A high-barrier biomedical consumable and a preparation method thereof

Abstract

The present invention relates to the field of polymer technology, and specifically discloses a high-barrier biomedical consumable and a preparation method thereof, wherein the consumable comprises the following raw materials in parts by weight: 50-80 parts of modified polypropylene resin, 1-3 parts of a cross-linking agent, 0.8-2.5 parts of an auxiliary cross-linking agent, and 0.2-0.8 parts of a dispersant; wherein the cross-linking agent is an organic peroxide cross-linking agent, and the number of the contained -O-O- groups is 1-2. The consumable provided by the present invention is a high-performance polypropylene consumable containing a cross-linking agent, having excellent cross-linking effect, good barrier properties, excellent mechanical properties, and strong dimensional stability. When applied to biomedical consumables such as polypropylene blow-injected medicine bottles and bottle caps, the performance advantages are significant.

Description

Technical Field

[0001] The invention belongs to the field of polymer technology, and in particular relates to a high-barrier biomedical consumable material and a preparation method thereof. Background Art

[0002] Polypropylene (PP) is made of propylene monomers and is widely used in the automotive industry, household appliances, electronics, packaging, building materials and furniture. At present, PP bottle caps are mainly produced by injection molding or compression molding. Since PP is a semi-crystalline material with a large shrinkage rate, the molding cooling time and pressure holding time of the injection molding machine or compression molding machine must be extended during the production process to prevent the appearance of the product from shrinking, warping, irregular internal teeth and other defective products. However, this series of operations will lead to a decrease in production efficiency.

[0003] In the prior art, the most commonly used means of modifying polypropylene is to reduce the shrinkage rate of polypropylene by adding filler masterbatch. However, the method of directly adding filler masterbatch will not only affect the physical properties of polypropylene materials, such as adverse effects on its surface gloss and mechanical properties, but also, when polypropylene is used in industries with very strict hygiene requirements such as beverages, food and medicine, the addition of a large amount of filler masterbatch will pose a great safety hazard.

[0004] The invention patent with application number CN201310160809.6 discloses a special modified material for polypropylene bottle caps and a preparation method thereof. The modified material for polypropylene bottle caps can reduce the shrinkage rate of polypropylene bottle caps, prevent the bottle caps from being too small in size and having irregular inner teeth, eliminate warping and deformation, provide excellent dimensional stability for the products, and accelerate the crystallization rate of polypropylene bottle caps, shorten the molding cycle of products, improve the molding efficiency of products, and increase factory profits. In addition, its components are safe and reliable, and the polypropylene bottle caps made therefrom can be used in the beverage, food and pharmaceutical industries. However, when the modified material for polypropylene bottle caps is used in the field of biomedical consumables, its barrier properties are insufficient, and its mechanical properties still have room for improvement.

[0005] In view of this, it is particularly important for the present invention application to disclose a high-barrier biomedical consumable. Summary of the invention

[0006] In view of the defects of the prior art, the present invention provides a high-barrier biomedical consumable and a preparation method thereof. The consumable is a high-performance polypropylene consumable containing a cross-linking agent, having excellent cross-linking effect, good barrier properties, excellent mechanical properties and strong dimensional stability. When applied to biomedical consumables such as polypropylene blow-injected medicine bottles and bottle caps, the performance advantages are particularly significant.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0008] On one hand, the present invention provides a high-barrier biomedical consumable, which comprises the following raw materials in parts by weight: 50 to 80 parts of modified polypropylene resin, 1 to 3 parts of a cross-linking agent, 0.8 to 2.5 parts of a co-cross-linking agent, and 0.2 to 0.8 parts of a dispersant;

[0009] Wherein, the cross-linking agent is an organic peroxide cross-linking agent, and the number of -OO- groups contained is 1-2.

[0010] In some embodiments of the present invention, the modified polypropylene resin is a calcium carbonate modified polypropylene resin.

[0011] In some embodiments of the present invention, the preparation steps of the calcium carbonate modified polypropylene resin are as follows:

[0012] Add nano calcium carbonate and antioxidant into the reactor in sequence, mix well and then add polypropylene resin for blending, transfer to a high-speed mixer, stir at a speed of 700-1000 r / min, stir for 2-5 minutes, and obtain the calcium carbonate modified polypropylene resin.

