A synergistic composition containing carbamate insecticides and its application

Abstract

The present invention belongs to the field of pesticides and relates to a synergistic compound composition containing a carbamate insecticide. It contains two active components A and B, component A is selected from compound I-72, and component B is selected from carbamate insecticides and miticides; the weight ratio of the two active components of components A and B is 1:99 to 99:1; wherein the structural formula of compound I-72 is as follows, and the composition of the present invention has obvious synergistic effects and can be used to prevent and control a variety of pests and mites. #imgabs0#

Description

Technical Field

[0001] The invention belongs to the field of pesticides and relates to a synergistic compound composition containing carbamate insecticides and application thereof. Background Art

[0002] Insecticides play an obvious role in preventing and controlling agricultural and forestry pests or urban health pests.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has an outstanding control effect on pests. The structural formula of the compound is as follows:

[0004]

[0005] Pesticides containing a single active ingredient are easily used to make pests resistant if used continuously in pest control. Mixing two active ingredient pesticides into a mixed component in a certain proportion can often improve the prevention effect, reduce the amount of active ingredients, save costs, and is also one of the effective methods for controlling resistant pests. However, there is no report on the composite composition of compound I-72 and carbamate pesticides. Summary of the invention

[0006] The purpose of the present invention is to provide a synergistic compound composition containing carbamate insecticides and application thereof.

[0007] To achieve the above purpose, the present invention adopts the following technical solution:

[0008] A synergistic composition containing a carbamate insecticide, the composition comprises two active components, component A and component B, component A is selected from a piperic acid derivative compound of the following structure (i.e., compound I-72), and component B is selected from a carbamate insecticide and acaricide; the weight ratio of the two active components, component A and component B, is 1:99 to 99:1; wherein the structural formula of the piperic acid derivative compound is as follows:

[0009]

[0010] The carbamate insecticide is selected from carbosulfan, CPMC, Dimetan, Pyrolan, Prramat, Isolan, Methomyl, Butocarboxim, Carbaryl, Fenothiocarb, Methiocarb, Mexathacarb, Metolcarb, Propoxur, Thiofanox ), Triazamate, Fenobucarb, Benfuracarb, Bendiocarb, Furathiocarb, Pirimicarb, Butoxycarboxim, Ethiofencarb, Isoprocarb, Trimethacarb, XMC, Xylylcarb, Fenoxycarb or Nitrilacarb.

[0011] Preferably, component A in the composition is selected from the above-mentioned piperic acid derivative compounds; component B is selected from carbosulfan, carbaryl, isoprocarb or sec-bucarb; and the weight ratio of the two active components A and B is 1:60 to 60:1.

[0012] Further preferably, component A in the composition is selected from the above-mentioned capsaicin derivative compounds; component B is selected from carbosulfan; and the weight ratio of the two active components A and B is 1:20 to 10:1.

[0013] In the composition, component A is selected from the above-mentioned capsaicin derivative compounds; component B is selected from carbaryl; and the weight ratio of the two active components of component A and component B is 1:60 to 1:1.

[0014] In the composition, component A is selected from the above-mentioned capsaicin derivative compounds; component B is selected from fenbucarb or isoprocarb; and the weight ratio of the two active components of components A and B is 1:40 to 10:1.

[0015] The application of the composition is to prepare insecticides and miticides for preventing and controlling pests, mites or nematodes on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops and various plant diseases.

[0016] The insecticide composition of the present invention has a significant synergistic effect in preventing and controlling pests on fruit trees, vegetables, ornamental plants, tea, cotton, and cereal crops. Indoor biological activity assay results show that compound A can be mixed with carbamate insecticides to improve the prevention effect, reduce the dosage, and expand the insecticide spectrum. Through a large number of experiments, it was found that after compound A was mixed with carbamate insecticides, there was a significant synergistic trend with the increase in the amount of the compound, which is conducive to the application of the compound in the field. Therefore, another technical solution of the present invention is the use of the two active component compositions of the present invention for preparing insecticides and acaricides.

[0017] The present invention also includes the use of the inventive composition to prepare an insecticide and acaricide preparation for controlling agricultural and forestry pests. Specifically, it is suitable for preventing and controlling a variety of important agricultural pests, such as aphids, diamondback moths, armyworms, cotton bollworms, beet armyworms, armyworms, cabbage armyworms, gypsy moths, cutworms, geometries, peach borers, pear borers, fall armyworms, tobacco budworms, geometries, rice leaf rollers, corn borers, striped stem borers, yellow stem borers, grass borers, bean pod borers, peach borers, citrus leaf miners, grape fruit moths, tussock moths, caterpillars, tea geometries, tea caterpillars, leafhoppers, flower scale insects, potato beetles, wireworms, grubs, flea beetles, leaf beetles, weevils, pine caterpillars, underground pests, nematodes, locusts, western flower thrips, palm thrips, onion thrips, rice thrips, ginger thrips, mango thrips, whiteflies, gall midges, blind bugs, etc.

