buffer solutions, cleaning solutions and / or diluents; wherein the common reagent bottles 114 and the reagent bottles 113 may be arranged in an array.

[0036] The single-portion reagent storage module 112 includes at least one reagent card storage channel 115, and the reagent card storage channel 115 is used to store a reagent card 116. The reagent card 116 includes at least one reagent storage position 117, and the reagent storage position 117 is used to store a single-portion detection reagent to perform a single-portion coagulation test. For example, the reagent card 116 includes four reagent storage positions 117, and the four reagents can be used to store PT reagent, APTT reagent, TT reagent and FIB reagent in the storage positions 117 respectively.

[0037] The distribution module 12 is used to inject the collected sample into the detection cup 14, and inject the detection reagent in the reagent bottle 113 or the single-portion detection reagent in the reagent card 116 into the detection cup 14. For example, the distribution module 12 injects the sample into the detection cup 14, and then injects the detection reagent in the reagent bottle 113 or the single-portion detection reagent in the reagent card 116 into the corresponding detection cup 14.

[0038] The incubation and detection module 13 is used to incubate the sample in the detection cup 14 and detect the sample in the detection cup 14 to obtain a coagulation detection result.

[0039] When the detection device performs a single-person coagulation test on a sample, the distribution module 12 is used to inject the sample and the single-person detection reagent into the detection cup 14 respectively, and then the detection cup 14 moves to the incubation detection module 13 to incubate the sample and the single-person detection reagent in the detection cup 14; the incubation detection module 13 detects the incubated sample to obtain the coagulation test result. When the detection device performs a multi-person coagulation test on a sample, the distribution module 12 is used to inject the sample and the detection reagent in the reagent bottle 113 into the detection cup 14 respectively, and then the detection cup 14 moves to the incubation detection module 13 to incubate the sample and the detection reagent in the detection cup 14; the incubation detection module 13 detects the incubated sample to obtain the coagulation test result.

[0040] Optionally, the detection device is used to perform four coagulation tests on the sample, for example, the detection device performs PT test item, APTT test item, TT test item and FIB test item on the sample.

[0041] The reagent storage module 11 of this embodiment includes a multi-person reagent storage module 111 and a single-person reagent storage module 112; the multi-person reagent storage module 111 is used to store reagent bottles 113 to perform multi-person coagulation tests; the single-person reagent storage module 112 includes at least one reagent card storage channel 115, and the reagent card storage channel 115 is used to store reagent cards 116; the reagent card 116 includes at least one reagent storage position 117, and the reagent storage position 117 is used to store single-person detection reagents to perform single-person coagulation tests; therefore, the detection device stores the reagent card 116 through the single-person reagent storage module 112, and the reagent storage position 117 of the reagent card 116 is used to store single-person detection reagents, so as to provide the detection device with single-person detection reagents, without using the reagent bottles 113 of the multi-person reagent storage module 111, so as to meet the detection device's detection of single-person samples and avoid the waste of large bottles of reagents (reagents in the reagent bottles 113). The detection device has various detection modes, which can meet the detection needs of users in different situations, and improve the user experience and detection convenience.

[0042] Optionally, the detection device includes a sample storage module 15 , a scanning module 16 , a detection cup storage module 17 and a grabbing module 18 .

[0043] The sample storage module 15 is used to store the test tube 151 . The test tube 151 can be used to store a sample, which can be a whole blood sample. The distribution module 12 can be used to inject the sample in the test tube 151 into the detection cup 14 .

[0044] The scanning module 16 is used to scan the identification information of the test tube 151. For example, the scanning module 16 scans the label or barcode of the test tube 151 to obtain the identification information. The detection device binds the identification information with the coagulation test result to achieve binding of the test tube 151 with the coagulation test result.

[0045] The detection cup storage module 17 is used to store the detection cup 14, wherein the detection cup storage module 17 and the incubation detection module 13 are spaced apart, and the distribution module 12 is used to inject the collected sample into the detection cup 14 in the detection cup storage module 17, and inject the detection reagent in the reagent bottle 113 or the single-person detection reagent in the reagent card 116 into the detection cup 14 in the detection cup storage module 17.