[0013] Preferably, the preparation steps of the calcium carbonate modified polypropylene resin are as follows:

[0014] Add nano calcium carbonate and antioxidant into the reactor in sequence, mix well, add polypropylene resin for blending, transfer to a high-speed mixer, stir at a speed of 850 r / min, stir for 3.5 minutes, and obtain the calcium carbonate modified polypropylene resin.

[0015] In some embodiments of the present invention, the mass ratio of the nano calcium carbonate to the polypropylene resin is 1:(2-2.6).

[0016] Preferably, the mass ratio of the nano calcium carbonate to the polypropylene resin is 1:2.3.

[0017] Preferably, the antioxidant is added in an amount of 0.1-0.5% of the total mass of the nano-calcium carbonate and the polypropylene resin.

[0018] Further preferably, the added amount of the antioxidant is 0.3% of the total mass of the nano-calcium carbonate and the polypropylene resin.

[0019] More preferably, the antioxidant is antioxidant 1010.

[0020] The present invention premixes nano calcium carbonate with an antioxidant, and then melt-blends the mixture with a polypropylene resin to obtain a filler-modified polypropylene resin. The applicant adjusts the mass ratio to uniformly disperse the nano filler in the matrix resin, thereby preventing the filler from forming larger agglomerates consisting of loose powder in the matrix, thereby ensuring the toughening effect. At the same time, it is found that the crystallization temperature and melting point of the modified polypropylene resin are improved, which may be due to the fact that the nano calcium carbonate can play the role of a nucleating agent in the matrix, thereby assisting in improving the impact strength of biomedical consumables, reducing deformation, and increasing dimensional stability.

[0021] In some embodiments of the present invention, the preparation steps of the cross-linking agent are as follows:

[0022] Add tert-butyl hydroperoxide and a dehydrating agent into a reactor, carry out a dehydration reaction at room temperature, then add 3,4-dihydroxybenzoic acid into the reactor, raise the temperature to 35-55°C, react for 20-60 minutes, and after the reaction is completed, wash, separate and dry to obtain a cross-linking agent.

[0023] Preferably, the preparation steps of the cross-linking agent are as follows:

[0024] Add tert-butyl hydroperoxide and a dehydrating agent into a reactor, carry out a dehydration reaction at room temperature, then add 3,4-dihydroxybenzoic acid into the reactor, raise the temperature to 45°C, react for 40 minutes, and after the reaction is completed, wash with water, separate the liquids and dry to obtain a crosslinking agent.

[0025] In some embodiments of the present invention, the dehydrating agent is acetic anhydride.

[0026] In some embodiments of the present invention, the mass ratio of the tert-butyl hydroperoxide to the dehydrating agent is 1:(1.5-3).

[0027] Preferably, the mass ratio of the tert-butyl hydroperoxide to the dehydrating agent is 1:2.25.

[0028] Further preferably, the mass fraction of the tert-butyl hydroperoxide is 70%.

[0029] In the prior art, when tert-butyl hydroperoxide is used for synthesis reaction, toluene is often added to stand and separate the liquid to remove water, and then an acidic catalyst is added to further catalyze the synthesis. Not only is the synthesis process complicated and the reaction cycle long, but the commonly used perchloric acid catalyst is extremely unstable, easy to decompose and easy to explode when heated. In view of this, the present invention preferably adds acetic anhydride during synthesis and makes acetic anhydride and water of tert-butyl hydroperoxide react preferentially by adjusting the preferred steps and mass ratio. The obtained product acetic acid is used as a catalyst for further synthesis reaction, and the reaction is promoted to proceed in the forward direction, thereby improving the yield and quality to a certain extent.

[0030] In some embodiments of the present invention, the molar ratio of tert-butyl hydroperoxide to 3,4-dihydroxybenzoic acid is 1:(1-1.2).

[0031] Preferably, the molar ratio of tert-butyl hydroperoxide to 3,4-dihydroxybenzoic acid is 1:1.1.