[0018] In particular, the insecticidal and acaricidal composition of the present invention can be used to control pests of the order Thysanoptera, and non-exhaustive examples of specific species include but are not limited to rice thrips, tobacco thrips, rice pipe thrips, wheat peel thrips, terminal band thrips, tobacco thrips, flower thrips, yellow thrips, sugarcane thrips, cucurbit thrips, western flower thrips, palm thrips, etc.; the combination can be used to control pests of the order Homoptera, and non-exhaustive examples of specific species include but are not limited to species of the genus Aleuroptera: greenhouse whitefly, tobacco whitefly, silverleaf whitefly, sweet potato whitefly, cabbage whitefly, cabbage whitefly, spiral whitefly, soft-haired whitefly, cotton whitefly, lemon fruit brown leafhopper, mango leafhopper, long foam cicada species, foam cicada; gray planthopper, small brown planthopper, rice brown planthopper, brown planthopper, corn planthopper, corn flower-winged planthopper , white-backed rice hopper, white-backed planthopper; aster leafhopper, aster leafhopper, raspberry leafhopper, black-tailed leafhopper species, leafhopper, black-tailed leafhopper, large green leafhopper, white-winged leafhopper, large green leafhopper, cotton leafhopper, elm leafhopper, small green leafhopper, Indian cotton leafhopper, spotted wax cicada, etc.; the combination can be used to control pests of Hemiptera, and non-exhaustive examples of specific species include but are not limited to pear web bugs, banana web bugs, fine-horned flower bugs, tiny flower bugs, needle-edged bugs, large rice edge bugs, rice spider bugs, rice brown bugs, rice black bugs, rice green bugs, green blind bugs, alfalfa blind bugs, middle black blind bugs, wheat root blind bugs, three-spotted blind bugs, pasture blind bugs, litchi bugs; the combination can be used to control pests of Lepidoptera, and non-exhaustive examples of specific species include but are not limited to grain moths, clothes moths, yellow thorn moths, brown thorn moths , flat moth, wheat moth, cotton bollworm, tobacco budworm, sweet potato moth, diamondback moth, soybean borer, peach borer, hemp borer, pear borer, pear borer, codling moth, apple leaf roller, apple leaf roller, apple leaf roller, apple leaf roller, yellow leaf roller, apple nest moth, brown-banded leaf roller, quasi-yellow leaf roller, black-spotted brown leaf roller, litchi butterfly , Chilo suppressalis, Bean pod borer, Corn borer, Yellow stem borer, Cabbage borer, Rice leaf roller, Millet ash borer, Duckweed ash borer, Duckweed borer, Striped stem borer, Cotton leaf roller, Sweet potato stem borer, One-spotted grain borer, Peach borer, Sunflower borer, Yellow stem borer, Two-spotted stem borer, White stem borer, White-banded stem borer, Grass borer, Armyworm, Spodoptera litura, Silver-striped armyworm, Pit-winged armyworm, Quinoa armyworm, Jute armyworm, Ramie armyworm, Mouth kettle armyworm , mango horizontal line tail armyworm, cabbage armyworm, beet armyworm, show armyworm, loquat yellow caterpillar, ramie red butterfly, ramie yellow butterfly, rice stem borer, cotton small bridge borer, large borer, cotton bollworm, cotton leaf roller, soybean leaf roller, peach borer, Dingdian diamond, emerald diamond, Egyptian diamond, small cutworm, large cutworm, yellow cutworm, white-edged cutworm, warning-marked cutworm, The thief moth, gypsy moth, sweet potato hawkmoth, bean hawkmoth, straight-striped rice hesperid, hidden-striped rice hesperid, citrus swallowtail, jade-banded swallowtail, cabbage butterfly, double-banded night butterfly, rice leaf night butterfly, powdery moth, tea caterpillar, geometrid, tea moth, big moth, small moth, tea tip moth, tea branch sickle moth, wild silkworm, mulberry caterpillar, tent caterpillar, walnut moth, persimmon calyx moth, citrus leaf miner, banana hesperid;The combination can be used to control pests of the order Coleoptera, and non-exhaustive examples of specific species include, but are not limited to, bean lycopersicon, yellow mealworm, black mealworm, red flour beetle, mixed flour beetle, large flour beetle, saw-shaped flour beetle, long-horned flat flour beetle, black wrinkled gill beetle, clouded gill beetle, yellow-brown beautiful beetle, copper-green beautiful beetle, dark beetle, North China large black gill beetle, mulberry longhorn beetle, star longhorn beetle, orange brown longhorn beetle, peach red neck longhorn beetle, red neck longhorn beetle, sugarcane saw-shaped longhorn beetle, ramie longhorn beetle, hemp longhorn beetle, brown longhorn beetle, light shield green longhorn beetle, big monkey leafworm, small monkey leafworm, rice root leaf beetle, millet scale leaf beetle, hemp leaf beetle, malignant leaf beetle, orange leaf beetle, citrus leaf beetle, yellow melon, yellow curved striped flea beetle, beet flea beetle, grain flea beetle, mung bean weevil, pea weevil, broad bean weevil, corn weevil, rice weevil, root nodule weevil, tea beautiful pattern weevil, tea Seed weevils, beet weevils, rape stem weevils, pear tigers, apricot tigers, peach tigers, black velvet beetles, net-meshed ground beetles, Mongolian ground beetles, rice weevils, rice mudworms, corn iron beetles, sweet potato green beetles, spike-backed glycoside turtles, light-backed glycoside turtles, yellow leafworms, banana weevils, banana double-black-banded weevils; the combination can be used to control pests of the order Diptera, and non-exhaustive examples of specific species include but are not limited to wheat red midges, wheat yellow midges, rice gall midges, rice chironomids, rice stalk flies, rice leaf miners, rice water flies, citrus fruit flies, citrus fruit flies, citrus fruit flies, melon fruit flies, wheat leaf gray leafminers, American spotted leafminers, bean stalk black leafminers, wheat stalk flies, seed flies, onion flies, radish flies, sorghum awn flies, millet stalk flies, astragalus leafminers, duckweed chironomids, beet leafminers, beet root maggots, and radish flies. Homoptera (aphids, scale insects, whiteflies, leafhoppers). A non-exhaustive list of these pests includes, but is not limited to: pea aphid, pea aphid, Aphid spp., Aphid spp., Aphid spp., Potato aphid, Potato aphid, Aphid spp., English wheat aphid, Rose aphid, Rose aphid, Aphid spp., Cotton aphid, Solanum oleraceum, Foxglove aphid, Wheat aphid, Russian aphid, Asparagus aphid, Plantago aphid, Apple pink aphid, Woolly apple aphid, Woolly apple aphid, Wheat aphid, Rose aphid, Green peach aphid, Phylloxera phylloxera, Phylloxera phylloxera, Cabbage aphid, Cabbage aphid, Aphid spp., Aphid, Corn leaf aphid, Corn aphid, Grain aphid, Grain aphid, Wheat aphid, Green aphid;Species of the genus Aphrophora, Amrasca bigutella bigutella, Species of the genus Aphrophora, Leafhoppers, Orange Round Kidney Scale, Orange Round Scale, Rice Flour Scale, Species of the genus Snow Shield, Scale Insects, Red Wax Scale, Red Wax Scale, Species of the genus Snow Shield, Scale Insects, Species of the genus Brown Round Shield, Scale Insects, Species of the genus Soft Scale, Scale Insects, Blowing Scale, Blowing Scale, Species of the genus Oyster Shield, Bran Flake Scale, Bran Flake Scale, Black Shield scale, ebony scale, spruce ball scale, spruce round shield scale, mealybug species, mealybug, mealybug species, mealybug, pineapple mealybug, pineapple mealybug, pear round scale, St. Joseph scale, black helmet scale species, scale insects, olive black helmet scale, black scale insects, arrow scale species, scale insects, arrow scale, arrow scale, and Zulia entreriana. ;