[0046] The grab module 18 is used to move the detection cup 14 from the detection cup storage module 17 to the incubation detection module 13. For example, the grab module 18 includes a grab arm and a grab hand, and the grab arm grabs the detection cup 14 through the grab hand to move the detection cup 14 from the detection cup storage module 17 to the incubation detection module 13.

[0047] Optionally, the reagent card 116 includes a first reagent card, and the first reagent card only includes at least one reagent storage position 117, such as Figure 2 As shown, at least one reagent storage position 117 is used to store a single-portion detection reagent. At least one reagent card storage channel 115 of the single-portion reagent storage module 112 includes a first reagent card storage channel, and the first reagent card storage channel is used to place a first reagent card.

[0048] Optionally, the reagent card 116 includes a handle 118 disposed at one end of the reagent card 116, and the user can conveniently hold the reagent card 116 by the handle 118. In addition, the reagent card 116 includes a reagent card label, which is disposed on the reagent card 116 and is used to indicate the production information of the reagent card 116.

[0049] Optionally, the single-portion detection reagent is a dry powder reagent; before the dispensing module 12 draws the single-portion detection reagent from the reagent storage position 117, the dispensing module 12 adds the reconstituted solution to the dry powder reagent of the reagent card 116. In addition, the surface of the reagent card 116 is sealed with a film for easy storage and transportation.

[0050] Optionally, the incubation detection module 13 includes a first incubation detection channel 131. When the first reagent card storage channel stores the first reagent card to perform a single-person coagulation test, or the detection device performs a multi-person coagulation test, the distribution module 12 injects the sample and the single-person detection reagent into the detection cup 14 respectively; or, the distribution module 12 injects the sample and the detection reagent in the reagent bottle 113 into the detection cup 14 respectively. The detection cup 14 is transferred to the first incubation detection channel 131, for example, the grabbing module 18 transfers the detection cup 14 to the first incubation detection channel 131.

[0051] The following describes the detection process of the detection device performing a single-portion coagulation test based on the first reagent card: the grab module 18 moves the detection cup 14 from the detection cup storage module 17 to the liquid separation position, which can be located in the detection cup storage module 17 or in the incubation detection module 13. The distribution module 12 injects the sample in the test tube 151 of the sample storage module 15 into the detection cup 14, and cleans the distribution module 12. The distribution module 12 draws a single-portion detection reagent from the reagent storage position 117 of the first reagent card, and injects the single-portion detection reagent into the detection cup 14. The grab module 18 moves the detection cup 14 from the liquid separation position to the first incubation detection channel 131 of the incubation detection module 13. After the sample in the detection cup 14 and the single-portion detection reagent are incubated, the sample in the detection cup 14 is detected through the first incubation detection channel 131 to calculate the coagulation test results such as the coagulation time of the sample, the concentration of the sample, or the activity index of the sample.

[0052] The following describes the detection process of the detection device performing a multi-person coagulation test: the grab module 18 moves the detection cup 14 from the detection cup storage module 17 to the liquid separation position. The distribution module 12 injects the sample in the test tube 151 of the sample storage module 15 into the detection cup 14 and cleans the distribution module 12; optionally, the distribution module 12 injects the quantitative diluent or quantitative buffer of the common reagent bottle 114 into the detection cup 14 to dilute the sample in the detection cup 14. The distribution module 12 draws the detection reagent from the reagent bottle 113 and injects the detection reagent into the detection cup 14. The grab module 18 moves the detection cup 14 from the liquid separation position to the first incubation detection channel 131 of the incubation detection module 13. After the sample and the detection reagent in the detection cup 14 are incubated, the sample in the detection cup 14 is detected through the first incubation detection channel 131 to calculate the coagulation test results such as the coagulation time of the sample, the concentration of the sample or the activity index of the sample.

[0053] Optionally, after the detection device completes the detection of the sample, the detection device is cleaned and maintained. Therefore, the detection device can meet the needs of both large-scale coagulation detection for multiple people and single-person coagulation detection, achieving multi-purpose use of one device, meeting different needs of users, improving user experience, and facilitating maintenance.