[0032] The applicant controls the amount of tert-butyl hydroperoxide added so that the two hydroxyl groups in 3,4-dihydroxybenzoic acid are not completely reacted, thereby generating a mixed crosslinking agent of a single-substituted substance and a fully substituted substance. The prepared crosslinking agent is an organic peroxide crosslinking agent with a high active oxygen content and a strong reaction activity of initiating free radicals. When it is thermally decomposed, free radicals are generated to crosslink the molecular chains of the polypropylene resin to significantly improve the toughness and strength of the polypropylene resin. On the other hand, the phenolic hydroxyl group is oxidized to a quinone structure, which reacts with the amino group in the dispersant to form a covalent bond crosslinking network, further increasing the crosslinking efficiency and effect, thereby increasing the high barrier performance of the system. When used in biomedical consumables such as medicine bottles and bottle caps blown by polypropylene resin, the performance is excellent. At the same time, the formation of the crosslinking structure simultaneously reduces the content of the introduced hydrophilic groups, reduces the possible water swelling, and ensures the water resistance of the consumables.

[0033] In some embodiments of the present invention, the auxiliary cross-linking agent is trimethylolpropane trimethacrylate.

[0034] The applicant also found that it is preferred to add a multifunctional monomer trimethylolpropane trimethacrylate as a co-crosslinking agent and control the amount of addition to further improve the crosslinking degree of the system. The possible reason is that the co-crosslinking agent, on the one hand, forms more stable new free radicals by adding to the tertiary carbon free radicals of polypropylene; on the other hand, it reacts with the free radicals through unsaturated double bonds to form crosslinking points, thereby promoting crosslinking and ultimately improving the crosslinking efficiency.

[0035] Preferably, the dispersant is tert-butylaminoethyl methacrylate.

[0036] Another aspect of the present invention provides a method for preparing a high-barrier biomedical consumable, comprising the following steps:

[0037] Add modified polypropylene resin, crosslinking agent, auxiliary crosslinking agent and dispersant into the reactor, stir and mix evenly, and pass through a twin-screw extruder with the temperature set at 190-220° C. to extrude and granulate to obtain the biopharmaceutical consumables.

[0038] Compared with the prior art, the present invention has the following beneficial effects:

[0039] (1) The present invention provides a high-barrier biomedical consumable. The polypropylene consumable is a high-performance consumable containing a cross-linking agent, having excellent cross-linking effect, good barrier properties, excellent mechanical properties and strong dimensional stability. When used in biomedical consumables such as polypropylene blow-molded medicine bottles and bottle caps, the performance advantages are particularly significant.

[0040] (2) The present invention premixes nano-calcium carbonate and an antioxidant, and melt-blends them with a polypropylene resin to obtain a filler-modified polypropylene resin. The mass ratio is adjusted to uniformly disperse the nano-filler in the matrix resin, thereby preventing the filler from forming larger agglomerates composed of loose powder in the matrix, thereby ensuring a toughening effect. At the same time, the nano-calcium carbonate plays a certain role as a nucleating agent when modifying the polypropylene resin, thereby assisting in improving the impact strength of the consumables, reducing deformation, and increasing dimensional stability.

[0041] (3) The present invention adds acetic anhydride during the synthesis of the cross-linking agent and adjusts the preferred steps and mass ratio to allow acetic anhydride and water of tert-butyl hydroperoxide to react preferentially. The obtained product acetic acid serves as a catalyst for further synthesis reaction and promotes the reaction to proceed in the forward direction, thereby improving the quality of the cross-linking agent to a certain extent.

[0042] (4) The present invention controls the amount of tert-butyl hydroperoxide added to prepare an organic peroxide cross-linking agent with a high active oxygen content and a strong reaction activity of initiating free radicals. When it is decomposed by heat, free radicals are generated to cross-link the molecular chains of the polypropylene resin to significantly improve the toughness and strength of the polypropylene resin. On the other hand, the phenolic hydroxyl group is oxidized to a quinone structure, which reacts with the amino group in the preferred dispersant to form a covalent bond cross-linking network, further increasing the cross-linking efficiency and effect, thereby increasing the high barrier performance of the system. At the same time, the formation of the cross-linking structure simultaneously reduces the content of the introduced hydrophilic group, reduces the possible water swelling, and ensures the water resistance of the consumables.