[0019] The composition of the present invention is applicable to, but not limited to, the following crops or plants: cereal crops, such as wheat, barley, rye, oats, rice, corn, sorghum, millet, etc.; tuber crops: including sweet potato, yam, potato, etc.; legume crops: including soybean, broad bean, pea, mung bean, etc.; fiber crops: including cotton, jute, kenaf, hemp, flax, sisal, mat grass, etc.; oil crops: including oilseed, rapan, mustard, peanut, sesame, hemp, sunflower, etc.; Sugar crops: including sugar cane, sugar beet, etc.; beverage crops: including tea, coffee, cocoa, etc.; dye crops: including indigo, saffron, etc.; spice crops: including lemongrass, mint, rose; fodder crops: including alfalfa, sweet clover, astragalus, vetch, clover, etc.; fodder crops: including ryegrass, oat grass, Sudan grass, etc.; green manure crops, such as vetch, astragalus, yellow alfalfa, sweet clover, tamarind, sesbania, amorpha, etc.; fruits, such as apples, pear, plum, peach, almond, cherry, citrus, mango, litchi, banana, grape; or berry, such as strawberry, raspberry or blackberry mustard, poppy, olive, coconut, castor, etc.; vegetable, such as cucumber, loofah, watermelon, melon, pumpkin, hanging melon, spinach, celery, kale, cabbage, cauliflower, gourd, pepper, eggplant, tomato, onion, ginger, garlic, leek, lettuce, kidney bean, cowpea, radish, carrot, yam, etc.; the composition of the present invention can also be used as a For any ornamental plants, including flowers, shrubs, broadleaf trees and evergreens, such as violets, begonias, dahlias, gerberas, hydrangeas, verbenas, roses, kalanchoe, poinsettias, aster, cornflowers, coreopsis, delphiniums, monopetalum, phlox, rhodiola, sedum, petunias, violas, impatiens, geraniums, chrysanthemums, ranunculus, fuchsias, sage, wild woodruff, rosemary, sage, St. John's wort, mint. When used to control urban pests, it can be used in homes, various public places, offices, and trees, etc.