[0054] In addition, the distribution module 12 is used to perform a mixing operation after injecting the collected sample into the detection cup 14 and injecting the detection reagent in the reagent bottle 113 or the single-person detection reagent in the reagent card 116 into the detection cup 14. For example, the dispensing needle of the distribution module 12 can achieve mixing by suction, vibration, etc.

[0055] Optionally, the distribution module 12 includes multiple dispensing needles, and the multiple dispensing needles of the distribution module 12 simultaneously draw multiple samples from different test tubes 151 in the sample storage module 15, and inject the multiple samples into corresponding detection cups 14; in addition, the multiple dispensing needles of the distribution module 12 simultaneously draw corresponding single-person detection reagents from multiple reagent cards 116, and inject the single-person detection reagents into multiple detection cups at the same time. The distribution module 12 can simultaneously collect or inject multiple samples and multiple single-person detection reagents to improve the detection throughput of the detection device and improve the detection efficiency.

[0056] Optionally, the detection device includes a reagent card strip scheduling module, which is used to move the reagent card 116 to the reagent card storage channel 115 when the detection device detects the sample, and to move the reagent card 116 out of the reagent card storage channel 115 when the detection device completes the detection of the sample. Therefore, the reagent card strip scheduling module can realize the loading and unloading of the reagent card 116, improve the automation of the detection device, and improve the detection efficiency.

[0057] Optionally, the detection device includes a test tube scheduling module, which is used to move the test tube rack to a preset position when the detection device detects the sample, and move the test tube rack out when the detection device completes the detection of the sample, which can improve the automation level of the detection device and simplify the operation.

[0058] Optionally, the detection device includes a telescopic mechanism, and the detection cup storage module 17 is installed on the telescopic mechanism. When the detection cup storage module 17 needs to replace the detection cup 14, the telescopic mechanism is used to move the detection cup storage module 17 out of the detection device to facilitate the user to replace the detection cup 14, which can ensure that the detection device can replace the detection cup 14 without stopping, and maintain the continuity of the test.

[0059] Optionally, the detection cup storage module 17 includes an automatic detection cup screening mechanism, which is used for the detection cup automatic screening mechanism, and moves the screened detection cups 14 to the grabbing module 18 to sort the scattered detection cups 14. In addition, when the detection cups 14 in the detection cup storage module 17 are insufficient, the detection cup storage module 17 generates an alarm signal to remind the user to add new detection cups 14 to the detection cup storage module 17.

[0060] Optionally, the first incubation detection channel 131 is an optical detection channel, such as Figure 3 As shown, the detection cup 14 is arranged in the first incubation detection channel 131, so that the optical detection module 30 can detect the sample and the single-person detection reagent in the detection cup 14. The optical detection module 30 includes a light source generator 31 and a light detector 32. The light source generator 31 is used to emit a light beam, and the light beam is irradiated to the sample to be tested in the detection cup 14 to generate scattered light or transmitted light; the light detector 32 is used to detect the scattered light or the transmitted light, and convert the scattered light or the transmitted light into an electrical signal, thereby obtaining the detection result. Therefore, the detection cup 14 used in the optical detection module 30 needs to be made of a material with good light transmittance; the cross-sectional shape of the detection cup 14 can be circular or rectangular, so that it can be arranged in the first incubation detection channel 131.

[0061] Optionally, the first incubation detection channel 131 is a magnetic bead detection channel, such as Figure 4 As shown, the detection cup 14 is arranged in the first incubation detection channel 131, so that the magnetic bead detection module 40 can detect the sample and the single-person detection reagent in the detection cup 14. The magnetic bead detection module 40 includes an alternating coil 41 and a detection coil 42, wherein the inner wall of the detection cup 14 is provided with a groove to facilitate the rolling of the magnetic beads in the groove. The alternating coil 41 is used to drive the magnetic beads to roll, and the rolling amplitude of the magnetic beads becomes smaller and smaller as the sample to be tested solidifies; the detection coil 42 is arranged in a plane perpendicular to the alternating coil 41, and is used to detect the induced current generated by cutting the alternating coil 41 during the rolling of the magnetic beads, and then obtain the detection result; the cross-sectional shape of the detection cup 14 can be circular or rectangular, so that it can be arranged in the first incubation detection channel 131.