[0043] (5) The present invention further improves the crosslinking degree of the system and assists in improving the crosslinking efficiency by adding the multifunctional monomer trimethylolpropane trimethacrylate as a co-crosslinking agent and controlling the added amount. DETAILED DESCRIPTION

[0044] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0045] If not otherwise specified, the reagents used below can be easily obtained from commercial companies, among which polypropylene resin was purchased from Sinopec (Beijing) Chemical Research Institute Co., Ltd.; nano calcium carbonate with a particle size of 50 nm was purchased from Jincheng Yangming Nano New Materials Co., Ltd.; polyethylene wax was purchased from Shanghai Joule Wax Co., Ltd.

[0046] Preparation Example 1

[0047] The preparation steps of modified polypropylene resin I are as follows:

[0048] 10 g of nano calcium carbonate and 0.1 g of antioxidant 1010 were added to the reactor in sequence, and after mixing evenly, 23 g of polypropylene resin was added and blended. The mixture was transferred to a high-speed mixer with a stirring speed of 850 r / min and stirred for 3.5 min to obtain modified polypropylene resin I.

[0049] Preparation Example 2

[0050] The preparation steps of modified polypropylene resin II are as follows:

[0051] 10 g of nano calcium carbonate and 0.09 g of antioxidant 1010 were added to the reactor in sequence, and after mixing evenly, 19 g of polypropylene resin was added and blended. The mixture was transferred to a high-speed mixer with a stirring speed of 850 r / min and stirred for 3.5 min to obtain modified polypropylene resin II.

[0052] Preparation Example 3

[0053] The preparation steps of modified polypropylene resin III are as follows:

[0054] 10 g of nano calcium carbonate and 0.11 g of antioxidant 1010 were added to the reactor in sequence, and after mixing evenly, 27 g of polypropylene resin was added for blending. The mixture was transferred to a high-speed mixer with a stirring speed of 850 r / min and stirred for 3.5 min to obtain modified polypropylene resin III.

[0055] Preparation Example 4

[0056] The preparation steps of the first cross-linking agent are as follows:

[0057] 5 g of tert-butyl hydroperoxide and 11.25 g of acetic anhydride were added to the reactor, and a dehydration reaction was carried out at room temperature. Then 10.78 g of 3,4-dihydroxybenzoic acid was added to the reactor, and the temperature was raised to 45° C. and the reaction was carried out for 40 minutes. After the reaction was completed, the first cross-linking agent was obtained by washing with water, separating the liquids and drying.

[0058] Preparation Example 5

[0059] The preparation steps of the second cross-linking agent are as follows:

[0060] 5 g of tert-butyl hydroperoxide and 11.25 g of acetic anhydride were added to the reactor, and a dehydration reaction was carried out at room temperature. Then 7.70 g of 3,4-dihydroxybenzoic acid was added to the reactor, and the temperature was raised to 45° C. and the reaction was carried out for 40 minutes. After the reaction was completed, the second cross-linking agent was obtained by washing with water, separating the liquids and drying.

[0061] Preparation Example 6

[0062] The preparation steps of the third cross-linking agent are as follows:

[0063] 5 g of tert-butyl hydroperoxide and 11.25 g of acetic anhydride were added to the reactor, and a dehydration reaction was carried out at room temperature. Then 12.32 g of 3,4-dihydroxybenzoic acid was added to the reactor, and the temperature was raised to 45° C. and the reaction was carried out for 40 minutes. After the reaction was completed, the third cross-linking agent was obtained by washing with water, separating the liquids and drying.

[0064] Example 1

[0065] A high-barrier biomedical consumable, the consumable comprising the following raw materials in parts by weight: 75 parts of modified polypropylene resin I, 2 parts of a first cross-linking agent, 1.65 parts of trimethylolpropane trimethacrylate, and 0.5 parts of tert-butylaminoethyl methacrylate;

[0066] The method for preparing the high-barrier biomedical consumables of this embodiment comprises the following steps:

[0067] Add modified polypropylene resin I, the first crosslinking agent, trimethylolpropane trimethacrylate and tert-butylaminoethyl methacrylate into the reactor, stir and mix evenly, and extrude and granulate through a twin-screw extruder at a temperature set to 205° C. to obtain the biopharmaceutical consumables.