[0020] The technical solution also includes the use of the insecticide and acaricide composition of the present invention in preparing agricultural insecticide and acaricide drugs.

[0021] The insecticide and acaricide composition of the present invention can be applied at an effective dose to the pests / mites to be controlled and / or their habitats.

[0022] Advantages of the present invention: The binary composition obtained by compounding compound I-72 with carbamate insecticides in an appropriate ratio has a good synergistic effect, thereby improving the control effect, reducing the dosage, and expanding the insecticide spectrum. Specifically,

[0023] 1. The two active components A and B in the compound have different mechanisms of action, which can delay the development of resistance of pests and mites. 2. The insecticide spectrum has been expanded, and it can be used to control a variety of pests and mites on various crops such as fruit trees, vegetables, ornamental plants, tea, and cotton; 3. The amount of pesticides used is reduced, the amount of pesticide residues on crops is reduced, and the friendliness to the environment is enhanced. 4. The two active components A and B are compounded within an appropriate ratio range, which improves the control effect of pests and mites such as the striped stem borer, rice brown planthopper, thrips, and peach aphid. DETAILED DESCRIPTION

[0024] The following examples are used to explain the present invention in detail, so as to facilitate further understanding of the present invention. The active component A is selected from compound I-72 (prepared according to the description in the patent document CN112457288, with a content of 97%); the active component B and other raw materials are all commercially available products. The active components in the formula examples are metered and added after 100%, and each component is measured by weight percentage.

[0025] Indoor Activity Assay Example

[0026] Example 1: Indoor joint toxicity test of compound I-72 and carbosulfan mixed with western flower thrips

[0027] Test subjects: Western flower thrips Frankliniella occidentalis, 2nd instar nymphs, sensitive strain reared indoors.

[0028] Preparation of drug solution: According to different test requirements, use an electronic analytical balance to accurately weigh the test samples in Table 1, dissolve the original drug in acetone, and then use 0.1% Tween 80 water to dilute into a series of drug solutions with a certain concentration gradient according to the designed experimental dosage.

[0029] Test conditions: Temperature: 25-27°C, Humidity: RH 60%, Light: L:D=14:10

[0030] Test method: Use the spray method to select greenhouse-grown kidney bean leaves, wrap the petioles with moistened cotton wool and sealing film, spray evenly in the order from low dose to high dose according to the test design, place in a culture dish with a diameter of 6 cm with filter paper, and inoculate the test insects after natural shade drying. Each treatment has 20 heads, repeated 3 times, and a blank control is set up. The number of dead and alive insects is investigated after 48 hours. The corrected mortality rate is calculated using the Abbott formula, and statistical analysis is performed using the DPS data processing software to calculate the toxicity LC of the test single agent and the test mixture at the test ratio. 50 value.

[0031] Evaluation method: Sun YP method was used to calculate the co-toxicity coefficient of each mixture ratio and evaluate the type of combined action of each mixture.

[0032] The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:

[0033]

[0034] Where: ATI-actual toxicity index of the mixture; S-LC of the standard agent 50 ; LC of M-mixture 50 .