[0062] Among them, the optical detection module 30 is easily affected by substances such as chyle, jaundice, hemolysis, etc. in the sample to be tested, which may lead to deviations in the test results; while the magnetic bead detection module 40 will not be affected by substances such as chyle, jaundice, hemolysis, etc. in the sample to be tested.

[0063] Optionally, the first incubation detection channel 131 is an optical and magnetic bead mixed detection channel, such as Figure 5 As shown, the detection cup 14 is arranged in the first incubation detection channel 131, so that the optical detection module and the magnetic bead detection module 50 detect the sample and the single-person detection reagent in the detection cup 14. It includes a light source generator 51, a light detector 52, an alternating coil 53 and a detection coil 54, wherein the light source generator 51 and the light detector 52 are arranged opposite to each other and are located above the alternating coil 53 and the detection coil 54; the detection coil 54 is arranged in a plane perpendicular to the alternating coil 53. Therefore, the optical detection module and the magnetic bead detection module 50 of this embodiment reduce the number of channels of the first incubation detection channel 131 by combining the optical detection method and the magnetic bead detection method in the same channel.

[0064] Optionally, the detection device includes a display screen 19 for displaying an operation interface, for example, the operation interface displays the detection items that can be detected by the detection device, so that the user can select the detection items on the operation interface; or, the operation interface is used to display the detection results.

[0065] Optionally, the detection device includes a scanner 20 for scanning identification information of the reagent card 116 .

[0066] Optionally, the detection device includes a cleaning liquid module 21, a waste liquid module 22, a power supply 23, a cleaning tank 24, a printer 25 and a waste cup barrel 26. The power supply 23 is used to power the detection device; the cleaning liquid module 21 is used to provide cleaning liquid to the detection device, including a cleaning liquid barrel 211 and a first pump body 212, and the first pump body 212 is used to extract cleaning liquid from the cleaning liquid barrel 211. The waste liquid module 22 is used to collect waste liquid of the detection device, including a waste liquid barrel 221 and a second pump body 222, and the second pump body 222 is used to extract waste liquid of the detection device to the waste liquid barrel 221. The cleaning tank 24 is used to clean the dispensing needle of the distribution module 12; the printer 25 is used to print the coagulation test results; the waste cup barrel 26 is used to place the detection cup 14 that has completed the test.

[0067] Among them, the scanning module 16, the sample storage module 15, the reagent storage module 11 and the display screen 19 are arranged in sequence along the first direction of the detection device, the reagent storage module 11 and the incubation detection module 13 are arranged in sequence along the second direction of the detection device, and the first direction is arranged perpendicular to the second direction to make the layout of the detection device compact and reduce the volume of the detection device.

[0068] Optionally, the detection device includes a needle storage area, the needle of the distribution module 12 is a disposable tip, the dispensing arm of the distribution module 12 picks up the needle from the needle storage area, and the dispensing arm of the distribution module 12 can be a pneumatic device, which does not require liquid circuit design, thereby reducing costs.

[0069] In one embodiment of the present application, Figure 6 As shown, the reagent card 116 includes a third reagent card, wherein the third reagent card includes at least one reagent storage position 117 and a sample storage position 119, wherein at least one reagent storage position 117 is used to store a single-portion detection reagent, and the sample storage position 119 is used to store a sample, such as a single-portion sample.

[0070] The at least one reagent card storage channel 115 of the reagent storage module 11 includes a third reagent card storage channel, and the third reagent card storage channel is used to store a third reagent card.

[0071] like Figure 1 As shown, the first incubation detection channel 131 further corresponds to the third reagent card storage channel. When the third reagent card storage channel stores the third reagent card to perform a single-person coagulation test, or the detection device performs a multi-person coagulation test, the distribution module 12 injects the sample and the single-person detection reagent into the detection cup 14 respectively; or, the distribution module 12 injects the sample and the detection reagent in the reagent bottle 113 into the detection cup 14 respectively. The detection cup 14 is transferred to the first incubation detection channel 131, for example, the grab module 18 transfers the detection cup 14 to the first incubation detection channel 131.