[0068] Example 2

[0069] A high-barrier biomedical consumable, the consumable comprising the following raw materials in parts by weight: 50 parts of modified polypropylene resin I, 1 part of a first cross-linking agent, 0.8 parts of trimethylolpropane trimethacrylate, and 0.2 parts of tert-butylaminoethyl methacrylate;

[0070] The method for preparing the high-barrier biomedical consumables of this embodiment comprises the following steps:

[0071] Add modified polypropylene resin I, the first crosslinking agent, trimethylolpropane trimethacrylate and tert-butylaminoethyl methacrylate into the reactor, stir and mix evenly, and extrude and granulate through a twin-screw extruder at a temperature set to 220° C. to obtain the biopharmaceutical consumables.

[0072] Example 3

[0073] A high-barrier biomedical consumable, the consumable comprising the following raw materials in parts by weight: 80 parts of modified polypropylene resin I, 3 parts of a first cross-linking agent, 2.5 parts of an auxiliary cross-linking agent, and 0.8 parts of tert-butylaminoethyl methacrylate;

[0074] The method for preparing the high-barrier biomedical consumables of this embodiment comprises the following steps:

[0075] Add modified polypropylene resin I, the first crosslinking agent, trimethylolpropane trimethacrylate and tert-butylaminoethyl methacrylate into the reactor, stir and mix evenly, and extrude and granulate through a twin-screw extruder at a temperature set to 190° C. to obtain the biopharmaceutical consumables.

[0076] Example 4

[0077] A high-barrier biomedical consumable and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of modified polypropylene resin II replaces modified polypropylene resin I.

[0078] Example 5

[0079] A high-barrier biomedical consumable and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that modified polypropylene resin III is used to replace modified polypropylene resin I in equal amounts.

[0080] Example 6

[0081] A high-barrier biomedical consumable and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of a second cross-linking agent is used to replace the first cross-linking agent.

[0082] Example 7

[0083] A high-barrier biomedical consumable and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that the first cross-linking agent is replaced by an equal amount of a third cross-linking agent.

[0084] Comparative Example 1

[0085] A high-barrier biomedical consumable and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that tert-butylaminoethyl methacrylate is replaced by an equal amount of polyethylene wax.

[0086] Comparative Example 2

[0087] A high-barrier biomedical consumable and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of polypropylene resin is used to replace modified polypropylene resin I.

[0088] Example 8

[0089] A high-barrier biomedical consumable and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of dibenzoyl peroxide is used to replace the first cross-linking agent.

[0090] Performance testing.

[0091] The biomedical consumables obtained in the above examples and comparative examples were subjected to the following performance tests:

[0092] (1) Mechanical properties test: The biomedical consumables obtained in the above embodiments and comparative examples were made into long strip samples with a length of 150 mm, a width of 10 mm, and a gauge length of 50 mm, and tensile and impact properties were tested. The tensile properties were tested in accordance with the standard GB / T 1040.2-2006; the impact properties were tested in accordance with the standard GB / T1043.1-2008.

[0093] (2) Barrier performance test: The biopharmaceutical consumables obtained in the above-mentioned embodiments and comparative examples were blow molded to obtain polypropylene medicine bottles with a bottle wall thickness of (0.3±0.05) mm. An oxygen permeability test was performed on a differential pressure oxygen permeability tester using 99.99% high-purity nitrogen as a carrier to represent the barrier performance. The higher the oxygen permeability, the worse the barrier performance.