[0035] TTI=TIA×PA+TIB×PB

[0036] Where: TTI-theoretical toxicity index of mixture; TIA-toxicity index of A agent; percentage of PA-A agent in the mixture; TIB-toxicity index of B agent; percentage of PB-B agent in the mixture.

[0037]

[0038] Where: CTC-co-toxicity coefficient; ATI-actual toxicity index of mixture; TTI-theoretical toxicity index of mixture.

[0039] The co-toxicity coefficient (CTC) of the compound agent ≥120 shows a synergistic effect; CTC ≤80 shows an antagonistic effect; 80<CTC<120 shows an additive effect.

[0040] As can be seen from the table (Table 1), compound I-72 and carbosulfan mixed at a ratio of 10:1-1:20 showed a synergistic effect against western flower thrips.

[0041] Table 1 Results of indoor combined toxicity test of compound I-72 and carbosulfan against western flower thrips

[0042]

[0043] Example 2: Indoor combined toxicity test of compound I-72 and carbaryl against Chilo suppressalis

[0044] Test target: Chilo suppressalis (Walker), 2nd instar larvae, collected from Nanchang, Jiangxi Province, 11th generation of indoor continuous culture, with high resistance to amides such as chlorantraniliprole.

[0045] Test method: Spray method was used. Rice stalks of uniform length and thickness were selected, cut to the same length, and sprayed evenly in the order from low dose to high dose according to the test design. 1.5 mL of the solution was placed in a 6 cm diameter culture dish with filter paper for each treatment. After natural shade drying, neat healthy test insects were inoculated. Each treatment was repeated 3 times, and a blank control was set up.

[0046] The treated test material is placed in an observation room, and the temperature, humidity and light of the observation room can be adjusted as needed. The test conditions, preparation of the drug solution and the evaluation method are the same as those in Example 1.

[0047] As can be seen from the table (Table 2), compound I-72 and carbaryl mixed at a ratio of 1:1-1:60 showed a synergistic effect against western flower thrips.

[0048] Table 2 Results of indoor combined toxicity test of compound I-72 and carbaryl against Chilo suppressalis

[0049]

[0050] Example 3: Indoor combined toxicity test of compound I-72 and fambutylcarb against elm leaf beetle

[0051] Test target: Pyrrhalta aenescens, indoor reared strain

[0052] Test method: The insect immersion method was used. Elm leaf beetles of the same size were selected and placed in the insect immersion cage. The insects were sprayed evenly in the order from low dose to high dose according to the test design. Each treatment was immersed for 10 seconds, and then placed in a culture dish with a diameter of 9 cm and filter paper. After natural shade drying, feed was placed in the dish. Each treatment was repeated 3 times, and a blank control was set up.

[0053] The treated test material is placed in an observation room, and the total number of test insects and the number of dead insects are investigated for 24 hours. The temperature, humidity and light of the observation room can be adjusted as needed. The test conditions, preparation of the drug solution and the evaluation method are the same as those in Example 1.

[0054] As can be seen from the table (Table 3), compound I-72 and famcarb mixed at a ratio of 10:1-1:40 showed a synergistic effect against the elm leaf beetle.

[0055] Table 3 Results of indoor combined toxicity test of compound I-72 and famoxadicarb against elm leaf beetles

[0056]

Claims

1. A synergistic composition containing carbamate insecticides, characterized in that: The composition comprises two active components, component A and component B, wherein component A is selected from the piperic acid derivative compounds of the following structure, and component B is selected from carbosulfan, carbaryl or fenbucarb; the weight ratio of the two active components, component A and component B, is 1:60 to 60:1; wherein the structural formula of the piperic acid derivative compounds is as follows:

2. The composition according to claim 1, characterized in that: Component A in the composition is selected from compounds of capsaicin derivatives; component B is selected from carbosulfan; The weight ratio of the two active components A and B is 1:20 to 10:

1.

3. The composition according to claim 1, characterized in that: Component A in the composition is selected from compounds of piperic acid derivatives; component B is selected from carbaryl; The weight ratio of the two active components, component A and component B, is 1:60 to 1:

1.

4. The composition according to claim 1, characterized in that: Component A in the composition is selected from compounds of capsic acid derivatives; component B is selected from fenbucarb; The weight ratio of the two active components A and B is 1:40 to 10:

1.

5. The use of the composition according to claim 1, characterized in that: The composition is used for preparing insecticides and miticides for preventing and controlling western flower thrips, striped stem borers and elm leaf beetles on fruit trees, vegetables, ornamental plants, tea, cotton and cereal crops.

Images