[0072] The following describes the detection process of the detection device performing a single-portion coagulation test based on the third reagent card: the grab module 18 moves the detection cup 14 from the detection cup storage module 17 to the liquid separation position, which can be located in the detection cup storage module 17 or in the incubation detection module 13. The distribution module 12 injects the sample in the sample storage position 119 of the third reagent card into the detection cup 14, and cleans the distribution module 12. The distribution module 12 draws a single-portion detection reagent from the reagent storage position 117 of the third reagent card, and injects the single-portion detection reagent into the detection cup 14. The grab module 18 moves the detection cup 14 from the liquid separation position to the first incubation detection channel 131 of the incubation detection module 13. After the sample in the detection cup 14 and the single-portion detection reagent are incubated, the sample in the detection cup 14 is detected through the first incubation detection channel 131 to calculate the coagulation test results such as the coagulation time of the sample, the concentration of the sample, or the activity index of the sample. In addition, the other components of the detection device can be the same as the detection device of the above embodiment, which will not be repeated here.

[0073] In one embodiment of the present application, Figure 7As shown, the reagent card 116 includes a second reagent card, wherein the second reagent card includes at least one reagent storage position 117 and at least one detection position 120, wherein at least one reagent storage position 117 is used to store a single-portion detection reagent, and the detection position 120 is used as a detection cup 14. The distribution module 12 injects the sample into the detection position 120, and injects the detection reagent of the reagent bottle 113 or the single-portion detection reagent of the second reagent card into the detection position 120.

[0074] The at least one reagent card storage channel 115 of the reagent storage module 11 includes a second reagent card storage channel, and the second reagent card storage channel is used to store a second reagent card.

[0075] like Figure 1 As shown, the incubation detection module 13 includes a second incubation detection channel 132, and the second incubation detection channel 132 is arranged corresponding to the second reagent card storage channel. When the second reagent card is placed in the second reagent card storage channel, the at least one detection position 120 in the second reagent card is placed in the second incubation detection channel 132, so that at least one detection position 120 is used as a detection cup 14, and the distribution module 12 injects the sample and the single-portion detection reagent into the detection position 120 respectively; or, the distribution module 12 injects the sample and the detection reagent in the reagent bottle 113 into the detection position 120 respectively.

[0076] The following describes the detection process of the detection device performing a single-person coagulation test based on the second reagent card: Figure 1 and 7 As shown, the distribution module 12 injects the sample in the test tube 151 of the sample storage module 15 into the corresponding detection position 120, and cleans the distribution module 12. The distribution module 12 draws the single-portion detection reagent from the reagent storage position 117 of the second reagent card, and injects the single-portion detection reagent into the corresponding detection position 120. After the sample in the detection position 120 and the single-portion detection reagent are incubated, the sample in the detection position 120 is detected through the second incubation detection channel 132 to calculate the coagulation test results such as the coagulation time of the sample, the concentration of the sample, or the activity index of the sample.

[0077] Optionally, the second incubation detection channel 132 is an optical detection channel or a magnetic bead detection channel or an optical and magnetic bead mixed detection channel, which is the same as the first incubation detection channel 131 and will not be described in detail herein.

[0078] In one embodiment of the present application, Figure 8As shown, the reagent card 116 includes a fourth reagent card, wherein the fourth reagent card includes at least one reagent storage position 117, a sample storage position 119 and at least one detection position 120, wherein at least one reagent storage position 117 is used to store a single-portion detection reagent, the sample storage position 119 is used to store a sample, and the detection position 120 is used as a detection cup 14. The distribution module 12 injects the sample into the detection position 120, and injects the detection reagent of the reagent bottle 113 or the single-portion detection reagent of the fourth reagent card into the detection position 120.

[0079] The at least one reagent card storage channel 115 of the reagent storage module 11 includes a fourth reagent card storage channel, and the fourth reagent card storage channel is used to store a fourth reagent card.