[0094] Table 1

[0095] Tensile strength / MPa <![CDATA[Impact strength / KJ / m 2 > Oxygen transmission rate / % Example 1 36.7 3.3 0.6 Example 2 35.9 3.4 0.9 Example 3 36.2 3.5 0.8 Example 4 37.5 2.2 1.5 Example 5 32.6 1.9 1.9 Example 6 35.3 2.8 2.6 Example 7 34.7 2.4 2.8 Comparative Example 1 34.1 1.7 3.1 Comparative Example 2 25.9 1.0 1.4 Example 8 32.2 1.8 3.4

[0096] As can be seen from Table 1, the high-barrier biomedical consumables provided by Examples 1 to 3 of the present invention have good barrier properties, excellent mechanical properties, and significant performance advantages; Examples 4 and 5 change the preparation conditions of the modified polypropylene resin, and the agglomeration of nano-calcium carbonate may occur, resulting in stress concentration and defects, which weaken the strength and reduce the toughness of the consumables. The formation of larger agglomerates composed of loose powders also has a certain impact on the barrier properties of the consumables; Examples 6 and 7 change the amount of tert-butyl hydroperoxide added in the preparation process of the cross-linking agent. Due to the escape of tert-butyl hydroperoxide during the reaction, its substitution reaction on the hydroxyl group is affected, thereby affecting the quality of the cross-linking agent, resulting in the consumables. The cross-linking effect of the system is poor, which affects the comprehensive performance of the consumables. Comparison of the test data of Example 1 and Comparative Example 1 shows that the cross-linking agent preferably prepared in the present invention can synergize with the specific dispersant of the system, tert-butylaminoethyl methacrylate, to exert stronger cross-linking activity, achieve better cross-linking effect, and greatly improve the barrier performance of the consumables. At the same time, the tensile strength and impact strength of the consumables are also greatly improved. Unmodified polypropylene resin is added in Comparative Example 2, resulting in a significant decrease in the tensile strength and impact strength of the consumables. Example 8 adds dibenzoyl peroxide as a cross-linking agent, and its cross-linking activity in this system is lower than that of the first cross-linking agent specifically prepared in the present invention. Affected by the cross-linking effect, the barrier performance of the consumables decreases.

[0097] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technician familiar with this profession can make some changes or modifications to equivalent embodiments of equivalent changes using the technical contents disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A high barrier biomedical consumables, characterized in that: The consumables include the following raw materials in parts by weight: 50 to 80 parts of modified polypropylene resin, 1 to 3 parts of a cross-linking agent, 0.8 to 2.5 parts of a co-cross-linking agent, and 0.2 to 0.8 parts of a dispersant; Wherein, the cross-linking agent is an organic peroxide cross-linking agent, and the number of -OO- groups contained is 1 to 2; The modified polypropylene resin is calcium carbonate modified polypropylene resin; The preparation steps of the calcium carbonate modified polypropylene resin are as follows: Add nano calcium carbonate and antioxidant in the reactor in sequence, mix well, add polypropylene resin and blend, transfer to a high-speed mixer, stir at a speed of 700 to 1000 r / min, stir for 2 to 5 minutes, and obtain the calcium carbonate modified polypropylene resin; The mass ratio of the nano calcium carbonate to the polypropylene resin is 1:(2-2.6); The preparation steps of the cross-linking agent are as follows: Add tert-butyl hydroperoxide and a dehydrating agent into a reactor, perform a dehydration reaction at room temperature, then add 3,4-dihydroxybenzoic acid into the reactor, raise the temperature to 35-55° C., react for 20-60 minutes, and wash, separate and dry after the reaction to obtain a crosslinking agent; The dehydrating agent is acetic anhydride; The mass ratio of the tert-butyl hydroperoxide to the dehydrating agent is 1:(1.5-3); The molar ratio of tert-butyl hydroperoxide to 3,4-dihydroxybenzoic acid is 1:(1-1.2); The dispersant is tert-butylaminoethyl methacrylate.

2. A high barrier biomedical consumable according to claim 1, characterized in that: The auxiliary cross-linking agent is trimethylolpropane trimethacrylate.

3. A method for preparing the high barrier biomedical consumables according to any one of claims 1 to 2, characterized in that: The following steps are involved: Add modified polypropylene resin, crosslinking agent, auxiliary crosslinking agent and dispersant into the reactor, stir and mix evenly, and extrude and granulate through a twin-screw extruder at a temperature set at 190-220° C. to obtain the biopharmaceutical consumables.