[0080] like Figure 1 As shown, the second incubation detection channel 132 is arranged corresponding to the fourth reagent card storage channel. When the fourth reagent card is placed in the fourth reagent card storage channel, the at least one detection position 120 in the fourth reagent card is placed in the second incubation detection channel 132, so that at least one detection position 120 is used as a detection cup 14, and the distribution module 12 injects the sample and the single-portion detection reagent into the detection position 120 respectively; or, the distribution module 12 injects the sample and the detection reagent in the reagent bottle 113 into the detection position 120 respectively.

[0081] The following describes the detection process of the detection device performing a single-person blood coagulation test based on the fourth reagent card: Figure 1 and 8 As shown, the distribution module 12 injects the sample in the sample storage position 119 of the fourth reagent card into the corresponding detection position 120, and cleans the distribution module 12. The distribution module 12 draws the single-portion detection reagent from the reagent storage position 117 of the fourth reagent card, and injects the single-portion detection reagent into the corresponding detection position 120. After the sample in the detection position 120 and the single-portion detection reagent are incubated, the sample in the detection position 120 is detected through the second incubation detection channel 132 to calculate the coagulation test results such as the coagulation time of the sample, the concentration of the sample, or the activity index of the sample.

[0082] The present application also provides a reagent card, such as Figure 2 As shown, the reagent card 116 includes a handle 118 and at least one reagent storage position 117. The handle 118 is disposed at one end of the reagent card 116. The at least one reagent storage position 117 is used to store a single-portion test reagent so that the detection device performs a single-portion coagulation test, which is the same as the above embodiment and will not be described in detail here. At this time, the reagent card 116 serves as the first reagent card of the above embodiment.

[0083] Alternatively, if Figure 6As shown, the reagent card 116 includes at least one reagent storage position 117 and a sample storage position 119, wherein at least one reagent storage position 117 is used to store a single-portion detection reagent, and the sample storage position 119 is used to store a sample, such as a single-portion sample. At this time, the reagent card 116 serves as the third reagent card of the above embodiment.

[0084] Alternatively, if Figure 7 As shown, the reagent card 116 includes at least one reagent storage position 117 and at least one detection position 120, wherein at least one reagent storage position 117 is used to store a single-person detection reagent, and the detection position 120 is used as a detection cup 14. At this time, the reagent card 116 serves as the second reagent card of the above embodiment.

[0085] Alternatively, if Figure 8 As shown, the reagent card 116 includes at least one reagent storage position 117, a sample storage position 119 and at least one detection position 120, wherein at least one reagent storage position 117 is used to store a single-person detection reagent, the sample storage position 119 is used to store the sample, and the detection position 120 is used as a detection cup 14. At this time, the reagent card 116 serves as the fourth reagent card of the above embodiment.

[0086] In summary, the reagent storage module 11 of the present application includes a multi-person reagent storage module 111 and a single-person reagent storage module 112; the multi-person reagent storage module 111 is used to store reagent bottles 113 to perform multi-person coagulation tests; the single-person reagent storage module 112 includes at least one reagent card storage channel 115, and the reagent card storage channel 115 is used to store reagent cards 116; the reagent card 116 includes at least one reagent storage position 117, and the reagent storage position 117 is used to store single-person detection reagents to perform single-person coagulation tests; therefore, the detection device stores the reagent card 116 through the single-person reagent storage module 112, and the reagent storage position 117 of the reagent card 116 is used to store single-person detection reagents, so as to provide the detection device with single-person detection reagents, without using the reagent bottles 113 of the multi-person reagent storage module 111, so as to meet the detection of single-person samples by the detection device, and also avoid the waste of large bottles of reagents. The detection method of the detection device is diverse, which can meet the detection needs of users in different situations, and improve the user experience and detection convenience.

[0087] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A detection device for detecting blood coagulation items, characterized in that: include: A reagent storage module, comprising a multi-person reagent storage module and a single-person reagent storage module, wherein the multi-person reagent storage module is used to store reagent bottles to perform multi-person coagulation tests; the single-person reagent storage module comprises at least one reagent card storage channel to store reagent cards, wherein the reagent card comprises at least one reagent storage position to store single-person detection reagents to perform single-person coagulation tests; A dispensing module, used for injecting the collected sample into the detection cup, and injecting the detection reagent in the reagent bottle or the single-portion detection reagent in the reagent card into the detection cup; The incubation detection module is used to incubate the sample in the detection cup and detect the sample in the detection cup to obtain a coagulation detection result.

2. The detection device according to claim 1, characterized in that: It further includes a sample storage module and a scanning module, wherein the sample storage module is used to store test tubes, and the distribution module is used to inject the samples in the test tubes into the detection cups; the scanning module is used to scan the identification information of the test tubes so that the detection device binds the identification information with the coagulation detection results.

3. The detection device according to claim 1, characterized in that: It further includes a detection cup storage module for storing the detection cup, and the distribution module is used to inject the collected sample into the detection cup in the detection cup storage module, and inject the detection reagent in the reagent bottle or the single-person detection reagent in the reagent card into the detection cup in the detection cup storage module.

4. The detection device according to claim 3, characterized in that: It further comprises a grabbing module, and the grabbing module is used to move the detection cup from the detection cup storage module to the incubation detection module.

5. The detection device according to claim 1, characterized in that: The reagent card includes a first reagent card, the first reagent card only includes at least one reagent storage position for storing the single-person detection reagent, and the at least one reagent card storage channel includes a first reagent card storage channel for placing the first reagent card; And / or, the reagent card includes a second reagent card, the second reagent card only includes at least one reagent storage position and at least one detection position, the reagent storage position is used to store the single-portion detection reagent, and the detection position is used as the detection cup; The distribution module is used to inject the sample into the detection position, and inject the detection reagent in the reagent bottle or the single-person detection reagent in the reagent card into the detection position; the at least one reagent card storage channel includes a second reagent card storage channel for placing the second reagent card.

6. The detection device according to claim 1, characterized in that: The reagent card includes a third reagent card, the third reagent card includes at least one reagent storage position and a sample storage position, the reagent storage position is used to store the single-person detection reagent, the sample storage position is used to store the sample, and the at least one reagent card storage channel includes a third reagent card storage channel for placing the third reagent card; And / or, the reagent card includes a fourth reagent card, the fourth reagent card only includes at least one reagent storage position, at least one detection position and a sample storage position, the reagent storage position is used to store the single-person detection reagent, the sample storage position is used to store the sample, and the detection position is used as the detection cup; The distribution module is used to inject the sample into the detection position, and inject the detection reagent in the reagent bottle or the single-person detection reagent in the reagent card into the detection position; the at least one reagent card storage channel includes a fourth reagent card storage channel for placing the fourth reagent card.

7. The detection device according to claim 5 or 6, characterized in that: The incubation detection module comprises a first incubation detection channel, and when the first reagent card storage channel stores the first reagent card or the third reagent card storage channel stores the third reagent card to perform a single-person coagulation test, or the detection device performs a multi-person coagulation test, the distribution module injects the sample and the single-person detection reagent into the detection cup respectively, or the distribution module injects the sample and the detection reagent in the reagent bottle into the detection cup respectively, and the detection cup is transferred to the first incubation detection channel; and / or The incubation detection module includes a second incubation detection channel, and the second incubation detection channel is arranged corresponding to the second reagent card storage channel and / or the fourth reagent card storage channel. When the second reagent card is placed in the second reagent card storage channel or the fourth reagent card is placed in the fourth reagent card storage channel, the at least one detection position in the second reagent card or the fourth reagent card is placed in the second incubation detection channel, so that the at least one detection position is used as the detection cup respectively, and the distribution module injects the sample and the single-person detection reagent into the detection position respectively, or the distribution module injects the sample and the detection reagent in the reagent bottle into the detection position respectively.

8. A reagent card, characterized in that: Applied to the detection device as described in any one of claims 1-7, the reagent card includes a handle and at least one reagent storage position, the handle is arranged at one end of the reagent card, and the reagent storage position is used to store a single-person detection reagent, so that the detection device performs a single-person coagulation test.

9. The reagent card according to claim 8, characterized in that: The reagent card comprises a sample storage position, and the sample storage position is used to store samples.

10. The reagent card according to claim 8 or 9, characterized in that: The reagent card includes at least one detection position, and the detection position is used as a detection cup of the detection device.

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